{"id":"https://openalex.org/W4408552002","doi":"https://doi.org/10.1021/jacs.5c00470","title":"Enantioselective Biosynthesis of (+)- and (\u2212)-Auranthines","display_name":"Enantioselective Biosynthesis of (+)- and (\u2212)-Auranthines","publication_year":2025,"publication_date":"2025-03-18","ids":{"openalex":"https://openalex.org/W4408552002","doi":"https://doi.org/10.1021/jacs.5c00470","pmid":"https://pubmed.ncbi.nlm.nih.gov/40099513"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.5c00470","doi":"https://doi.org/10.1021/jacs.5c00470","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5c00470","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059879383","display_name":"Shinji Kishimoto","orcid":"https://orcid.org/0000-0003-4318-6805","observed_orcids":["https://orcid.org/0000-0003-4318-6805"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Kishimoto","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Shizuoka"],"raw_orcid":"https://orcid.org/0000-0003-4318-6805","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Shizuoka","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063566389","display_name":"Tsubasa Tamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsubasa Tamura","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Shizuoka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Shizuoka","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000909481","display_name":"Takumi Okamoto","orcid":"https://orcid.org/0000-0002-2002-3715","observed_orcids":["https://orcid.org/0000-0002-2002-3715"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takumi Okamoto","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Shizuoka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Shizuoka","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035244813","display_name":"Kenji Watanabe","orcid":"https://orcid.org/0000-0002-0463-4831","observed_orcids":["https://orcid.org/0000-0002-0463-4831"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Watanabe","raw_affiliation_strings":["Department of Pharmaceutical Sciences","University of Shizuoka"],"raw_orcid":"https://orcid.org/0000-0002-0463-4831","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"University of Shizuoka","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035244813"],"corresponding_institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.8638,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.93712658,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"147","issue":"12","first_page":"10612","last_page":"10617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillus-lentulus","display_name":"Aspergillus lentulus","score":0.8450000286102295},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/epimerization","display_name":"epimerization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/anthranilic-acid","display_name":"anthranilic acid","score":0.843999981880188},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9614112973213196},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.9224767684936523},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5985651612281799},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26541128754615784},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.17511281371116638},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07879266142845154}],"mesh":[{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.5c00470","doi":"https://doi.org/10.1021/jacs.5c00470","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5c00470","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:40099513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40099513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1756637430","display_name":null,"funder_award_id":"22H05121","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3727836411","display_name":"Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymes","funder_award_id":"22H04979","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4483207381","display_name":null,"funder_award_id":"22H05119","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7205166042","display_name":"Toward engineered biosynthesis of drugs in human cells","funder_award_id":"22K19158","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8035553924","display_name":"Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymes","funder_award_id":"22H00362","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8355249261","display_name":"\u30a2\u30ba\u30e9\u30af\u30c8\u30f3\u3092\u5408\u6210\u3059\u308b\u975e\u30ea\u30dc\u30bd\u30fc\u30e0\u30da\u30d7\u30c1\u30c9\u5408\u6210\u9175\u7d20\u306e\u89e6\u5a92\u6a5f\u69cb\u89e3\u660e","funder_award_id":"24K08731","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320322525","display_name":"Secom Science and Technology Foundation","ror":"https://ror.org/05ggzej07"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2006673908","https://openalex.org/W2022845961","https://openalex.org/W2027876986","https://openalex.org/W2045809294","https://openalex.org/W2048186673","https://openalex.org/W2049709457","https://openalex.org/W2061974499","https://openalex.org/W2071834209","https://openalex.org/W2072754741","https://openalex.org/W2104539795","https://openalex.org/W2140624283","https://openalex.org/W2147240347","https://openalex.org/W2252553152","https://openalex.org/W2895874698","https://openalex.org/W2952039249","https://openalex.org/W3177828909","https://openalex.org/W3190579890","https://openalex.org/W4220964158","https://openalex.org/W4310058955","https://openalex.org/W4390579575"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"In":[0],"nature,":[1],"organisms":[2],"produce":[3],"various":[4],"bioactive":[5],"natural":[6,52],"products":[7],"(NPs).":[8],"Most":[9],"NPs":[10,21],"target":[11],"naturally":[12],"occurring":[13],"macromolecules,":[14],"such":[15],"as":[16,142,216],"proteins":[17],"and":[18,110,123,132,137,158,187,201],"nucleotides.":[19],"Thus,":[20],"are":[22,35,46,139],"produced":[23,78,93],"in":[24,37,84,127],"a":[25,60,64,87,217],"stereocontrolled":[26],"manner":[27],"except":[28],"for":[29,101,146],"the":[30,38,55,70,128,144,147,166,180,192,224,234,248],"cases":[31],"where":[32],"nonenzymatic":[33],"reactions":[34],"involved":[36,126],"biosynthesis.":[39],"This":[40,219],"is":[41,77,92,143,178,183,197],"why":[42],"stereoisomers,":[43],"especially":[44],"enantiomers,":[45],"rarely":[47],"found":[48,204],"among":[49],"metabolites":[50,243],"from":[51],"sources.":[53],"During":[54],"biosynthetic":[56,99],"study":[57,220],"of":[58,72,130,155,161,191,227,237,241,247],"auranthine,":[59],"fungal":[61,250],"NP":[62],"containing":[63],"nitrile":[65],"group,":[66],"we":[67],"discovered":[68],"that":[69,115,177,196],"(\u2212)-isomer":[71],"auranthine":[73],"(":[74],"1":[75,131,200],")":[76],"by":[79,94,106,185,208,244],"Aspergillus":[80],"lentulus":[81],"strains":[82,246],"isolated":[83,96],"Japan,":[85],"while":[86],"previously":[88],"unreported":[89],"(+)-enantiomer":[90],"2":[91,202],"those":[95],"elsewhere.":[97],"The":[98],"genes":[100],"both":[102],"isomers":[103],"were":[104,125],"determined":[105],"transcriptomic,":[107],"gene":[108],"deletion,":[109],"heterologous":[111],"expression":[112],"experiments,":[113],"revealing":[114],"two":[116,153],"different":[117,245],"nonribosomal":[118],"peptide":[119,167],"synthetases":[120],"(NRPSs)":[121],"NitA":[122,136,186],"NitC":[124,138,171],"biosynthesis":[129,190,231],"2,":[133],"respectively.":[134],"Both":[135],"bimodular":[140],"NRPSs,":[141],"case":[145],"asperlicin-synthesizing":[148],"enzyme":[149],"AspA.":[150],"All":[151],"incorporate":[152],"molecules":[154],"anthranilic":[156],"acid":[157,163,230],"one":[159],"molecule":[160],"amino":[162,229],"to":[164,205],"form":[165],"core.":[168],"However,":[169],"only":[170,223],"contains":[172],"an":[173,209,238],"epimerization":[174],"domain,":[175],"suggesting":[176],"how":[179],"enantiomeric":[181,239],"pair":[182,240],"biosynthesized":[184],"NitC.":[188],"Furthermore,":[189],"nitrile-bearing":[193],"l":[194,214],"-\u03b3-cyanohomoalanine":[195],"incorporated":[198],"into":[199],"was":[203],"be":[206],"catalyzed":[207],"argininosuccinate":[210],"synthetase-like":[211],"NitB":[212],"using":[213],"-glutamine":[215],"substrate.":[218],"reports":[221],"not":[222],"unique":[225],"mechanism":[226],"nitrile-containing":[228],"but":[232],"also":[233],"intriguing":[235],"production":[236],"secondary":[242],"same":[249],"species":[251],"(250/250).":[252]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}