{"id":"https://openalex.org/W4408536636","doi":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","title":"Discovery of novel Quinazoline based Thiazolotriazole hybrids as potential EGFR inhibitor: Synthesis, anticancer evaluation and in silico studies","display_name":"Discovery of novel Quinazoline based Thiazolotriazole hybrids as potential EGFR inhibitor: Synthesis, anticancer evaluation and in silico studies","publication_year":2025,"publication_date":"2025-01-18","ids":{"openalex":"https://openalex.org/W4408536636","doi":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261"},"language":"en","primary_location":{"id":"doi:10.62110/sciencein.cbl.2025.v12.1261","doi":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","is_oa":true,"landing_page_url":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","pdf_url":null,"source":{"id":"https://openalex.org/S4306505971","display_name":"Chemical Biology Letters","issn_l":"2347-9825","issn":["2347-9825"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115727440","display_name":"MD Farveen","orcid":"https://orcid.org/0009-0005-5550-346X","observed_orcids":["https://orcid.org/0009-0005-5550-346X"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"MD Farveen","raw_affiliation_strings":["Osmania University, Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osmania University, Hyderabad","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088393012","display_name":"Sudhakar Kalagara","orcid":"https://orcid.org/0000-0002-2374-9167","observed_orcids":["https://orcid.org/0000-0002-2374-9167"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhakar Kalagara","raw_affiliation_strings":["The University of Texas at EI Paso, EI Paso, TX-79968, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at EI Paso, EI Paso, TX-79968, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119151457","display_name":"E. Balraju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"E. Balraju","raw_affiliation_strings":["Osmania University, Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osmania University, Hyderabad","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116665246","display_name":"B. Jaysree","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Jaysree","raw_affiliation_strings":["Telangana Mahila Viswavidyalayam, Koti, Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telangana Mahila Viswavidyalayam, Koti, Hyderabad","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063032434","display_name":"Ayub Shaik","orcid":"https://orcid.org/0000-0003-2000-9347","observed_orcids":["https://orcid.org/0000-0003-2000-9347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayub Shaik","raw_affiliation_strings":["Telangana Mahila Viswavidyalayam, Koti, Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telangana Mahila Viswavidyalayam, Koti, Hyderabad","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066287423","display_name":"Bilal Alia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Begum Alia","raw_affiliation_strings":["Telangana Mahila Viswavidyalayam, Koti, Hyderabad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telangana Mahila Viswavidyalayam, Koti, Hyderabad","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.791,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58990122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"12","issue":"2","first_page":"1261","last_page":"1261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.39329999685287476,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinazolines","display_name":"quinazolines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":1.0},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.777999997138977},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7734661102294922},{"id":"https://openalex.org/C2778866207","wikidata":"https://www.wikidata.org/wiki/Q426278","display_name":"Quinazoline","level":2,"score":0.7084060311317444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44731009006500244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41805434226989746},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.341630756855011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28302550315856934},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.24405691027641296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19256946444511414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.62110/sciencein.cbl.2025.v12.1261","doi":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","is_oa":true,"landing_page_url":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","pdf_url":null,"source":{"id":"https://openalex.org/S4306505971","display_name":"Chemical Biology Letters","issn_l":"2347-9825","issn":["2347-9825"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology Letters","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.62110/sciencein.cbl.2025.v12.1261","doi":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","is_oa":true,"landing_page_url":"https://doi.org/10.62110/sciencein.cbl.2025.v12.1261","pdf_url":null,"source":{"id":"https://openalex.org/S4306505971","display_name":"Chemical Biology Letters","issn_l":"2347-9825","issn":["2347-9825"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386851396","https://openalex.org/W7124935048","https://openalex.org/W4408481017","https://openalex.org/W2896235985","https://openalex.org/W4405952593","https://openalex.org/W4409698602","https://openalex.org/W4415581259","https://openalex.org/W7165193795","https://openalex.org/W7128741965","https://openalex.org/W3009922507"],"abstract_inverted_index":{"Significant":[0],"efforts":[1],"have":[2],"been":[3],"made":[4],"to":[5,91],"design":[6],"and":[7,17,54,66,78,99],"synthesize":[8],"novel":[9],"series":[10],"of":[11,37,86,116],"quinazoline":[12],"based":[13],"thiazolotriazole":[14],"analogues":[15,39,120],"(8a-8n)":[16],"examined":[18],"for":[19,124],"their":[20,93],"anticancer":[21,34,128],"activity":[22,35],"against":[23,40,57],"two":[24],"cancer":[25],"cell":[26,59],"lines":[27],"(MCF-7":[28],"&":[29],"A549).":[30],"The":[31],"in":[32],"vitro":[33],"assessment":[36],"these":[38],"the":[41,72,96,100,106,114,117],"EGFR":[42,97],"tyrosine":[43],"kinase":[44],"revealed":[45],"that":[46,63],"six":[47],"compounds":[48,64,76,87],"8d,":[49],"8e,":[50],"8f,":[51],"8j,":[52],"8m,":[53],"8nexhibited":[55],"efficacy":[56],"tested":[58],"lines.The":[60],"results":[61],"showed":[62],"8d":[65],"8e":[67],"were":[68,80,88,103],"more":[69],"efficient":[70],"than":[71],"standard":[73],"erlotinib,":[74],"although":[75],"8m":[77],"8n":[79],"equally":[81],"effective.":[82],"In":[83],"silico":[84],"investigations":[85],"also":[89],"performed":[90],"detect":[92],"interactions":[94],"with":[95,105],"receptor,":[98],"energy":[101],"estimates":[102],"consistent":[104],"reported":[107],"IC50":[108],"values.":[109],"Overall,":[110],"this":[111],"study":[112],"highlighted":[113],"potential":[115],"newly":[118],"prepared":[119],"as":[121],"promising":[122],"leads":[123],"further":[125],"development":[126],"into":[127],"drugs.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-03-18T00:00:00"}
