{"id":"https://openalex.org/W4408535697","doi":"https://doi.org/10.1158/1078-0432.28606447","title":"Supplementary Figure S7 from MAPK Pathway\u2013Activating Alteration and Immunotherapy Efficacy in Squamous Cell Lung Carcinoma: Results from the Randomized, Prospective SQUINT Trial","display_name":"Supplementary Figure S7 from MAPK Pathway\u2013Activating Alteration and Immunotherapy Efficacy in Squamous Cell Lung Carcinoma: Results from the Randomized, Prospective SQUINT Trial","publication_year":2025,"publication_date":"2025-03-17","ids":{"openalex":"https://openalex.org/W4408535697","doi":"https://doi.org/10.1158/1078-0432.28606447"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.28606447","doi":"https://doi.org/10.1158/1078-0432.28606447","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28606447","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.28606447","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001928949","display_name":"Federico Cappuzzo","orcid":"https://orcid.org/0000-0002-6295-6767","observed_orcids":["https://orcid.org/0000-0002-6295-6767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federico Cappuzzo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6295-6767","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030450694","display_name":"Biagio Ricciuti","orcid":"https://orcid.org/0000-0002-0651-2678","observed_orcids":["https://orcid.org/0000-0002-0651-2678"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biagio Ricciuti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0651-2678","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069655328","display_name":"Angelo Delmonte","orcid":"https://orcid.org/0009-0004-2629-8519","observed_orcids":["https://orcid.org/0009-0004-2629-8519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angelo Delmonte","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-2629-8519","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064162399","display_name":"Laura Bonanno","orcid":"https://orcid.org/0000-0001-5218-4970","observed_orcids":["https://orcid.org/0000-0001-5218-4970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Bonanno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5218-4970","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107889602","display_name":"Xiaoyue Wang","orcid":"https://orcid.org/0009-0000-4276-041X","observed_orcids":["https://orcid.org/0009-0000-4276-041X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyue Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-4276-041X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110870053","display_name":"Weng Kit Lye","orcid":"https://orcid.org/0000-0001-7392-2717","observed_orcids":["https://orcid.org/0000-0001-7392-2717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weng Kit Lye","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7392-2717","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059362378","display_name":"Andreas G\u00f6rtz","orcid":"https://orcid.org/0009-0000-2224-0679","observed_orcids":["https://orcid.org/0009-0000-2224-0679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas G\u00f6rtz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2224-0679","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081324410","display_name":"Kalliopi Andrikou","orcid":"https://orcid.org/0000-0002-0572-5321","observed_orcids":["https://orcid.org/0000-0002-0572-5321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalliopi Andrikou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0572-5321","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069143288","display_name":"Alessandro Dal Maso","orcid":"https://orcid.org/0000-0003-3743-717X","observed_orcids":["https://orcid.org/0000-0003-3743-717X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Dal Maso","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3743-717X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005147875","display_name":"Gabriele Minuti","orcid":"https://orcid.org/0000-0003-2363-0446","observed_orcids":["https://orcid.org/0000-0003-2363-0446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriele Minuti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2363-0446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086879732","display_name":"Maximilian Papi","orcid":"https://orcid.org/0009-0004-1174-6665","observed_orcids":["https://orcid.org/0009-0004-1174-6665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian Papi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-1174-6665","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085305921","display_name":"Joao V. Alessi","orcid":"https://orcid.org/0000-0002-8072-5946","observed_orcids":["https://orcid.org/0000-0002-8072-5946"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joao Victor Alessi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8072-5946","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071447422","display_name":"Alessandro Di Federico","orcid":"https://orcid.org/0000-0001-8877-4315","observed_orcids":["https://orcid.org/0000-0001-8877-4315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Di Federico","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8877-4315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Rodig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1761-9769","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086249998","display_name":"Mark Magdi Awad","orcid":"https://orcid.org/0000-0003-0928-5244","observed_orcids":["https://orcid.org/0000-0003-0928-5244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Magdi Awad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0928-5244","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034761732","display_name":"Giulio Metro","orcid":"https://orcid.org/0000-0002-4978-9212","observed_orcids":["https://orcid.org/0000-0002-4978-9212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulio Metro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4978-9212","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011383802","display_name":"Ilaria Attili","orcid":"https://orcid.org/0000-0003-1333-6622","observed_orcids":["https://orcid.org/0000-0003-1333-6622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilaria Attili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1333-6622","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082055508","display_name":"Fabiana Vitiello","orcid":"https://orcid.org/0009-0007-2984-4257","observed_orcids":["https://orcid.org/0009-0007-2984-4257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiana Vitiello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2984-4257","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016783216","display_name":"Sara Pilotto","orcid":"https://orcid.org/0000-0003-2229-4874","observed_orcids":["https://orcid.org/0000-0003-2229-4874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Pilotto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2229-4874","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022206145","display_name":"Stefania Gori","orcid":"https://orcid.org/0000-0001-6320-405X","observed_orcids":["https://orcid.org/0000-0001-6320-405X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefania Gori","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6320-405X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051378203","display_name":"Giulio Rossi","orcid":"https://orcid.org/0000-0001-8855-1218","observed_orcids":["https://orcid.org/0000-0001-8855-1218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulio Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008029111","display_name":"Simonetta Buglioni","orcid":"https://orcid.org/0000-0002-5066-1523","observed_orcids":["https://orcid.org/0000-0002-5066-1523"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simonetta Buglioni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5066-1523","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086743021","display_name":"Diana Giannarelli","orcid":"https://orcid.org/0000-0002-6085-1195","observed_orcids":["https://orcid.org/0000-0002-6085-1195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Giannarelli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6085-1195","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063424146","display_name":"Lorenza Maria Landi","orcid":"https://orcid.org/0000-0003-2604-6595","observed_orcids":["https://orcid.org/0000-0003-2604-6595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenza Landi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2604-6595","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.628000020980835},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5550000071525574},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.663760244846344},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5970174074172974},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5684338212013245},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5641451478004456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5286308526992798},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5194910764694214},{"id":"https://openalex.org/C2779327097","wikidata":"https://www.wikidata.org/wiki/Q5749020","display_name":"Squamous-cell carcinoma of the lung","level":3,"score":0.4826098680496216},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.42818135023117065},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11945617198944092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.28606447","doi":"https://doi.org/10.1158/1078-0432.28606447","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28606447","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.28606447","doi":"https://doi.org/10.1158/1078-0432.28606447","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28606447","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406665680","https://openalex.org/W4408538456","https://openalex.org/W3138071154","https://openalex.org/W4388045085","https://openalex.org/W4295817065","https://openalex.org/W6901982287","https://openalex.org/W3012986347","https://openalex.org/W3110560341","https://openalex.org/W4362596749","https://openalex.org/W3137960754"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"7.":[2],"Exploratory":[3],"analysis":[4],"of":[5],"median":[6],"overall":[7],"survival":[8,12],"(A-C)":[9],"and":[10,21],"progression-free":[11,45],"(B-D)":[13],"according":[14],"to":[15],"TMB":[16,26,34],"status":[17],"in":[18],"NI":[19],"(A-B)":[20],"N-CT":[22],"(C-D)":[23],"treatment":[24],"arm.":[25],"low":[27],"(yellow":[28],"line;":[29,37],"n":[30,38],"=":[31,39],"30/40)":[32],"vs":[33],"high":[35],"(blue":[36],"43/23).":[40],"OS:":[41],"Overall":[42],"survival;":[43],"PFS:":[44],"survival.":[46]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-03-18T00:00:00"}