{"id":"https://openalex.org/W4408522013","doi":"https://doi.org/10.1158/2159-8290.28609140","title":"Supplementary Figure 3 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax","display_name":"Supplementary Figure 3 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax","publication_year":2025,"publication_date":"2025-03-17","ids":{"openalex":"https://openalex.org/W4408522013","doi":"https://doi.org/10.1158/2159-8290.28609140"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.28609140","doi":"https://doi.org/10.1158/2159-8290.28609140","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.28609140","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.28609140","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056060551","display_name":"Alexander Waclawiczek","orcid":"https://orcid.org/0000-0002-8749-6736","observed_orcids":["https://orcid.org/0000-0002-8749-6736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Waclawiczek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8749-6736","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037129838","display_name":"Aino\u2010Maija Lepp\u00e4","orcid":"https://orcid.org/0000-0003-0849-1759","observed_orcids":["https://orcid.org/0000-0003-0849-1759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aino-Maija Lepp\u00e4","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0849-1759","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039581367","display_name":"Simon Renders","orcid":"https://orcid.org/0000-0001-7883-2956","observed_orcids":["https://orcid.org/0000-0001-7883-2956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Renders","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7883-2956","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039781031","display_name":"Karolin Stumpf","orcid":"https://orcid.org/0000-0002-8930-7265","observed_orcids":["https://orcid.org/0000-0002-8930-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karolin Stumpf","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8930-7265","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077898802","display_name":"Cecilia Reyneri","orcid":"https://orcid.org/0000-0002-9950-5468","observed_orcids":["https://orcid.org/0000-0002-9950-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Reyneri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9950-5468","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039312879","display_name":"Barbara Betz","orcid":"https://orcid.org/0000-0002-2767-5062","observed_orcids":["https://orcid.org/0000-0002-2767-5062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Betz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2767-5062","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018380807","display_name":"Maike Janssen","orcid":"https://orcid.org/0000-0001-9899-1022","observed_orcids":["https://orcid.org/0000-0001-9899-1022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maike Janssen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9899-1022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073258894","display_name":"Rabia Shahswar","orcid":"https://orcid.org/0000-0001-6266-6316","observed_orcids":["https://orcid.org/0000-0001-6266-6316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabia Shahswar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6266-6316","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012482394","display_name":"Elisa Donato","orcid":"https://orcid.org/0000-0003-3541-9170","observed_orcids":["https://orcid.org/0000-0003-3541-9170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa Donato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3541-9170","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062422556","display_name":"Darja Karpova","orcid":"https://orcid.org/0000-0003-0695-1854","observed_orcids":["https://orcid.org/0000-0003-0695-1854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darja Karpova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0695-1854","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043668590","display_name":"Vera Thiel","orcid":"https://orcid.org/0000-0003-1245-0175","observed_orcids":["https://orcid.org/0000-0003-1245-0175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vera Thiel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1245-0175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087384301","display_name":"Julia Marie Unglaub","orcid":"https://orcid.org/0000-0002-3577-5493","observed_orcids":["https://orcid.org/0000-0002-3577-5493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia M. Unglaub","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3577-5493","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053591758","display_name":"Susanna Grabowski","orcid":"https://orcid.org/0000-0003-1544-482X","observed_orcids":["https://orcid.org/0000-0003-1544-482X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanna Grabowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1544-482X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013161320","display_name":"Stefanie Gryzik","orcid":"https://orcid.org/0000-0001-5871-539X","observed_orcids":["https://orcid.org/0000-0001-5871-539X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie Gryzik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5871-539X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088988110","display_name":"Lisa Vierbaum","orcid":"https://orcid.org/0000-0003-3661-6512","observed_orcids":["https://orcid.org/0000-0003-3661-6512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Vierbaum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3661-6512","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053949970","display_name":"Richard F. Schlenk","orcid":"https://orcid.org/0000-0003-2215-2059","observed_orcids":["https://orcid.org/0000-0003-2215-2059","https://orcid.org/0000-0002-5298-3120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard F. Schlenk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2215-2059","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026359397","display_name":"Christoph R\u00f6llig","orcid":"https://orcid.org/0000-0002-3791-0548","observed_orcids":["https://orcid.org/0000-0002-3791-0548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph R\u00f6llig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3791-0548","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084645599","display_name":"Michael Hundemer","orcid":"https://orcid.org/0000-0002-5596-2405","observed_orcids":["https://orcid.org/0000-0002-5596-2405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hundemer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5596-2405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009753849","display_name":"Caroline Pabst","orcid":"https://orcid.org/0000-0001-9716-5909","observed_orcids":["https://orcid.org/0000-0001-9716-5909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Pabst","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9716-5909","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053578678","display_name":"Michael Heuser","orcid":"https://orcid.org/0000-0001-5318-9044","observed_orcids":["https://orcid.org/0000-0001-5318-9044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Heuser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5318-9044","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080023449","display_name":"Simon Raffel","orcid":"https://orcid.org/0000-0003-4671-1097","observed_orcids":["https://orcid.org/0000-0003-4671-1097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Raffel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4671-1097","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028388949","display_name":"Carsten M\u00fcller\u2010Tidow","orcid":"https://orcid.org/0000-0002-7166-5232","observed_orcids":["https://orcid.org/0000-0002-7166-5232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten M\u00fcller-Tidow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7166-5232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089981698","display_name":"Tim Sauer","orcid":"https://orcid.org/0000-0001-5412-324X","observed_orcids":["https://orcid.org/0000-0001-5412-324X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Sauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5412-324X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081577791","display_name":"Andreas Trumpp","orcid":"https://orcid.org/0000-0002-6212-3466","observed_orcids":["https://orcid.org/0000-0002-6212-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Trumpp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6212-3466","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-2-family-genes","display_name":"Bcl-2 family genes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":1.0},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9160000085830688},{"id":"https://openalex.org/keywords/clinical-response-prediction","display_name":"clinical response prediction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.882197380065918},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.8725650310516357},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7305583953857422},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5275428295135498},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5239003896713257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4988563060760498},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4080654978752136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3989775776863098},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34696513414382935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3265310525894165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2865075469017029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17027157545089722},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14350038766860962},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10155734419822693},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.05737835168838501},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.28609140","doi":"https://doi.org/10.1158/2159-8290.28609140","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.28609140","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/28609140","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Combinatorial_BCL2_Family_Expression_in_Acute_Myeloid_Leukemia_Stem_Cells_Predicts_Clinical_Response_to_Azacitidine_Venetoclax/28609140","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.28609140","doi":"https://doi.org/10.1158/2159-8290.28609140","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.28609140","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4323652032","https://openalex.org/W4379142041"],"abstract_inverted_index":{"Bcl-2":[0],"family":[1],"gene":[2],"expression":[3],"in":[4,7],"LSCs":[5],"predicts":[6],"vitro":[8],"response":[9],"to":[10],"HMA/VEN":[11]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-18T00:00:00"}