{"id":"https://openalex.org/W4408519622","doi":"https://doi.org/10.1134/s0006350924701094","title":"Glycerol Permeation Through the Human Sperm Membrane During Cryopreservation","display_name":"Glycerol Permeation Through the Human Sperm Membrane During Cryopreservation","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4408519622","doi":"https://doi.org/10.1134/s0006350924701094"},"language":"en","primary_location":{"id":"doi:10.1134/s0006350924701094","doi":"https://doi.org/10.1134/s0006350924701094","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006350924701094","pdf_url":null,"source":{"id":"https://openalex.org/S53701631","display_name":"BIOPHYSICS","issn_l":"0006-3509","issn":["0006-3509","1555-6654"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101709876","display_name":"\u0410. \u0410. \u0418\u0432\u0430\u043d\u043e\u0432\u0430","orcid":"https://orcid.org/0009-0005-5588-5824","observed_orcids":["https://orcid.org/0009-0005-5588-5824"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. A. Ivanova","raw_affiliation_strings":["Physical Faculty, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Faculty, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033265059","display_name":"I. I. Leonov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. I. Leonov","raw_affiliation_strings":["Physical Faculty, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Faculty, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115553653","display_name":"E. S. Gnilozub-Volobueva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. S. Gnilozub-Volobueva","raw_affiliation_strings":["Physical Faculty, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Faculty, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040557654","display_name":"Mikhail A. Ovchinnikov","orcid":"https://orcid.org/0000-0002-1163-5170","observed_orcids":["https://orcid.org/0000-0002-1163-5170"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4405279538","display_name":"Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University","ror":"https://ror.org/01mjggc44","country_code":"RU","type":"facility","lineage":["https://openalex.org/I19880235","https://openalex.org/I4405279538"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. A. Ovchinnikov","raw_affiliation_strings":["Skobeltsyn Institute of Nuclear Physics, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skobeltsyn Institute of Nuclear Physics, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235","https://openalex.org/I4405279538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047592894","display_name":"S.A. Yakovenko","orcid":"https://orcid.org/0000-0003-2587-9333","observed_orcids":["https://orcid.org/0000-0003-2587-9333"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. A. Yakovenko","raw_affiliation_strings":["Physical Faculty, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Faculty, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078746574","display_name":"E. Yu. Simonenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. Yu. Simonenko","raw_affiliation_strings":["Physical Faculty, Moscow State University, 119991, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Faculty, Moscow State University, 119991, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101709876"],"corresponding_institution_ids":["https://openalex.org/I19880235"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3467578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"6","first_page":"1010","last_page":"1018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.6021000146865845,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.2720000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-spermatozoa","display_name":"human spermatozoa","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cryopreservation","display_name":"cryopreservation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/glycerol","display_name":"glycerol","score":0.8220000267028809},{"id":"https://openalex.org/keywords/aquaporin-7","display_name":"AQP7","score":0.6930000185966492},{"id":"https://openalex.org/keywords/sperm-membrane-permeability","display_name":"sperm membrane permeability","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cryoprotective-media","display_name":"cryoprotective media","score":0.7440000176429749},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.7390000224113464},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8679999709129333},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.7974553108215332},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7868665456771851},{"id":"https://openalex.org/C2780881558","wikidata":"https://www.wikidata.org/wiki/Q132501","display_name":"Glycerol","level":2,"score":0.6907801628112793},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5840925574302673},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.48716089129447937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43435537815093994},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4036807417869568},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3050360679626465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2087600827217102},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1194290816783905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11449819803237915},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.07387298345565796}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s0006350924701094","doi":"https://doi.org/10.1134/s0006350924701094","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0006350924701094","pdf_url":null,"source":{"id":"https://openalex.org/S53701631","display_name":"BIOPHYSICS","issn_l":"0006-3509","issn":["0006-3509","1555-6654"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1492977628","https://openalex.org/W1904511128","https://openalex.org/W1972598951","https://openalex.org/W1979547244","https://openalex.org/W1990521605","https://openalex.org/W1997303085","https://openalex.org/W2005005437","https://openalex.org/W2011535120","https://openalex.org/W2050043857","https://openalex.org/W2070463771","https://openalex.org/W2082268117","https://openalex.org/W2093240936","https://openalex.org/W2095382272","https://openalex.org/W2097094397","https://openalex.org/W2107618142","https://openalex.org/W2135647805","https://openalex.org/W2607136061","https://openalex.org/W2767631576","https://openalex.org/W2771476940","https://openalex.org/W2803788794","https://openalex.org/W2888089578","https://openalex.org/W2908945185","https://openalex.org/W2910255684","https://openalex.org/W3155271074","https://openalex.org/W3161499145","https://openalex.org/W3165438656","https://openalex.org/W3165784052","https://openalex.org/W3206085777","https://openalex.org/W4309351748","https://openalex.org/W4322631166","https://openalex.org/W4380142828"],"related_works":["https://openalex.org/W2964591455","https://openalex.org/W2983806957","https://openalex.org/W2187289991","https://openalex.org/W2057934646","https://openalex.org/W1984230762","https://openalex.org/W4320487076","https://openalex.org/W2582653153","https://openalex.org/W3172647743","https://openalex.org/W4396594780","https://openalex.org/W2363854128"],"abstract_inverted_index":{"Cryopreservation":[0],"of":[1,11,32,49,53,62,70,77,86,99,108,119,148,152,188],"biological":[2],"material":[3],"is":[4,38],"an":[5,206],"important":[6],"issue":[7],"in":[8,101,112,145,172,208,218,221],"many":[9],"fields":[10],"biology":[12],"and":[13,24,110,134],"medicine,":[14],"especially":[15],"for":[16,29,125],"assisted":[17],"reproductive":[18],"technologies.":[19],"Cryoprotective":[20],"media,":[21],"including":[22],"cell-permeating":[23],"non-permeating":[25],"components,":[26],"are":[27],"used":[28,40],"effective":[30],"cryopreservation":[31],"cells.":[33],"Glycerol":[34],"at":[35,161],"various":[36],"concentrations":[37],"often":[39],"as":[41,56,58],"a":[42,113,117,193],"permeating":[43],"component.":[44],"However,":[45],"elucidating":[46],"the":[47,50,60,75,84,97,106,120,122,129,135,146,163,173,181,189,209,215,219,224],"mechanisms":[48],"cryoprotective":[51,114,130,174],"effect":[52],"these":[54],"compounds,":[55],"well":[57],"increasing":[59],"proportion":[61],"surviving":[63],"cells":[64,136],"after":[65,170,213],"cryopreservation,":[66],"remain":[67],"urgent":[68],"tasks":[69],"cryobiology.":[71],"In":[72],"this":[73],"study,":[74],"mechanism":[76],"glycerol":[78,109],"transfer":[79],"through":[80],"sperm":[81,102,183,210],"membranes":[82],"with":[83,192,223],"participation":[85],"aquaporins":[87,187],"was":[88,137,140,159],"investigated":[89],"by":[90],"mathematical":[91],"modeling.":[92],"The":[93,154,202],"presented":[94],"model":[95],"describes":[96],"dynamics":[98],"changes":[100],"volume":[103,169],"depending":[104],"on":[105],"concentration":[107,156,217],"sucrose":[111,155,216],"medium.":[115,175],"As":[116],"result":[118],"analysis,":[121],"characteristic":[123],"time":[124],"establishing":[126],"equilibrium":[127],"between":[128],"medium":[131],"under":[132],"study":[133],"calculated,":[138],"which":[139,162],"t":[141],"=":[142,197],"80":[143],"s":[144],"presence":[147],"12":[149],"vol.":[150],"%":[151],"glycerol.":[153],"(0.16":[157],"M)":[158],"determined":[160],"cell":[164],"returns":[165],"to":[166],"its":[167],"original":[168],"incubation":[171],"It":[176],"has":[177],"been":[178],"shown":[179],"that":[180],"human":[182],"can":[184],"contain":[185],"6750":[186],"7th":[190],"type":[191],"permeability":[194],"P":[195],"AQP7":[196],"0.00366":[198],"\u00b5m":[199],"3":[200],"/s.":[201],"experiments":[203],"performed":[204],"showed":[205],"increase":[207],"motility":[211],"index":[212],"adjusting":[214],"solution":[220],"accordance":[222],"simulation":[225],"results.":[226]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}