{"id":"https://openalex.org/W4408498967","doi":"https://doi.org/10.1101/2025.03.13.643163","title":"Electrochemical Paper Fluidic Device for Extended Real-time Cocaine Monitoring in Simulated Sweat","display_name":"Electrochemical Paper Fluidic Device for Extended Real-time Cocaine Monitoring in Simulated Sweat","publication_year":2025,"publication_date":"2025-03-15","ids":{"openalex":"https://openalex.org/W4408498967","doi":"https://doi.org/10.1101/2025.03.13.643163"},"language":"en","primary_location":{"id":"doi:10.1101/2025.03.13.643163","doi":"https://doi.org/10.1101/2025.03.13.643163","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.13.643163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/15/2025.03.13.643163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/15/2025.03.13.643163.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028427269","display_name":"Orlando S. Hoilett","orcid":"https://orcid.org/0000-0002-9091-349X","observed_orcids":["https://orcid.org/0000-0002-9091-349X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orlando S. Hoilett","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116647305","display_name":"Jenna Foust","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna F. Foust","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nikhil Dav\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Dav\u00e9","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072949652","display_name":"Bethany M. Balash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany M. Balash","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000668033","display_name":"Dana L Moryl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana L. Moryl","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anusha Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anusha Kumar","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053899113","display_name":"Jacqueline Callihan Linnes","orcid":"https://orcid.org/0000-0003-4962-0908","observed_orcids":["https://orcid.org/0000-0003-4962-0908"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacqueline C. Linnes","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907"],"raw_orcid":"https://orcid.org/0000-0003-4962-0908","affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053899113"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.6523000001907349,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-detection","display_name":"cocaine detection","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sweat-analysis","display_name":"sweat analysis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/continuous-monitoring","display_name":"continuous monitoring","score":0.546999990940094},{"id":"https://openalex.org/keywords/aptasensor","display_name":"aptasensor","score":0.7599999904632568},{"id":"https://openalex.org/keywords/wearable-sensors","display_name":"wearable sensors","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.6924771070480347},{"id":"https://openalex.org/C63398376","wikidata":"https://www.wikidata.org/wiki/Q7395168","display_name":"SWEAT","level":2,"score":0.5887189507484436},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.43974006175994873},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42971915006637573},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.343672513961792},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.33010393381118774},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25051507353782654},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20651137828826904},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.18056774139404297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12398505210876465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08604279160499573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.03.13.643163","doi":"https://doi.org/10.1101/2025.03.13.643163","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.13.643163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/15/2025.03.13.643163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.03.13.643163","doi":"https://doi.org/10.1101/2025.03.13.643163","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.13.643163","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/03/15/2025.03.13.643163.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408498967.pdf","grobid_xml":"https://content.openalex.org/works/W4408498967.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W27447964","https://openalex.org/W1488060318","https://openalex.org/W1568084954","https://openalex.org/W1966465995","https://openalex.org/W1973934064","https://openalex.org/W1983641108","https://openalex.org/W1985076132","https://openalex.org/W1993603706","https://openalex.org/W1997116342","https://openalex.org/W1997511581","https://openalex.org/W2003547631","https://openalex.org/W2003717349","https://openalex.org/W2023824729","https://openalex.org/W2024197486","https://openalex.org/W2024744166","https://openalex.org/W2024763722","https://openalex.org/W2026007831","https://openalex.org/W2036886659","https://openalex.org/W2038769992","https://openalex.org/W2045889911","https://openalex.org/W2053716842","https://openalex.org/W2054345707","https://openalex.org/W2064267134","https://openalex.org/W2068311077","https://openalex.org/W2069491648","https://openalex.org/W2074448281","https://openalex.org/W2079828968","https://openalex.org/W2081737898","https://openalex.org/W2091762673","https://openalex.org/W2098802302","https://openalex.org/W2108754443","https://openalex.org/W2109106723","https://openalex.org/W2109413910","https://openalex.org/W2119527242","https://openalex.org/W2119638450","https://openalex.org/W2123444554","https://openalex.org/W2145168763","https://openalex.org/W2154874237","https://openalex.org/W2162097818","https://openalex.org/W2266175888","https://openalex.org/W2306164109","https://openalex.org/W2314637171","https://openalex.org/W2330011604","https://openalex.org/W2330229856","https://openalex.org/W2342406716","https://openalex.org/W2475292059","https://openalex.org/W2547045813","https://openalex.org/W2549976854","https://openalex.org/W2552540631","https://openalex.org/W2567526705","https://openalex.org/W2567786944","https://openalex.org/W2791093037","https://openalex.org/W2811425118","https://openalex.org/W2897909773","https://openalex.org/W2901148394","https://openalex.org/W2911678674","https://openalex.org/W2976547375","https://openalex.org/W2977356226","https://openalex.org/W2999592980","https://openalex.org/W3013923612","https://openalex.org/W3018049995","https://openalex.org/W3091978857","https://openalex.org/W4254720078"],"related_works":["https://openalex.org/W2045889911","https://openalex.org/W3000583740","https://openalex.org/W4281399219","https://openalex.org/W4313251512","https://openalex.org/W2184934793","https://openalex.org/W4406421458","https://openalex.org/W7166873848","https://openalex.org/W7138121001","https://openalex.org/W2060567921","https://openalex.org/W4321380156"],"abstract_inverted_index":{"Abstract":[0],"Cocaine":[1],"and":[2,23,28,70,77,116],"other":[3],"illicit":[4,34,146],"substances":[5,35,147],"are":[6,123],"known":[7],"to":[8],"excrete":[9],"from":[10],"the":[11,49,84,100],"body":[12],"into":[13],"sweat,":[14],"making":[15],"sweat":[16,37,79,93,130],"an":[17,52],"advantageous":[18],"matrix":[19],"for":[20,44,67,75],"non-invasive":[21],"detection":[22,32,57,86,144],"monitoring":[24,47],"of":[25,33,51,87,102,145],"substance":[26],"use":[27],"abuse.":[29],"However,":[30],"existing":[31],"in":[36,91,148],"remain":[38],"single-use":[39],"technologies":[40],"that":[41],"aren\u2019t":[42],"suitable":[43],"real-time,":[45],"continuous":[46,56,85,143],"over":[48,99],"course":[50,101],"entire":[53],"day.":[54],"Long-term,":[55],"is":[58],"hampered":[59],"by":[60,125],"large,":[61],"bulky":[62],"instrumentation,":[63],"limited":[64],"sensor":[65],"stability":[66],"multi-hour":[68],"measurements,":[69],"fluidic":[71,97],"systems":[72],"not":[73],"optimized":[74],"minute":[76],"variable":[78],"flow":[80,127],"rates.":[81],"We":[82],"demonstrate":[83],"0.5":[88],"mM":[89],"cocaine":[90],"simulated":[92],"via":[94],"a":[95,109,113,117],"paper":[96],"device":[98],"17":[103],"hours.":[104],"Our":[105,121,136],"sensing":[106],"system":[107],"uses":[108],"biosensor":[110],"functionalized":[111],"with":[112],"cocaine-binding":[114],"aptamer":[115],"miniaturized":[118],"electrochemical":[119],"potentiostat.":[120],"fluidics":[122],"driven":[124],"evaporation":[126],"at":[128],"physiological":[129],"rates":[131],"(0.3-0.5":[132],"\u00b5L/min/cm":[133],"2":[134],").":[135],"development":[137],"lays":[138],"critical":[139],"groundwork":[140],"towards":[141],"wearable,":[142],"sweat.":[149]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-03-17T00:00:00"}
