{"id":"https://openalex.org/W4408367385","doi":"https://doi.org/10.3390/ph18030396","title":"Expanding the Role of Heparin Derivatives in Oncology: From Anticoagulation to Antitumor Activity","display_name":"Expanding the Role of Heparin Derivatives in Oncology: From Anticoagulation to Antitumor Activity","publication_year":2025,"publication_date":"2025-03-12","ids":{"openalex":"https://openalex.org/W4408367385","doi":"https://doi.org/10.3390/ph18030396","pmid":"https://pubmed.ncbi.nlm.nih.gov/40143176","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11944584"},"language":"en","primary_location":{"id":"doi:10.3390/ph18030396","doi":"https://doi.org/10.3390/ph18030396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18030396","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4408367385"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ph18030396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009964501","display_name":"Jasmine Holail","orcid":"https://orcid.org/0000-0001-7743-6740","observed_orcids":["https://orcid.org/0000-0001-7743-6740"]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jasmine Holail","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia","institution_ids":["https://openalex.org/I134359838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000070555","display_name":"Hatouf Husni Sukkarieh","orcid":"https://orcid.org/0000-0003-3736-5989","observed_orcids":["https://orcid.org/0000-0003-3736-5989"]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hatouf Husni Sukkarieh","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-3736-5989","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia","institution_ids":["https://openalex.org/I134359838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032881983","display_name":"Ahmad Aljada","orcid":"https://orcid.org/0000-0001-8337-5454","observed_orcids":["https://orcid.org/0000-0001-8337-5454"]},"institutions":[{"id":"https://openalex.org/I134359838","display_name":"Alfaisal University","ror":"https://ror.org/00cdrtq48","country_code":"SA","type":"education","lineage":["https://openalex.org/I134359838"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Ahmad Aljada","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-8337-5454","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia","institution_ids":["https://openalex.org/I134359838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032881983"],"corresponding_institution_ids":["https://openalex.org/I134359838"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.4303,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.37830033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"18","issue":"3","first_page":"396","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heparin-derivatives","display_name":"heparin derivatives","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/heparin-pentasaccharide","display_name":"heparin pentasaccharide","score":0.7860000133514404},{"id":"https://openalex.org/keywords/heparanase-inhibition","display_name":"heparanase inhibition","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-associated-thrombosis","display_name":"cancer-associated thrombosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cxcl12-cxcr4-signaling","display_name":"CXCL12/CXCR4 signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/enzymatic-cleavage","display_name":"enzymatic cleavage","score":0.6930000185966492},{"id":"https://openalex.org/keywords/derivatization","display_name":"derivatization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6740000247955322},{"id":"https://openalex.org/keywords/heparin-fractionation","display_name":"heparin fractionation","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.6075528860092163},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5634492635726929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5524055361747742},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47996973991394043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3941647410392761},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3381667733192444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1947532296180725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14774706959724426}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph18030396","doi":"https://doi.org/10.3390/ph18030396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18030396","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11944584","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11944584/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11944584/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:40143176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40143176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:88de599471634fab947c6afb876d8cad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88de599471634fab947c6afb876d8cad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 18, Iss 3, p 396 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph18030396","doi":"https://doi.org/10.3390/ph18030396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18030396","pdf_url":null,"source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408367385.pdf","grobid_xml":"https://content.openalex.org/works/W4408367385.grobid-xml"},"referenced_works_count":220,"referenced_works":["https://openalex.org/W54325654","https://openalex.org/W81435479","https://openalex.org/W91547674","https://openalex.org/W776017106","https://openalex.org/W851112836","https://openalex.org/W1476658428","https://openalex.org/W1493851369","https://openalex.org/W1505366254","https://openalex.org/W1506411149","https://openalex.org/W1527730067","https://openalex.org/W1574448963","https://openalex.org/W1603230122","https://openalex.org/W1769858503","https://openalex.org/W1912969395","https://openalex.org/W1966556597","https://openalex.org/W1966913546","https://openalex.org/W1967339745","https://openalex.org/W1967547757","https://openalex.org/W1972384384","https://openalex.org/W1973509710","https://openalex.org/W1974957201","https://openalex.org/W1979522770","https://openalex.org/W1980809306","https://openalex.org/W1981675650","https://openalex.org/W1982684154","https://openalex.org/W1984091422","https://openalex.org/W1984402172","https://openalex.org/W1985897491","https://openalex.org/W1987359771","https://openalex.org/W1987779442","https://openalex.org/W1990134290","https://openalex.org/W1994741189","https://openalex.org/W1994921672","https://openalex.org/W1996600303","https://openalex.org/W2006793070","https://openalex.org/W2010684352","https://openalex.org/W2014646375","https://openalex.org/W2015405233","https://openalex.org/W2015735304","https://openalex.org/W2015976976","https://openalex.org/W2017592559","https://openalex.org/W2020098579","https://openalex.org/W2021006564","https://openalex.org/W2021036829","https://openalex.org/W2022979958","https://openalex.org/W2023699475","https://openalex.org/W2023938246","https://openalex.org/W2024483474","https://openalex.org/W2024882177","https://openalex.org/W2027495439","https://openalex.org/W2027568895","https://openalex.org/W2028534260","https://openalex.org/W2028915127","https://openalex.org/W2029342633","https://openalex.org/W2030984529","https://openalex.org/W2033361043","https://openalex.org/W2034301908","https://openalex.org/W2035981572","https://openalex.org/W2036385193","https://openalex.org/W2038114362","https://openalex.org/W2038276233","https://openalex.org/W2039664199","https://openalex.org/W2041420763","https://openalex.org/W2041510943","https://openalex.org/W2044815206","https://openalex.org/W2046653567","https://openalex.org/W2047534454","https://openalex.org/W2050413041","https://openalex.org/W2053896427","https://openalex.org/W2054032705","https://openalex.org/W2054140794","https://openalex.org/W2054497088","https://openalex.org/W2054724286","https://openalex.org/W2057123343","https://openalex.org/W2057815575","https://openalex.org/W2058986169","https://openalex.org/W2060529002","https://openalex.org/W2061413664","https://openalex.org/W2064040661","https://openalex.org/W2064070223","https://openalex.org/W2067205052","https://openalex.org/W2069565722","https://openalex.org/W2070503172","https://openalex.org/W2071000690","https://openalex.org/W2074523891","https://openalex.org/W2074736160","https://openalex.org/W2075535107","https://openalex.org/W2080154144","https://openalex.org/W2083027019","https://openalex.org/W2083637906","https://openalex.org/W2085888525","https://openalex.org/W2091759198","https://openalex.org/W2102240846","https://openalex.org/W2103247642","https://openalex.org/W2107235506","https://openalex.org/W2113183319","https://openalex.org/W2113383342","https://openalex.org/W2118386327","https://openalex.org/W2118817277","https://openalex.org/W2126517766","https://openalex.org/W2127185770","https://openalex.org/W2128540560","https://openalex.org/W2130812849","https://openalex.org/W2133172137","https://openalex.org/W2133351291","https://openalex.org/W2134124835","https://openalex.org/W2134789155","https://openalex.org/W2138321048","https://openalex.org/W2138831343","https://openalex.org/W2140074915","https://openalex.org/W2141089620","https://openalex.org/W2141100626","https://openalex.org/W2142386661","https://openalex.org/W2143674709","https://openalex.org/W2148881770","https://openalex.org/W2152821878","https://openalex.org/W2152893708","https://openalex.org/W2154099252","https://openalex.org/W2156311318","https://openalex.org/W2160715301","https://openalex.org/W2163538215","https://openalex.org/W2167217534","https://openalex.org/W2171042251","https://openalex.org/W2171569093","https://openalex.org/W2196970594","https://openalex.org/W2210532669","https://openalex.org/W2226283205","https://openalex.org/W2233811338","https://openalex.org/W2274372787","https://openalex.org/W2301383968","https://openalex.org/W2319213750","https://openalex.org/W2331598353","https://openalex.org/W2346208465","https://openalex.org/W2411932433","https://openalex.org/W2419604693","https://openalex.org/W2419667335","https://openalex.org/W2424386514","https://openalex.org/W2438602659","https://openalex.org/W2516744470","https://openalex.org/W2531138060","https://openalex.org/W2543619090","https://openalex.org/W2551096297","https://openalex.org/W2556776492","https://openalex.org/W2557238929","https://openalex.org/W2591457854","https://openalex.org/W2591493658","https://openalex.org/W2597673381","https://openalex.org/W2597795073","https://openalex.org/W2599261875","https://openalex.org/W2624979306","https://openalex.org/W2763332267","https://openalex.org/W2792228267","https://openalex.org/W2792485334","https://openalex.org/W2793802518","https://openalex.org/W2888294728","https://openalex.org/W2889140044","https://openalex.org/W2899891944","https://openalex.org/W2900367378","https://openalex.org/W2902266137","https://openalex.org/W2907210139","https://openalex.org/W2908242192","https://openalex.org/W2923737794","https://openalex.org/W2945920619","https://openalex.org/W2952148536","https://openalex.org/W2966354200","https://openalex.org/W2983035105","https://openalex.org/W2985004919","https://openalex.org/W2989820549","https://openalex.org/W2998844457","https://openalex.org/W3000671292","https://openalex.org/W3006575710","https://openalex.org/W3016077653","https://openalex.org/W3022434596","https://openalex.org/W3023829317","https://openalex.org/W3035593737","https://openalex.org/W3041538241","https://openalex.org/W3042028358","https://openalex.org/W3042063261","https://openalex.org/W3046073716","https://openalex.org/W3048838336","https://openalex.org/W3080736968","https://openalex.org/W3097031935","https://openalex.org/W3103176672","https://openalex.org/W3110167781","https://openalex.org/W3121794229","https://openalex.org/W3121918553","https://openalex.org/W3127460195","https://openalex.org/W3128822542","https://openalex.org/W3168039299","https://openalex.org/W3172923132","https://openalex.org/W3176802416","https://openalex.org/W3178632520","https://openalex.org/W3187320905","https://openalex.org/W3199142349","https://openalex.org/W3200728991","https://openalex.org/W3211800067","https://openalex.org/W4200284203","https://openalex.org/W4232239451","https://openalex.org/W4235231077","https://openalex.org/W4241358301","https://openalex.org/W4248250129","https://openalex.org/W4248689247","https://openalex.org/W4250801983","https://openalex.org/W4253671872","https://openalex.org/W4253826237","https://openalex.org/W4286771163","https://openalex.org/W4296793570","https://openalex.org/W4306673373","https://openalex.org/W4323875239","https://openalex.org/W4366266039","https://openalex.org/W4377097851","https://openalex.org/W4386443861","https://openalex.org/W4387063617","https://openalex.org/W4387816364","https://openalex.org/W4389027159","https://openalex.org/W4399768134","https://openalex.org/W4404109189","https://openalex.org/W6679871074","https://openalex.org/W6803644617","https://openalex.org/W7036293838"],"related_works":["https://openalex.org/W4407876589","https://openalex.org/W2369858035","https://openalex.org/W2476936157","https://openalex.org/W4391551507","https://openalex.org/W4392391682","https://openalex.org/W4414830316","https://openalex.org/W2340121745","https://openalex.org/W2038114362","https://openalex.org/W2900367378","https://openalex.org/W2222017301"],"abstract_inverted_index":{"Current":[0],"research":[1],"demonstrates":[2],"the":[3,21,120,165],"expanding":[4],"therapeutic":[5,27,167],"potential":[6,90,168],"of":[7,29,44,66,92,119,169],"heparin":[8],"derivatives":[9],"in":[10,32,84,128,142,172],"oncology,":[11],"extending":[12],"beyond":[13],"traditional":[14],"anticoagulation":[15],"mechanisms.":[16],"This":[17],"systematic":[18],"analysis":[19],"examines":[20],"structural":[22],"characteristics,":[23],"molecular":[24,46,113],"mechanisms,":[25],"and":[26,51,70,102,115,147,159],"applications":[28],"heparin-based":[30],"compounds":[31,171],"malignancy":[33],"treatment.":[34],"The":[35,95],"essential":[36],"antithrombin":[37],"binding":[38],"pentasaccharide":[39],"sequence":[40],"has":[41],"enabled":[42],"development":[43],"specialized":[45],"variants,":[47],"particularly":[48,63],"fractionated":[49],"heparins":[50,110],"their":[52],"non-anticoagulant":[53],"counterparts.":[54],"These":[55],"agents":[56],"exert":[57],"antineoplastic":[58],"effects":[59],"via":[60],"multiple":[61],"pathways,":[62],"through":[64],"modulation":[65],"heparanase":[67],"enzymatic":[68,99],"activity":[69,127],"specific":[71,133],"protein-glycosaminoglycan":[72],"interactions.":[73],"Evidence":[74],"from":[75],"pivotal":[76],"clinical":[77,161,173],"trials":[78,162],"(FRAGMATIC,":[79],"MAGNOLIA,":[80],"GASTRANOX)":[81],"confirms":[82],"efficacy":[83],"managing":[85],"cancer-associated":[86],"thrombosis":[87],"while":[88],"indicating":[89],"enhancement":[91],"chemotherapeutic":[93],"outcomes.":[94],"preparation":[96],"methods":[97],"utilize":[98],"cleavage":[100],"reactions":[101],"selective":[103],"chemical":[104],"derivatization":[105],"to":[106,163],"generate":[107],"structurally":[108],"modified":[109],"exhibiting":[111],"unique":[112],"characteristics":[114],"biological":[116],"activities.":[117],"Analysis":[118],"glycosaminoglycan":[121],"analog":[122],"dociparstat":[123],"sodium":[124],"reveals":[125],"significant":[126],"myeloid":[129],"malignancies,":[130],"mediated":[131],"by":[132],"interference":[134],"with":[135],"CXCL12/CXCR4":[136],"signaling":[137],"cascades.":[138],"Significant":[139],"challenges":[140],"remain":[141],"manufacturing":[143],"scale-up,":[144],"analytical":[145],"validation,":[146],"long-term":[148],"safety":[149],"assessment.":[150],"Future":[151],"studies":[152],"must":[153],"address":[154],"dose":[155],"optimization,":[156],"combination":[157],"strategies,":[158],"controlled":[160],"determine":[164],"full":[166],"these":[170],"oncology.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-03-13T00:00:00"}
