{"id":"https://openalex.org/W4408331908","doi":"https://doi.org/10.1002/rai2.12173","title":"Human CD141 + dendritic cells: A unique tolerogenic subset inducing immune tolerance in systemic lupus erythematosus patients","display_name":"Human CD141 + dendritic cells: A unique tolerogenic subset inducing immune tolerance in systemic lupus erythematosus patients","publication_year":2025,"publication_date":"2025-02-27","ids":{"openalex":"https://openalex.org/W4408331908","doi":"https://doi.org/10.1002/rai2.12173"},"language":"en","primary_location":{"id":"doi:10.1002/rai2.12173","doi":"https://doi.org/10.1002/rai2.12173","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rai2.12173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rai2.12173","source":{"id":"https://openalex.org/S4210222208","display_name":"Rheumatology & autoimmunity","issn_l":"2767-1410","issn":["2767-1410","2767-1429"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology &amp; Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rai2.12173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022884030","display_name":"Xiaodong Qin","orcid":"https://orcid.org/0000-0001-7655-2635","observed_orcids":["https://orcid.org/0000-0001-7655-2635"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Qin","raw_affiliation_strings":["Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China","Division of Spine Surgery, Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0001-7655-2635","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Division of Spine Surgery, Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yujiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujiao Wang","raw_affiliation_strings":["Department of Rheumatology and Immunology Nanjing Drum Tower Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology Nanjing Drum Tower Hospital, Chinese Academy of Medical Science &amp; Peking Union Medical College Nanjing Jiangsu China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104103840","display_name":"Yi Chen","orcid":"https://orcid.org/0009-0007-0108-3708","observed_orcids":["https://orcid.org/0009-0007-0108-3708"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Division of Spine Surgery, Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Spine Surgery, Department of Orthopedic Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054533615","display_name":"Dong Xie","orcid":"https://orcid.org/0009-0000-8542-7609","observed_orcids":["https://orcid.org/0009-0000-8542-7609"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Xie","raw_affiliation_strings":["Division of Spine Surgery, Department of Orthopedic Surgery Nanjing Drum Tower Hospital, Clinical College of Jiangsu University Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Spine Surgery, Department of Orthopedic Surgery Nanjing Drum Tower Hospital, Clinical College of Jiangsu University Nanjing Jiangsu China","institution_ids":["https://openalex.org/I115592961","https://openalex.org/I4210111013"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110356327","display_name":"Xinran Yuan","orcid":"https://orcid.org/0009-0008-3132-9200","observed_orcids":["https://orcid.org/0009-0008-3132-9200"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinran Yuan","raw_affiliation_strings":["Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China"],"raw_orcid":"https://orcid.org/0009-0008-3132-9200","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110356327"],"corresponding_institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05144372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"140","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd141-dendritic-cells","display_name":"CD141+ dendritic cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cd1c-dendritic-cells","display_name":"CD1c+ dendritic cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tolerogenic-dendritic-cells","display_name":"tolerogenic dendritic cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7620000243186951},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell-transplantation","display_name":"mesenchymal stem cell transplantation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.6275085806846619},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6194141507148743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6187124848365784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45004802942276},{"id":"https://openalex.org/C3019664528","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus","level":3,"score":0.43833717703819275},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10092127323150635},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09852969646453857}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/rai2.12173","doi":"https://doi.org/10.1002/rai2.12173","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rai2.12173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rai2.12173","source":{"id":"https://openalex.org/S4210222208","display_name":"Rheumatology & autoimmunity","issn_l":"2767-1410","issn":["2767-1410","2767-1429"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology &amp; Autoimmunity","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f6bff18ae319404d880bb82fc7d8e0d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f6bff18ae319404d880bb82fc7d8e0d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rheumatology & Autoimmunity, Vol 5, Iss 2, Pp 144-150 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/rai2.12173","doi":"https://doi.org/10.1002/rai2.12173","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rai2.12173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rai2.12173","source":{"id":"https://openalex.org/S4210222208","display_name":"Rheumatology & autoimmunity","issn_l":"2767-1410","issn":["2767-1410","2767-1429"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology &amp; Autoimmunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2007307037","display_name":null,"funder_award_id":"82002260","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7222666428","display_name":null,"funder_award_id":"81901649","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408331908.pdf","grobid_xml":"https://content.openalex.org/works/W4408331908.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1661544713","https://openalex.org/W2065907531","https://openalex.org/W2070527591","https://openalex.org/W2126705611","https://openalex.org/W2132491932","https://openalex.org/W2158692368","https://openalex.org/W2164113284","https://openalex.org/W2168401979","https://openalex.org/W2556671754","https://openalex.org/W2558485988","https://openalex.org/W2605810679","https://openalex.org/W2781617771","https://openalex.org/W2782507410","https://openalex.org/W2806773774","https://openalex.org/W2909900992","https://openalex.org/W2918286325","https://openalex.org/W2948725181","https://openalex.org/W2973863415","https://openalex.org/W2980750684","https://openalex.org/W3005015205","https://openalex.org/W3132732945","https://openalex.org/W3190209457","https://openalex.org/W4231495302","https://openalex.org/W4289783344","https://openalex.org/W4294316904","https://openalex.org/W4309699631","https://openalex.org/W4313404737"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W2006744010","https://openalex.org/W2009142766"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tolerogenic":[2],"dendritic":[3],"cells":[4],"(DCs)":[5],"are":[6],"promising":[7],"for":[8,11,363],"cell\u2010based":[9],"treatment":[10,33],"systemic":[12],"lupus":[13,47],"erythematosus":[14],"(SLE).":[15],"We":[16,36],"previously":[17],"showed":[18],"that":[19,136],"tolerogenic":[20,113,190],"CD1c":[21,119,248,333],"+":[22,44,88,117,120,142,182,240,249,322,334,369],"DCs":[23,45,89,121,143,183,241,250,323,335],"play":[24,324],"an":[25],"important":[26],"role":[27,328],"in":[28,65,145,184,251,336,344],"mesenchymal":[29],"stem":[30],"cell":[31],"transplantation":[32],"of":[34,42,52,71,84,94,115,139,199,256,288,353],"SLE.":[35,345],"further":[37],"investigated":[38],"the":[39,66,112,137,166,194,330,354,361],"immunoregulatory":[40,355],"effects":[41],"CD141":[43,87,116,141,181,239,321,368],"on":[46],"pathogenesis.":[48],"Methods":[49],"A":[50],"total":[51],"12":[53,57],"SLE":[54,107,130,146,167,187,282,317,358],"patients":[55,105,147,185],"and":[56,59,90,100,108,118,202,285,340,359],"age\u2010":[58],"sex\u2010matched":[60],"healthy":[61,109],"subjects":[62],"were":[63,102,122],"included":[64],"Affiliated":[67],"Drum":[68],"Tower":[69],"Hospital":[70],"Nanjing":[72],"University":[73],"Medical":[74],"School":[75],"from":[76],"January":[77,80],"2019":[78],"to":[79,247,349],"2021.":[81],"The":[82],"percentage":[83],"peripheral":[85,140],"blood":[86],"their":[91],"functional":[92],"expressions":[93],"costimulatory":[95],"markers":[96],"(CD40,":[97],"CD80,":[98,201],"CD83,":[99],"CD86)":[101],"compared":[103,123,148,205,246],"between":[104],"with":[106,126,149,165,186,206],"controls.":[110],"Moreover,":[111,180],"properties":[114,191],"following":[124],"stimulation":[125],"lipopolysaccharide":[127],"(LPS)":[128],"or":[129],"serum.":[131],"Results":[132],"Our":[133,346],"research":[134],"revealed":[135],"presence":[138],"decreased":[144],"controls":[150,207],"(1.03%":[151],"\u00b1":[152,156,209,213,219,223,229,233,259,263,272,276,294,298,307,311],"0.40%":[153],"vs.":[154,211,221,231,261,274,296,309],"1.44%":[155],"0.36%,":[157],"p":[158,177,215,225,235,265,278,300,313],"<":[159,216,226,236,266,279,301,314],"0.05),":[160],"which":[161],"was":[162],"negatively":[163],"correlated":[164],"disease":[168],"activity":[169],"index":[170],"score":[171],"(":[172],"R":[173],"2":[174],"=":[175,178],"0.5547,":[176],"0.0055).":[179],"exhibited":[188,242],"distinct":[189],"by":[192,253,268,281,303,316],"decreasing":[193],"mean":[195],"fluorescence":[196],"intensity":[197],"(MFI)":[198],"CD40,":[200],"CD86":[203,257],"when":[204,245],"(2447.00":[208],"1386.14":[210],"11,357.25":[212],"4581.05,":[214],"0.001;":[217,227],"1528.00":[218],"876.61":[220],"14,181.42":[222],"7599.33,":[224],"17,409.42":[228],"8180.98":[230],"33,614.25":[232],"7408.69,":[234],"0.001).":[237],"Furthermore,":[238],"superior":[243],"tolerogenicity":[244],"SLE,":[252],"reducing":[254,286],"MFI":[255],"(93,526.58":[258],"51,763.00":[260],"169,552.00":[262],"51,225.74,":[264],"0.01":[267],"LPS":[269,304],"stimulation;":[270,305],"107,837.40":[271],"26,124.76":[273],"145,450.90":[275],"50,436.69,":[277],"0.05":[280,302,315],"serum":[283,318],"stimulation),":[284],"production":[287],"tumor":[289],"necrosis":[290],"factor":[291],"\u03b1":[292],"(8.83%":[293],"3.51%":[295],"13.94%":[297],"2.87%,":[299],"10.12%":[306],"2.34%":[308],"14.39%":[310],"2.70%,":[312],"stimulation).":[319],"Conclusions":[320],"a":[325,350],"more":[326],"significant":[327],"than":[329],"commonly":[331],"studied":[332],"ameliorating":[337],"immune":[338,342],"dysfunction":[339],"maintaining":[341],"homeostasis":[343],"findings":[347],"contribute":[348],"better":[351],"understanding":[352],"mechanisms":[356],"underlying":[357],"pave":[360],"way":[362],"novel":[364],"therapeutic":[365],"approaches":[366],"targeting":[367],"DCs.":[370]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}