{"id":"https://openalex.org/W4408317173","doi":"https://doi.org/10.1053/j.gastro.2025.01.252","title":"Mucosal Macrophages Govern Intestinal Regeneration in Response to Injury","display_name":"Mucosal Macrophages Govern Intestinal Regeneration in Response to Injury","publication_year":2025,"publication_date":"2025-03-12","ids":{"openalex":"https://openalex.org/W4408317173","doi":"https://doi.org/10.1053/j.gastro.2025.01.252","pmid":"https://pubmed.ncbi.nlm.nih.gov/40086603"},"language":"en","primary_location":{"id":"doi:10.1053/j.gastro.2025.01.252","doi":"https://doi.org/10.1053/j.gastro.2025.01.252","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2025.01.252","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1053/j.gastro.2025.01.252","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035652839","display_name":"Ilias Moraitis","orcid":"https://orcid.org/0000-0002-3879-8623","observed_orcids":["https://orcid.org/0000-0002-3879-8623"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ilias Moraitis","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain; Biomedicine PhD Program, Universitat de Barcelona, Barcelona, Spain","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain; Biomedicine PhD Program, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059566655","display_name":"Jasin Taelman","orcid":"https://orcid.org/0000-0001-7712-3437","observed_orcids":["https://orcid.org/0000-0001-7712-3437"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jasin Taelman","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116583505","display_name":"Borja Arozamena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Borja Arozamena","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074157416","display_name":"Loris Mularoni","orcid":"https://orcid.org/0000-0001-7053-7717","observed_orcids":["https://orcid.org/0000-0001-7053-7717"]},"institutions":[{"id":"https://openalex.org/I4210138155","display_name":"Center of Regenerative Medicine in Barcelona","ror":"https://ror.org/03q0p7c86","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138155","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Loris Mularoni","raw_affiliation_strings":["Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210138155"]},{"raw_affiliation_string":"Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210138155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116583506","display_name":"Olga Wienskowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Wienskowska","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083985867","display_name":"Xavier Sanj\u00faan Garriga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Sanjuan Garriga","raw_affiliation_strings":["Department of Pathology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain","Department of Pathology, Bellvitge University Hospital (HUB), L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225"]},{"raw_affiliation_string":"Department of Pathology, Bellvitge University Hospital (HUB), L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I2802050225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006665174","display_name":"Laura Arregui","orcid":"https://orcid.org/0000-0002-7296-8526","observed_orcids":["https://orcid.org/0000-0002-7296-8526"]},"institutions":[{"id":"https://openalex.org/I2802050225","display_name":"Bellvitge University Hospital","ror":"https://ror.org/00epner96","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Arregui","raw_affiliation_strings":["HUB-ICO-IDIBELL Biobank, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","HUB-ICO-IDIBELL Biobank, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HUB-ICO-IDIBELL Biobank, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I2802050225","https://openalex.org/I4210087039"]},{"raw_affiliation_string":"HUB-ICO-IDIBELL Biobank, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047304195","display_name":"Milica Stefanovi\u0107","orcid":"https://orcid.org/0000-0001-9293-4385","observed_orcids":["https://orcid.org/0000-0001-9293-4385"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milica Stefanovic","raw_affiliation_strings":["Department of Radiobiology and Cancer, ONCOBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","Department of Radiobiology and Cancer, ONCOBELL - IDIBELL, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, Avinguda Granvia, 199-203, 08908, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiobiology and Cancer, ONCOBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]},{"raw_affiliation_string":"Department of Radiobiology and Cancer, ONCOBELL - IDIBELL, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, Avinguda Granvia, 199-203, 08908, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ignasi Modolell Farr\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignasi Modolell Farr\u00e9","raw_affiliation_strings":["Servei de F\u00edsica M\u00e8dica i Protecci\u00f3 Radiol\u00f2gica, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","Servei de F\u00edsica M\u00e8dica i Protecci\u00f3 Radiol\u00f2gica. Institut Catal\u00e0 d'Oncologia. l'Hospitalet del Llobregat, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servei de F\u00edsica M\u00e8dica i Protecci\u00f3 Radiol\u00f2gica, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147"]},{"raw_affiliation_string":"Servei de F\u00edsica M\u00e8dica i Protecci\u00f3 Radiol\u00f2gica. Institut Catal\u00e0 d'Oncologia. l'Hospitalet del Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040582597","display_name":"Ferr\u00e1n Guedea","orcid":"https://orcid.org/0000-0001-8798-8696","observed_orcids":["https://orcid.org/0000-0001-8798-8696"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ferran Guedea","raw_affiliation_strings":["Department of Radiobiology and Cancer, ONCOBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","Department of Radiobiology and Cancer, ONCOBELL - IDIBELL, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, Avinguda Granvia, 199-203, 08908, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiobiology and Cancer, ONCOBELL, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]},{"raw_affiliation_string":"Department of Radiobiology and Cancer, ONCOBELL - IDIBELL, Barcelona, Spain; Department of Radiation Oncology, Institut Catal\u00e0 d'Oncologia, L'Hospitalet de Llobregat, Avinguda Granvia, 199-203, 08908, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014712288","display_name":"M\u00f2nica D\u0131\u0301az","orcid":"https://orcid.org/0000-0002-4428-4258","observed_orcids":["https://orcid.org/0000-0002-4428-4258"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f2nica Diaz","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain","institution_ids":["https://openalex.org/I4210087039"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain","institution_ids":["https://openalex.org/I4210087039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085290390","display_name":"Jordi Guiu","orcid":"https://orcid.org/0000-0003-0297-2543","observed_orcids":["https://orcid.org/0000-0003-0297-2543"]},"institutions":[{"id":"https://openalex.org/I4210087039","display_name":"Institut d'Investigaci\u00f3 Biom\u00e9dica de Bellvitge","ror":"https://ror.org/0008xqs48","country_code":"ES","type":"facility","lineage":["https://openalex.org/I157913058","https://openalex.org/I2802050225","https://openalex.org/I4210087039","https://openalex.org/I4210096656","https://openalex.org/I4210106543","https://openalex.org/I4210107147","https://openalex.org/I4210153292","https://openalex.org/I4387153040","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Guiu","raw_affiliation_strings":["Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain; Centre for Networked Biomedical Research on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, Spain. Electronic address: jguiu@idibell.cat","Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain. Electronic address: jguiu@idibell.cat"],"raw_orcid":"https://orcid.org/0000-0003-0297-2543","affiliations":[{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Program for Advancing the Clinical Translation of Regenerative Medicine of Catalonia (P-CMR[C]), L'Hospitalet de Llobregat, Barcelona, Spain; Centre for Networked Biomedical Research on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, Spain. Electronic address: jguiu@idibell.cat","institution_ids":["https://openalex.org/I4210087039","https://openalex.org/I4210105141"]},{"raw_affiliation_string":"Cell Plasticity and Regeneration Group, Regenerative Medicine Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain; Program for advancing the Clinical Translation of Regenerative Medicine of Catalonia, P-CMR[C], L'Hospitalet de Llobregat, Spain. Electronic address: jguiu@idibell.cat","institution_ids":["https://openalex.org/I4210087039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":21.1239,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.99831406,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"169","issue":"1","first_page":"119","last_page":"135.e26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.09790000319480896,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-intestinal-injury","display_name":"radiation enteritis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/intestinal-regeneration","display_name":"intestinal regeneration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.8019999861717224},{"id":"https://openalex.org/keywords/intestinal-stem-cells","display_name":"intestinal stem cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.6759999990463257},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":1.0},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.777999997138977},{"id":"https://openalex.org/keywords/cancer-radiotherapy","display_name":"cancer radiotherapy","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.783435583114624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49421265721321106},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4415547251701355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34100258350372314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3199676275253296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2887369394302368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07315835356712341}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004751","descriptor_name":"Enteritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1053/j.gastro.2025.01.252","doi":"https://doi.org/10.1053/j.gastro.2025.01.252","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2025.01.252","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:40086603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40086603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:diposit.ub.edu:2445/223769","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2445/223769","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Facultat - Medicina i Ci\u00e8ncies de la Salut","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/695525","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10803/695525","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.1053/j.gastro.2025.01.252","doi":"https://doi.org/10.1053/j.gastro.2025.01.252","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2025.01.252","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1817775333","display_name":"Desarrollando terapias para sobrevivientes de c\u00e1ncer","funder_award_id":"PI21/01152","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3522678809","display_name":null,"funder_award_id":"PT20/00171","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5565443144","display_name":"Potenciando la regeneraci\u00f3n intestinal para mejorar la calidad de vida de los pacientes y sobrevivientes de c\u00e1ncer (Q-Life-4-Survivors)","funder_award_id":"PI24/00189","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6725885745","display_name":null,"funder_award_id":"CP20/00115","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320328517","display_name":"Xarxa de Bancs de Tumors de Catalunya","ror":"https://ror.org/03bbghz75"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1566325063","https://openalex.org/W1872124954","https://openalex.org/W1982603620","https://openalex.org/W1984798403","https://openalex.org/W1988903229","https://openalex.org/W1989940296","https://openalex.org/W1993057579","https://openalex.org/W1994216131","https://openalex.org/W1998536076","https://openalex.org/W2014636138","https://openalex.org/W2030890903","https://openalex.org/W2038847295","https://openalex.org/W2054540776","https://openalex.org/W2075935381","https://openalex.org/W2078710631","https://openalex.org/W2082493388","https://openalex.org/W2092271761","https://openalex.org/W2120950548","https://openalex.org/W2130410032","https://openalex.org/W2140380746","https://openalex.org/W2145955680","https://openalex.org/W2157910818","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2262448048","https://openalex.org/W2332292689","https://openalex.org/W2406872093","https://openalex.org/W2530406573","https://openalex.org/W2613762446","https://openalex.org/W2759615793","https://openalex.org/W2759760274","https://openalex.org/W2767423581","https://openalex.org/W2773293509","https://openalex.org/W2804230186","https://openalex.org/W2807022503","https://openalex.org/W2810563185","https://openalex.org/W2883907811","https://openalex.org/W2889537463","https://openalex.org/W2912913685","https://openalex.org/W2941492678","https://openalex.org/W2941549157","https://openalex.org/W2945765254","https://openalex.org/W2945777288","https://openalex.org/W2950975031","https://openalex.org/W2995043840","https://openalex.org/W3006653136","https://openalex.org/W3011623125","https://openalex.org/W3023907854","https://openalex.org/W3043815129","https://openalex.org/W3115703421","https://openalex.org/W3126961763","https://openalex.org/W3138104526","https://openalex.org/W3157353881","https://openalex.org/W3164692211","https://openalex.org/W3186873953","https://openalex.org/W3192533141","https://openalex.org/W3207746722","https://openalex.org/W3217151720","https://openalex.org/W4205496949","https://openalex.org/W4220828290","https://openalex.org/W4226232593","https://openalex.org/W4295898355","https://openalex.org/W4306168838","https://openalex.org/W4308484211","https://openalex.org/W4324020320","https://openalex.org/W4366815560","https://openalex.org/W4384027539","https://openalex.org/W4385711684","https://openalex.org/W4386171364","https://openalex.org/W4387826385","https://openalex.org/W4387936941","https://openalex.org/W4399492666"],"related_works":["https://openalex.org/W4402946548","https://openalex.org/W4323349405","https://openalex.org/W4389504853","https://openalex.org/W4416221274","https://openalex.org/W3080794963","https://openalex.org/W4388668534","https://openalex.org/W4388821640","https://openalex.org/W4288060426","https://openalex.org/W2530406573","https://openalex.org/W2762936155"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"Radiation-induced":[3],"enteritis":[4,72],"develops":[5],"in":[6,12,33,73,126,216,236,241,267],"cancer":[7,277],"patients":[8],"treated":[9],"with":[10],"radiotherapy":[11],"the":[13,37,45,48,51,55,58,89,94,117,149,156,170,189,231,238,272],"abdominal":[14,76],"and":[15,83,99,109,113,143,158,182,211,226,270],"pelvic":[16],"cavity,":[17],"a":[18,40,104,179],"condition":[19],"that":[20,43,53,165,187],"impairs":[21],"their":[22,257],"quality":[23,273],"of":[24,47,57,91,129,152,184,222,233,274],"life.":[25],"Radiation":[26],"injury":[27,98],"depletes":[28],"proliferative":[29],"intestinal":[30,59,111,141,153,171,254],"stem":[31,172],"cells;":[32],"response":[34],"to":[35,93,115,197,253],"this,":[36],"epithelium":[38],"activates":[39],"regenerative":[41,60,239],"program":[42,61,240],"facilitates":[44],"healing":[46],"intestine.":[49],"However,":[50],"mechanisms":[52],"induce":[54],"activation":[56],"are":[62,167],"poorly":[63],"characterized.":[64],"METHODS:":[65],"In":[66,192],"this":[67,218],"study,":[68],"we":[69,87,102,147],"induced":[70],"radiation-induced":[71],"mice":[74],"through":[75],"irradiation,":[77],"mimicking":[78],"clinical":[79],"scenarios.":[80],"Through":[81],"imaging":[82],"flow":[84],"cytometric":[85],"analysis,":[86,146],"investigated":[88],"recruitment":[90],"macrophages":[92,114,166,249,262],"small":[95],"intestine":[96],"during":[97],"healing.":[100],"Additionally,":[101,220],"developed":[103],"coculture":[105],"system":[106],"for":[107,276],"mouse":[108],"human":[110,140,223,243],"organoids":[112],"explore":[116],"cross":[118],"talk":[119],"between":[120],"these":[121],"cells.":[122,244],"Then":[123],"by":[124],"combining":[125],"vivo":[127],"ablation":[128,195],"macrophages,":[130],"fluorescent":[131],"lineage":[132],"tracing,":[133],"imaging,":[134],"bulk":[135],"RNA-sequencing":[136],"(RNA-seq),":[137],"single-cell":[138,202],"RNA-seq,":[139],"organoids,":[142],"cell":[144,173,227],"trajectory":[145,228],"studied":[148],"macrophage":[150,194],"induction":[151],"regeneration":[154,190,255,269],"at":[155],"cellular":[157],"molecular":[159],"level.":[160],"RESULTS:":[161],"Our":[162],"findings":[163],"revealed":[164],"recruited":[168],"around":[169],"compartment":[174],"upon":[175],"radiation":[176],"injury,":[177],"promoting":[178],"fetal-like":[180],"reprogramming":[181],"proliferation":[183],"epithelial":[185],"cells":[186],"drives":[188],"process.":[191,219],"contrast,":[193],"led":[196],"compromised":[198],"regeneration.":[199],"Moreover,":[200],"our":[201],"RNA-seq":[203],"analysis":[204],"identified":[205],"key":[206],"secreted":[207],"molecules,":[208],"neuregulin":[209],"1":[210],"osteopontin,":[212],"as":[213,250],"pivotal":[214],"players":[215],"regulating":[217],"characterization":[221],"macrophage/organoid":[224],"cocultures":[225],"inference":[229],"confirmed":[230],"conservation":[232],"macrophages'":[234],"role":[235],"triggering":[237],"primary":[242],"CONCLUSIONS:":[245],"This":[246],"study":[247],"identifies":[248],"essential":[251],"contributors":[252],"beyond":[256],"innate":[258],"immune":[259],"response.":[260],"Targeting":[261],"therapeutically":[263],"may":[264],"hold":[265],"promise":[266],"enhancing":[268],"improving":[271],"life":[275],"survivors.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":12}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-03-12T00:00:00"}