{"id":"https://openalex.org/W4408244108","doi":"https://doi.org/10.1002/advs.202416629","title":"Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High\u2010Efficiency mRNA\u2010Based Cell Reprogramming","display_name":"Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High\u2010Efficiency mRNA\u2010Based Cell Reprogramming","publication_year":2025,"publication_date":"2025-03-05","ids":{"openalex":"https://openalex.org/W4408244108","doi":"https://doi.org/10.1002/advs.202416629","pmid":"https://pubmed.ncbi.nlm.nih.gov/40042035"},"language":"en","primary_location":{"id":"doi:10.1002/advs.202416629","doi":"https://doi.org/10.1002/advs.202416629","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202416629","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/advs.202416629","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070756716","display_name":"Z.D. Zhang","orcid":"https://orcid.org/0009-0008-7884-4402","observed_orcids":["https://orcid.org/0009-0008-7884-4402"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziwei Zhang","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China"],"raw_orcid":"https://orcid.org/0009-0008-7884-4402","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weiyu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyu Li","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","Sino\u2010Danish College University of Chinese Academy of Sciences  Huairou District Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Sino\u2010Danish College University of Chinese Academy of Sciences  Huairou District Beijing 100190 China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102773751","display_name":"Xiangyu Ren","orcid":"https://orcid.org/0000-0002-7923-7507","observed_orcids":["https://orcid.org/0000-0002-7923-7507"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyu Ren","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","College of Nanoscience and Technology University of Chinese Academy of Sciences  Huairou District Beijing 100049 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"College of Nanoscience and Technology University of Chinese Academy of Sciences  Huairou District Beijing 100049 China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113394359","display_name":"Dengwang Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dengwang Luo","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University  Jinnan District Tianjin 300072 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University  Jinnan District Tianjin 300072 China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108988782","display_name":"Xiushuang Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiushuang Yuan","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719439","display_name":"Li Zhi Yu","orcid":"https://orcid.org/0000-0002-5325-400X","observed_orcids":["https://orcid.org/0000-0002-5325-400X"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yu","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691328","display_name":"Daming Wang","orcid":"https://orcid.org/0000-0002-1937-6695","observed_orcids":["https://orcid.org/0000-0002-1937-6695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daming Wang","raw_affiliation_strings":["BiosynRNA Biotechnology Company  Haidian District Beijing 100192 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiosynRNA Biotechnology Company  Haidian District Beijing 100192 China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030979504","display_name":"Yuhong Cao","orcid":"https://orcid.org/0000-0001-8065-4634","observed_orcids":["https://orcid.org/0000-0001-8065-4634"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210141483","display_name":"National Center for Nanoscience and Technology","ror":"https://ror.org/04f49ff35","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuhong Cao","raw_affiliation_strings":["CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","College of Nanoscience and Technology University of Chinese Academy of Sciences  Huairou District Beijing 100049 China"],"raw_orcid":"https://orcid.org/0000-0001-8065-4634","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences  Haidian District Beijing 100190 China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483"]},{"raw_affiliation_string":"College of Nanoscience and Technology University of Chinese Academy of Sciences  Huairou District Beijing 100049 China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030979504"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210141483","https://openalex.org/I4210165038"],"apc_list":{"value":6730,"currency":"USD","value_usd":6730},"apc_paid":{"value":6730,"currency":"USD","value_usd":6730},"fwci":4.9332,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.96428879,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"12","issue":"16","first_page":"e2416629","last_page":"e2416629"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pollutant-removal","display_name":"pollutant removal","score":0.7319999933242798},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8489999771118164},{"id":"https://openalex.org/keywords/5-triphosphate","display_name":"5'-triphosphate","score":0.8769999742507935},{"id":"https://openalex.org/keywords/rna-hydrolysis","display_name":"RNA hydrolysis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-reprogramming","display_name":"induced pluripotent stem cell reprogramming","score":0.8939999938011169},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/enzymatic-treatment","display_name":"enzymatic treatment","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.800749659538269},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6408788561820984},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4605506956577301},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43907102942466736},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39283716678619385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38369429111480713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3737269341945648},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22526979446411133},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.07770043611526489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07036569714546204}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/advs.202416629","doi":"https://doi.org/10.1002/advs.202416629","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202416629","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmid:40042035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40042035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10831250","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12021033","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12021033","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12021033","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9dc5289b16d24a32ba5c0a22281abb32","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9dc5289b16d24a32ba5c0a22281abb32","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Science, Vol 12, Iss 16, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/advs.202416629","doi":"https://doi.org/10.1002/advs.202416629","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202416629","pdf_url":null,"source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5899999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G39115863","display_name":null,"funder_award_id":"32271516","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8474246786","display_name":null,"funder_award_id":"2021YFA1201101","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G8665749876","display_name":null,"funder_award_id":"2021YFC2302402","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1846946632","https://openalex.org/W2017515700","https://openalex.org/W2044843509","https://openalex.org/W2071136305","https://openalex.org/W2076361525","https://openalex.org/W2099866950","https://openalex.org/W2104005232","https://openalex.org/W2116692899","https://openalex.org/W2117623697","https://openalex.org/W2125566625","https://openalex.org/W2144103846","https://openalex.org/W2179438025","https://openalex.org/W2473991067","https://openalex.org/W2626686215","https://openalex.org/W2774072836","https://openalex.org/W2791520226","https://openalex.org/W2811482166","https://openalex.org/W2915388137","https://openalex.org/W2923639686","https://openalex.org/W2942134847","https://openalex.org/W2955067089","https://openalex.org/W3037578051","https://openalex.org/W3175752499","https://openalex.org/W3200074293","https://openalex.org/W3207060908","https://openalex.org/W4200435560","https://openalex.org/W4207017806","https://openalex.org/W4226027283","https://openalex.org/W4226368062","https://openalex.org/W4285728587","https://openalex.org/W4295222570","https://openalex.org/W4318616170","https://openalex.org/W4320712161","https://openalex.org/W4362722040","https://openalex.org/W4365151374","https://openalex.org/W4375954875","https://openalex.org/W4385298686","https://openalex.org/W4385563396","https://openalex.org/W4388616649","https://openalex.org/W4391513525","https://openalex.org/W4395041513","https://openalex.org/W4400211346","https://openalex.org/W4404563327"],"related_works":["https://openalex.org/W3029540856","https://openalex.org/W2418603484","https://openalex.org/W4254937032","https://openalex.org/W2744405843","https://openalex.org/W2243107914","https://openalex.org/W2415743749","https://openalex.org/W3032669875","https://openalex.org/W1888433033","https://openalex.org/W2990520546","https://openalex.org/W2479215566"],"abstract_inverted_index":{"Synthetic":[0],"circular":[1],"RNA":[2,43],"(circRNA)":[3],"holds":[4],"great":[5],"promise":[6],"for":[7,144,161,172],"biomedical":[8],"research":[9],"and":[10,22,41,67,81,122,158,175],"therapeutic":[11],"applications,":[12],"but":[13],"impurities":[14],"introduced":[15],"during":[16],"synthesis":[17],"trigger":[18],"innate":[19],"immune":[20,79],"responses":[21],"significantly":[23,77],"compromise":[24],"its":[25],"efficacy.":[26],"In":[27],"this":[28],"study,":[29],"key":[30],"immunogenic":[31],"byproducts,":[32],"including":[33],"double-stranded":[34],"RNA,":[35,40,164],"5'":[36],"triphosphates":[37],"from":[38],"uncircularized":[39],"hydrolyzed":[42],"fragments,":[44],"are":[45],"identified":[46],"as":[47,155],"impairing":[48],"circRNA":[49,86,92,112,118],"functionality":[50],"via":[51],"RNA-sensing":[52],"pathways.":[53],"To":[54],"address":[55],"this,":[56],"a":[57,141,156],"multi-step":[58],"purification":[59,153],"process":[60],"is":[61],"developed":[62],"that":[63],"combines":[64],"enzymatic":[65],"treatments":[66],"cellulose-based":[68],"filtration":[69],"to":[70],"effectively":[71],"remove":[72],"these":[73],"contaminants.":[74],"This":[75],"approach":[76],"reduces":[78],"activation":[80],"increases":[82],"manufacturing":[83],"yields":[84],"of":[85,125],"by":[87],"over":[88,104],"10-fold.":[89],"The":[90],"purified":[91,117],"demonstrates":[93],"exceptional":[94],"performance":[95],"in":[96,130,168],"induced":[97],"pluripotent":[98],"stem":[99],"cells":[100,132],"(iPSCs)":[101],"reprogramming,":[102],"achieving":[103],"300%":[105],"reprogramming":[106,171],"efficiency":[107],"with":[108,133,165],"just":[109],"three":[110],"OSKMLN":[111],"transfection":[113],"treatments.":[114],"Additionally,":[115],"the":[116,152],"achieves":[119],"high":[120,134],"levels":[121],"persistent":[123],"expression":[124],"chimeric":[126],"antigen":[127],"receptor":[128],"(CAR)":[129],"T":[131],"cytotoxicity":[135],"against":[136],"tumor":[137],"cells,":[138],"making":[139],"it":[140],"promising":[142],"candidate":[143],"mRNA-based":[145,169],"CAR-T":[146],"cell":[147,170],"therapy.":[148],"These":[149],"findings":[150],"establish":[151],"strategy":[154],"scalable":[157],"reliable":[159],"platform":[160],"producing":[162],"therapeutic-grade":[163],"broad":[166],"applications":[167],"regenerative":[173],"medicine":[174],"cancer":[176],"immunotherapy.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}