{"id":"https://openalex.org/W4408220816","doi":"https://doi.org/10.17760/d20670411","title":"Sex, glaucoma, and iris biomechanics","display_name":"Sex, glaucoma, and iris biomechanics","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4408220816","doi":"https://doi.org/10.17760/d20670411"},"language":"en","primary_location":{"id":"doi:10.17760/d20670411","doi":"https://doi.org/10.17760/d20670411","is_oa":false,"landing_page_url":"https://doi.org/10.17760/d20670411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400714","display_name":"Digital Repository Service (Northeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12912129","host_organization_name":"Northeastern University","host_organization_lineage":["https://openalex.org/I12912129"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northeastern University","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010214607","display_name":"Frederick Sebastian","orcid":"https://orcid.org/0000-0002-7446-4989","observed_orcids":["https://orcid.org/0000-0002-7446-4989"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Frederick Sebastian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010214607"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8479999899864197},{"id":"https://openalex.org/keywords/primary-angle-closure-glaucoma","display_name":"primary angle-closure glaucoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sex-bias-in-research","display_name":"sex bias in research","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sex-as-a-biological-variable","display_name":"sex as a biological variable","score":0.8190000057220459},{"id":"https://openalex.org/keywords/microindentation","display_name":"microindentation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/inverse-finite-element-method","display_name":"inverse finite element method","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.7835763692855835},{"id":"https://openalex.org/C2779503344","wikidata":"https://www.wikidata.org/wiki/Q5973514","display_name":"IRIS (biosensor)","level":3,"score":0.652327299118042},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6322318315505981},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.44642966985702515},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4196874499320984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31255215406417847},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17966246604919434},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13090506196022034},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1253824532032013},{"id":"https://openalex.org/C184297639","wikidata":"https://www.wikidata.org/wiki/Q177765","display_name":"Biometrics","level":2,"score":0.07262933254241943}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17760/d20670411","doi":"https://doi.org/10.17760/d20670411","is_oa":false,"landing_page_url":"https://doi.org/10.17760/d20670411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400714","display_name":"Digital Repository Service (Northeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12912129","host_organization_name":"Northeastern University","host_organization_lineage":["https://openalex.org/I12912129"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Northeastern University","raw_type":"dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410954594","https://openalex.org/W7212309331","https://openalex.org/W2368117677","https://openalex.org/W3208176446","https://openalex.org/W4283829053","https://openalex.org/W4387376927","https://openalex.org/W2384604692","https://openalex.org/W2886322942","https://openalex.org/W2086839274","https://openalex.org/W2008228413"],"abstract_inverted_index":{"In":[0],"this":[1],"dissertation":[2],"the":[3,14,34,56,68,72,98,102,105,125,142,157,167,171,209,212,242,263,279,287],"critical":[4],"intersections":[5],"of":[6,16,22,36,58,71,89,101,108,115,145,159,170,208,246,265,289],"sex":[7,37,267,284],"biases":[8,54],"in":[9,13,39,55,61,75,110,119,132,185,235,272,282],"biomechanics":[10,15,40,273,288],"research,":[11],"particularly":[12],"glaucoma":[17,92],"-":[18,28],"a":[19,47,269],"leading":[20],"cause":[21],"blindness":[23],"that":[24,124,141,217,251,307],"disproportionately":[25],"affects":[26],"women":[27,111],"were":[29],"investigated.":[30],"First,":[31],"we":[32,122,155,174,215,298],"delineated":[33],"pattern":[35],"representation":[38],"research":[41,274],"by":[42,97,195],"analyzing":[43],"abstracts":[44],"submitted":[45],"to":[46,136,180,204,230,277,300],"major":[48],"conference":[49],"and":[50,53,77,112,164,191,201,244,255,275,295,304],"uncovered":[51],"trends":[52],"inclusion":[57],"both":[59,189,241],"sexes":[60],"study":[62],"samples.":[63,138],"We":[64,197],"then":[65],"experimentally":[66],"characterized":[67],"elastic":[69,126],"modulus":[70,127],"iris":[73,117,183,224,236],"stroma":[74],"female":[76,133,218],"male":[78,137],"porcine":[79],"samples":[80],"ex":[81],"vivo,":[82],"utilizing":[83],"micro-indentation":[84],"techniques.":[85],"The":[86],"complex":[87],"pathophysiology":[88],"primary":[90],"angle-closure":[91],"(PACG)":[93],"is":[94],"significantly":[95,130,150,222],"influenced":[96],"mechanical":[99,168,206],"properties":[100,169,207],"iris.":[103,172,210],"Given":[104,211],"higher":[106],"incidence":[107],"PACG":[109,120,192],"prior":[113],"evidence":[114],"increased":[116],"stiffness":[118,184],"patients,":[121],"hypothesized":[123,216],"will":[128],"be":[129],"greater":[131,223],"irides":[134],"compared":[135],"Additionally,":[139],"recognizing":[140],"intrinsic":[143],"behaviors":[144],"soft":[146],"tissues":[147],"can":[148],"vary":[149],"under":[151],"different":[152],"environmental":[153],"conditions,":[154],"investigated":[156],"effects":[158],"factors":[160],"such":[161],"as":[162,268],"temperature":[163],"hydration":[165],"on":[166],"Finally,":[173],"employed":[175],"inverse":[176],"finite":[177],"element":[178],"analysis":[179],"quantify":[181],"in-vivo":[182],"human":[186],"subjects":[187,219],"from":[188,315],"healthy":[190],"groups,":[193],"stratified":[194],"sex.":[196],"utilized":[198],"clinical":[199,294],"imaging":[200],"computational":[202],"modeling":[203],"assess":[205],"aforementioned":[213],"reasons,":[214],"would":[220],"exhibit":[221],"stiffness.":[225],"This":[226],"nuanced":[227],"approach":[228],"aimed":[229],"reveal":[231],"how":[232,283],"sex-specific":[233],"differences":[234,285],"mechanics":[237],"could":[238,252],"potentially":[239],"influence":[240],"risk":[243],"progression":[245],"glaucoma,":[247],"thereby":[248],"offering":[249],"insights":[250],"refine":[253],"diagnostic":[254],"therapeutic":[256],"strategies":[257],"for":[258,310],"PACG.":[259],"Our":[260],"findings":[261],"underscore":[262],"necessity":[264],"incorporating":[266],"biological":[270],"variable":[271],"strive":[276],"bridge":[278],"knowledge":[280],"gap":[281],"affect":[286],"ocular":[290],"tissues.":[291],"By":[292],"integrating":[293],"pre-clinical":[296],"findings,":[297],"aim":[299],"inform":[301],"more":[302],"precise":[303],"effective":[305],"treatments":[306],"improve":[308],"outcomes":[309],"patients":[311],"with":[312],"vision":[313],"impairments":[314],"PACG.--Author's":[316],"abstract":[317]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-03-08T00:00:00"}