{"id":"https://openalex.org/W4408165240","doi":"https://doi.org/10.1016/j.brainresbull.2025.111291","title":"Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey","display_name":"Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey","publication_year":2025,"publication_date":"2025-03-05","ids":{"openalex":"https://openalex.org/W4408165240","doi":"https://doi.org/10.1016/j.brainresbull.2025.111291","pmid":"https://pubmed.ncbi.nlm.nih.gov/40054539"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainresbull.2025.111291","doi":"https://doi.org/10.1016/j.brainresbull.2025.111291","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2025.111291","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.brainresbull.2025.111291","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031148539","display_name":"Xue Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Shi","raw_affiliation_strings":["Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769092","display_name":"Jingdong Zhang","orcid":"https://orcid.org/0000-0002-3475-3321","observed_orcids":["https://orcid.org/0000-0002-3475-3321"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingdong Zhang","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huangying Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huangying Zhao","raw_affiliation_strings":["Division of Pharmaceutical Science, University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutical Science, University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065155774","display_name":"Hongjun Li","orcid":"https://orcid.org/0000-0003-1102-6225","observed_orcids":["https://orcid.org/0000-0003-1102-6225","https://orcid.org/0000-0002-1765-8445"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147332","display_name":"Beijing YouAn Hospital","ror":"https://ror.org/04etaja30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjun Li","raw_affiliation_strings":["Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064114224","display_name":"Junyi Zhu","orcid":"https://orcid.org/0009-0009-2963-0632","observed_orcids":["https://orcid.org/0009-0009-2963-0632"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junyi Zhu","raw_affiliation_strings":["Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Molecular Biological Targeted Therapies of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: zhujunyi@hust.edu.cn"],"raw_orcid":"https://orcid.org/0009-0009-2963-0632","affiliations":[{"raw_affiliation_string":"Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Key Laboratory of Molecular Biological Targeted Therapies of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: zhujunyi@hust.edu.cn","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035117703","display_name":"Huangui Xiong","orcid":"https://orcid.org/0000-0003-3450-8876","observed_orcids":["https://orcid.org/0000-0003-3450-8876"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huangui Xiong","raw_affiliation_strings":["Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: hxiong@unmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: hxiong@unmc.edu","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5035117703","https://openalex.org/A5064114224"],"corresponding_institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641","https://openalex.org/I59130452"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":{"value":3280,"currency":"USD","value_usd":3280},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07374884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"223","issue":null,"first_page":"111291","last_page":"111291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.2312999963760376,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.5690000057220459},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/siv-infection","display_name":"SIV infection","score":0.8560000061988831},{"id":"https://openalex.org/keywords/monkey-brain","display_name":"monkey brain","score":0.6959999799728394},{"id":"https://openalex.org/keywords/grey-matter","display_name":"grey matter","score":0.9210000038146973},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":1.0},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ependyma","display_name":"ependyma","score":0.902999997138977},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.5460000038146973},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/perivascular-cells","display_name":"perivascular cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8569999933242798},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/viral-reservoir","display_name":"viral reservoir","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.7097650766372681},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6254213452339172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6217515468597412},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5803160667419434},{"id":"https://openalex.org/C2776488936","wikidata":"https://www.wikidata.org/wiki/Q5452918","display_name":"Simian","level":3,"score":0.5444350242614746},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5304405689239502},{"id":"https://openalex.org/C186382791","wikidata":"https://www.wikidata.org/wiki/Q3648585","display_name":"CCL21","level":5,"score":0.49973392486572266},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4730781018733978},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.41834574937820435},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2877148389816284},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.142723947763443}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.brainresbull.2025.111291","doi":"https://doi.org/10.1016/j.brainresbull.2025.111291","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2025.111291","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},{"id":"pmid:40054539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40054539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research bulletin","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0f314f3a219c4bf4b3c890ff3bff7027","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f314f3a219c4bf4b3c890ff3bff7027","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Research Bulletin, Vol 223, Iss , Pp 111291- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.brainresbull.2025.111291","doi":"https://doi.org/10.1016/j.brainresbull.2025.111291","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brainresbull.2025.111291","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.5699999928474426,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1174742","https://openalex.org/W99549095","https://openalex.org/W1558962636","https://openalex.org/W1608043318","https://openalex.org/W1790197493","https://openalex.org/W1968977838","https://openalex.org/W1974060304","https://openalex.org/W1975280688","https://openalex.org/W1980788503","https://openalex.org/W1985519018","https://openalex.org/W1985568324","https://openalex.org/W1992069054","https://openalex.org/W1993184572","https://openalex.org/W1993778379","https://openalex.org/W1994600662","https://openalex.org/W2003365576","https://openalex.org/W2007070091","https://openalex.org/W2012184356","https://openalex.org/W2023444242","https://openalex.org/W2027580727","https://openalex.org/W2031196287","https://openalex.org/W2035112280","https://openalex.org/W2044239887","https://openalex.org/W2062799036","https://openalex.org/W2062873434","https://openalex.org/W2095929237","https://openalex.org/W2102512302","https://openalex.org/W2102653571","https://openalex.org/W2107020854","https://openalex.org/W2122450355","https://openalex.org/W2129719133","https://openalex.org/W2131940906","https://openalex.org/W2135035597","https://openalex.org/W2147703338","https://openalex.org/W2149443760","https://openalex.org/W2164343016","https://openalex.org/W2280077905","https://openalex.org/W2295774726","https://openalex.org/W2761980504","https://openalex.org/W2765432785","https://openalex.org/W2767042563","https://openalex.org/W2793707549","https://openalex.org/W2893038030","https://openalex.org/W2912440168","https://openalex.org/W2946416424","https://openalex.org/W2953601804","https://openalex.org/W2970867475","https://openalex.org/W2981131320","https://openalex.org/W3008255277","https://openalex.org/W3012632989","https://openalex.org/W3019676802","https://openalex.org/W3033465307","https://openalex.org/W3087685115","https://openalex.org/W3133053110","https://openalex.org/W3137124421","https://openalex.org/W3138593302","https://openalex.org/W3194227678","https://openalex.org/W4226083763","https://openalex.org/W4226414780","https://openalex.org/W4293697921","https://openalex.org/W4312196186","https://openalex.org/W6600052125","https://openalex.org/W6604091608"],"related_works":["https://openalex.org/W205653339","https://openalex.org/W2122287572","https://openalex.org/W2041187342","https://openalex.org/W2161164629","https://openalex.org/W2414812568","https://openalex.org/W1604914713","https://openalex.org/W2521551508","https://openalex.org/W2091559378","https://openalex.org/W2328322027","https://openalex.org/W2127240382"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"shown":[3],"that":[4],"CCL2":[5,29,34,168,227,243,250,269,287,293,306],"concentration":[6],"is":[7],"higher":[8],"in":[9,13,30,39,50,60,94,115,119,132,141,144,157,169,228,244,252,272,295,309],"cerebrospinal":[10],"fluid":[11],"than":[12,143],"plasma":[14],"of":[15,28,90,105,130,186,199,210,226,242,254,268,282],"health":[16],"and":[17,42,62,75,82,97,118,135,160,173,224,234,256,279,298],"human":[18],"immunodeficiency":[19,77],"virus":[20,78],"(HIV)":[21],"infected":[22,80,192,258],"individuals,":[23],"suggesting":[24,195],"an":[25],"extra":[26],"source":[27,89,129],"brain.":[31,171],"Brain":[32,123],"cellular":[33,45,58,222],"has":[35,47],"been":[36,48],"broadly":[37],"studied":[38,261],"cultured":[40],"cells":[41,125,176,188,278],"its":[43,57],"in-vivo":[44],"distribution":[46,59,251],"investigated":[49],"rodent":[51],"experimental":[52],"autoimmune":[53],"encephalomyelitis":[54],"model.":[55],"However,":[56],"grey":[61,273],"white":[63],"matter":[64,274],"(GM,":[65],"WM)":[66],"remains":[67],"elusive.":[68],"We":[69],"explored":[70],"this":[71],"issue":[72],"using":[73],"healthy":[74,170],"simian":[76],"(SIV)":[79],"monkeys":[81],"found:":[83],"1)":[84],"Neurons":[85,263],"were":[86,126,151,177,189],"a":[87,127,196],"major":[88],"CCL2-like":[91],"immunoreactivity":[92,271,294],"(CCL2-ir)":[93],"normal":[95,133,233,255,296],"GM,":[96],"corpus":[98,283],"callosum":[99,284],"(CC)":[100],"ependyma":[101],"showed":[102,264,285],"high":[103,266],"density":[104,267],"CCL2-ir.":[106],"2)":[107],"Upon":[108],"SIV":[109,155,181,257,301],"infection,":[110],"CCL2-ir":[111,131,148,174],"was":[112,138,260,290],"strikingly":[113],"raised":[114,304],"GM":[116,134,159],"neurons,":[117],"CC":[120,193],"ependyma.":[121],"3)":[122],"vascular-perivascular":[124],"large":[128,197],"WM,":[136],"which":[137,204,237],"relatively":[139],"larger":[140],"CC-WM":[142],"GM.":[145],"4)":[146],"Vascular-perivascular":[147],"proportional":[149],"areas":[150],"significantly":[152,178,303],"enhanced":[153],"by":[154,180],"infection":[156,302],"both":[158],"CC-WM.":[161],"5)":[162],"Microglia":[163],"seemed":[164],"not":[165,308],"to":[166,208],"express":[167],"Microglia-marker":[172],"co-labeled":[175],"increased":[179],"infection.":[182],"6)":[183],"A":[184],"vast":[185],"macrophage-like":[187],"situated":[190],"along":[191],"ependyma,":[194,203],"number":[198],"monocytes":[200],"be":[201,206],"crossing":[202],"may":[205,238],"related":[207,245],"establishment":[209],"viral":[211],"reservoir.":[212],"In":[213],"conclusion,":[214],"our":[215],"study":[216],"provides":[217],"valuable":[218],"insights":[219],"into":[220],"the":[221,229],"sources":[223],"alterations":[225],"monkey":[230,259],"brain":[231,253],"under":[232],"SIV-infected":[235],"conditions,":[236],"promote":[239],"better":[240],"understanding":[241],"neurological":[246],"processes.":[247],"\u2022":[248,262,275,288,300],"Cellular":[249],"significant":[265],"like":[270],"Vascular":[276],"endothelial":[277],"ependymal":[280],"layer":[281],"more":[286],"There":[289],"sparse":[291],"detectable":[292],"astrocyte":[297,310],"microglia":[299],"perivascular":[305],"but":[307],"endfeet":[311]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}