{"id":"https://openalex.org/W4408165077","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","title":"Glucose protects cultured retinal cells from oxidative injury via the pentose phosphate pathway","display_name":"Glucose protects cultured retinal cells from oxidative injury via the pentose phosphate pathway","publication_year":2025,"publication_date":"2025-03-05","ids":{"openalex":"https://openalex.org/W4408165077","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","pmid":"https://pubmed.ncbi.nlm.nih.gov/40054635"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2025.03.006","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048134789","display_name":"John P. M. Wood","orcid":"https://orcid.org/0000-0001-8233-7640","observed_orcids":["https://orcid.org/0000-0001-8233-7640"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John P.M. Wood","raw_affiliation_strings":["Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia. Electronic address: john.wood2@sa.gov.au"],"raw_orcid":"https://orcid.org/0000-0001-8233-7640","affiliations":[{"raw_affiliation_string":"Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia. Electronic address: john.wood2@sa.gov.au","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025934263","display_name":"Glyn Chidlow","orcid":"https://orcid.org/0000-0001-7371-0239","observed_orcids":["https://orcid.org/0000-0001-7371-0239"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Glyn Chidlow","raw_affiliation_strings":["Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086317817","display_name":"Robert James Casson","orcid":"https://orcid.org/0000-0003-2822-4076","observed_orcids":["https://orcid.org/0000-0003-2822-4076"]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert J. Casson","raw_affiliation_strings":["Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Ophthalmology & Visual Sciences, Level 7 Adelaide Health and Medical Sciences Building, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Port Road, SA, 5000, Australia","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025934263","https://openalex.org/A5048134789"],"corresponding_institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":{"value":4240,"currency":"USD","value_usd":4240},"fwci":0.2611,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41644768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"232","issue":null,"first_page":"142","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.41359999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.41359999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2946999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.1477999985218048,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9319999814033508},{"id":"https://openalex.org/keywords/retinal-neurons","display_name":"retinal neurons","score":0.8209999799728394},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.871999979019165},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.9769999980926514},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cystine-uptake","display_name":"cystine uptake","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tert-butyl-hydroperoxide","display_name":"tert-butyl hydroperoxide","score":0.8040000200271606},{"id":"https://openalex.org/keywords/retinal-neurodegeneration","display_name":"retinal neurodegeneration","score":0.746999979019165},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.9621186256408691},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.7273695468902588},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6203038096427917},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5890073180198669},{"id":"https://openalex.org/C2780261296","wikidata":"https://www.wikidata.org/wiki/Q205654","display_name":"Pentose","level":3,"score":0.5504138469696045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47920307517051697},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.39396414160728455},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1842801570892334},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010427","descriptor_name":"Pentose Phosphate Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010427","descriptor_name":"Pentose Phosphate Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010427","descriptor_name":"Pentose Phosphate Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055351","descriptor_name":"Retinal Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063928","descriptor_name":"Ependymoglial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2025.03.006","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:40054635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40054635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/147281","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2440/147281","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1016/j.freeradbiomed.2025.03.006","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6600000262260437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5707406082","display_name":"Retinal Ganglion Cell Bioenergetics with Clinical Translation","funder_award_id":"1102568","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322506","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W108819547","https://openalex.org/W1536070820","https://openalex.org/W1543729365","https://openalex.org/W1545385353","https://openalex.org/W1673751863","https://openalex.org/W1707133078","https://openalex.org/W1891967301","https://openalex.org/W1933759996","https://openalex.org/W1976217954","https://openalex.org/W1978895733","https://openalex.org/W1979167676","https://openalex.org/W1979234150","https://openalex.org/W1980578349","https://openalex.org/W1980710871","https://openalex.org/W1985451517","https://openalex.org/W1986320836","https://openalex.org/W1988449390","https://openalex.org/W1989369955","https://openalex.org/W1993802774","https://openalex.org/W1996492681","https://openalex.org/W2003895213","https://openalex.org/W2004008188","https://openalex.org/W2005920747","https://openalex.org/W2007255509","https://openalex.org/W2008423767","https://openalex.org/W2009080781","https://openalex.org/W2009383015","https://openalex.org/W2016933143","https://openalex.org/W2017119076","https://openalex.org/W2020943046","https://openalex.org/W2026525843","https://openalex.org/W2035360955","https://openalex.org/W2044151121","https://openalex.org/W2044606478","https://openalex.org/W2049332269","https://openalex.org/W2054129051","https://openalex.org/W2056840435","https://openalex.org/W2061265791","https://openalex.org/W2070621262","https://openalex.org/W2081361584","https://openalex.org/W2084852143","https://openalex.org/W2101084484","https://openalex.org/W2109661060","https://openalex.org/W2113966521","https://openalex.org/W2119036728","https://openalex.org/W2128473487","https://openalex.org/W2143373379","https://openalex.org/W2144171223","https://openalex.org/W2144839999","https://openalex.org/W2149927719","https://openalex.org/W2155162140","https://openalex.org/W2163294546","https://openalex.org/W2166337262","https://openalex.org/W2273624704","https://openalex.org/W2286748995","https://openalex.org/W2326556521","https://openalex.org/W2471180029","https://openalex.org/W2517194940","https://openalex.org/W2609261615","https://openalex.org/W2609699760","https://openalex.org/W2970735954","https://openalex.org/W3014564914","https://openalex.org/W3049305782","https://openalex.org/W3130601840","https://openalex.org/W3184392159","https://openalex.org/W4211242412","https://openalex.org/W4220710302","https://openalex.org/W4220760346","https://openalex.org/W4248078302","https://openalex.org/W4283701282","https://openalex.org/W4362663603","https://openalex.org/W6604452123","https://openalex.org/W6675199586","https://openalex.org/W6681680072","https://openalex.org/W6696824459"],"related_works":["https://openalex.org/W2034786422","https://openalex.org/W2410805819","https://openalex.org/W2420885858","https://openalex.org/W2472294291","https://openalex.org/W1546997066","https://openalex.org/W1975928831","https://openalex.org/W2281856601","https://openalex.org/W1751206423","https://openalex.org/W4285114920","https://openalex.org/W206315617"],"abstract_inverted_index":{"PURPOSE:":[0],"Oxidative":[1,145],"injury":[2],"has":[3],"been":[4],"implicated":[5],"in":[6,48,66,93,148,167,179],"a":[7,248],"range":[8],"of":[9,124,128,137,196,202,207,218,247],"common":[10],"retinal":[11,46,52,152,226],"neurodegenerative":[12],"disorders.":[13],"Protecting":[14],"the":[15,34,162,180,215,229,245,256],"retina":[16],"from":[17,57,77],"such":[18],"an":[19],"insult":[20],"could":[21,173],"therefore":[22],"prove":[23],"clinically":[24],"beneficial.":[25],"We":[26],"sought":[27],"to":[28,41,45,96,110,150,160,164,177,193,225,235],"investigate":[29],"whether":[30],"glucose,":[31],"acting":[32],"via":[33,228],"pentose":[35],"phosphate":[36],"pathway":[37],"(PPP),":[38],"was":[39,158,190],"able":[40,159],"counteract":[42],"oxidative":[43,98,199,223],"cytotoxicity":[44,149],"cells":[47,166,185,227,241],"culture.":[49],"EXPERIMENTAL:":[50],"Mixed":[51],"neuron-glial":[53],"cultures":[54,83,101,182],"were":[55,74,84,102,108,141,186,232,242],"prepared":[56,76],"Sprague-Dawley":[58],"rat":[59],"neonates":[60],"and":[61,69,118,139,154,169,198,204],"used":[62],"at":[63],"7":[64],"days":[65],"vitro;":[67],"neuron-only":[68],"M\u00fcller":[70],"glial":[71,155,165,184,240],"cell-only":[72],"mono-cultures":[73,168],"subsequently":[75],"these":[78],"cultures.":[79],"At":[80],"appropriate":[81],"stages,":[82],"treated":[85],"with":[86,104],"t-butyl":[87],"hydroperoxide":[88],"(tbH;":[89],"10":[90],"nM-1":[91],"mM)":[92],"glucose/pyruvate-free":[94],"DMEM":[95],"induce":[97],"stress.":[99],"Some":[100],"co-treated":[103],"glucose.":[105,219],"Additional":[106],"compounds":[107],"co-applied":[109],"inhibit":[111],"glycolysis,":[112],"PPP,":[113,208],"cystine":[114,209],"uptake,":[115],"glutathione":[116,119,138,203],"biosynthesis":[117],"reductase":[120],"(GR).":[121],"The":[122],"effect":[123],"glucose":[125],"on":[126],"stimulation":[127,195],"reactive":[129],"oxygen":[130],"species":[131],"(ROS),":[132],"as":[133,135],"well":[134],"levels":[136],"NADPH":[140],"also":[142,187],"investigated.":[143],"RESULTS:":[144],"stress":[146,224],"resulted":[147],"both":[151],"neurons":[153,178],"cells.":[156],"Glucose":[157,189,221],"abrogate":[161],"toxicity":[163],"mixed":[170,181],"cultures,":[171],"but":[172],"only":[174],"provide":[175],"protection":[176,237],"when":[183,239],"present.":[188],"additionally":[191],"shown":[192],"prevent":[194],"ROS":[197],"stress-induced":[200],"depletions":[201],"NADPH.":[205],"Inhibition":[206],"uptake":[210],"or":[211,251],"GR":[212],"all":[213],"diminished":[214],"protective":[216,253],"response":[217],"CONCLUSION:":[220],"prevented":[222],"PPP.":[230],"Neurons":[231],"not":[233],"subjected":[234],"glucose-induced":[236],"except":[238],"present,":[243],"implying":[244],"passage":[246],"transmissible":[249],"mediator":[250],"other":[252],"action":[254],"between":[255],"two":[257],"cell":[258],"types.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-10T00:00:00"}
