{"id":"https://openalex.org/W4408148271","doi":"https://doi.org/10.1177/17588359251318853","title":"Efficacy and safety of trastuzumab deruxtecan in Chinese patients with HER2-positive and HER2-low advanced breast cancer: a multicenter, observational, real-world study","display_name":"Efficacy and safety of trastuzumab deruxtecan in Chinese patients with HER2-positive and HER2-low advanced breast cancer: a multicenter, observational, real-world study","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4408148271","doi":"https://doi.org/10.1177/17588359251318853","pmid":"https://pubmed.ncbi.nlm.nih.gov/40034603","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11873904"},"language":"en","primary_location":{"id":"doi:10.1177/17588359251318853","doi":"https://doi.org/10.1177/17588359251318853","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359251318853","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/17588359251318853","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057738771","display_name":"Die Sang","orcid":"https://orcid.org/0009-0001-9637-4220","observed_orcids":["https://orcid.org/0009-0001-9637-4220"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]},{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Die Sang","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, China"],"raw_orcid":"https://orcid.org/0009-0001-9637-4220","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]},{"raw_affiliation_string":"Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193453","display_name":"Yanfang Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanfang Su","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100651399","display_name":"Yurong Zhang","orcid":"https://orcid.org/0000-0002-3302-0943","observed_orcids":["https://orcid.org/0000-0002-3302-0943"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Zhang","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022023489","display_name":"Yanfeng Guan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanfeng Guan","raw_affiliation_strings":["Department of Oncology, Beijing Jingxin Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Beijing Jingxin Hospital, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113321400","display_name":"Shanmin Fan","orcid":"https://orcid.org/0009-0000-7024-3751","observed_orcids":["https://orcid.org/0009-0000-7024-3751"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanmin Fan","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101766205","display_name":"Jintao Zhang","orcid":"https://orcid.org/0000-0002-1309-6836","observed_orcids":["https://orcid.org/0000-0002-1309-6836"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jintao Zhang","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101975295","display_name":"Lijun Zheng","orcid":"https://orcid.org/0000-0002-2890-7494","observed_orcids":["https://orcid.org/0000-0002-2890-7494"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Zheng","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023032952","display_name":"Yanling Wang","orcid":"https://orcid.org/0000-0002-1172-1917","observed_orcids":["https://orcid.org/0000-0002-1172-1917"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Wang","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015978094","display_name":"Ying Guo","orcid":"https://orcid.org/0000-0001-8151-8431","observed_orcids":["https://orcid.org/0000-0001-8151-8431"]},"institutions":[{"id":"https://openalex.org/I4210129249","display_name":"Cancer Hospital of Huanxing Chaoyang District Beijing","ror":"https://ror.org/03pt6v373","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129249"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Guo","raw_affiliation_strings":["Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Beijing Chaoyang District Sanhuan Cancer Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210129249"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zixuan Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixuan Lei","raw_affiliation_strings":["Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107229247","display_name":"Man Li","orcid":"https://orcid.org/0000-0003-1672-2190","observed_orcids":["https://orcid.org/0000-0003-1672-2190","https://orcid.org/0000-0002-7660-5896"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Man Li","raw_affiliation_strings":["Department of Oncology, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, 116023, China"],"raw_orcid":"https://orcid.org/0000-0003-1672-2190","affiliations":[{"raw_affiliation_string":"Department of Oncology, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, 116023, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018813194","display_name":"Peng Yuan","orcid":"https://orcid.org/0000-0002-5968-0368","observed_orcids":["https://orcid.org/0000-0002-5968-0368"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Yuan","raw_affiliation_strings":["Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018813194","https://openalex.org/A5107229247"],"corresponding_institution_ids":["https://openalex.org/I191996457","https://openalex.org/I200296433","https://openalex.org/I4210100868","https://openalex.org/I4210141458"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":4.4223,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.95471088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"17","issue":null,"first_page":"17588359251318853","last_page":"17588359251318853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":1.0},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/her2-low-breast-cancer","display_name":"HER2-low breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/advanced-breast-cancer","display_name":"advanced breast cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8370000123977661},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7039999961853027},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6690000295639038},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6940000057220459},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6449999809265137},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9406411647796631},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.7214387655258179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7108902335166931},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6374011635780334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6296338438987732},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5598813891410828},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5347522497177124},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47588029503822327},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.43612173199653625},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33305859565734863},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2492278516292572}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/17588359251318853","doi":"https://doi.org/10.1177/17588359251318853","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359251318853","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11873904","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11873904/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11873904/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Med Oncol","raw_type":"Text"},{"id":"pmid:40034603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40034603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in medical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1660ba6601e843cfbdea55dc7685a5a3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1660ba6601e843cfbdea55dc7685a5a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Therapeutic Advances in Medical Oncology, Vol 17 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/17588359251318853","doi":"https://doi.org/10.1177/17588359251318853","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17588359251318853","pdf_url":null,"source":{"id":"https://openalex.org/S41085503","display_name":"Therapeutic Advances in Medical Oncology","issn_l":"1758-8340","issn":["1758-8340","1758-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Medical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7814412023","display_name":null,"funder_award_id":"82172650","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408148271.pdf","grobid_xml":"https://content.openalex.org/works/W4408148271.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1994655768","https://openalex.org/W2083296039","https://openalex.org/W2089042535","https://openalex.org/W2590417095","https://openalex.org/W2599076725","https://openalex.org/W2902218997","https://openalex.org/W2996630100","https://openalex.org/W3011274212","https://openalex.org/W3018222852","https://openalex.org/W3021119615","https://openalex.org/W3044796934","https://openalex.org/W4211005384","https://openalex.org/W4211032970","https://openalex.org/W4211038303","https://openalex.org/W4211247697","https://openalex.org/W4212917132","https://openalex.org/W4281640394","https://openalex.org/W4285299659","https://openalex.org/W4290993146","https://openalex.org/W4292229870","https://openalex.org/W4307292724","https://openalex.org/W4311116389","https://openalex.org/W4315631613","https://openalex.org/W4317914696","https://openalex.org/W4372338080","https://openalex.org/W4379285713","https://openalex.org/W4385212704","https://openalex.org/W4385659305","https://openalex.org/W4387835007","https://openalex.org/W4388653253","https://openalex.org/W4389538252","https://openalex.org/W4396213256","https://openalex.org/W4400460538","https://openalex.org/W4400832932","https://openalex.org/W4400835954","https://openalex.org/W4402548585","https://openalex.org/W4408302414"],"related_works":["https://openalex.org/W7136505564","https://openalex.org/W7084289008","https://openalex.org/W4413297648","https://openalex.org/W7220660035","https://openalex.org/W4407631544","https://openalex.org/W4414169450","https://openalex.org/W4405141707","https://openalex.org/W4410821382","https://openalex.org/W4416218200","https://openalex.org/W4411158680"],"abstract_inverted_index":{"Objective:":[0],"Limited":[1],"real-world":[2,35,257],"efficacy":[3,41],"and":[4,26,42,54,84,104,124,127,135,155,172,183,189,191,198,228],"safety":[5,43],"data":[6,176],"exist":[7],"regarding":[8],"the":[9,16,40,47,88,98,105,132,152,162,166,170,192,203,254],"use":[10],"of":[11,44,49,62,71,87,91,97,259,287],"trastuzumab":[12],"deruxtecan":[13],"(T-DXd)":[14],"in":[15,151,161,169,264,281],"Chinese":[17,50,89],"population":[18],"with":[19,52,208,212,237,277,283],"human":[20],"epidermal":[21],"growth":[22],"factor":[23],"receptor":[24],"(HER2)-positive":[25],"HER2-low":[27,55,153,171],"advanced":[28,56,262,284],"breast":[29],"cancer":[30],"(BC).":[31],"This":[32,251],"multicenter,":[33,256],"observational,":[34],"study":[36,99,252,258],"aimed":[37],"to":[38,121,222],"evaluate":[39],"T-DXd":[45,209,223,260,270],"for":[46,261],"treatment":[48,207,224,276],"patients":[51,64,282],"HER2-positive":[53,163,173],"BC.":[57],"Methods:":[58],"The":[59,68,94,139,216,266],"medical":[60],"records":[61],"61":[63],"were":[65,108,129,177,181,187,196,225,233],"collected":[66],"from":[67],"Second":[69],"Hospital":[70,86],"Dalian":[72],"Medical":[73,92],"University,":[74],"Beijing":[75,81],"Chaoyang":[76],"District":[77],"Sanhuan":[78],"Cancer":[79,85],"Hospital,":[80,83],"Jingxin":[82],"Academy":[90],"Sciences.":[93],"primary":[95,140,217],"endpoint":[96],"was":[100,143,210,253],"progression-free":[101],"survival":[102,110],"(PFS),":[103],"secondary":[106,167],"endpoints":[107,168],"overall":[109],"(OS),":[111],"objective":[112],"response":[113,122],"rate":[114,118],"(ORR),":[115],"disease":[116],"control":[117],"(DCR),":[119],"time":[120],"(TTR),":[123],"safety.":[125],"PFS":[126,142],"OS":[128,175],"analyzed":[130],"using":[131],"Kaplan-Meier":[133],"method":[134],"log-rank":[136],"test.":[137],"Results:":[138],"endpoint,":[141],"10.51":[144],"months":[145,157],"(95%":[146,158],"confidence":[147],"interval":[148],"(CI),":[149],"3.02-NE)":[150],"group":[154],"10.18":[156],"CI,":[159],"3.88-NE)":[160],"group.":[164],"Regarding":[165],"groups,":[174],"immature,":[178],"ORR":[179],"rates":[180,186,195],"37.93%":[182],"62.50%,":[184],"DCR":[185],"79.31%":[188],"87.50%,":[190],"median":[193],"TTR":[194],"1.28":[197],"1.31":[199],"months,":[200],"respectively.":[201],"In":[202],"subgroup":[204],"analysis,":[205],"front-line":[206],"associated":[211],"increased":[213],"beneficial":[214],"effects.":[215],"adverse":[218,279],"events":[219],"(AEs)":[220],"related":[221],"gastrointestinal":[226],"reactions":[227,280],"bone":[229],"marrow":[230],"suppression,":[231],"which":[232],"predominantly":[234],"grades":[235],"1-2,":[236],"no":[238],"severe":[239],"grade":[240],"4/5":[241],"AEs":[242],"reported,":[243],"only":[244],"one":[245],"patient":[246],"developed":[247],"infectious":[248],"pneumonia.":[249],"Conclusion:":[250],"first":[255],"BC":[263,285],"China.":[265],"findings":[267],"demonstrated":[268],"that":[269],"may":[271],"be":[272],"an":[273],"effective":[274],"antitumor":[275],"controllable":[278],"irrespective":[286],"HER2":[288],"expression":[289],"levels.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-03-05T00:00:00"}