{"id":"https://openalex.org/W4408142160","doi":"https://doi.org/10.1146/annurev-immunol-082323-031642","title":"The Integrated Pulmonary Immune Response to Pneumonia","display_name":"The Integrated Pulmonary Immune Response to Pneumonia","publication_year":2025,"publication_date":"2025-03-04","ids":{"openalex":"https://openalex.org/W4408142160","doi":"https://doi.org/10.1146/annurev-immunol-082323-031642","pmid":"https://pubmed.ncbi.nlm.nih.gov/40036700"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-immunol-082323-031642","doi":"https://doi.org/10.1146/annurev-immunol-082323-031642","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-082323-031642","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1146/annurev-immunol-082323-031642","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089512301","display_name":"Katrina E. Traber","orcid":"https://orcid.org/0000-0002-8534-4480","observed_orcids":["https://orcid.org/0000-0002-8534-4480"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrina E. Traber","raw_affiliation_strings":["1Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; email: jmizgerd@bu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; email: jmizgerd@bu.edu","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076243223","display_name":"Joseph P. Mizgerd","orcid":"https://orcid.org/0000-0002-4042-3169","observed_orcids":["https://orcid.org/0000-0002-4042-3169"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Mizgerd","raw_affiliation_strings":["1Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; email: jmizgerd@bu.edu","2Department of Virology, Immunology, and Microbiology and Department of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; email: jmizgerd@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"2Department of Virology, Immunology, and Microbiology and Department of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":2.3328,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.91033472,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"43","issue":"1","first_page":"545","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.2125999927520752,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.984000027179718},{"id":"https://openalex.org/keywords/pulmonary-immune-response","display_name":"pulmonary immune response","score":0.7400000095367432},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.5630000233650208},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lung-epithelial-cells","display_name":"lung epithelial cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8999999761581421},{"id":"https://openalex.org/keywords/respiratory-pathogens","display_name":"respiratory pathogens","score":0.640999972820282},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lower-respiratory-tract-infection","display_name":"lower respiratory tract infection","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8468362092971802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7255113124847412},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7172772884368896},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.7036425471305847},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6871399879455566},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6127186417579651},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6081109642982483},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.5643622875213623},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5445913672447205},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5002694129943848},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.44323065876960754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1638936996459961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06360363960266113},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-immunol-082323-031642","doi":"https://doi.org/10.1146/annurev-immunol-082323-031642","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-082323-031642","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},{"id":"pmid:40036700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40036700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1146/annurev-immunol-082323-031642","doi":"https://doi.org/10.1146/annurev-immunol-082323-031642","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev-immunol-082323-031642","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6317714385","display_name":"Lung-resident antibacterial heterotypic immunity","funder_award_id":"R01AI115053","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G642974387","display_name":"Pneumonia Biology","funder_award_id":"R35HL135756","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000856360","display_name":"Pulmonary pathophysiology sub-phenotypes of pneumonia","funder_award_id":"R01AI162850","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000880333","display_name":"Fibrin in the Infected Lung","funder_award_id":"R01HL171499","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000883101","display_name":"Transcriptional Regulation of Migrating Neutrophils during Pneumonia","funder_award_id":"R01HL158732","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":183,"referenced_works":["https://openalex.org/W1841831106","https://openalex.org/W1984567215","https://openalex.org/W1988511365","https://openalex.org/W2000714505","https://openalex.org/W2024085541","https://openalex.org/W2024524568","https://openalex.org/W2036182565","https://openalex.org/W2040579661","https://openalex.org/W2076787697","https://openalex.org/W2092572163","https://openalex.org/W2095748236","https://openalex.org/W2099604050","https://openalex.org/W2100847015","https://openalex.org/W2104784243","https://openalex.org/W2105053798","https://openalex.org/W2131964383","https://openalex.org/W2137870902","https://openalex.org/W2150872976","https://openalex.org/W2155051381","https://openalex.org/W2160034017","https://openalex.org/W2160805048","https://openalex.org/W2164957007","https://openalex.org/W2210206421","https://openalex.org/W2230635575","https://openalex.org/W2266367473","https://openalex.org/W2280404143","https://openalex.org/W2295850804","https://openalex.org/W2523585551","https://openalex.org/W2525110976","https://openalex.org/W2557525334","https://openalex.org/W2562858382","https://openalex.org/W2562980016","https://openalex.org/W2593148326","https://openalex.org/W2606914681","https://openalex.org/W2608651137","https://openalex.org/W2614796552","https://openalex.org/W2619163335","https://openalex.org/W2746600415","https://openalex.org/W2763533536","https://openalex.org/W2766731631","https://openalex.org/W2769350174","https://openalex.org/W2785317170","https://openalex.org/W2785530199","https://openalex.org/W2790394319","https://openalex.org/W2793619072","https://openalex.org/W2793882959","https://openalex.org/W2793993128","https://openalex.org/W2804524829","https://openalex.org/W2804581180","https://openalex.org/W2806579973","https://openalex.org/W2897753640","https://openalex.org/W2898375074","https://openalex.org/W2902442004","https://openalex.org/W2906294599","https://openalex.org/W2907471984","https://openalex.org/W2911555743","https://openalex.org/W2911608593","https://openalex.org/W2919274753","https://openalex.org/W2921168633","https://openalex.org/W2939209922","https://openalex.org/W2944584167","https://openalex.org/W2946250860","https://openalex.org/W2953485213","https://openalex.org/W2969302025","https://openalex.org/W2971790873","https://openalex.org/W2977101849","https://openalex.org/W2987433676","https://openalex.org/W2990386843","https://openalex.org/W2999714391","https://openalex.org/W3000597097","https://openalex.org/W3003241695","https://openalex.org/W3003512459","https://openalex.org/W3006597775","https://openalex.org/W3010551088","https://openalex.org/W3024578227","https://openalex.org/W3025098045","https://openalex.org/W3035965283","https://openalex.org/W3044190151","https://openalex.org/W3047493479","https://openalex.org/W3081077931","https://openalex.org/W3081723269","https://openalex.org/W3090049663","https://openalex.org/W3093916434","https://openalex.org/W3094836236","https://openalex.org/W3097817819","https://openalex.org/W3104394245","https://openalex.org/W3107905689","https://openalex.org/W3113921996","https://openalex.org/W3118480663","https://openalex.org/W3120405378","https://openalex.org/W3120576609","https://openalex.org/W3124901567","https://openalex.org/W3125073942","https://openalex.org/W3128688942","https://openalex.org/W3132011599","https://openalex.org/W3156773893","https://openalex.org/W3159107390","https://openalex.org/W3160585082","https://openalex.org/W3162485228","https://openalex.org/W3164277943","https://openalex.org/W3177810550","https://openalex.org/W3179826439","https://openalex.org/W3180212617","https://openalex.org/W3195130348","https://openalex.org/W3195752138","https://openalex.org/W3199107710","https://openalex.org/W3202164430","https://openalex.org/W3213473256","https://openalex.org/W3216325046","https://openalex.org/W4205434219","https://openalex.org/W4205480269","https://openalex.org/W4206183808","https://openalex.org/W4206320827","https://openalex.org/W4206398574","https://openalex.org/W4206764390","https://openalex.org/W4210658082","https://openalex.org/W4210855928","https://openalex.org/W4210876793","https://openalex.org/W4213120745","https://openalex.org/W4220872606","https://openalex.org/W4220922761","https://openalex.org/W4223501771","https://openalex.org/W4225161598","https://openalex.org/W4229459188","https://openalex.org/W4237939525","https://openalex.org/W4280525750","https://openalex.org/W4286588273","https://openalex.org/W4293804743","https://openalex.org/W4294637032","https://openalex.org/W4295745405","https://openalex.org/W4295786903","https://openalex.org/W4296029797","https://openalex.org/W4297255518","https://openalex.org/W4312140323","https://openalex.org/W4318541530","https://openalex.org/W4319336434","https://openalex.org/W4319339279","https://openalex.org/W4321748739","https://openalex.org/W4322617246","https://openalex.org/W4328136182","https://openalex.org/W4360612394","https://openalex.org/W4365136175","https://openalex.org/W4365385340","https://openalex.org/W4372294557","https://openalex.org/W4378211904","https://openalex.org/W4381893298","https://openalex.org/W4385216881","https://openalex.org/W4386316752","https://openalex.org/W4386438245","https://openalex.org/W4386863728","https://openalex.org/W4387115799","https://openalex.org/W4387199981","https://openalex.org/W4387231703","https://openalex.org/W4388488104","https://openalex.org/W4389614205","https://openalex.org/W4390048302","https://openalex.org/W4390414342","https://openalex.org/W4390706786","https://openalex.org/W4391112845","https://openalex.org/W4391375855","https://openalex.org/W4391451915","https://openalex.org/W4392112563","https://openalex.org/W4392663706","https://openalex.org/W4392711632","https://openalex.org/W4392978695","https://openalex.org/W4394824789","https://openalex.org/W4395045954","https://openalex.org/W4395465361","https://openalex.org/W4396576528","https://openalex.org/W4396578405","https://openalex.org/W4396583562","https://openalex.org/W4396592856","https://openalex.org/W4398156485","https://openalex.org/W4398221442","https://openalex.org/W4400980843","https://openalex.org/W4401163184","https://openalex.org/W4401548056","https://openalex.org/W4402221539","https://openalex.org/W4402580992","https://openalex.org/W4402968457","https://openalex.org/W4403136210","https://openalex.org/W4403899361","https://openalex.org/W4407944872"],"related_works":["https://openalex.org/W2131964383","https://openalex.org/W2588839878","https://openalex.org/W2804524829","https://openalex.org/W4321769560","https://openalex.org/W2137870902","https://openalex.org/W2120772552","https://openalex.org/W7140277418","https://openalex.org/W4375865726","https://openalex.org/W2232578563","https://openalex.org/W101122984"],"abstract_inverted_index":{"Pneumonia":[0],"is":[1],"an":[2],"acute":[3],"respiratory":[4,9,52,101,135],"infection":[5,53,87],"of":[6,13,21,82],"the":[7,14,19,61,83,89,125],"lower":[8,51],"tract.":[10],"The":[11,29,80],"effectiveness":[12],"host":[15,44],"immune":[16,36,58,84,90,121,132],"response":[17,85],"determines":[18],"severity":[20],"infection,":[22],"or":[23],"whether":[24],"pneumonia":[25],"occurs":[26],"at":[27],"all.":[28],"lungs":[30],"house":[31],"both":[32],"innate":[33,118],"and":[34,49,65,74,88,119,130],"adaptive":[35,120],"systems,":[37],"which":[38],"integrate":[39],"their":[40],"activities":[41,122],"to":[42,76,93,127],"provide":[43,128],"defense":[45,94],"that":[46,108],"eliminates":[47],"microbes":[48],"prevents":[50],"from":[54],"becoming":[55],"severe.":[56],"Professional":[57],"cells":[59,73],"in":[60,106],"lung,":[62],"like":[63,71],"macrophages":[64],"lymphocytes,":[66],"work":[67],"with":[68,100],"lung":[69,104,126],"constituents,":[70],"epithelial":[72],"fibroblasts,":[75],"optimize":[77],"antimicrobial":[78],"defense.":[79],"dynamics":[81],"during":[86],"components":[91],"contributing":[92],"are":[95],"influenced":[96],"by":[97],"prior":[98],"experiences":[99],"pathogens,":[102],"remodeling":[103],"immunity":[105],"ways":[107],"improve":[109],"responses":[110],"against":[111,134],"subsequent":[112],"infections.":[113],"This":[114],"review":[115],"covers":[116],"how":[117],"coordinate":[123],"inside":[124],"integrated":[129],"effective":[131],"resistance":[133],"pathogens.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-03-05T00:00:00"}