{"id":"https://openalex.org/W4408140362","doi":"https://doi.org/10.1093/sexmed/qfaf007","title":"The conserved molecular mechanism of erectile dysfunction in type 2 diabetes rats and mice by cross-species transcriptomic comparisons","display_name":"The conserved molecular mechanism of erectile dysfunction in type 2 diabetes rats and mice by cross-species transcriptomic comparisons","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4408140362","doi":"https://doi.org/10.1093/sexmed/qfaf007","pmid":"https://pubmed.ncbi.nlm.nih.gov/40041301","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11879191"},"language":"en","primary_location":{"id":"doi:10.1093/sexmed/qfaf007","doi":"https://doi.org/10.1093/sexmed/qfaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfaf007","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/sexmed/qfaf007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013378131","display_name":"Ming Xiao","orcid":"https://orcid.org/0000-0003-3576-3617","observed_orcids":["https://orcid.org/0000-0003-3576-3617"]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Xiao","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":"https://orcid.org/0000-0003-3576-3617","affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huanqing Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanqing Zeng","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113387578","display_name":"Yanghua Xu","orcid":"https://orcid.org/0000-0002-9140-2069","observed_orcids":["https://orcid.org/0000-0002-9140-2069"]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanghua Xu","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100552928","display_name":"Jiarong Xu","orcid":"https://orcid.org/0000-0003-0344-8890","observed_orcids":["https://orcid.org/0000-0003-0344-8890"]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiarong Xu","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101670917","display_name":"Xiaoli Tan","orcid":"https://orcid.org/0000-0001-5464-5224","observed_orcids":["https://orcid.org/0000-0001-5464-5224"]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Tan","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001549014","display_name":"Yuxin Tang","orcid":"https://orcid.org/0000-0003-4694-558X","observed_orcids":["https://orcid.org/0000-0003-4694-558X"]},"institutions":[{"id":"https://openalex.org/I4210113039","display_name":"Fifth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/023te5r95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113039"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxin Tang","raw_affiliation_strings":["Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,"],"raw_orcid":"https://orcid.org/0000-0003-4694-558X","affiliations":[{"raw_affiliation_string":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University , Zhuhai, Guangdong Province 519000 ,","institution_ids":["https://openalex.org/I4210113039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001549014"],"corresponding_institution_ids":["https://openalex.org/I4210113039"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":1.3457,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77536432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"qfaf007","last_page":"qfaf007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/corpus-cavernosum","display_name":"corpus cavernosum","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cross-species-transcriptomics","display_name":"cross-species transcriptomics","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mouse-and-rat-models","display_name":"mouse and rat models","score":0.7850000262260437},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.949999988079071},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"smooth muscle","score":0.6000000238418579},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.8169999718666077},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8009999990463257},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8370000123977661},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cavernosal-fibrosis","display_name":"cavernosal fibrosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.7825416326522827},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7371993660926819},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6812672019004822},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5658271312713623},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5270305275917053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4451439082622528},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43086281418800354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4108262062072754},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4014189839363098},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.388603538274765},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34079962968826294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32479023933410645},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14793628454208374},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/sexmed/qfaf007","doi":"https://doi.org/10.1093/sexmed/qfaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfaf007","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11879191","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11879191","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sex Med","raw_type":"Text"},{"id":"pmid:40041301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40041301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/sexmed/qfaf007","doi":"https://doi.org/10.1093/sexmed/qfaf007","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sexmed/qfaf007","pdf_url":null,"source":{"id":"https://openalex.org/S2739331564","display_name":"Sexual Medicine","issn_l":"2050-1161","issn":["2050-1161"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexual Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3663192306","display_name":null,"funder_award_id":"82371632","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5889349244","display_name":null,"funder_award_id":"2024A1515013146","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1810028515","https://openalex.org/W1832887128","https://openalex.org/W2010457001","https://openalex.org/W2015426450","https://openalex.org/W2024876112","https://openalex.org/W2035618305","https://openalex.org/W2038186952","https://openalex.org/W2069831243","https://openalex.org/W2074468058","https://openalex.org/W2094202435","https://openalex.org/W2096565553","https://openalex.org/W2103912979","https://openalex.org/W2109131520","https://openalex.org/W2109995938","https://openalex.org/W2122948438","https://openalex.org/W2138793275","https://openalex.org/W2152187474","https://openalex.org/W2179438025","https://openalex.org/W2307839435","https://openalex.org/W2476542314","https://openalex.org/W2526160474","https://openalex.org/W2735252503","https://openalex.org/W2900569176","https://openalex.org/W2995309855","https://openalex.org/W3037012236","https://openalex.org/W3039712743","https://openalex.org/W3096828292","https://openalex.org/W3106539179","https://openalex.org/W3112600195","https://openalex.org/W3112950773","https://openalex.org/W4200026682","https://openalex.org/W4229007681","https://openalex.org/W4295346357","https://openalex.org/W4309440909","https://openalex.org/W4310172054","https://openalex.org/W4317910189","https://openalex.org/W4375954776","https://openalex.org/W4377287329","https://openalex.org/W4381803987","https://openalex.org/W4385076783","https://openalex.org/W4386387118","https://openalex.org/W4394795740","https://openalex.org/W4398231688","https://openalex.org/W4399711999","https://openalex.org/W4402598187"],"related_works":["https://openalex.org/W7166644426","https://openalex.org/W3136917930","https://openalex.org/W2526691032","https://openalex.org/W2462945252","https://openalex.org/W4220700551","https://openalex.org/W4399462455","https://openalex.org/W2078288255","https://openalex.org/W2109109397","https://openalex.org/W4411874515","https://openalex.org/W2101435302"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,49,234,250],"poor":[3],"clinical":[4],"situation":[5],"of":[6,28,60,92,109,128,168,177,227,248,256],"type":[7],"2":[8],"diabetes-induced":[9],"erectile":[10,225],"dysfunction":[11],"(T2DMED)":[12],"creates":[13],"an":[14],"urgent":[15],"need":[16],"for":[17,46,86,222,272,281],"new":[18,220],"therapeutic":[19,279],"targets.":[20],"Aim":[21],"To":[22,217],"reveal":[23],"the":[24,57,165,193,224,244,254,260,274],"conserved":[25,245],"molecular":[26,246],"mechanism":[27],"T2DMED":[29,33,93,178,261],"across":[30],"species.":[31],"Methods":[32],"rat":[34],"and":[35,56,62,68,81,95,99,111,151,158,162,172,180,197,207,232,277],"mouse":[36],"models":[37],"were":[38,54,72,84,97,141,187,190],"constructed":[39],"to":[40,148],"extract":[41],"mRNA":[42],"from":[43],"corpus":[44,107],"cavernosum":[45,108,175],"high-throughput":[47],"sequencing.":[48],"differentially":[50],"expressed":[51],"genes":[52,132],"(DEGs)":[53],"analyzed":[55,98],"Kyoto":[58],"Encyclopedia":[59],"Genes":[61],"Genomes":[63],"(KEGG),":[64],"Gene":[65,102],"Ontology":[66],"(GO),":[67],"Protein\u2013Protein":[69],"Interaction":[70],"Networks":[71],"performed":[73],"by":[74,156],"bioinformatics":[75],"methods.":[76],"Immunohistochemistry,":[77],"immunofluorescence,":[78],"hematoxylin-":[79],"eosin":[80],"Masson":[82],"staining":[83],"used":[85],"subsequent":[87],"verification.":[88],"Outcomes":[89],"Cross-species":[90,264],"transcriptomics":[91],"rats":[94,112],"mice":[96,110,179],"validated.":[100],"Results":[101],"expression":[103,167,206],"patterns":[104],"in":[105,145,174,192,213,259],"normal":[106],"showed":[113],"a":[114,126,219,269],"strong":[115],"correlation":[116],"(r":[117],"=":[118],"0.75,":[119],"P":[120],"<":[121],"2.2":[122],"\u00d7":[123],"10-16),":[124],"with":[125,229],"total":[127],"15":[129],"691":[130],"homologous":[131,138,184],"identified.":[133],"In":[134],"both":[135],"species,":[136],"553":[137],"down-regulated":[139],"DEGs":[140,186],"identified,":[142,188],"mainly":[143],"enriched":[144,191],"pathways":[146],"related":[147],"smooth":[149],"muscle":[150,170],"mitochondrial":[152],"functions,":[153],"as":[154],"revealed":[155,243],"KEGG":[157],"GO":[159],"analyses.":[160],"Immunohistochemistry":[161],"immunofluorescence":[163],"confirmed":[164,203],"decreased":[166],"\u03b1-smooth":[169],"actin":[171],"Uqcr10":[173],"tissues":[176],"rats.":[181],"Additionally,":[182],"239":[183],"up-regulated":[185],"which":[189],"Wnt":[194],"signaling":[195],"pathway":[196],"extracellular":[198],"matrix":[199],"composition.":[200],"Subsequent":[201],"experiments":[202],"increased":[204],"\u03b2-catenin":[205],"significant":[208],"collagen":[209],"accumulation,":[210],"indicating":[211],"fibrosis":[212],"T2DMED.":[214,230,249,282],"Clinical":[215],"implications":[216],"provide":[218],"direction":[221],"improving":[223],"ability":[226],"patients":[228],"Strengths":[231],"limitations":[233],"main":[235,251],"strength":[236],"is":[237,253],"that":[238],"cross-species":[239],"transcriptomic":[240,265],"sequencing":[241],"has":[242],"mechanisms":[247,276],"limitation":[252],"lack":[255],"further":[257],"validation":[258],"patients.":[262],"Conclusions":[263],"comparisons":[266],"may":[267],"offer":[268],"novel":[270],"strategy":[271],"uncovering":[273],"underlying":[275],"identifying":[278],"targets":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-03-05T00:00:00"}
