{"id":"https://openalex.org/W4408123767","doi":"https://doi.org/10.18311/jnr/2025/45968","title":"Evaluation of Hypolipidemic Activity of Ceiba pentandra (L.) Gaertn. Leaves Extract in Experimental Rat Model","display_name":"Evaluation of Hypolipidemic Activity of Ceiba pentandra (L.) Gaertn. Leaves Extract in Experimental Rat Model","publication_year":2025,"publication_date":"2025-02-28","ids":{"openalex":"https://openalex.org/W4408123767","doi":"https://doi.org/10.18311/jnr/2025/45968"},"language":"en","primary_location":{"id":"doi:10.18311/jnr/2025/45968","doi":"https://doi.org/10.18311/jnr/2025/45968","is_oa":true,"landing_page_url":"https://doi.org/10.18311/jnr/2025/45968","pdf_url":null,"source":{"id":"https://openalex.org/S2764727456","display_name":"Journal of Natural Remedies","issn_l":"0972-5547","issn":["0972-5547","2320-3358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972300","host_organization_name":"Informatics Publishing Limited","host_organization_lineage":["https://openalex.org/P4323972300"],"host_organization_lineage_names":["Informatics Publishing Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Remedies","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18311/jnr/2025/45968","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116490464","display_name":"Dhruti C. Nagda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dhruti C. Nagda","raw_affiliation_strings":["Gujarat Technological University, Ahmedabad - 382424, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gujarat Technological University, Ahmedabad - 382424, Gujarat","institution_ids":["https://openalex.org/I29563240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052987028","display_name":"Anandkumari D. Captain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anandkumari D. Captain","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat","institution_ids":["https://openalex.org/I29563240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113085906","display_name":"Musaratafrin Saiyed","orcid":"https://orcid.org/0000-0003-1816-8154","observed_orcids":["https://orcid.org/0000-0003-1816-8154"]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Musaratafrin S. Saiyed","raw_affiliation_strings":["Department of Pharmacology, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat"],"raw_orcid":"https://orcid.org/0000-0003-1816-8154","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat","institution_ids":["https://openalex.org/I29563240"]}]},{"author_position":"last","author":{"id":null,"display_name":"Payal J. Panchal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29563240","display_name":"Gujarat Technological University","ror":"https://ror.org/059x8vm09","country_code":"IN","type":"education","lineage":["https://openalex.org/I29563240"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Payal J. Panchal","raw_affiliation_strings":["Department of Pharmacognosy, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Gujarat Technological University, Vallabh Vidyanagar - 388120, Anand, Gujarat","institution_ids":["https://openalex.org/I29563240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29563240"],"apc_list":null,"apc_paid":null,"fwci":0.8924,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68631305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"357","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13238","display_name":"Botanical Studies and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kapok-tree","display_name":"Ceiba pentandra","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hypolipidemic-activity","display_name":"hypolipidemic activity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-fat-diet-induced-hyperlipidemia","display_name":"high-fat diet-induced hyperlipidemia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.8479999899864197},{"id":"https://openalex.org/keywords/atherogenic-index","display_name":"atherogenic index","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6620000004768372},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.593999981880188},{"id":"https://openalex.org/keywords/malvaceae","display_name":"Malvaceae","score":0.7480000257492065},{"id":"https://openalex.org/keywords/sprague-dawley-rats","display_name":"Sprague-Dawley rats","score":0.734000027179718},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2778228072","wikidata":"https://www.wikidata.org/wiki/Q284019","display_name":"Ceiba","level":2,"score":0.9706336259841919},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6894132494926453},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39769282937049866},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.32884907722473145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.303935170173645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2622660994529724},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18311/jnr/2025/45968","doi":"https://doi.org/10.18311/jnr/2025/45968","is_oa":true,"landing_page_url":"https://doi.org/10.18311/jnr/2025/45968","pdf_url":null,"source":{"id":"https://openalex.org/S2764727456","display_name":"Journal of Natural Remedies","issn_l":"0972-5547","issn":["0972-5547","2320-3358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972300","host_organization_name":"Informatics Publishing Limited","host_organization_lineage":["https://openalex.org/P4323972300"],"host_organization_lineage_names":["Informatics Publishing Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Remedies","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18311/jnr/2025/45968","doi":"https://doi.org/10.18311/jnr/2025/45968","is_oa":true,"landing_page_url":"https://doi.org/10.18311/jnr/2025/45968","pdf_url":null,"source":{"id":"https://openalex.org/S2764727456","display_name":"Journal of Natural Remedies","issn_l":"0972-5547","issn":["0972-5547","2320-3358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972300","host_organization_name":"Informatics Publishing Limited","host_organization_lineage":["https://openalex.org/P4323972300"],"host_organization_lineage_names":["Informatics Publishing Limited"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Remedies","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1075980666","https://openalex.org/W1834474486","https://openalex.org/W1914830178","https://openalex.org/W1976616659","https://openalex.org/W1982814698","https://openalex.org/W2004050305","https://openalex.org/W2031836536","https://openalex.org/W2080438774","https://openalex.org/W2096659451","https://openalex.org/W2106715055","https://openalex.org/W2123662055","https://openalex.org/W2272059387","https://openalex.org/W2275753179","https://openalex.org/W2323632312","https://openalex.org/W2345895781","https://openalex.org/W2346818270","https://openalex.org/W2498856847","https://openalex.org/W2518833741","https://openalex.org/W2548424326","https://openalex.org/W2582826742","https://openalex.org/W2593006830","https://openalex.org/W2906018263","https://openalex.org/W2951545240","https://openalex.org/W2981878992","https://openalex.org/W3110525017","https://openalex.org/W3183685313","https://openalex.org/W4220738089","https://openalex.org/W4313437944","https://openalex.org/W4382133759","https://openalex.org/W4387683267","https://openalex.org/W4387956968","https://openalex.org/W7038296880"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W3129758991","https://openalex.org/W2102031811","https://openalex.org/W2618123884"],"abstract_inverted_index":{"Background:":[0],"Hyperlipidemia":[1,82],"is":[2,49],"a":[3,42,90,189,225],"major":[4],"risk":[5],"factor":[6],"for":[7,28,53,100,228],"atherosclerosis":[8],"and":[9,31,106,138,144,161,164,241,267],"coronary":[10],"artery":[11],"diseases,":[12],"significantly":[13,152,175,204],"contributing":[14],"to":[15,114,194],"cardiovascular":[16],"disease-related":[17],"deaths.":[18],"Plant-based":[19],"treatments,":[20],"particularly":[21,220],"those":[22],"rich":[23],"in":[24,33,74,78,85,205,278],"flavonoids,":[25],"are":[26],"recognized":[27],"their":[29],"safety":[30],"efficacy":[32,240],"managing":[34],"hyperlipidemia.":[35,233,292],"Ceiba":[36,252],"pentandra":[37,71,217,253],"Gaertn.":[38,254],"(Silk":[39,255],"Cotton":[40,256],"tree),":[41],"tropical":[43],"plant":[44],"from":[45,111],"the":[46,61,120,139,166,181,195,206,213,229],"Malvaceae":[47],"family,":[48],"of":[50,64,69,186,215,231,247,251,281],"particular":[51],"interest":[52],"its":[54,238,264],"potential":[55,214],"hypolipidemic":[56,62,191,265],"properties.":[57],"Aim:":[58],"To":[59],"evaluate":[60],"activity":[63],"80":[65],"%":[66],"hydroalcoholic":[67],"extract":[68,250],"C.":[70,216],"leaves":[72,258],"(CPHAE)":[73],"high-fat":[75,91,150,282],"diet-induced":[76,232],"hyperlipidemia":[77],"Sprague-Dawley":[79,86],"rats.":[80],"Methods:":[81],"was":[83,109],"induced":[84,291],"rats":[87],"by":[88],"administering":[89],"diet":[92,151,283],"(Indian":[93,284],"vanaspati":[94,285],"ghee:":[95,286],"coconut":[96,287],"oil,":[97,288],"3:1":[98,289],"v/v)":[99,290],"21":[101,113],"days.":[102],"CPHAE":[103,171,187],"(250":[104],"mg/kg":[105],"500":[107],"mg/kg)":[108,185],"administered":[110],"day":[112,115],"42.":[116],"Atorvastatin":[117],"served":[118],"as":[119,224],"standard":[121,196],"drug.":[122],"Lipid":[123],"parameters,":[124,156],"including":[125,157],"Triglycerides":[126],"(TG),":[127],"Total":[128],"Cholesterol":[129],"(TC),":[130],"Low-Density":[131,135],"Lipoprotein":[132,136],"(LDL),":[133],"Very":[134],"(VLDL),":[137],"Atherogenic":[140,167,200],"Index,":[141],"were":[142,276],"assessed":[143],"compared":[145],"between":[146],"groups.":[147,208],"Results:":[148],"The":[149,199,210],"(p<0.05)":[153,176],"elevated":[154],"lipid":[155,178],"TG,":[158],"TC,":[159],"LDL,":[160],"VLDL":[162],"levels,":[163],"increased":[165],"Index.":[168],"Treatment":[169],"with":[170],"at":[172,221,271],"both":[173],"doses":[174],"reduced":[177],"parameters.":[179],"Notably,":[180],"higher":[182,222,272],"dose":[183],"(500":[184],"exhibited":[188],"significant":[190],"effect":[192,266],"comparable":[193],"drug,":[197],"Atorvastatin.":[198],"Index":[201],"also":[202],"decreased":[203],"treatment":[207],"Conclusion:":[209],"results":[211],"demonstrate":[212],"leaf":[218],"extract,":[219],"doses,":[223],"promising":[226],"agent":[227],"management":[230],"Further":[234],"studies":[235],"may":[236],"confirm":[237],"clinical":[239],"safety.":[242],"Major":[243],"Findings:":[244],"Pre-clinical":[245],"evaluation":[246],"80%":[248],"hydro-alcoholic":[249],"tree)":[257],"which":[259],"contains":[260],"high":[261],"flavonoid":[262],"exhibit":[263],"diminish":[268],"atherogenic":[269],"index":[270],"dose.":[273],"These":[274],"effects":[275],"evaluated":[277],"Rat":[279],"model":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2025-10-10T00:00:00"}