{"id":"https://openalex.org/W4408104368","doi":"https://doi.org/10.1016/j.jare.2025.02.042","title":"Cracking melanoma\u2019s armor: Supramolecular dual-strike on XPO1 and \u03b2-catenin to overcome resistance","display_name":"Cracking melanoma\u2019s armor: Supramolecular dual-strike on XPO1 and \u03b2-catenin to overcome resistance","publication_year":2025,"publication_date":"2025-03-03","ids":{"openalex":"https://openalex.org/W4408104368","doi":"https://doi.org/10.1016/j.jare.2025.02.042","pmid":"https://pubmed.ncbi.nlm.nih.gov/40044035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12627874"},"language":"en","primary_location":{"id":"doi:10.1016/j.jare.2025.02.042","doi":"https://doi.org/10.1016/j.jare.2025.02.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2025.02.042","pdf_url":null,"source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jare.2025.02.042","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023084414","display_name":"Yinliang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinliang Lu","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ruishan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruishan Guo","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenfei Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfei Song","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101089287","display_name":"Hanmin Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanmin Tang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Minghui Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Wei","raw_affiliation_strings":["The School of Future Technology of Xi'an Jiaotong University, Xi'an 710049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The School of Future Technology of Xi'an Jiaotong University, Xi'an 710049, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108574153","display_name":"Jing Zhao","orcid":"https://orcid.org/0000-0003-2205-1581","observed_orcids":["https://orcid.org/0000-0003-2205-1581"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhao","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102325698","display_name":"Jinlu Ma","orcid":"https://orcid.org/0009-0005-9014-6947","observed_orcids":["https://orcid.org/0009-0005-9014-6947"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinlu Ma","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002321201","display_name":"Tianya Liu","orcid":"https://orcid.org/0000-0002-5371-6497","observed_orcids":["https://orcid.org/0000-0002-5371-6497"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianya Liu","raw_affiliation_strings":["Institute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082223726","display_name":"Wangxiao He","orcid":"https://orcid.org/0000-0002-2054-6022","observed_orcids":["https://orcid.org/0000-0002-2054-6022"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wangxiao He","raw_affiliation_strings":["Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: hewangxiao5366@xjtu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: hewangxiao5366@xjtu.edu.cn","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101751332","display_name":"Suxia Han","orcid":"https://orcid.org/0000-0003-3442-9641","observed_orcids":["https://orcid.org/0000-0003-3442-9641"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Suxia Han","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: shan87@xjtu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: shan87@xjtu.edu.cn","institution_ids":["https://openalex.org/I4210121771"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082223726","https://openalex.org/A5101751332"],"corresponding_institution_ids":["https://openalex.org/I4210121771"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01915769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":null,"first_page":"793","last_page":"806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.09629999846220016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9700000286102295},{"id":"https://openalex.org/keywords/xpo1","display_name":"CRM1","score":0.890999972820282},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/carnosic-acid","display_name":"carnosic acid","score":0.7820000052452087},{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.8149999976158142},{"id":"https://openalex.org/keywords/macropinocytosis","display_name":"macropinocytosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.6629999876022339},{"id":"https://openalex.org/keywords/dual-targeted-therapy","display_name":"dual-targeted therapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.627253532409668},{"id":"https://openalex.org/C58396970","wikidata":"https://www.wikidata.org/wiki/Q212749","display_name":"Cracking","level":2,"score":0.566726565361023},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.5549008250236511},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.49791932106018066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42740583419799805},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33388277888298035},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.27655333280563354},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22908201813697815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16217464208602905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11595436930656433},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.10782870650291443},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07464548945426941},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097606","descriptor_name":"Exportin 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D028884","descriptor_name":"Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jare.2025.02.042","doi":"https://doi.org/10.1016/j.jare.2025.02.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2025.02.042","pdf_url":null,"source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11435930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12627874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40044035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40044035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of advanced research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jare.2025.02.042","doi":"https://doi.org/10.1016/j.jare.2025.02.042","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jare.2025.02.042","pdf_url":null,"source":{"id":"https://openalex.org/S57607125","display_name":"Journal of Advanced Research","issn_l":"2090-1224","issn":["2090-1224","2090-1232"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advanced Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1246751225","display_name":"DDR signaling\u8bf1\u5bfcApoptin\u4fc3\u80bf\u7624\u653e\u5c04\u589e\u654f\u6cbb\u7597\u7684\u7814\u7a76","funder_award_id":"81272488","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7000335052","display_name":null,"funder_award_id":"81602802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7216041914","display_name":null,"funder_award_id":"82373204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8642847394","display_name":null,"funder_award_id":"2018TD-002","funder_id":"https://openalex.org/F4320329783","funder_display_name":"Key Industry Innovation Chain of Shaanxi"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320329783","display_name":"Key Industry Innovation Chain of Shaanxi","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1970537520","https://openalex.org/W1971708920","https://openalex.org/W1988100051","https://openalex.org/W1993951553","https://openalex.org/W2004136552","https://openalex.org/W2015009944","https://openalex.org/W2028762978","https://openalex.org/W2028930390","https://openalex.org/W2031004160","https://openalex.org/W2041817118","https://openalex.org/W2046931214","https://openalex.org/W2096849855","https://openalex.org/W2099655761","https://openalex.org/W2109941804","https://openalex.org/W2132665334","https://openalex.org/W2134390575","https://openalex.org/W2155085170","https://openalex.org/W2168298407","https://openalex.org/W2171258458","https://openalex.org/W2208803527","https://openalex.org/W2218364825","https://openalex.org/W2290633618","https://openalex.org/W2467491414","https://openalex.org/W2508216621","https://openalex.org/W2530014580","https://openalex.org/W2587768464","https://openalex.org/W2746977721","https://openalex.org/W2785171422","https://openalex.org/W2888885038","https://openalex.org/W2944232267","https://openalex.org/W2969931905","https://openalex.org/W3020836567","https://openalex.org/W3028886265","https://openalex.org/W3037697670","https://openalex.org/W3047027486","https://openalex.org/W3103404395","https://openalex.org/W3108389912","https://openalex.org/W3124412386","https://openalex.org/W3207790531","https://openalex.org/W3211936933","https://openalex.org/W4292283598","https://openalex.org/W4308834893","https://openalex.org/W4318753918","https://openalex.org/W6642880981"],"related_works":["https://openalex.org/W1970537520","https://openalex.org/W7099904890","https://openalex.org/W7170080123","https://openalex.org/W3103404395","https://openalex.org/W4362542753","https://openalex.org/W4210525006","https://openalex.org/W3028886265","https://openalex.org/W4405462616","https://openalex.org/W2567178014","https://openalex.org/W4398774044"],"abstract_inverted_index":{"INTRODUCTION:":[0],"XPO1":[1,31,70,78,90,114,129,163,197,222,246,299],"plays":[2],"a":[3,41,64,126,134,283],"crucial":[4],"role":[5],"in":[6,20,60,207],"the":[7,54,75,87,93,110,152,166,172,179,243,266,273,276],"nuclear":[8,167],"export":[9],"machinery,":[10],"making":[11],"it":[12],"an":[13,208],"attractive":[14],"target":[15,69],"for":[16,45,291],"inhibiting":[17],"nuclear-cytoplasmic":[18,173],"transport":[19],"melanoma,":[21],"where":[22],"its":[23],"overexpression":[24],"is":[25],"linked":[26],"to":[27,38,51,73,85,108,150,165,219],"unfavorable":[28],"prognosis.":[29],"However,":[30],"monotherapy":[32,220],"has":[33],"not":[34],"demonstrated":[35,203],"sufficient":[36],"efficacy":[37,206,268],"be":[39],"considered":[40],"first-line":[42],"treatment":[43,225],"option":[44],"melanoma.":[46,97],"OBJECTIVES:":[47],"This":[48,263],"research":[49],"aimed":[50],"delve":[52],"into":[53,187],"resistance":[55,111],"mechanism":[56,112],"of":[57,77,89,96,113,155,162,169,175,195,232,256,269,275],"XPO1-targeting":[58],"therapy":[59,271,294],"melanoma":[61,188,210,257,296],"and":[62,71,102,133,143,177,198,242,280,300],"fabricate":[63],"proteinoid":[65,118,284],"microsphere":[66,119,285],"which":[67],"could":[68],"\u03b2-catenin":[72,135],"maximize":[74],"effect":[76,154],"inhibitors.":[79],"METHODS:":[80],"Transcriptome":[81],"sequencing":[82],"was":[83,122,184],"used":[84,149],"analyze":[86],"effects":[88,217],"interference":[91],"on":[92],"signaling":[94,181,278],"pathways":[95],"Nuclear-cytoplasmic":[98],"protein":[99],"separation,":[100],"co-immunoprecipitation,":[101],"confocal":[103],"microscopic":[104],"analyses":[105],"were":[106,148],"conducted":[107],"clarify":[109],"targeting":[115,221,293],"therapy.":[116],"A":[117],"named":[120],"XPin\u03b2":[121,183,202,228,251],"developed":[123],"by":[124],"co-assembling":[125],"specially":[127],"designed":[128],"antagonistic":[130],"peptide":[131],"(XPin)":[132],"antagonist":[136],"(Carnosic":[137],"acid/CA).":[138],"Cell":[139],"model,":[140,212],"mouse":[141,211],"allograft":[142,209],"patient-derived":[144,233],"xenograft":[145,234],"(PDX)":[146,235],"models":[147],"evaluate":[151],"antitumor":[153],"XPin\u03b2.":[156],"RESULTS:":[157],"In":[158],"our":[159],"study,":[160],"inhibition":[161,194,274],"led":[164],"accumulation":[168],"\u03b2-catenin,":[170],"altered":[171],"localization":[174],"APC,":[176],"activated":[178],"Wnt/\u03b2-catenin":[180,277],"pathway.":[182],"efficiently":[185],"internalized":[186],"cells":[189],"via":[190],"macropinocytosis,":[191],"achieving":[192],"simultaneous":[193],"both":[196,240,298],"\u03b2-catenin.":[199,301],"As":[200],"expected,":[201],"robust":[204],"anti-tumor":[205],"with":[213,286],"significantly":[214,252],"superior":[215],"therapeutic":[216],"compared":[218],"or":[223],"CA":[224,241],"alone.":[226],"Moreover,":[227],"effectively":[229],"inhibited":[230],"growth":[231],"tumors":[236],"overexpressing":[237],"XPO1,":[238],"outperforming":[239],"commercially":[244],"available":[245],"inhibitor":[247],"KPT-330.":[248],"Most":[249],"importantly,":[250],"suppressed":[253],"pulmonary":[254],"metastasis":[255],"while":[258],"maintaining":[259],"excellent":[260],"biosafety.":[261],"CONCLUSIONS:":[262],"study":[264],"demonstrates":[265],"enhanced":[267],"XPO1-targeted":[270],"through":[272],"pathway":[279],"introduces":[281],"XPin\u03b2,":[282],"promising":[287],"clinical":[288],"translational":[289],"potential":[290],"dual":[292],"against":[295],"involving":[297]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-03-04T00:00:00"}