{"id":"https://openalex.org/W4408093767","doi":"https://doi.org/10.1158/2767-9764.c.7700611","title":"Data from Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory","display_name":"Data from Evaluating the Radiation Sensitivity Index and 12-Chemokine Gene Expression Signature for Clinical Use in a CLIA Laboratory","publication_year":2025,"publication_date":"2025-03-03","ids":{"openalex":"https://openalex.org/W4408093767","doi":"https://doi.org/10.1158/2767-9764.c.7700611"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.c.7700611","doi":"https://doi.org/10.1158/2767-9764.c.7700611","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7700611","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.c.7700611","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035616597","display_name":"Anders Berglund","orcid":"https://orcid.org/0000-0002-0393-3530","observed_orcids":["https://orcid.org/0000-0002-0393-3530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anders E. Berglund","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0393-3530","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031918955","display_name":"John Puskas","orcid":"https://orcid.org/0009-0003-7489-2777","observed_orcids":["https://orcid.org/0009-0003-7489-2777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Puskas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7489-2777","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064043273","display_name":"Sean Yoder","orcid":"https://orcid.org/0000-0002-3120-3279","observed_orcids":["https://orcid.org/0000-0002-3120-3279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean J. Yoder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3120-3279","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203473","display_name":"Andrew T. Smith","orcid":"https://orcid.org/0009-0004-2626-663X","observed_orcids":["https://orcid.org/0009-0004-2626-663X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew T. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-2626-663X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064856723","display_name":"Douglas C. Marchion","orcid":"https://orcid.org/0009-0003-7673-0149","observed_orcids":["https://orcid.org/0009-0003-7673-0149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas C. Marchion","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7673-0149","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055965341","display_name":"Dahui Qin","orcid":"https://orcid.org/0000-0001-9618-5836","observed_orcids":["https://orcid.org/0000-0001-9618-5836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dahui Qin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9618-5836","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004554374","display_name":"James J. Mul\u00e9","orcid":"https://orcid.org/0000-0001-7354-0516","observed_orcids":["https://orcid.org/0000-0001-7354-0516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Mul\u00e9","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7354-0516","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080324794","display_name":"Javier F. Torres\u2013Roca","orcid":"https://orcid.org/0000-0001-5169-2121","observed_orcids":["https://orcid.org/0000-0001-5169-2121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier F. Torres-Roca","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5169-2121","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086603901","display_name":"Steven A. Eschrich","orcid":"https://orcid.org/0000-0002-9833-2788","observed_orcids":["https://orcid.org/0000-0002-9833-2788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven A. Eschrich","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9833-2788","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.1356000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.902999997138977},{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.9829999804496765},{"id":"https://openalex.org/keywords/assay-reproducibility","display_name":"assay reproducibility","score":0.8769999742507935},{"id":"https://openalex.org/keywords/assay-precision","display_name":"assay precision","score":0.5580000281333923},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8360000252723694},{"id":"https://openalex.org/keywords/macrodissection","display_name":"macrodissection","score":0.5770000219345093},{"id":"https://openalex.org/keywords/clinical-trial-biomarkers","display_name":"clinical trial biomarkers","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.7349150776863098},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6225666403770447},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.583217978477478},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.5509848594665527},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4959937036037445},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44812294840812683},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.415030837059021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36915647983551025},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35964083671569824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35457536578178406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27640417218208313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23160526156425476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15444111824035645},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12614458799362183},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10776695609092712},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.09579190611839294},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.09462261199951172},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.c.7700611","doi":"https://doi.org/10.1158/2767-9764.c.7700611","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7700611","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.c.7700611","doi":"https://doi.org/10.1158/2767-9764.c.7700611","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.7700611","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407371821","https://openalex.org/W4408093823","https://openalex.org/W4408122122","https://openalex.org/W4408093778","https://openalex.org/W4408093775","https://openalex.org/W4408093782","https://openalex.org/W4410344334","https://openalex.org/W4408093772","https://openalex.org/W4408093809","https://openalex.org/W4408093781"],"abstract_inverted_index":{"Abstract":[0],"The":[1,224],"radiation":[2,26,235],"sensitivity":[3,27,236],"index":[4],"(RSI)":[5],"and":[6,81,88,95,104,118,124,146,189,203,226,263],"12-chemokine":[7],"gene":[8,15],"expression":[9,16],"signature":[10],"(12CK":[11],"GES)":[12],"are":[13,229,276],"two":[14,230],"signatures":[17,268],"(GES)":[18],"that":[19,159,232],"were":[20,101,107,206,249],"previously":[21],"developed":[22],"to":[23,122,216],"predict":[24,233],"tumor":[25,234],"or":[28,237],"identify":[29],"the":[30,41,56,59,76,128,132,160,178,209,238,252],"presence":[31,239],"of":[32,43,58,79,131,139,142,152,155,163,183,186,193,196,240],"tertiary":[33,241],"lymphoid":[34,242],"structures":[35,243],"in":[36,244,269],"tumors,":[37,245],"respectively.":[38,246],"To":[39],"advance":[40],"use":[42],"these":[44,274],"GESs":[45,219,231,248,275],"into":[46],"clinical":[47,221,257,282],"trial":[48],"evaluation,":[49],"their":[50],"assays":[51],"must":[52],"be":[53,217],"assessed":[54,250],"within":[55,251,280],"context":[57],"Clinical":[60],"Laboratory":[61,215],"Improvement":[62],"Amendments":[63],"(CLIA)":[64],"process.":[65],"Using":[66],"HG-U133Plus2.0":[67],"arrays,":[68],"we":[69],"first":[70],"established":[71,260],"CLIA":[72,173,253],"laboratory":[73,100,174],"proficiency.":[74],"Then":[75],"accuracy":[77],"(limit":[78],"detection":[80],"macrodissection":[82],"impact),":[83],"precision":[84],"(variability":[85],"by":[86,208],"time":[87,123],"operator),":[89],"sample":[90],"type":[91],"(surgery":[92],"vs.":[93],"biopsy),":[94],"concordance":[96],"with":[97,120,170,177],"a":[98,135,147,171,270],"reference":[99],"evaluated.":[102],"RSI":[103,137,180,202,225],"12CK":[105,113,149,190,204,227],"GES":[106,150,191,205,228],"reproducible":[108,218],"(RSI:":[109],"0.01":[110],"mean":[111,116],"difference,":[112],"GES:":[114],"0.17":[115],"difference)":[117],"precise":[119],"respect":[121],"operator.":[125],"Taken":[126],"together,":[127],"reproducibility":[129],"analysis":[130],"scores":[133],"indicated":[134,158],"median":[136,148,179],"difference":[138,151,182,192],"0.06":[140],"(6.47%":[141],"range)":[143,188],"across":[144],"samples":[145],"0.92":[153],"(12.29%":[154],"range).":[156,198],"Experiments":[157],"lower":[161],"limit":[162],"input":[164],"RNA":[165],"is":[166],"5":[167],"ng.":[168],"Reproducibility":[169],"second":[172],"demonstrated":[175,207],"reliability":[176,264],"score":[181],"0.065":[184],"(6%":[185],"full":[187],"0.93":[194],"(12%":[195],"observed":[197],"Overall,":[199],"under":[200],"CLIA,":[201],"Moffitt":[210],"Cancer":[211],"Center":[212],"Advanced":[213],"Diagnostic":[214],"for":[220,255,266,278],"usage.":[222],"Significance:":[223],"These":[247],"process":[254],"future":[256,281],"use.":[258],"We":[259],"proficiency,":[261],"reproducibility,":[262],"characteristics":[265],"both":[267],"controlled":[271],"setting,":[272],"indicating":[273],"suitable":[277],"validation":[279],"trials.":[283]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-03-04T00:00:00"}