{"id":"https://openalex.org/W4408084973","doi":"https://doi.org/10.1038/s41598-026-76125-4","title":"Temporal mapping of the anti-tumor effects of nanobody-based MSLN.CAR-T cell therapy in metastatic solid tumors","display_name":"Temporal mapping of the anti-tumor effects of nanobody-based MSLN.CAR-T cell therapy in metastatic solid tumors","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W4408084973","doi":"https://doi.org/10.1038/s41598-026-76125-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/40568084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12190766"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-76125-4","doi":"https://doi.org/10.1038/s41598-026-76125-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76125-4","pdf_url":"https://www.nature.com/articles/s41598-026-76125-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-76125-4_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021791991","display_name":"Chaido Stathopoulou","orcid":"https://orcid.org/0000-0003-4760-1973","observed_orcids":["https://orcid.org/0000-0003-4760-1973"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaido Stathopoulou","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101879401","display_name":"Mingming Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingming Zhao","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074192474","display_name":"Qun Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qun Jiang","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091769570","display_name":"Jessica Hong","orcid":"https://orcid.org/0000-0001-8726-4575","observed_orcids":["https://orcid.org/0000-0001-8726-4575"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hong","raw_affiliation_strings":["Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160288594","display_name":"Jing Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Bian","raw_affiliation_strings":["Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160296190","display_name":"Abhilash Venugopalan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhilash Venugopalan","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","NCI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"NCI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160031064","display_name":"Jingli Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingli Zhang","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","National Cancer Institute, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"National Cancer Institute, NIH","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036066519","display_name":"Mitchell Ho","orcid":"https://orcid.org/0000-0002-9152-5405","observed_orcids":["https://orcid.org/0000-0002-9152-5405"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Ho","raw_affiliation_strings":["Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029872582","display_name":"Raffit Hassan","orcid":"https://orcid.org/0000-0002-4012-3633","observed_orcids":["https://orcid.org/0000-0002-4012-3633"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raffit Hassan","raw_affiliation_strings":["Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10-CCR Rm. 4E-5330, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029872582"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.5933,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.83220994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nanobodies","display_name":"nanobodies","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mesothelin","display_name":"mesothelin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/metastatic-solid-tumors","display_name":"metastatic solid tumors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.703000009059906},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.906000018119812},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-adaptation","display_name":"tumor adaptation","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.6900946497917175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5252622961997986},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.5129827857017517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40572649240493774},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33120909333229065},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32953542470932007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2744527757167816},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17379456758499146}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-026-76125-4","doi":"https://doi.org/10.1038/s41598-026-76125-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76125-4","pdf_url":"https://www.nature.com/articles/s41598-026-76125-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.26.640438","doi":"https://doi.org/10.1101/2025.02.26.640438","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.26.640438","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40568084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40568084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10998586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12190766","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12190766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12190766","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-76125-4","doi":"https://doi.org/10.1038/s41598-026-76125-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-76125-4","pdf_url":"https://www.nature.com/articles/s41598-026-76125-4_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6199036136","display_name":"Immunotherapy for Malignant Mesothelioma","funder_award_id":"Z01BC010816","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000868596","display_name":"Adoptive cell therapy for malignant mesothelioma and other mesothelin expressing","funder_award_id":"ZIABC010816","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408084973.pdf","grobid_xml":"https://content.openalex.org/works/W4408084973.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1981734925","https://openalex.org/W1982632906","https://openalex.org/W1999574084","https://openalex.org/W2007161969","https://openalex.org/W2008188798","https://openalex.org/W2023917164","https://openalex.org/W2036491571","https://openalex.org/W2037042031","https://openalex.org/W2041785651","https://openalex.org/W2072697288","https://openalex.org/W2098981101","https://openalex.org/W2104449005","https://openalex.org/W2112417973","https://openalex.org/W2116576596","https://openalex.org/W2138787512","https://openalex.org/W2143158335","https://openalex.org/W2146512944","https://openalex.org/W2157023326","https://openalex.org/W2159707944","https://openalex.org/W2169456326","https://openalex.org/W2288933986","https://openalex.org/W2429031812","https://openalex.org/W2551553748","https://openalex.org/W2604805073","https://openalex.org/W2777540525","https://openalex.org/W2788142646","https://openalex.org/W2795515854","https://openalex.org/W2890087043","https://openalex.org/W2927684362","https://openalex.org/W2979687916","https://openalex.org/W2995257393","https://openalex.org/W2999989312","https://openalex.org/W3001363353","https://openalex.org/W3042898438","https://openalex.org/W3097472706","https://openalex.org/W3120762645","https://openalex.org/W3122724341","https://openalex.org/W3123371217","https://openalex.org/W3127189019","https://openalex.org/W3128657608","https://openalex.org/W3134390016","https://openalex.org/W3139581890","https://openalex.org/W3158282211","https://openalex.org/W3160890790","https://openalex.org/W3164692211","https://openalex.org/W3198374638","https://openalex.org/W4220724757","https://openalex.org/W4225286294","https://openalex.org/W4308620781","https://openalex.org/W4312116120","https://openalex.org/W4318200441","https://openalex.org/W4361269839","https://openalex.org/W4382400160","https://openalex.org/W4384945595","https://openalex.org/W4386067114","https://openalex.org/W4388035659","https://openalex.org/W4390505828","https://openalex.org/W4390507337","https://openalex.org/W4391992014","https://openalex.org/W4392096696","https://openalex.org/W4395118048","https://openalex.org/W4399928928","https://openalex.org/W4405774581","https://openalex.org/W4406081093","https://openalex.org/W7125096331","https://openalex.org/W7140299768","https://openalex.org/W7159783719"],"related_works":["https://openalex.org/W4317911418","https://openalex.org/W4362593912","https://openalex.org/W7160113239","https://openalex.org/W7167129781","https://openalex.org/W4400773931","https://openalex.org/W4405042986","https://openalex.org/W7165765535","https://openalex.org/W3213123833","https://openalex.org/W3129250092","https://openalex.org/W2499376085"],"abstract_inverted_index":{"Abstract":[0,186],"Studies":[1],"on":[2],"the":[3,8,85,121,153],"dynamic":[4,150],"changes":[5,151],"occurring":[6],"in":[7,51,84,128,138,152],"tumor":[9,40,59,143],"microenvironment":[10],"(TME)":[11],"following":[12],"CAR-T":[13,32,163,182,194],"cell":[14,33,68,164,183,195],"therapy":[15],"have":[16],"been":[17],"confounded":[18],"by":[19,72],"host":[20],"lymphodepletion,":[21],"multiple":[22],"dosing":[23],"and":[24,44,78,111,130,155,172],"immunodeficient":[25],"models.":[26],"Here,":[27],"a":[28,48,97,131,142],"nanobody-based,":[29],"mouse":[30,54],"mesothelin-targeting":[31],"(A101)":[34],"was":[35,94,136],"developed,":[36],"achieving":[37],"effective":[38],"primary":[39],"suppression,":[41],"metastasis":[42],"reduction,":[43],"improved":[45],"survival":[46],"after":[47],"single":[49],"dose":[50],"immunocompetent,":[52],"syngeneic":[53],"models":[55],"without":[56],"lymphodepletion.":[57],"Temporal":[58],"profiling":[60],"using":[61],"RNA":[62],"sequencing":[63],"revealed":[64],"initial":[65],"downregulation":[66,103],"of":[67,74,104,113,125,159],"proliferation":[69],"genes":[70,83],"followed":[71],"upregulation":[73,112,124],"inflammation,":[75],"epithelial-to-mesenchymal-transition":[76],"(EMT)":[77],"extracellular":[79],"matrix":[80],"(ECM)":[81],"modification":[82],"CAR-T-treated":[86,139],"tumors":[87,161],"relative":[88],"to":[89,162,192],"mock-T-treated":[90],"controls.":[91],"This":[92,146],"phenotype":[93,135],"reversed":[95],"at":[96],"later":[98],"timepoint":[99],"which":[100],"coincided":[101],"with":[102],"immunosuppressive":[105],"Cd274":[106],"+":[107,109,116,127,170,174],"Lcn2":[108,169],"neutrophils":[110,171],"anti-tumor":[114,184],"P2rx1":[115],"Nrf2":[117],"-":[118],"neutrophils.":[119],"At":[120],"same":[122],"time,":[123],"Ccl2":[126,173],"fibroblasts":[129,175],"more":[132],"immunomodulatory":[133],"macrophage":[134],"observed":[137],"tumors,":[140],"indicating":[141],"adaptation":[144],"mechanism.":[145],"study":[147],"demonstrates":[148],"complex":[149],"TME,":[154],"highlights":[156,168],"time-dependent":[157],"responses":[158,191],"solid":[160],"therapy.":[165],"It":[166],"further":[167],"as":[176],"potential":[177],"therapeutic":[178],"targets":[179],"for":[180],"improving":[181],"efficacy.":[185],"Figure":[187],"Graphical":[188],"abstract.":[189],"Tumor":[190],"A101":[193],"treatment.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-03T00:00:00"}