{"id":"https://openalex.org/W4408074124","doi":"https://doi.org/10.26502/josm.511500177","title":"Potential of Astaxanthin in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial","display_name":"Potential of Astaxanthin in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial","publication_year":2025,"publication_date":"2025-01-27","ids":{"openalex":"https://openalex.org/W4408074124","doi":"https://doi.org/10.26502/josm.511500177"},"language":"en","primary_location":{"id":"doi:10.26502/josm.511500177","doi":"https://doi.org/10.26502/josm.511500177","is_oa":true,"landing_page_url":"https://doi.org/10.26502/josm.511500177","pdf_url":null,"source":{"id":"https://openalex.org/S4210240947","display_name":"Journal of Orthopaedics and Sports Medicine","issn_l":"2688-5115","issn":["2688-5115"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedics and Sports Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.26502/josm.511500177","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025378612","display_name":"Masuma Tabassum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masuma Tabassum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Md. Sayedur Rahman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md. Sayedur Rahman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087937852","display_name":"Syed Mozaffar Ahmed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Mozaffar Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026793196","display_name":"Iftekhar Hossain Chowdhury","orcid":"https://orcid.org/0009-0008-7741-0311","observed_orcids":["https://orcid.org/0009-0008-7741-0311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iftekhar Hossain Chowdhury","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116470538","display_name":"Nazmul Huda SM","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nazmul Huda SM","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shahrin Sultana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahrin Sultana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Shirin Aktar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shirin Aktar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093043515","display_name":"Muhammad Marnush","orcid":"https://orcid.org/0009-0009-5466-2222","observed_orcids":["https://orcid.org/0009-0009-5466-2222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Marnush","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012705118","display_name":"Md. Abdul Jalil","orcid":"https://orcid.org/0000-0003-4393-4607","observed_orcids":["https://orcid.org/0000-0003-4393-4607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Md. Abdul Jalil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5233,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58835127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"23","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":1.0},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":0.9430000185966492},{"id":"https://openalex.org/keywords/joint-stiffness","display_name":"joint stiffness","score":0.8730000257492065},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/womac-index","display_name":"WOMAC index","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.78956139087677},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7436404228210449},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6246083974838257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5805866122245789},{"id":"https://openalex.org/C2780962900","wikidata":"https://www.wikidata.org/wiki/Q413740","display_name":"Astaxanthin","level":3,"score":0.5452604293823242},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5276236534118652},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4840075671672821},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.23589393496513367},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17400607466697693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09035256505012512},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26502/josm.511500177","doi":"https://doi.org/10.26502/josm.511500177","is_oa":true,"landing_page_url":"https://doi.org/10.26502/josm.511500177","pdf_url":null,"source":{"id":"https://openalex.org/S4210240947","display_name":"Journal of Orthopaedics and Sports Medicine","issn_l":"2688-5115","issn":["2688-5115"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedics and Sports Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.26502/josm.511500177","doi":"https://doi.org/10.26502/josm.511500177","is_oa":true,"landing_page_url":"https://doi.org/10.26502/josm.511500177","pdf_url":null,"source":{"id":"https://openalex.org/S4210240947","display_name":"Journal of Orthopaedics and Sports Medicine","issn_l":"2688-5115","issn":["2688-5115"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedics and Sports Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407131742","https://openalex.org/W7171653806","https://openalex.org/W4285167836","https://openalex.org/W4387798435","https://openalex.org/W2092652282","https://openalex.org/W4386250924","https://openalex.org/W3156687101","https://openalex.org/W3159806184","https://openalex.org/W4210343583","https://openalex.org/W2527137999"],"abstract_inverted_index":{"Background:":[0],"Osteoarthritis":[1,140],"(OA)":[2],"is":[3,38],"a":[4,35,39,48,65],"major":[5],"disabling":[6],"disorder":[7],"of":[8,57,149,166],"the":[9,58,108,134,164,197,226],"elderly":[10],"population":[11],"worldwide.":[12],"Pharmacotherapy":[13],"focuses":[14],"on":[15],"symptomatic":[16],"relief":[17],"through":[18],"nonsteroidal":[19],"anti-inflammatory":[20],"drugs":[21],"(NSAIDs)":[22],"or":[23,123],"intra":[24],"articular":[25],"steroids,":[26],"which":[27,45],"are":[28],"associated":[29],"with":[30,42,81,89,100,180,246,252],"significant":[31],"adverse":[32],"effects.":[33],"Astaxanthin,":[34],"marine":[36],"carotenoid,":[37],"strong":[40],"antioxidant":[41],"antiinflammatory":[43],"properties":[44],"may":[46],"be":[47],"safe":[49],"and":[50,76,137,153,162,172,220,241],"effective":[51],"alternative":[52],"treatment.":[53],"Objectives:":[54],"The":[55],"purpose":[56],"research":[59],"was":[60],"to":[61,83,102,126,147,202,214,248],"look":[62],"into":[63],"how":[64],"commercially":[66],"available":[67],"astaxanthin":[68,119,127,184,198,227],"supplement":[69],"affected":[70],"knee":[71,85,90,104,238,250],"pain,":[72,239],"stiffness,":[73,240],"physical":[74,173,242],"function":[75,174,243],"inflammatory":[77,255],"markers":[78],"in":[79,107,177,196,225,233,237,244,254],"persons":[80],"moderate":[82,101,247],"severe":[84,103,249],"osteoarthritis.":[86],"Methods:":[87],"Adults":[88],"pain":[91,171],"(n":[92],"=":[93],"71,":[94],">40":[95],"years":[96],"old),":[97],"radiologically":[98],"diagnosed":[99],"OA,":[105],"participated":[106],"8-weeks":[109],"double-blind,":[110],"randomized,":[111],"placebo-controlled":[112],"trial.":[113],"Participants":[114],"consumed":[115],"either":[116],"12":[117],"mg":[118],"capsule":[120],"each":[121],"day":[122],"placebo":[124,188,209],"identical":[125],"capsule.":[128],"Knee":[129,170],"outcomes":[130],"were":[131,155,158],"assessed":[132,159],"using":[133],"Western":[135],"Ontario":[136],"McMaster":[138],"Universities":[139],"Index":[141],"(WOMAC)":[142],"visual":[143],"analog":[144],"scale":[145],"(normalized":[146],"scores":[148],"0\u2013100),":[150],"serum":[151],"hsCRP":[152,219],"IL-6":[154,221],"measured.":[156],"Outcomes":[157],"at":[160,163],"baseline,":[161],"end":[165],"8th":[167],"week.":[168],"Results:":[169],"score":[175,193],"improved":[176,194],"both":[178],"groups":[179],"greater":[181],"improvements":[182,236,253],"for":[183,187,208],"(p<0.05)":[185],"than":[186,207],"(p>0.05)":[189],"group.":[190,228],"Total":[191],"WOMAC":[192],"significantly":[195,224],"(177.36":[199],"\u00b1":[200,204,212,216],"12.6":[201],"166.95":[203],"12.96)":[205],"group":[206,210],"(177.24":[211],"12.45":[213],"175.09":[215],"12.21).":[217],"Serum":[218],"also":[222],"reduced":[223],"Conclusions:":[229],"Astaxanthin":[230],"consumption":[231],"resulted":[232],"modest":[234],"subjective":[235],"adults":[245],"OA":[251],"markers.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-03-02T00:00:00"}
