{"id":"https://openalex.org/W4408043362","doi":"https://doi.org/10.1177/2050313x251324079","title":"Successful treatment of pediatric patient with Dravet syndrome with cenobamate: Case report","display_name":"Successful treatment of pediatric patient with Dravet syndrome with cenobamate: Case report","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4408043362","doi":"https://doi.org/10.1177/2050313x251324079","pmid":"https://pubmed.ncbi.nlm.nih.gov/40028240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11869260"},"language":"en","primary_location":{"id":"doi:10.1177/2050313x251324079","doi":"https://doi.org/10.1177/2050313x251324079","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2050313x251324079","pdf_url":null,"source":{"id":"https://openalex.org/S2764719888","display_name":"SAGE Open Medical Case Reports","issn_l":"2050-313X","issn":["2050-313X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/2050313x251324079","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033599050","display_name":"Oleg V. Lobanov","orcid":"https://orcid.org/0000-0002-7778-2253","observed_orcids":["https://orcid.org/0000-0002-7778-2253"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oleg V Lobanov","raw_affiliation_strings":["Department of Neurology, Washington University, St. Louis, MO, USA"],"raw_orcid":"https://orcid.org/0000-0002-7778-2253","affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006861194","display_name":"Mary E. Bertrand","orcid":"https://orcid.org/0000-0002-7830-3293","observed_orcids":["https://orcid.org/0000-0002-7830-3293"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Bertrand","raw_affiliation_strings":["Department of Neurology, Washington University, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Washington University, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033599050"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":3.7583,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.93333626,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"2050313X251324079","last_page":"2050313X251324079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dravet-syndrome","display_name":"Dravet syndrome","score":1.0},{"id":"https://openalex.org/keywords/cenobamate","display_name":"cenobamate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/generalized-tonic-clonic-seizures","display_name":"generalized tonic-clonic seizures","score":0.8330000042915344},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.6150000095367432},{"id":"https://openalex.org/keywords/seizure-frequency-reduction","display_name":"seizure frequency reduction","score":0.6169999837875366},{"id":"https://openalex.org/keywords/sudden-unexpected-death-in-epilepsy","display_name":"sudden unexpected death in epilepsy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/fenfluramine","display_name":"fenfluramine","score":0.7620000243186951},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clobazam","display_name":"clobazam","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780623815","wikidata":"https://www.wikidata.org/wiki/Q1255956","display_name":"Dravet syndrome","level":3,"score":0.9968576431274414},{"id":"https://openalex.org/C2777907850","wikidata":"https://www.wikidata.org/wiki/Q412164","display_name":"Clobazam","level":3,"score":0.9254909753799438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.906893253326416},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.699607253074646},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6929954886436462},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.5998338460922241},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5384670495986938},{"id":"https://openalex.org/C2779307984","wikidata":"https://www.wikidata.org/wiki/Q1544884","display_name":"Lennox\u2013Gastaut syndrome","level":3,"score":0.5229098200798035},{"id":"https://openalex.org/C2775859823","wikidata":"https://www.wikidata.org/wiki/Q11883686","display_name":"Myoclonic epilepsy","level":3,"score":0.4830206334590912},{"id":"https://openalex.org/C2777332695","wikidata":"https://www.wikidata.org/wiki/Q417227","display_name":"Levetiracetam","level":3,"score":0.4763743579387665},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4446507394313812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15172305703163147},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10681143403053284},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1177/2050313x251324079","doi":"https://doi.org/10.1177/2050313x251324079","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2050313x251324079","pdf_url":null,"source":{"id":"https://openalex.org/S2764719888","display_name":"SAGE Open Medical Case Reports","issn_l":"2050-313X","issn":["2050-313X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11869260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11869260","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Med Case Rep","raw_type":"Text"},{"id":"pmid:40028240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40028240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE open medical case reports","raw_type":"Case Reports"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-6289","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/5304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d4360b30218f43ceb51021c9503e62fe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d4360b30218f43ceb51021c9503e62fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SAGE Open Medical Case Reports, Vol 13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/2050313x251324079","doi":"https://doi.org/10.1177/2050313x251324079","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2050313x251324079","pdf_url":null,"source":{"id":"https://openalex.org/S2764719888","display_name":"SAGE Open Medical Case Reports","issn_l":"2050-313X","issn":["2050-313X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SAGE Open Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2048186906","https://openalex.org/W2059287604","https://openalex.org/W2101383744","https://openalex.org/W2105423985","https://openalex.org/W2170194739","https://openalex.org/W2544534185","https://openalex.org/W2620218661","https://openalex.org/W2750672687","https://openalex.org/W2944392111","https://openalex.org/W2996672198","https://openalex.org/W3025465714","https://openalex.org/W3092685772","https://openalex.org/W3161204932","https://openalex.org/W4225248989","https://openalex.org/W4225332941","https://openalex.org/W4285092783","https://openalex.org/W4297994782"],"related_works":["https://openalex.org/W4409893191","https://openalex.org/W7164185945","https://openalex.org/W4415258054","https://openalex.org/W4417245921","https://openalex.org/W7162757540","https://openalex.org/W4297994782","https://openalex.org/W7204539288","https://openalex.org/W4285092783","https://openalex.org/W2976958970","https://openalex.org/W4412736125"],"abstract_inverted_index":{"Dravet":[0,39,70,85],"syndrome,":[1,86],"also":[2],"known":[3],"as":[4],"severe":[5,16],"myoclonic":[6],"epilepsy":[7,17,74],"of":[8,31,57,61,81,99,117,138,149],"infancy,":[9],"is":[10,26,49],"an":[11,124],"epileptic":[12],"encephalopathy":[13],"characterized":[14],"by":[15,19],"accompanied":[18],"impaired":[20],"psychomotor":[21],"and":[22,44,72,79,90,155],"neurologic":[23],"development.":[24],"Onset":[25],"in":[27,33,38,63],"the":[28,45,54,58,76,97,133,147],"first":[29,55],"year":[30],"life":[32],"apparently":[34],"healthy":[35],"infants.":[36],"Seizures":[37],"syndrome":[40,71],"are":[41,143],"highly":[42],"pharmacoresistant,":[43],"SUDEP":[46],"mortality":[47],"rate":[48],"high.":[50],"Here,":[51],"we":[52],"present":[53],"case":[56,135],"successful":[59],"use":[60,78],"cenobamate":[62,150],"a":[64,114],"pediatric":[65],"patient":[66],"(9-year-old":[67],"female)":[68],"with":[69],"pharmacoresistant":[73],"despite":[75],"prior":[77],"failure":[80],"typical":[82],"medications":[83],"for":[84],"including":[87],"fenfluramine,":[88],"valproate,":[89],"clobazam,":[91],"among":[92],"others.":[93],"At":[94],"6-month":[95],"follow-up,":[96],"frequency":[98],"generalized":[100],"tonic-clonic":[101],"seizures":[102],"decreased":[103],"from":[104],"8":[105],"per":[106,110],"month":[107,111],"to":[108,145],"1":[109],"upon":[112],"reaching":[113],"daily":[115],"dose":[116],"50":[118],"mg":[119],"(1.9":[120],"mg/kg/day),":[121],"which":[122],"represents":[123],"87.5%":[125],"reduction.":[126],"No":[127],"side":[128],"effects":[129],"were":[130],"reported.":[131],"Given":[132],"single-patient":[134],"report":[136],"nature":[137],"this":[139],"study,":[140],"further":[141],"investigations":[142],"needed":[144],"extrapolate":[146],"usefulness":[148],"across":[151],"different":[152],"age":[153],"groups":[154],"genetic":[156],"variants.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-03-01T00:00:00"}
