{"id":"https://openalex.org/W4408029757","doi":"https://doi.org/10.1371/journal.pbio.3003046","title":"Innovations in noninvasive sensory stimulation treatments to combat Alzheimer\u2019s disease","display_name":"Innovations in noninvasive sensory stimulation treatments to combat Alzheimer\u2019s disease","publication_year":2025,"publication_date":"2025-02-28","ids":{"openalex":"https://openalex.org/W4408029757","doi":"https://doi.org/10.1371/journal.pbio.3003046","pmid":"https://pubmed.ncbi.nlm.nih.gov/40019895","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11870349"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.3003046","doi":"https://doi.org/10.1371/journal.pbio.3003046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3003046","pdf_url":null,"source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pbio.3003046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079399858","display_name":"Jung M. Park","orcid":"https://orcid.org/0000-0002-3615-2001","observed_orcids":["https://orcid.org/0000-0002-3615-2001"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung M. Park","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3615-2001","affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042440695","display_name":"Li\u2010Huei Tsai","orcid":"https://orcid.org/0000-0003-1262-0592","observed_orcids":["https://orcid.org/0000-0003-1262-0592"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Huei Tsai","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1262-0592","affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042440695"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I63966007"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":1.6734,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83508604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"23","issue":"2","first_page":"e3003046","last_page":"e3003046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.06369999796152115,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/non-invasive-brain-stimulation","display_name":"non-invasive brain stimulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sensory-stimulation","display_name":"sensory stimulation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/40-hz-stimulation","display_name":"40 Hz stimulation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neurotechnology","display_name":"neurotechnology","score":0.7440000176429749},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.48899999260902405},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6000000238418579},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7716662883758545},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6393455862998962},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4723811149597168},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.46485981345176697},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.41675400733947754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38753798604011536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3576847314834595},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35150450468063354},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2994786202907562},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.1427212655544281},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13813287019729614}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pbio.3003046","doi":"https://doi.org/10.1371/journal.pbio.3003046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3003046","pdf_url":null,"source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11870349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11870349","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:40019895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40019895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:958f96f3bd364252ac4ac271ec6ac78a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/958f96f3bd364252ac4ac271ec6ac78a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 23, Iss 2, p e3003046 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.3003046","doi":"https://doi.org/10.1371/journal.pbio.3003046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3003046","pdf_url":null,"source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4066294895","display_name":"Plasticity of cortical circuits in health, aging, and Alzheimer's disease","funder_award_id":"F99AG073558","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4671539442","display_name":null,"funder_award_id":"AG073558","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4826654820","display_name":"Manipulating neural oscillations with non-invasive sensory stimulation for Alzheimer's disease intervention","funder_award_id":"R56AG069232","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G763036535","display_name":null,"funder_award_id":"AG069232","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906492","display_name":"Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease Intervention","funder_award_id":"R01AG069232","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000915265","display_name":"Plasticity of cortical circuits in health, aging, and Alzheimer's disease","funder_award_id":"K00AG073558","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1974522563","https://openalex.org/W1978722261","https://openalex.org/W1979612107","https://openalex.org/W1984851727","https://openalex.org/W1995087873","https://openalex.org/W2005926822","https://openalex.org/W2013090092","https://openalex.org/W2014114637","https://openalex.org/W2066250017","https://openalex.org/W2095060637","https://openalex.org/W2117586085","https://openalex.org/W2131180711","https://openalex.org/W2146249493","https://openalex.org/W2148230634","https://openalex.org/W2149561999","https://openalex.org/W2157586156","https://openalex.org/W2158256695","https://openalex.org/W2163225965","https://openalex.org/W2204819948","https://openalex.org/W2331404224","https://openalex.org/W2346016739","https://openalex.org/W2504553485","https://openalex.org/W2510806376","https://openalex.org/W2560234750","https://openalex.org/W2563078526","https://openalex.org/W2810691179","https://openalex.org/W2884982789","https://openalex.org/W2887664586","https://openalex.org/W2906772580","https://openalex.org/W2922175568","https://openalex.org/W2944762438","https://openalex.org/W2947842732","https://openalex.org/W2949441364","https://openalex.org/W2992893037","https://openalex.org/W2995189233","https://openalex.org/W2995828272","https://openalex.org/W3004609956","https://openalex.org/W3018921295","https://openalex.org/W3026283900","https://openalex.org/W3034646835","https://openalex.org/W3044413849","https://openalex.org/W3123626380","https://openalex.org/W3125322711","https://openalex.org/W3131910442","https://openalex.org/W3155966446","https://openalex.org/W3160428532","https://openalex.org/W3161242812","https://openalex.org/W3169036062","https://openalex.org/W3179949484","https://openalex.org/W3189205237","https://openalex.org/W3201878985","https://openalex.org/W4200006726","https://openalex.org/W4200081716","https://openalex.org/W4200338022","https://openalex.org/W4206046172","https://openalex.org/W4210574564","https://openalex.org/W4213226158","https://openalex.org/W4213433015","https://openalex.org/W4214574386","https://openalex.org/W4223533048","https://openalex.org/W4224247151","https://openalex.org/W4310461604","https://openalex.org/W4310503841","https://openalex.org/W4319459034","https://openalex.org/W4323295031","https://openalex.org/W4323310034","https://openalex.org/W4362460394","https://openalex.org/W4365449029","https://openalex.org/W4377108408","https://openalex.org/W4379231939","https://openalex.org/W4384564307","https://openalex.org/W4385690032","https://openalex.org/W4388114932","https://openalex.org/W4388213281","https://openalex.org/W4389475051","https://openalex.org/W4390012824","https://openalex.org/W4392242084","https://openalex.org/W4392502763","https://openalex.org/W4392507618","https://openalex.org/W4393233503","https://openalex.org/W4394714208","https://openalex.org/W4394894506","https://openalex.org/W4401377232","https://openalex.org/W4401436208"],"related_works":["https://openalex.org/W7124431320","https://openalex.org/W7220830929","https://openalex.org/W4412487810","https://openalex.org/W1999429511","https://openalex.org/W4401041877","https://openalex.org/W7135079373","https://openalex.org/W4320906584","https://openalex.org/W4403538161","https://openalex.org/W4389373860","https://openalex.org/W4390012824"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,95],"(AD)":[2],"is":[3,12],"a":[4,32,40,53,119,161,169],"progressive":[5],"neurodegenerative":[6],"disorder":[7],"affecting":[8],"millions":[9],"worldwide.":[10],"There":[11],"no":[13],"known":[14],"cure":[15],"for":[16,22,43,69,152,173],"AD,":[17,166],"highlighting":[18],"an":[19],"urgent":[20],"need":[21],"new,":[23],"innovative":[24],"treatments.":[25],"Recent":[26],"studies":[27],"have":[28],"shed":[29],"light":[30,48],"on":[31],"promising,":[33],"noninvasive":[34,157],"approach":[35],"using":[36],"sensory":[37],"stimulation":[38],"as":[39],"potential":[41],"therapy":[42],"AD.":[44],"Exposing":[45],"patients":[46],"to":[47,83],"and":[49,88,98,128,176],"sound":[50],"pulses":[51],"at":[52],"frequency":[54,64],"of":[55,103,122,171,181],"40":[56],"hertz":[57],"induces":[58],"brain":[59,71,146],"rhythms":[60,147],"in":[61,76,94,138,164],"the":[62,85,104,109,125,179],"gamma":[63],"range":[65],"that":[66,91,107,117,140],"are":[67,80,148],"important":[68],"healthy":[70,145],"activity.":[72],"Using":[73],"this":[74,182],"treatment":[75,111,123],"animal":[77],"models,":[78],"we":[79],"now":[81],"beginning":[82],"understand":[84],"molecular,":[86],"cellular,":[87],"circuit-level":[89],"changes":[90],"underlie":[92],"improvements":[93],"pathology,":[96],"cognition,":[97],"behavior.":[99],"A":[100],"mechanistic":[101],"understanding":[102],"basic":[105],"biology":[106],"underlies":[108],"40-hertz":[110],"will":[112],"inform":[113],"ongoing":[114],"clinical":[115],"trials":[116],"offer":[118],"promising":[120],"avenue":[121],"without":[124],"side":[126],"effects":[127],"high":[129],"costs":[130],"typically":[131],"associated":[132],"with":[133],"pharmacological":[134],"interventions.":[135],"Concurrent":[136],"advancements":[137],"neurotechnology":[139],"can":[141],"also":[142],"noninvasively":[143],"stimulate":[144],"illuminating":[149],"new":[150,162],"possibilities":[151],"alternative":[153],"therapies.":[154],"Altogether,":[155],"these":[156],"approaches":[158],"could":[159],"herald":[160],"era":[163],"treating":[165],"making":[167],"them":[168],"beacon":[170],"hope":[172],"patients,":[174],"families,":[175],"caregivers":[177],"facing":[178],"challenges":[180],"debilitating":[183],"condition.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-28T00:00:00"}
