{"id":"https://openalex.org/W4407976872","doi":"https://doi.org/10.1016/j.jtct.2025.01.287","title":"Safety of Addition of Inotuzumab Ozogamicin to One Alkylator-Containing Reduced-Intensity Conditioning Regimen in Hematopoietic Cell Transplantation (HCT) for Patients with Acute Lymphoblastic Leukemia and CD22 (+) Aggressive Lymphoid Malignancies: A Prospective Trial","display_name":"Safety of Addition of Inotuzumab Ozogamicin to One Alkylator-Containing Reduced-Intensity Conditioning Regimen in Hematopoietic Cell Transplantation (HCT) for Patients with Acute Lymphoblastic Leukemia and CD22 (+) Aggressive Lymphoid Malignancies: A Prospective Trial","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4407976872","doi":"https://doi.org/10.1016/j.jtct.2025.01.287"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtct.2025.01.287","doi":"https://doi.org/10.1016/j.jtct.2025.01.287","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.287","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jtct.2025.01.287","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033737136","display_name":"Issa F. Khouri","orcid":"https://orcid.org/0000-0003-2473-911X","observed_orcids":["https://orcid.org/0000-0003-2473-911X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Issa F. Khouri","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111926111","display_name":"Hagop M. Kantarjian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M Kantarjian","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055885925","display_name":"Alison M. Gulbis","orcid":"https://orcid.org/0000-0003-1921-9152","observed_orcids":["https://orcid.org/0000-0003-1921-9152"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Gulbis","raw_affiliation_strings":["Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015524203","display_name":"Fadi Haddad","orcid":"https://orcid.org/0000-0002-9702-8485","observed_orcids":["https://orcid.org/0000-0002-9702-8485"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadi G. Haddad","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029750735","display_name":"Koji Sasaki","orcid":"https://orcid.org/0000-0002-9140-0610","observed_orcids":["https://orcid.org/0000-0002-9140-0610"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koji Sasaki","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035321251","display_name":"David Mar\u00edn","orcid":"https://orcid.org/0000-0003-0812-9346","observed_orcids":["https://orcid.org/0000-0003-0812-9346"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Marin","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nitin Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Jain","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016928938","display_name":"Gabriela Rond\u00f3n","orcid":"https://orcid.org/0000-0003-3841-3567","observed_orcids":["https://orcid.org/0000-0003-3841-3567"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Rondon","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041917404","display_name":"Hind Rafei","orcid":"https://orcid.org/0000-0002-5724-4183","observed_orcids":["https://orcid.org/0000-0002-5724-4183"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hind Rafei","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022871468","display_name":"Jeremy Ramdial","orcid":"https://orcid.org/0000-0002-8984-3420","observed_orcids":["https://orcid.org/0000-0002-8984-3420"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy L. Ramdial","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011838589","display_name":"Jin Seon Im","orcid":"https://orcid.org/0000-0002-5249-1177","observed_orcids":["https://orcid.org/0000-0002-5249-1177"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin S. Im","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069460930","display_name":"Partow Kebriaei","orcid":"https://orcid.org/0000-0002-8607-9404","observed_orcids":["https://orcid.org/0000-0002-8607-9404"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Partow Kebriaei","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109786962","display_name":"Richard E. Champlin","orcid":"https://orcid.org/0000-0002-4314-5037","observed_orcids":["https://orcid.org/0000-0002-4314-5037"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Champlin","raw_affiliation_strings":["Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Elias Jabbour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Jabbour","raw_affiliation_strings":["Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033737136"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04514728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"2","first_page":"S186","last_page":"S187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reduced-intensity-conditioning","display_name":"reduced-intensity conditioning","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hepatic-veno-occlusive-disease","display_name":"veno-occlusive disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.6299999952316284},{"id":"https://openalex.org/keywords/graft-versus-leukemia-effect","display_name":"graft-versus-leukemia effect","score":0.6990000009536743},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.6890000104904175},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9789999723434448},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4189999997615814},{"id":"https://openalex.org/keywords/richter-transformation","display_name":"Richter transformation","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2993801483","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Conditioning regimen","level":4,"score":0.671391487121582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6041815876960754},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5734544992446899},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.5629112720489502},{"id":"https://openalex.org/C111700020","wikidata":"https://www.wikidata.org/wiki/Q5009798","display_name":"CD22","level":4,"score":0.5602458119392395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5106428265571594},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5092819929122925},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.49708321690559387},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.46222153306007385},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4536842107772827},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.24793338775634766},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2239917814731598},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18752017617225647},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.16526830196380615},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.16472968459129333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06853914260864258},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtct.2025.01.287","doi":"https://doi.org/10.1016/j.jtct.2025.01.287","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.287","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtct.2025.01.287","doi":"https://doi.org/10.1016/j.jtct.2025.01.287","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.287","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405045462","https://openalex.org/W4392137184","https://openalex.org/W4390572415","https://openalex.org/W3095729381","https://openalex.org/W4310120143","https://openalex.org/W4386012933","https://openalex.org/W3166543567","https://openalex.org/W4405052027","https://openalex.org/W4385197765","https://openalex.org/W3171082370"],"abstract_inverted_index":{"Background":[0],"Inotuzumab":[1],"ozogamicin":[2],"(INO)":[3],"has":[4,457],"been":[5,458],"associated":[6],"with":[7,67,158,186,196,204,349,354,359,374,430],"an":[8,89],"increased":[9],"risk":[10,463],"of":[11,32,47,110,162,201,230,278,300,307,325,393,414,452,464],"veno-occlusive":[12,312],"disease":[13,69,149],"in":[14,49,173,180,218,383,448],"patients":[15,50,74,157,195,220,260,310,344,373,415],"receiving":[16,51],"hematopoietic":[17],"cell":[18],"transplantation":[19],"(HCT).":[20],"Risk":[21,192],"factors":[22,193],"included":[23,155,169,198,221],"the":[24,45,199,308,330,411,462],"use":[25,31],"a":[26,83,108,159,276,298,322,346,431,449],"two-alkylator":[27],"containing":[28,55],"regimens,":[29],"prior":[30,137,216,233],"INO":[33,48,98,225,231,425],"and":[34,58,82,93,126,141,178,182,189,211,224,241,254,334,340,357,377,382,388,443],"elevated":[35],"liver":[36,80],"function":[37,81],"tests.":[38],"In":[39,72],"this":[40],"study,":[41],"we":[42],"prospectively":[43],"studied":[44],"safety":[46],"HCT":[52,235,282,435],"after":[53,281,297,368],"one-alkylator":[54],"conditioning.":[56],"Patients":[57],"Methods":[59],"The":[60,153,227,370,391,438],"eligibility":[61],"criteria":[62],"were":[63,75,135,143,236,338],"age":[64,161],"18-70":[65],"years":[66,318],"CD22(+)":[68],"requiring":[70],"HCT.":[71,139,369],"addition,":[73],"required":[76],"to":[77,124,138,234,268,289,417,445,460],"have":[78],"adequate":[79],"6/6":[84],"HLA-compatible":[85],"sibling":[86,252],"donor":[87,96,263],"or":[88],"HLA-A,":[90],"HLA-B,":[91],"HLA-C,":[92],"DRB1-matched":[94],"unrelated":[95],"(MUD)":[97],"was":[99,319,397],"infused":[100],"intravenously":[101],"(IV)":[102],"on":[103,121,132],"day":[104,133],"-13":[105],"outpatient,":[106],"at":[107,316,366,386],"dose":[109],"0.3":[111],"mg/m":[112,117,129,243],"2":[113,118,130,244,317,371],".":[114,245],"Fludarabine":[115],"30":[116],"IV":[119,131],"daily":[120],"days":[122,280,302],"-5":[123],"-2":[125,134],"melphalan":[127,432],"140":[128],"given":[136],"Tacrolimus":[140],"methotrexate":[142],"used":[144],"for":[145,194],"graft":[146],"versus":[147],"host":[148],"(GVHD)":[150],"prophylaxis.":[151],"Results":[152],"study":[154],"9":[156,274,295],"median":[160,277,299,323],"54":[163],"(range,":[164,283,303,328],"27-64)":[165],"years.":[166],"Disease":[167],"types":[168],"B-ALL":[170],"(n=7":[171],"[6":[172],"first":[174],"complete":[175],"remission":[176,385],"(CR1)":[177],"1":[179,185,348,358],"CR2])":[181],"lymphoma":[183],"(n=2;":[184],"Richter's":[187],"transformation":[188],"17p":[190],"deletion).":[191],"ALL":[197,219],"presence":[200],"TP53":[202,355,375],"mutation":[203,209,213,356,361,376],"complex":[205,378],"cytogenetics":[206,379],"(n=3),":[207],"KMT2A":[208,360],"(n=2),":[210],"IKZF1":[212],"(n=1).":[214],"Key":[215],"therapies":[217],"blinatumomab":[222],"(n=5)":[223],"(n=5).":[226],"maximum":[228],"doses":[229],"received":[232,248],"1.2,":[237],"1.5,":[238],"2.7,":[239,240],"2.7":[242],"Six":[246],"(67%)":[247],"their":[249],"transplants":[250],"from":[251,257],"donors":[253],"3":[255],"(33%)":[256],"MUDs.":[258],"All":[259],"experienced":[261,345],"100%":[262],"engraftment.":[264],"Neutrophil":[265],"counts":[266,287],"recovered":[267,288],"more":[269,290],"than":[270,291],"0.5":[271],"\u00d7":[272,293],"10":[273,294],"/L":[275,296],"12":[279],"9-19":[284],"days).":[285,305],"Platelet":[286],"20":[292],"13":[301,326],"0-27":[304],"None":[306],"treated":[309],"developed":[311],"disease.":[313],"Treatment-related":[314],"mortality":[315],"14%.":[320],"With":[321],"follow-up":[324],"months":[327],"1-36),":[329],"2-year":[331],"overall":[332],"survival":[333,336,439],"progression-free":[335],"rates":[337],"60%":[339],"62%,":[341],"respectively.":[342],"Two":[343],"relapse:":[347],"initial":[350],"primary":[351],"induction":[352],"failure":[353],"who":[362],"had":[363,401],"extramedullary":[364],"sarcoma":[365],"relapse":[367],"other":[372],"remained":[380],"alive":[381],"molecular":[384],"18":[387],"36":[389],"months.":[390],"incidence":[392],"grade":[394],"II-IV":[395],"GVHD":[396],"48%.":[398],"One":[399],"patient":[400],"chronic":[402],"extensive":[403],"GVHD.":[404,465],"Conclusions":[405],"Our":[406],"conclusions":[407],"are":[408,441],"limited":[409],"by":[410],"small":[412],"number":[413,451],"due":[416],"slow":[418],"accrual.":[419],"However,":[420],"our":[421],"data":[422],"suggest":[423],"that":[424],"is":[426],"safe":[427],"when":[428],"combined":[429],"plus":[433],"fludarabine":[434],"conditioning":[436],"regimen.":[437],"outcomes":[440],"encouraging":[442],"need":[444],"be":[446],"validated":[447],"larger":[450],"patients.":[453],"Currently,":[454],"post-transplant":[455],"cyclophosphamide":[456],"implemented":[459],"lessen":[461]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-02-27T00:00:00"}