{"id":"https://openalex.org/W4407976824","doi":"https://doi.org/10.1016/j.jtct.2025.01.157","title":"High-Intensity Maintenance Post Autologous Stem Cell Transplant Is Independently Associated with Improved Event-Free Survival in Multiple Myeloma","display_name":"High-Intensity Maintenance Post Autologous Stem Cell Transplant Is Independently Associated with Improved Event-Free Survival in Multiple Myeloma","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4407976824","doi":"https://doi.org/10.1016/j.jtct.2025.01.157"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtct.2025.01.157","doi":"https://doi.org/10.1016/j.jtct.2025.01.157","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.157","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jtct.2025.01.157","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ivan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivan Huang","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040546506","display_name":"Grace Baek","orcid":"https://orcid.org/0000-0001-9972-4794","observed_orcids":["https://orcid.org/0000-0001-9972-4794","https://orcid.org/0009-0004-9428-7061"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Baek","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026424772","display_name":"Gui Zhen Chen","orcid":"https://orcid.org/0000-0002-5483-7178","observed_orcids":["https://orcid.org/0000-0002-5483-7178"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gui Zhen Chen","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030154952","display_name":"Omar Marzouk","orcid":"https://orcid.org/0000-0002-7994-2839","observed_orcids":["https://orcid.org/0000-0002-7994-2839"]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omar Marzouk","raw_affiliation_strings":["Northwell Health Cancer Institute, Manhattan, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwell Health Cancer Institute, Manhattan, NY","institution_ids":["https://openalex.org/I1302444339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022331310","display_name":"Rahul Kumar Banerjee","orcid":"https://orcid.org/0000-0003-3781-5441","observed_orcids":["https://orcid.org/0000-0003-3781-5441"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Banerjee","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004025497","display_name":"Ajay K. Gopal","orcid":"https://orcid.org/0000-0003-3023-6834","observed_orcids":["https://orcid.org/0000-0003-3023-6834"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay K Gopal","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010023051","display_name":"Leona Holmberg","orcid":"https://orcid.org/0000-0003-3277-1910","observed_orcids":["https://orcid.org/0000-0003-3277-1910","https://orcid.org/0000-0002-2803-0469"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leona A. Holmberg","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066540747","display_name":"Jonathan B. Cohen","orcid":"https://orcid.org/0000-0001-7075-077X","observed_orcids":["https://orcid.org/0000-0001-7075-077X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Cohen","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089585044","display_name":"Kara I. Cicero","orcid":"https://orcid.org/0000-0003-3030-3005","observed_orcids":["https://orcid.org/0000-0003-3030-3005"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara I. Cicero","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA","University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046553822","display_name":"Mary Kwok","orcid":"https://orcid.org/0000-0002-3002-8130","observed_orcids":["https://orcid.org/0000-0002-3002-8130"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary L. Kwok","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028514579","display_name":"Andrew Jay Portuguese","orcid":"https://orcid.org/0000-0003-1010-4578","observed_orcids":["https://orcid.org/0000-0003-1010-4578"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Portuguese","raw_affiliation_strings":["Fred Hutchinson Cancer Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024384857","display_name":"Andrew J. Cowan","orcid":"https://orcid.org/0000-0002-1880-7094","observed_orcids":["https://orcid.org/0000-0002-1880-7094","https://orcid.org/0000-0003-2326-2727"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Cowan","raw_affiliation_strings":["Division of Hematology & Oncology, University of Washington School of Medicine, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology & Oncology, University of Washington School of Medicine, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.7158,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6575171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"31","issue":"2","first_page":"S99","last_page":"S99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/post-transplant-maintenance","display_name":"post-transplant maintenance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/high-risk-cytogenetics","display_name":"high-risk cytogenetics","score":0.9399999976158142},{"id":"https://openalex.org/keywords/high-risk-multiple-myeloma","display_name":"high-risk myeloma","score":0.5170000195503235},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.5070000290870667},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.597000002861023},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7504123449325562},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6084132194519043},{"id":"https://openalex.org/C2779662365","wikidata":"https://www.wikidata.org/wiki/Q5416694","display_name":"Event (particle physics)","level":2,"score":0.5089321136474609},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.47683826088905334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45120370388031006},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.4410727024078369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38966062664985657},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3699890673160553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35532280802726746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2903793752193451},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1403254270553589},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0918188989162445},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtct.2025.01.157","doi":"https://doi.org/10.1016/j.jtct.2025.01.157","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.157","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtct.2025.01.157","doi":"https://doi.org/10.1016/j.jtct.2025.01.157","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.157","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3214512886","https://openalex.org/W4362657670","https://openalex.org/W2988923936","https://openalex.org/W4289861055","https://openalex.org/W2806489281","https://openalex.org/W4220808997","https://openalex.org/W3120452471","https://openalex.org/W2036555006","https://openalex.org/W7096144746","https://openalex.org/W7108441250"],"abstract_inverted_index":{"Following":[0,239],"induction":[1,179,257],"therapy,":[2,66],"consolidative":[3],"autologous":[4],"stem":[5],"cell":[6,260],"transplant":[7],"(ASCT)":[8],"and":[9,44,183,195,212,219,247,274,303,409],"post-transplant":[10],"maintenance":[11,27,36,64,96,103,112,402,419],"remain":[12],"a":[13,83,102,117,153,286,339,365,390],"cornerstone":[14],"for":[15,48,245,324,403,412,418],"eligible":[16],"patients":[17,49,89,156,201,404],"with":[18,41,50,105,132,159,270,285,364,385,389,405],"multiple":[19],"myeloma":[20],"(MM).":[21],"Historically,":[22],"lenalidomide":[23,220],"or":[24,139],"bortezomib-based":[25],"monotherapy":[26],"has":[28],"been":[29],"the":[30,59,168,230,241,280,320,325,346,353,398,410],"standard":[31],"of":[32,61,87,126,155,178,185,199,232,253,256,263,267,290,342,400,415],"care.":[33],"More":[34],"aggressive":[35],"regimens":[37,214],"may":[38],"be":[39],"associated":[40,284,384],"improved":[42,368,387,393],"outcomes":[43],"are":[45],"often":[46],"recommended":[47],"high-risk":[51,186,406],"MM":[52,88],"(Joseph":[53],"et":[54],"al":[55],"2020).":[56],"We":[57,81],"examined":[58],"impact":[60,75],"high":[62],"intensity":[63],"(HIM)":[65],"utilizing":[67],"propensity":[68],"score":[69],"matching":[70],"(PSM)":[71],"to":[72,151,229],"determine":[73],"its":[74],"on":[76],"those":[77,163],"who":[78,90],"received":[79],"it.":[80],"conducted":[82],"single-center,":[84],"retrospective":[85],"study":[86,414],"underwent":[91],"single":[92,118],"ASCT":[93],"followed":[94],"by":[95],"therapy.":[97],"HIM":[98,211,224,246,281,381],"was":[99,114,128,149,225,283,350,382],"defined":[100,115,135],"as":[101,116,136,162],"regimen":[104],">1":[106,233],"agent,":[107,119],"excluding":[108,120],"dexamethasone":[109,121],".":[110,122],"Standard-intensity":[111],"(SIM)":[113],"The":[123,208],"primary":[124],"outcome":[125],"interest":[127],"event-free":[129],"survival":[130,370],"(EFS),":[131],"failure":[133],"events":[134],"death,":[137],"progression,":[138],"new":[140],"non-maintenance":[141],"treatment.":[142],"To":[143],"assess":[144],"outcomes,":[145],"optimal":[146],"full":[147],"PSM":[148,169,278,326,347],"employed":[150],"create":[152],"pseudo-population":[154],"receiving":[157,164],"SIM":[158,213,248],"similar":[160,250],"characteristics":[161,244],"HIM.":[165],"Covariates":[166],"in":[167,251,292,345,352],"model":[170],"included":[171],"CD34":[172,259],"infusion":[173],"dose,":[174,182,261],"pre-ASCT":[175],"response,":[176],"number":[177,184,255,266],"lines,":[180,258],"melphalan":[181,275],"cytogenetic":[187],"abnormalities":[188],"(HRCA),":[189],"namely":[190],"t(4;14),":[191],"t(14;16),":[192],"t(14;20),":[193],"del(17p),":[194],"amp(1q).":[196],"A":[197,315],"total":[198],"412":[200],"(HIM,":[202],"n=79;":[203],"SIM,":[204],"n=333)":[205],"were":[206,215,249],"included.":[207],"most":[209],"common":[210],"bortezomib/lenalidomide":[216],"(n=40,":[217],"51%)":[218],"(n=187,":[221],"56%),":[222],"respectively.":[223],"primarily":[226],"given":[227],"due":[228],"presence":[231],"HRCA":[234],"(odds":[235],"ratio":[236,296],"8.18,":[237],"p<0.001).":[238],"PSM,":[240],"resulting":[242],"baseline":[243],"terms":[252],"age,":[254],"percentage":[262,269],"R-ISS":[264],"3,":[265],"HRCAs,":[268],"circulating":[271],"plasma":[272],"cells,":[273],"dose.":[276],"With":[277,338],"applied,":[279],"cohort":[282],"significantly":[287,386],"reduced":[288],"hazard":[289],"EFS":[291,349,388],"both":[293],"univariate":[294],"(hazard":[295],"(HR)":[297],"0.58,":[298,307],"95%":[299,308,334],"CI":[300,309,335],"0.35-0.96,":[301],"p=0.033)":[302],"multivariable":[304,316],"(adjusted":[305,323,331],"HR":[306,332],"0.34-0.99,":[310],"p=0.045)":[311],"models":[312],"(Panel":[313],"A).":[314],"sensitivity":[317],"analysis":[318],"using":[319],"original":[321],"dataset":[322],"covariates)":[327],"confirmed":[328],"these":[329],"results":[330],"0.60,":[333],"0.37-0.95,":[336],"p=0.031).":[337],"median":[340],"follow-up":[341],"4.7":[343],"years":[344,373],"analysis,":[348],"longer":[351],"high-intensity":[354,401],"group":[355],"(3.2":[356],"vs.":[357,374],"6.7":[358],"years,":[359],"p=0.033;":[360],"Panel":[361,378],"B":[362],"),":[363],"trend":[366,391],"toward":[367,392],"overall":[369],"(OS)":[371],"(7.1":[372],"not":[375],"reached,":[376],"p=0.31;":[377],"C":[379],").":[380],"independently":[383],"OS.":[394],"Our":[395],"findings":[396],"support":[397],"application":[399],"chromosomal":[407],"features,":[408],"need":[411],"further":[413],"risk-adapted":[416],"strategies":[417],"post-ASCT.":[420]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-02-27T00:00:00"}