{"id":"https://openalex.org/W4407976254","doi":"https://doi.org/10.1016/j.jtct.2025.01.299","title":"Plerixafor Dosing in Obese Patients with Multiple Myeloma: A Single Center Experience","display_name":"Plerixafor Dosing in Obese Patients with Multiple Myeloma: A Single Center Experience","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4407976254","doi":"https://doi.org/10.1016/j.jtct.2025.01.299"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtct.2025.01.299","doi":"https://doi.org/10.1016/j.jtct.2025.01.299","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.299","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jtct.2025.01.299","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Megan Vince","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Vince","raw_affiliation_strings":["Pharmacy, Cleveland Clinic, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Cleveland Clinic, Cleveland, OH","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049280706","display_name":"Elizabeth C. DiMaggio","orcid":"https://orcid.org/0000-0002-8745-7753","observed_orcids":["https://orcid.org/0000-0002-8745-7753"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth DiMaggio","raw_affiliation_strings":["Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060979074","display_name":"Hanna Bailey","orcid":"https://orcid.org/0009-0005-9959-7162","observed_orcids":["https://orcid.org/0009-0005-9959-7162"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanna Bailey","raw_affiliation_strings":["Pharmacy, Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy, Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023535165","display_name":"Janelle Perkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janelle Perkins","raw_affiliation_strings":["Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069651924","display_name":"Kirsten K. Arrendale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten K Arrendale","raw_affiliation_strings":["BMT, Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BMT, Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062691289","display_name":"Taiga Nishihori","orcid":"https://orcid.org/0000-0002-2621-7924","observed_orcids":["https://orcid.org/0000-0002-2621-7924"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taiga Nishihori","raw_affiliation_strings":["Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047819225","display_name":"Doris K. Hansen","orcid":"https://orcid.org/0000-0002-9813-3578","observed_orcids":["https://orcid.org/0000-0002-9813-3578"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris K Hansen","raw_affiliation_strings":["Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087799564","display_name":"Melissa Alsina","orcid":"https://orcid.org/0000-0003-4946-823X","observed_orcids":["https://orcid.org/0000-0003-4946-823X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Alsina","raw_affiliation_strings":["Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055261814","display_name":"Hien D. Liu","orcid":"https://orcid.org/0000-0002-9945-4381","observed_orcids":["https://orcid.org/0000-0002-9945-4381"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hien Liu","raw_affiliation_strings":["Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055261814"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04010234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"2","first_page":"S193","last_page":"S194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plerixafor","display_name":"plerixafor","score":0.996999979019165},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.925000011920929},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.47699999809265137},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cd34-cell-collection","display_name":"CD34+ cell collection","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cxcr4-antagonist","display_name":"CXCR4 antagonist","score":0.7279999852180481},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.4690000116825104},{"id":"https://openalex.org/keywords/apheresis-duration","display_name":"apheresis duration","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2778828106","wikidata":"https://www.wikidata.org/wiki/Q905835","display_name":"Plerixafor","level":5,"score":0.8572072982788086},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8491218090057373},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6922370195388794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5710579752922058},{"id":"https://openalex.org/C2779463800","wikidata":"https://www.wikidata.org/wiki/Q5062222","display_name":"Center (category theory)","level":2,"score":0.490416020154953},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3979969024658203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3482876718044281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05974981188774109},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.0},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.0},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtct.2025.01.299","doi":"https://doi.org/10.1016/j.jtct.2025.01.299","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.299","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtct.2025.01.299","doi":"https://doi.org/10.1016/j.jtct.2025.01.299","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtct.2025.01.299","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation and Cellular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407977187","https://openalex.org/W2591537899","https://openalex.org/W7127313473","https://openalex.org/W2808676644","https://openalex.org/W4232754254","https://openalex.org/W2548975104","https://openalex.org/W2985350284","https://openalex.org/W2790648964","https://openalex.org/W2047025080","https://openalex.org/W3111573605"],"abstract_inverted_index":{"Introduction":[0],"Plerixafor":[1],",":[2,9],"an":[3],"inhibitor":[4],"of":[5,44,60,158,165,173,206,250,262,285,308,362,366,372,393,413],"CXCR4":[6],"chemokine":[7],"receptor":[8],"is":[10,31,53],"frequently":[11],"given":[12],"to":[13,22,37,54,78,120,218,277,404,427],"patients":[14,64,72,88,109,127,178,221,237,294,369,375,395,418],"with":[15,40,246],"multiple":[16],"myeloma":[17],"(MM)":[18],"for":[19,35,85,195],"mobilization":[20,99],"prior":[21,403],"autologous":[23],"hematopoietic":[24],"cell":[25],"transplantation":[26],"(HCT).":[27],"Standard":[28],"weight-based":[29,240,433],"dosing":[30,113,118,388],"0.24":[32],"mg/kg":[33],"daily":[34],"up":[36],"4":[38,209],"days":[39,311],"a":[41,56,102,247,257,390],"maximum":[42],"dose":[43,59],"40":[45,278],"mg/day.":[46],"Current":[47],"practice":[48],"at":[49],"Moffitt":[50],"Cancer":[51],"Center":[52],"administer":[55],"fixed":[57],"(capped)":[58],"24":[61],"mg":[62,276],"in":[63,101,141,417,423],"weighing":[65,128,179,396],"more":[66],"than":[67,181,208,224,398],"100":[68,182],"kg,":[69,183],"however":[70],"some":[71],"received":[73,111,133,231,238],"standard":[74,116,239,431],"(higher)":[75],"doses":[76,167,175,233,272,287,416],"according":[77,119],"the":[79,147,204,331,344,347,360,367,373],"label":[80,121],"instructions.":[81],"The":[82,192,229,282,305],"optimal":[83],"strategy":[84,412],"higher":[86],"weight":[87,261],"has":[89],"not":[90],"been":[91],"defined.":[92],"Here,":[93],"we":[94],"describe":[95],"our":[96,142,410],"experience":[97],"and":[98,115,137,171,189,256,292,370],"outcomes":[100,426],"large":[103,391],"MM":[104,126,394],"HCT":[105],"population,":[106],"comparing":[107],"those":[108,428],"who":[110,132,429],"capped":[112,232],"(CD)":[114],"full":[117,432],"(SD).":[122],"Methods":[123],"All":[124],"consecutive":[125],"over":[129],"10":[130,211],"kg":[131,226,264,400,421],"plerixafor":[134,169,174,271,286,387,415],"between":[135,187,290,312],"2015":[136,217],"2023":[138],"were":[139,185,222,243,288],"included":[140,146],"analysis.":[143],"Data":[144],"collection":[145,310,378,425],"following:":[148],"disease":[149],"state,":[150],"age,":[151],"gender,":[152],"height,":[153],"weight,":[154],"serum":[155],"creatinine,":[156],"number":[157,164,172,284,307],"CD34":[159,334,350],"cells":[160],"collected,":[161],"GCSF":[162,166],"dose,":[163,170],"administered,":[168],"administered.":[176],"In":[177,268,328,343],"greater":[180,207,223,397],"comparisons":[184],"made":[186],"CD":[188,291,329,368],"SD":[190,269,293,322,345,374],"patients.":[191],"final":[193,333,349],"outcome":[194],"each":[196],"group":[197],"was":[198,314,338,354],"successful":[199,363],"collection,":[200],"defined":[201],"as":[202],"meeting":[203],"target":[205],"\u00d7":[210],"6":[212],"CD34+":[213],"cells/kg.":[214],"Results":[215],"From":[216],"2023,":[219],"177":[220],"102":[225,399,420],"(Table":[227,280,382],"1).":[228],"majority":[230],"(n=161)":[234],"while":[235],"16":[236],"dosing.":[241,434],"Most":[242],"male":[244],"(78.5%),":[245],"median":[248,258,283,306,332,348],"age":[249],"60":[251],"years":[252],"(range,":[253,265],"32-74":[254],"years),":[255],"actual":[259],"body":[260],"113.8":[263],"102.1-161.9":[266],"kg).":[267],"patients,":[270,330,346],"varied":[273],"from":[274],"25":[275],"mg/day":[279],"2).":[281],"similar":[289,315,424],"(1":[295],"day,":[296,301,318,324],"range":[297,302,319,325],"1-4,":[298,320],"vs":[299,321],"1":[300,317,323],"1-2,":[303],"respectively).":[304,327],"apheresis":[309,402],"groups":[313],"(CD":[316],"1-2;":[326],"million":[335,351],"cells/kg":[336,352],"count":[337,353],"6.18":[339],"(2.06":[340],"\u2013":[341,357],"17.3).":[342],"5.93":[355],"(2.48":[356],"19.3).":[358],"Regarding":[359],"proportion":[361],"collections,":[364],"95.7%":[365],"100%":[371],"achieved":[376],"goal":[377],"(":[379],"p":[380],"=1)":[381],"3).":[383],"Conclusion":[384],"We":[385],"report":[386],"on":[389],"cohort":[392],"undergoing":[401],"HCT.":[405],"Our":[406],"results":[407,422],"indicate":[408],"that":[409],"current":[411],"capping":[414],"above":[419],"receive":[430]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-02-27T00:00:00"}