{"id":"https://openalex.org/W4407967958","doi":"https://doi.org/10.5582/ddt.2025.01010","title":"Suzetrigine: The first Nav1.8 inhibitor approved for the treatment of moderate to severe acute pain","display_name":"Suzetrigine: The first Nav1.8 inhibitor approved for the treatment of moderate to severe acute pain","publication_year":2025,"publication_date":"2025-02-26","ids":{"openalex":"https://openalex.org/W4407967958","doi":"https://doi.org/10.5582/ddt.2025.01010","pmid":"https://pubmed.ncbi.nlm.nih.gov/40010720"},"language":"en","primary_location":{"id":"doi:10.5582/ddt.2025.01010","doi":"https://doi.org/10.5582/ddt.2025.01010","is_oa":true,"landing_page_url":"https://doi.org/10.5582/ddt.2025.01010","pdf_url":"https://www.jstage.jst.go.jp/article/ddt/19/1/19_2025.01010/_pdf","source":{"id":"https://openalex.org/S2764561415","display_name":"Drug Discoveries & Therapeutics","issn_l":"1881-7831","issn":["1881-7831","1881-784X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discoveries & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/ddt/19/1/19_2025.01010/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103029365","display_name":"Shasha Hu","orcid":"https://orcid.org/0000-0001-6926-0984","observed_orcids":["https://orcid.org/0000-0001-6926-0984"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shasha Hu","raw_affiliation_strings":["Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116429825","display_name":"Dong Lyu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Lyu","raw_affiliation_strings":["Department of Burn and Plastic Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn and Plastic Surgery, Weihai Central Hospital Affiliated to Qingdao University, Weihai, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069915515","display_name":"Jianjun Gao","orcid":"https://orcid.org/0000-0001-6138-4472","observed_orcids":["https://orcid.org/0000-0001-6138-4472"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Gao","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.1464,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.99484429,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"80","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.16259999573230743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suzetrigine","display_name":"suzetrigine","score":1.0},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.9319999814033508},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.7889999747276306},{"id":"https://openalex.org/keywords/non-opioid-analgesics","display_name":"non-opioid analgesics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.6539999842643738},{"id":"https://openalex.org/keywords/multimodal-analgesia","display_name":"multimodal analgesia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/fda-approval","display_name":"FDA approval","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5738297700881958},{"id":"https://openalex.org/C2993997175","wikidata":"https://www.wikidata.org/wiki/Q81938","display_name":"Acute pain","level":2,"score":0.5640347003936768},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.28098076581954956}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059787","descriptor_name":"Acute Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D061567","descriptor_name":"Voltage-Gated Sodium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D061567","descriptor_name":"Voltage-Gated Sodium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D062559","descriptor_name":"NAV1.8 Voltage-Gated Sodium Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062559","descriptor_name":"NAV1.8 Voltage-Gated Sodium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5582/ddt.2025.01010","doi":"https://doi.org/10.5582/ddt.2025.01010","is_oa":true,"landing_page_url":"https://doi.org/10.5582/ddt.2025.01010","pdf_url":"https://www.jstage.jst.go.jp/article/ddt/19/1/19_2025.01010/_pdf","source":{"id":"https://openalex.org/S2764561415","display_name":"Drug Discoveries & Therapeutics","issn_l":"1881-7831","issn":["1881-7831","1881-784X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discoveries & Therapeutics","raw_type":"journal-article"},{"id":"pmid:40010720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40010720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discoveries & therapeutics","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.5582/ddt.2025.01010","doi":"https://doi.org/10.5582/ddt.2025.01010","is_oa":true,"landing_page_url":"https://doi.org/10.5582/ddt.2025.01010","pdf_url":"https://www.jstage.jst.go.jp/article/ddt/19/1/19_2025.01010/_pdf","source":{"id":"https://openalex.org/S2764561415","display_name":"Drug Discoveries & Therapeutics","issn_l":"1881-7831","issn":["1881-7831","1881-784X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-70","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discoveries & Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407967958.pdf","grobid_xml":"https://content.openalex.org/works/W4407967958.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W2055390636","https://openalex.org/W3140644077","https://openalex.org/W4385476232","https://openalex.org/W4406160428"],"related_works":["https://openalex.org/W7214718009","https://openalex.org/W7212239053","https://openalex.org/W4415845309","https://openalex.org/W7117987208","https://openalex.org/W4410075765","https://openalex.org/W4411057921","https://openalex.org/W4408799587","https://openalex.org/W4412037583","https://openalex.org/W7124540831","https://openalex.org/W4415046607"],"abstract_inverted_index":{"Opioids":[0],"are":[1,83],"commonly":[2],"prescribed":[3],"for":[4,33,59,85,129],"the":[5,25,47,55,60,93,112,133],"management":[6,139],"of":[7,27,62,135],"moderate":[8,35,63],"to":[9,36,64],"severe":[10,37,65],"pain,":[11],"but":[12],"their":[13],"use":[14],"is":[15,69,75],"associated":[16],"with":[17,132],"dependency":[18],"and":[19,29,50,125,140],"other":[20],"adverse":[21],"effects.":[22],"For":[23],"decades,":[24],"development":[26],"safe":[28],"effective":[30],"non-addictive":[31],"alternatives":[32],"treating":[34],"pain":[38,87,138],"has":[39],"seen":[40],"limited":[41],"progress.":[42],"On":[43],"January":[44],"30,":[45],"2025,":[46],"U.S.":[48],"Food":[49],"Drug":[51],"Administration":[52],"approved":[53],"suzetrigine,":[54],"first":[56],"Nav1.8":[57,68,94],"inhibitor,":[58],"treatment":[61,143],"acute":[66,137],"pain.":[67,100],"a":[70,121,126],"voltage-gated":[71],"sodium":[72],"channel":[73],"that":[74],"selectively":[76,91],"expressed":[77],"in":[78,111],"peripheral":[79],"nociceptive":[80],"neurons,":[81],"which":[82],"responsible":[84],"transmitting":[86],"signals.":[88],"By":[89],"highly":[90],"inhibiting":[92],"channel,":[95],"suzetrigine":[96],"can":[97],"effectively":[98],"alleviate":[99],"Unlike":[101],"opioids,":[102],"this":[103],"drug":[104],"does":[105],"not":[106],"induce":[107],"euphoria":[108],"or":[109],"excitement":[110],"brain,":[113],"thereby":[114],"eliminating":[115],"concerns":[116],"about":[117],"addiction.":[118],"Suzetrigine":[119],"offers":[120],"novel":[122],"therapeutic":[123],"option":[124],"potential":[127],"combination":[128],"multimodal":[130],"analgesia,":[131],"promise":[134],"transforming":[136],"establishing":[141],"new":[142],"standards.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-27T00:00:00"}