{"id":"https://openalex.org/W4407954565","doi":"https://doi.org/10.1016/j.tiv.2025.106038","title":"A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury","display_name":"A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury","publication_year":2025,"publication_date":"2025-02-26","ids":{"openalex":"https://openalex.org/W4407954565","doi":"https://doi.org/10.1016/j.tiv.2025.106038","pmid":"https://pubmed.ncbi.nlm.nih.gov/40020762"},"language":"en","primary_location":{"id":"doi:10.1016/j.tiv.2025.106038","doi":"https://doi.org/10.1016/j.tiv.2025.106038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tiv.2025.106038","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.tiv.2025.106038","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michelle Lechtenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle Lechtenberg","raw_affiliation_strings":["TissUse GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissUse GmbH, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073775341","display_name":"Coraline Ch\u00e9neau","orcid":"https://orcid.org/0000-0003-2503-9174","observed_orcids":["https://orcid.org/0000-0003-2503-9174"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Coraline Ch\u00e9neau","raw_affiliation_strings":["INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038913809","display_name":"Kevin Riquin","orcid":"https://orcid.org/0000-0003-1774-0286","observed_orcids":["https://orcid.org/0000-0003-1774-0286"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kevin Riquin","raw_affiliation_strings":["INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112467853","display_name":"Leopold Koenig","orcid":"https://orcid.org/0000-0002-3893-0284","observed_orcids":["https://orcid.org/0000-0002-3893-0284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leopold Koenig","raw_affiliation_strings":["TissUse GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissUse GmbH, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058979303","display_name":"Carlos Mota","orcid":"https://orcid.org/0000-0001-5935-6245","observed_orcids":["https://orcid.org/0000-0001-5935-6245","https://orcid.org/0000-0002-3103-2588"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Carlos Mota","raw_affiliation_strings":["Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020374851","display_name":"Franck Albert Halary","orcid":"https://orcid.org/0000-0003-0336-9615","observed_orcids":["https://orcid.org/0000-0003-0336-9615"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4392021198","display_name":"Center for Research in Transplantation and Translational Immunology","ror":"https://ror.org/01165k395","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Halary","raw_affiliation_strings":["INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, Nantes Universit\u00e9, Center for Research in Transplantation and Translational Immunology, UMR 1064, F-44000 Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4392021198","https://openalex.org/I97188460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064688771","display_name":"Eva\u2010Maria Dehne","orcid":"https://orcid.org/0000-0001-5694-6549","observed_orcids":["https://orcid.org/0000-0001-5694-6549"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eva-Maria Dehne","raw_affiliation_strings":["TissUse GmbH, Berlin, Germany. Electronic address: eva.dehne@tissuse.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TissUse GmbH, Berlin, Germany. Electronic address: eva.dehne@tissuse.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064688771"],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":{"value":4200,"currency":"USD","value_usd":4200},"fwci":2.8631,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89175353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"105","issue":null,"first_page":"106038","last_page":"106038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7080000042915344,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7080000042915344,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ipsc-derived-cells","display_name":"iPSC-derived cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-culture-inserts","display_name":"cell culture inserts","score":0.6510000228881836},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.968999981880188},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6809999942779541},{"id":"https://openalex.org/keywords/in-vitro-toxicity-prediction","display_name":"in vitro toxicity prediction","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6074352860450745},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.5355799794197083},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5093001127243042},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4867727756500244},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47082334756851196},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43052583932876587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.423954039812088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34956613183021545}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tiv.2025.106038","doi":"https://doi.org/10.1016/j.tiv.2025.106038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tiv.2025.106038","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:40020762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40020762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/f9c19827-de2f-4ea0-8dc4-972141dedfeb","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/f9c19827-de2f-4ea0-8dc4-972141dedfeb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lechtenberg, M, Ch\u00e9neau, C, Riquin, K, Koenig, L, Mota, C, Halary, F & Dehne, E M 2025, 'A perfused iPSC-derived proximal tubule model for predicting drug-induced kidney injury', Toxicology in Vitro, vol. 105, 106038. https://doi.org/10.1016/j.tiv.2025.106038","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:inserm-05039878v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-05039878","pdf_url":"https://inserm.hal.science/inserm-05039878v1/file/1-s2.0-S0887233325000323-main.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Toxicology in Vitro, 2025, 105, pp.106038. &#x27E8;10.1016/j.tiv.2025.106038&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.tiv.2025.106038","doi":"https://doi.org/10.1016/j.tiv.2025.106038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tiv.2025.106038","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2230998379","display_name":"RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs","funder_award_id":"964537","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2714256167","display_name":null,"funder_award_id":"964537","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G2772014271","display_name":null,"funder_award_id":"RISK-HUNT3R","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4159691882","display_name":null,"funder_award_id":"964452","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G8036887874","display_name":"Bioprinting on-chip microphysiological models of humanized kidney tubulointerstitium","funder_award_id":"964452","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407954565.pdf","grobid_xml":"https://content.openalex.org/works/W4407954565.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1978569657","https://openalex.org/W1978605704","https://openalex.org/W1986633060","https://openalex.org/W1989932182","https://openalex.org/W1997664579","https://openalex.org/W2013051865","https://openalex.org/W2020757879","https://openalex.org/W2020773684","https://openalex.org/W2021041146","https://openalex.org/W2073400184","https://openalex.org/W2085472280","https://openalex.org/W2097259163","https://openalex.org/W2104458391","https://openalex.org/W2108751380","https://openalex.org/W2114964586","https://openalex.org/W2136256418","https://openalex.org/W2141559993","https://openalex.org/W2144479843","https://openalex.org/W2150121486","https://openalex.org/W2159277297","https://openalex.org/W2172958821","https://openalex.org/W2179438025","https://openalex.org/W2222653645","https://openalex.org/W2262159466","https://openalex.org/W2268538914","https://openalex.org/W2289990939","https://openalex.org/W2409292451","https://openalex.org/W2530360197","https://openalex.org/W2566076583","https://openalex.org/W2579340176","https://openalex.org/W2787158099","https://openalex.org/W2796019185","https://openalex.org/W2796392037","https://openalex.org/W2802600358","https://openalex.org/W2803107511","https://openalex.org/W2807227439","https://openalex.org/W2811397251","https://openalex.org/W2885232549","https://openalex.org/W2895351357","https://openalex.org/W2895504481","https://openalex.org/W2900768728","https://openalex.org/W2901822793","https://openalex.org/W2904111838","https://openalex.org/W2905499843","https://openalex.org/W2913845712","https://openalex.org/W2919899673","https://openalex.org/W2922284572","https://openalex.org/W2941869121","https://openalex.org/W2953811093","https://openalex.org/W2971476125","https://openalex.org/W2973197879","https://openalex.org/W2995121336","https://openalex.org/W2995748321","https://openalex.org/W3031439051","https://openalex.org/W3033953218","https://openalex.org/W3035724495","https://openalex.org/W3089930184","https://openalex.org/W3126361789","https://openalex.org/W3134688768","https://openalex.org/W3143381404","https://openalex.org/W3155078472","https://openalex.org/W3159014620","https://openalex.org/W3164118628","https://openalex.org/W3171646083","https://openalex.org/W3180728306","https://openalex.org/W3196794138","https://openalex.org/W3208537377","https://openalex.org/W4220970233","https://openalex.org/W4225093358","https://openalex.org/W4250831108","https://openalex.org/W4294266835","https://openalex.org/W4294734198","https://openalex.org/W4303613917","https://openalex.org/W4304889865","https://openalex.org/W4318066110","https://openalex.org/W4320482525","https://openalex.org/W4353094150","https://openalex.org/W4372335657","https://openalex.org/W4375950533","https://openalex.org/W4379598175","https://openalex.org/W4380631052","https://openalex.org/W4381251590","https://openalex.org/W4385684390","https://openalex.org/W4386046657","https://openalex.org/W4389430930","https://openalex.org/W4394840288","https://openalex.org/W4399495065","https://openalex.org/W4403051572","https://openalex.org/W6682234436","https://openalex.org/W6793034951"],"related_works":["https://openalex.org/W6904896644","https://openalex.org/W2318331671","https://openalex.org/W7169260132","https://openalex.org/W2003310479","https://openalex.org/W2796019185","https://openalex.org/W4400874641","https://openalex.org/W2318407122","https://openalex.org/W2767352418","https://openalex.org/W4315851685","https://openalex.org/W4415423544"],"abstract_inverted_index":{"The":[0],"kidney":[1,17],"is":[2,102,111,147],"frequently":[3],"exposed":[4],"to":[5,27,71,92,128],"high":[6],"levels":[7],"of":[8,99,172],"drugs":[9,110],"and":[10,18,45,81,83,149,157,161,179],"their":[11],"metabolites,":[12],"which":[13,53],"can":[14,54],"injure":[15],"the":[16,19,68,97,134,169],"proximal":[20],"tubule":[21],"(PT)":[22],"in":[23,35,57,104,114,119,152,163],"particular.":[24],"In":[25],"order":[26],"detect":[28],"nephrotoxicity":[29,131,156],"early":[30,170],"during":[31],"drug":[32,181],"development,":[33],"relevant":[34],"vitro":[36,120,153,164],"models":[37,165],"are":[38],"essential.":[39],"Here,":[40],"we":[41,124],"introduce":[42],"a":[43,58],"robust":[44],"versatile":[46,148],"cell":[47],"culture":[48],"insert-based":[49],"iPSC-derived":[50,144],"PT":[51,74,121,145],"model,":[52],"be":[55],"maintained":[56],"microphysiological":[59],"system":[60],"for":[61,151],"at":[62],"least":[63],"ten":[64],"days.":[65],"We":[66,94],"demonstrate":[67],"model's":[69,90],"ability":[70],"predict":[72],"drug-induced":[73],"injury":[75],"using":[76],"polymyxin":[77],"B,":[78],"cyclosporin":[79],"A,":[80],"cisplatin,":[82],"observe":[84,95],"that":[85,96,101,141],"perfusion":[86],"distinctly":[87],"impacts":[88],"our":[89,126,142],"response":[91],"xenobiotics.":[93],"upregulation":[98],"metallothioneins":[100],"described":[103],"vivo":[105],"after":[106],"treatment":[107],"with":[108],"these":[109,138],"reliably":[112],"detected":[113],"dynamic,":[115],"but":[116],"not":[117],"static":[118],"models.":[122],"Finally,":[123],"use":[125],"model":[127,146],"alleviate":[129],"polymyxin-induced":[130],"by":[132],"supplementing":[133],"antioxidant":[135],"curcumin.":[136],"Together,":[137],"findings":[139],"illustrate":[140],"perfused":[143],"well-suited":[150],"studies":[154],"investigating":[155],"its":[158],"prevention.":[159],"Reliable":[160],"user-friendly":[162],"like":[166],"this":[167],"enable":[168],"detection":[171],"nephrotoxic":[173],"potential,":[174],"thereby":[175],"minimizing":[176],"adverse":[177],"effects":[178],"reducing":[180],"attrition.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-02-27T00:00:00"}
