{"id":"https://openalex.org/W4407944657","doi":"https://doi.org/10.15360/1813-9779-2025-1-55-61","title":"Heterogeneity of NeuN Protein Distribution as a Marker of Morphological Personalization of Cerebral Cortex Neurons: an Experimental Study","display_name":"Heterogeneity of NeuN Protein Distribution as a Marker of Morphological Personalization of Cerebral Cortex Neurons: an Experimental Study","publication_year":2025,"publication_date":"2025-01-31","ids":{"openalex":"https://openalex.org/W4407944657","doi":"https://doi.org/10.15360/1813-9779-2025-1-55-61"},"language":"en","primary_location":{"id":"doi:10.15360/1813-9779-2025-1-55-61","doi":"https://doi.org/10.15360/1813-9779-2025-1-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.15360/1813-9779-2025-1-55-61","pdf_url":"https://www.reanimatology.com/rmt/article/download/2516/1912","source":{"id":"https://openalex.org/S4210169628","display_name":"General Reanimatology","issn_l":"1813-9779","issn":["1813-9779","2411-7110"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312831","host_organization_name":"Russian Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310312831"],"host_organization_lineage_names":["Russian Academy of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Reanimatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.reanimatology.com/rmt/article/download/2516/1912","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061697179","display_name":"Arkady M. Golubev","orcid":"https://orcid.org/0000-0002-3165-0378","observed_orcids":["https://orcid.org/0000-0002-3165-0378"]},"institutions":[{"id":"https://openalex.org/I4210120300","display_name":"V.A. Negovsky Scientific Research Institute of General Reanimatology","ror":"https://ror.org/01w84qj32","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210120300"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Arkady M. Golubev","raw_affiliation_strings":["V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology"],"raw_orcid":"https://orcid.org/0000-0002-3165-0378","affiliations":[{"raw_affiliation_string":"V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology","institution_ids":["https://openalex.org/I4210120300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089974983","display_name":"Maxim A. Lyubomudrov","orcid":"https://orcid.org/0000-0002-1735-592X","observed_orcids":["https://orcid.org/0000-0002-1735-592X"]},"institutions":[{"id":"https://openalex.org/I4210120300","display_name":"V.A. Negovsky Scientific Research Institute of General Reanimatology","ror":"https://ror.org/01w84qj32","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210120300"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim A. Lyubomudrov","raw_affiliation_strings":["V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology"],"raw_orcid":"https://orcid.org/0000-0002-1735-592X","affiliations":[{"raw_affiliation_string":"V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology","institution_ids":["https://openalex.org/I4210120300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016008640","display_name":"Anastasiya S. Babkina","orcid":"https://orcid.org/0000-0003-1780-9829","observed_orcids":["https://orcid.org/0000-0003-1780-9829"]},"institutions":[{"id":"https://openalex.org/I4210120300","display_name":"V.A. Negovsky Scientific Research Institute of General Reanimatology","ror":"https://ror.org/01w84qj32","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210120300"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasia S. Babkina","raw_affiliation_strings":["V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology"],"raw_orcid":"https://orcid.org/0000-0003-1780-9829","affiliations":[{"raw_affiliation_string":"V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology","institution_ids":["https://openalex.org/I4210120300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069826761","display_name":"\u0417. \u0418. \u0426\u043e\u043a\u043e\u043b\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0003-2441-6062","observed_orcids":["https://orcid.org/0000-0003-2441-6062"]},"institutions":[{"id":"https://openalex.org/I4210120300","display_name":"V.A. Negovsky Scientific Research Institute of General Reanimatology","ror":"https://ror.org/01w84qj32","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210120300"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Zoya I. Tsokolaeva","raw_affiliation_strings":["V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology"],"raw_orcid":"https://orcid.org/0000-0003-2441-6062","affiliations":[{"raw_affiliation_string":"V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology","institution_ids":["https://openalex.org/I4210120300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210120300"],"apc_list":null,"apc_paid":null,"fwci":4.8902,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.92247347,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"55","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14134","display_name":"Classical Anatomy and Histology","score":0.600600004196167,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14134","display_name":"Classical Anatomy and Histology","score":0.600600004196167,"subfield":{"id":"https://openalex.org/subfields/2702","display_name":"Anatomy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.16060000658035278,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neun","display_name":"NeuN","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neuronal-phenotype","display_name":"neuronal phenotype","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cortical-layers","display_name":"cortical layers","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neuronal-heterogeneity","display_name":"neuronal heterogeneity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neuronal-morphology","display_name":"neuronal morphology","score":0.5130000114440918},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2781100881","wikidata":"https://www.wikidata.org/wiki/Q21123811","display_name":"NeuN","level":3,"score":0.867241382598877},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.6539469957351685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6502957344055176},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6007644534111023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4053259789943695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18996447324752808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17868822813034058},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.17690297961235046}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15360/1813-9779-2025-1-55-61","doi":"https://doi.org/10.15360/1813-9779-2025-1-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.15360/1813-9779-2025-1-55-61","pdf_url":"https://www.reanimatology.com/rmt/article/download/2516/1912","source":{"id":"https://openalex.org/S4210169628","display_name":"General Reanimatology","issn_l":"1813-9779","issn":["1813-9779","2411-7110"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312831","host_organization_name":"Russian Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310312831"],"host_organization_lineage_names":["Russian Academy of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Reanimatology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c6b72638ef0f4d5dbea9f742353ab12a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c6b72638ef0f4d5dbea9f742353ab12a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041e\u0431\u0449\u0430\u044f \u0440\u0435\u0430\u043d\u0438\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f, Vol 21, Iss 1, Pp 55-61 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15360/1813-9779-2025-1-55-61","doi":"https://doi.org/10.15360/1813-9779-2025-1-55-61","is_oa":true,"landing_page_url":"https://doi.org/10.15360/1813-9779-2025-1-55-61","pdf_url":"https://www.reanimatology.com/rmt/article/download/2516/1912","source":{"id":"https://openalex.org/S4210169628","display_name":"General Reanimatology","issn_l":"1813-9779","issn":["1813-9779","2411-7110"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312831","host_organization_name":"Russian Academy of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310312831"],"host_organization_lineage_names":["Russian Academy of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"General Reanimatology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407944657.pdf","grobid_xml":"https://content.openalex.org/works/W4407944657.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1496823793","https://openalex.org/W1570600309","https://openalex.org/W1977749822","https://openalex.org/W1993059184","https://openalex.org/W1994725998","https://openalex.org/W2035329875","https://openalex.org/W2037344075","https://openalex.org/W2039372333","https://openalex.org/W2055353932","https://openalex.org/W2064420850","https://openalex.org/W2092985749","https://openalex.org/W2097861281","https://openalex.org/W2147270524","https://openalex.org/W2158496649","https://openalex.org/W2300378598","https://openalex.org/W2515381021","https://openalex.org/W2791956767","https://openalex.org/W2991224943","https://openalex.org/W3037380949","https://openalex.org/W3135230910","https://openalex.org/W3135419746","https://openalex.org/W3166584668","https://openalex.org/W4376115227"],"related_works":["https://openalex.org/W4413324848","https://openalex.org/W2040953951","https://openalex.org/W4401499252","https://openalex.org/W890895450","https://openalex.org/W2410702314","https://openalex.org/W2359673377","https://openalex.org/W1965841902","https://openalex.org/W4394923519","https://openalex.org/W2385131724","https://openalex.org/W2033682969"],"abstract_inverted_index":{"Aim.":[0],"To":[1],"identify":[2],"personalized":[3],"morphological":[4],"neuronal":[5,14,47,87,104,182,212],"phenotypes":[6,105,183],"based":[7,108,184],"on":[8,109,162,185],"the":[9,13,18,29,46,80,95,163,166,169,174,180,195,203,228],"distribution":[10],"pattern":[11],"of":[12,28,82,158,168,178,198,202,205,211,231],"protein":[15,49],"NeuN":[16,50,66,83,110,186,206,221],"in":[17,34,93,99,165],"cerebral":[19,30,170],"cortex":[20,31],"layers.":[21],"Materials":[22],"and":[23,43,45,61,72,97,134],"Methods.":[24],"A":[25,150],"histologic":[26],"study":[27],"was":[32,51,57,91,153],"performed":[33,58],"rats":[35],"(N=10).":[36],"Tissue":[37],"sections":[38],"were":[39,106],"stained":[40,116,124,132,138,147],"with":[41,115,123,131,140,146],"hematoxylin":[42],"eosin,":[44],"nuclear":[48,86],"visualized":[52],"by":[53,59],"immunohistochemical":[54,67,222],"staining.":[55],"Analysis":[56],"microscopy":[60],"image":[62],"analysis":[63],"software.":[64],"Results.":[65],"staining":[68,111,207,223],"revealed":[69],"distinct":[70,237],"localization":[71,90,164,187],"intensity":[73,157],"patterns":[74],"within":[75],"cortical":[76],"neurons.":[77,101,199],"Contrary":[78],"to":[79],"definition":[81],"as":[84,191,208],"a":[85,209],"protein,":[88],"its":[89],"observed":[92],"both":[94],"nucleus":[96],"cytoplasm":[98,125],"most":[100],"The":[102,200],"following":[103],"identified":[107,181],"patterns:":[112],"1)":[113],"Neurons":[114,122,130,145],"nuclei":[117,133],"but":[118,126,234],"unstained":[119,127],"cytoplasm;":[120,135],"2)":[121],"nuclei;":[128,143],"3)":[129],"4)":[136],"Fully":[137],"neurons":[139,160],"no":[141],"visible":[142],"5)":[144],"processes":[148],"(dendrites/axons).":[149],"significant":[151],"difference":[152],"found":[154],"between":[155],"mean":[156],"NeuN-positive":[159,232],"depending":[161],"layers":[167],"cortex.":[171],"Conclusion.":[172],"Given":[173],"critical":[175],"biological":[176],"role":[177],"NeuN,":[179],"warrant":[188],"further":[189],"research":[190],"they":[192],"may":[193],"reflect":[194],"functional":[196],"states":[197],"interpretation":[201],"absence":[204],"marker":[210],"damage":[213],"is":[214],"not":[215,226],"scientifically":[216],"justified.":[217],"Future":[218],"studies":[219],"using":[220],"should":[224],"consider":[225],"only":[227],"total":[229],"number":[230],"neurons,":[233],"also":[235],"their":[236],"phenotypes.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-02-26T00:00:00"}