{"id":"https://openalex.org/W4407936877","doi":"https://doi.org/10.55730/1300-0144.5938","title":"Paradigm shift in obesity treatment: an extensive review of current pipeline agents","display_name":"Paradigm shift in obesity treatment: an extensive review of current pipeline agents","publication_year":2025,"publication_date":"2025-02-18","ids":{"openalex":"https://openalex.org/W4407936877","doi":"https://doi.org/10.55730/1300-0144.5938","pmid":"https://pubmed.ncbi.nlm.nih.gov/40104296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11913498"},"language":"en","primary_location":{"id":"doi:10.55730/1300-0144.5938","doi":"https://doi.org/10.55730/1300-0144.5938","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5938","pdf_url":null,"source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.55730/1300-0144.5938","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104250170","display_name":"Ecesu \u00c7etin","orcid":"https://orcid.org/0000-0001-7682-3597","observed_orcids":["https://orcid.org/0000-0001-7682-3597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ECESU \u00c7ET\u0130N","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023794099","display_name":"Brian Pedersen","orcid":"https://orcid.org/0000-0001-6266-9904","observed_orcids":["https://orcid.org/0000-0001-6266-9904"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BRIAN PEDERSEN","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015982085","display_name":"Mehmet Furkan Burak","orcid":"https://orcid.org/0000-0001-6222-1552","observed_orcids":["https://orcid.org/0000-0001-6222-1552"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"MEHMET FURKAN BURAK","raw_affiliation_strings":["Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, United States","Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015982085"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":2.6364,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.89364588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"55","issue":"1","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.8489999771118164},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.8669999837875366},{"id":"https://openalex.org/keywords/drug-pipeline","display_name":"drug development pipeline","score":0.734000027179718},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9819999933242798},{"id":"https://openalex.org/keywords/satiety-hormones","display_name":"satiety hormones","score":0.7770000100135803},{"id":"https://openalex.org/keywords/metabolic-surgery","display_name":"metabolic surgery","score":0.4959999918937683},{"id":"https://openalex.org/keywords/metabolic-associated-fatty-liver-disease","display_name":"metabolic-associated fatty liver disease","score":0.6150000095367432},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9120000004768372},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.996999979019165},{"id":"https://openalex.org/keywords/muscle-mass-preservation","display_name":"muscle mass preservation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mitochondrial-uncouplers","display_name":"mitochondrial uncouplers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.8220000267028809},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/obesity-related-comorbidities","display_name":"obesity-related comorbidities","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9760384559631348},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.671775758266449},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5441322326660156},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4578610062599182},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4186159074306488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23629814386367798},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.10137754678726196},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.057509928941726685},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.55730/1300-0144.5938","doi":"https://doi.org/10.55730/1300-0144.5938","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5938","pdf_url":null,"source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11913498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11913498","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11913498/pdf/tjmed-55-01-1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turk J Med Sci","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:10729098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11913498","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40104296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40104296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55730/1300-0144.5938","doi":"https://doi.org/10.55730/1300-0144.5938","is_oa":true,"landing_page_url":"https://doi.org/10.55730/1300-0144.5938","pdf_url":null,"source":{"id":"https://openalex.org/S68332911","display_name":"TURKISH JOURNAL OF MEDICAL SCIENCES","issn_l":"1300-0144","issn":["1300-0144","1303-6165"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-b","medline","norway-1","poland-40","russia-white-list-1","tr-dizin"],"host_organization":"https://openalex.org/P4310318422","host_organization_name":"Scientific and Technological Research Council of Turkey (TUBITAK)","host_organization_lineage":["https://openalex.org/P4310318422"],"host_organization_lineage_names":["Scientific and Technological Research Council of Turkey (TUBITAK)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407936877.pdf","grobid_xml":"https://content.openalex.org/works/W4407936877.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4229074058"],"related_works":["https://openalex.org/W7215143722","https://openalex.org/W4411376400","https://openalex.org/W4414139324","https://openalex.org/W4319459377","https://openalex.org/W2791667241","https://openalex.org/W7140116319","https://openalex.org/W2906647975","https://openalex.org/W7223109714","https://openalex.org/W2888039409","https://openalex.org/W7128318192"],"abstract_inverted_index":{"Obesity":[0],"is":[1],"a":[2,7,27,184],"multifaceted":[3],"disease":[4,125],"that":[5,19],"poses":[6],"significant":[8],"public":[9],"health":[10],"challenge.":[11],"Recent":[12],"discoveries":[13],"in":[14,29,79,110,158,239],"understanding":[15],"the":[16,30,36,142,159,240],"biological":[17],"pathways":[18,87],"regulate":[20],"satiety":[21],"and":[22,40,82,105,118,137,171,179,208,233,249],"metabolism":[23],"have":[24],"led":[25],"to":[26,51,56,101,167,187,190,229],"shift":[28],"treatment":[31,83],"paradigm":[32],"for":[33,199,205,211,246],"obesity.":[34],"Thus,":[35],"gap":[37],"between":[38],"pharmacological":[39],"surgical":[41],"interventions":[42],"has":[43],"diminished.":[44],"The":[45],"latest":[46],"approved":[47],"antiobesity":[48,149],"medications":[49,150,238],"help":[50],"achieve":[52],"weight":[53,66,97,112,213,231],"loss":[54,67,98,104,214,232],"comparable":[55],"surgery.":[57],"These":[58,236],"GLP-1":[59,192],"analog-based":[60],"therapies":[61,173],"not":[62],"only":[63],"cause":[64],"substantial":[65],"but":[68],"also":[69],"improve":[70],"obesity-associated":[71],"comorbidities.":[72],"However,":[73],"there":[74],"are":[75,88,156,164,196,226],"still":[76],"unmet":[77],"needs":[78],"obesity":[80,117,251],"care,":[81],"options":[84],"with":[85,133,151,174],"alternative":[86,186],"necessary.":[89],"Whether":[90],"achieved":[91],"through":[92],"lifestyle":[93],"changes":[94],"or":[95,221],"medication,":[96],"often":[99],"leads":[100],"muscle":[102,169],"mass":[103],"reduced":[106],"energy":[107,201],"expenditure,":[108,202],"resulting":[109],"rebound":[111],"gain.":[113],"Moreover,":[114],"addressing":[115],"severe":[116],"comorbidities,":[119],"such":[120,218],"as":[121,219],"metabolic-associated":[122],"fatty":[123],"liver":[124],"(MAFLD),":[126],"metabolic":[127],"dysfunction-associated":[128],"steatohepatitis":[129],"(MASH),":[130],"heart":[131],"failure":[132],"preserved":[134],"ejection":[135],"fraction,":[136],"obstructive":[138],"sleep":[139],"apnea,":[140],"necessitates":[141],"development":[143,166],"of":[144,154],"additional":[145,212],"therapeutic":[146],"strategies.":[147],"Various":[148],"novel":[152],"mechanisms":[153],"action":[155],"currently":[157],"pipeline.":[160],"Myostatin-activin":[161],"pathway":[162],"inhibitors":[163,204],"under":[165,197],"preserve":[168],"mass,":[170],"combination":[172],"glucagon":[175],"agonists":[176,182],"address":[177],"MAFLD":[178],"MASH.":[180],"Amylin":[181],"offer":[183],"promising":[185],"those":[188],"unable":[189],"tolerate":[191],"analogs.":[193],"Mitochondrial":[194],"uncouplers":[195],"investigation":[198],"enhancing":[200],"NLRP-3":[203],"reducing":[206],"inflammation,":[207],"GWAS":[209],"targets":[210],"benefits.":[215],"Combination":[216],"therapies,":[217],"dual":[220],"triple":[222],"hormonal":[223],"receptor":[224],"agonists,":[225],"being":[227],"developed":[228],"maximize":[230],"optimize":[234],"tolerability.":[235],"emerging":[237],"clinical":[241],"trial":[242],"pipeline":[243],"show":[244],"promise":[245],"more":[247],"tolerable":[248],"sustainable":[250],"management.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-26T00:00:00"}