{"id":"https://openalex.org/W4407908558","doi":"https://doi.org/10.3233/978-1-61499-024-6-113","title":"Molecular cytogenetic evidence for multistep tumorigenesis: Implications for risk assessment and early detection","display_name":"Molecular cytogenetic evidence for multistep tumorigenesis: Implications for risk assessment and early detection","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W4407908558","doi":"https://doi.org/10.3233/978-1-61499-024-6-113"},"language":"en","primary_location":{"id":"doi:10.3233/978-1-61499-024-6-113","doi":"https://doi.org/10.3233/978-1-61499-024-6-113","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-024-6-113","pdf_url":null,"source":{"id":"https://openalex.org/S4306463470","display_name":"IOS Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Pathology of Early Cancer","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039200530","display_name":"Subrata Sen","orcid":"https://orcid.org/0000-0001-6884-6246","observed_orcids":["https://orcid.org/0000-0001-6884-6246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sen Subrata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112021673","display_name":"Vicki L. Hopwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hopwood Vicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66373938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multistep-carcinogenesis","display_name":"multistep carcinogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9490000009536743},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6990000009536743},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.7670000195503235},{"id":"https://openalex.org/keywords/precursor-lesions","display_name":"precursor lesions","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cancer-risk-assessment","display_name":"cancer risk assessment","score":0.7269999980926514},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.843999981880188},{"id":"https://openalex.org/keywords/array-based-comparative-genomic-hybridization","display_name":"array comparative genomic hybridization","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.7590000033378601},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.47600001096725464},{"id":"https://openalex.org/keywords/exfoliated-cells","display_name":"exfoliated cells","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4751681685447693},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3574650287628174},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33619463443756104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2509196102619171},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23566004633903503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10883024334907532}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/978-1-61499-024-6-113","doi":"https://doi.org/10.3233/978-1-61499-024-6-113","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-024-6-113","pdf_url":null,"source":{"id":"https://openalex.org/S4306463470","display_name":"IOS Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Pathology of Early Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144377209","https://openalex.org/W2413010680","https://openalex.org/W1547893298","https://openalex.org/W4409630842","https://openalex.org/W2092132944","https://openalex.org/W1788861643","https://openalex.org/W2588460379","https://openalex.org/W2039773000","https://openalex.org/W4391442828","https://openalex.org/W2040191321"],"abstract_inverted_index":{"There":[0],"is":[1,20,34],"strong":[2],"evidence":[3],"that":[4,33,92],"multistep":[5],"tumorigenesis":[6],"begins":[7],"with":[8],"the":[9,30,37,53,61,137],"acquisition":[10],"of":[11,55,63,95,112,139,144,150],"somatic":[12],"mutations":[13],"which":[14],"promote":[15],"genomic":[16,26],"instability.":[17],"Genomic":[18,48,82],"instability":[19,27,49,57],"an":[21,140],"important":[22],"malignant":[23,119],"trait":[24],"because":[25],"can":[28],"generate":[29],"genetic":[31,110],"diversity":[32],"necessary":[35],"for":[36,109],"transforming":[38],"cell":[39],"to":[40,60],"acquire":[41],"increasingly":[42],"variable":[43],"and":[44,79,99,117,130,147],"aggressive":[45],"tumor":[46],"phenotypes.":[47],"often":[50],"manifests":[51],"in":[52,75,115,124],"form":[54],"chromosomal":[56,96],"(CIN)":[58],"leading":[59],"induction":[62],"aneuploidy,":[64],"a":[65],"phenomenon":[66],"identified":[67],"by":[68],"high":[69,87,102],"resolution":[70,88,103],"molecular":[71,89,104,133],"cytogenetic":[72,90,105,134],"techniques.":[73],"Fluorescent":[74],"situ":[76],"hybridization":[77],"(FISH)":[78],"Array":[80],"Comparative":[81],"Hybridization":[83],"(aCGH)":[84],"are":[85,107],"two":[86],"techniques":[91,106],"allow":[93],"detection":[94,149],"aneuploidyandstructuralrearrangementsoccurringinpre-malignantand":[97],"malignantlesionsduringtumorprogression":[98],"invasion.":[100],"These":[101],"used":[108],"screening":[111],"single":[113],"cells":[114,126],"pre-malignant":[116],"precursor":[118],"lesions":[120],"as":[121,123],"well":[122],"exfoliated":[125],"from":[127],"body":[128],"fluids":[129],"excreta.":[131],"Consequently,":[132],"testing":[135],"offers":[136],"promise":[138],"extremely":[141],"powerful":[142],"method":[143],"risk":[145],"assessment":[146],"early":[148],"cancer.":[151]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-02-25T00:00:00"}