{"id":"https://openalex.org/W4407889306","doi":"https://doi.org/10.1530/endoabs.109.p218","title":"Response to kisspeptin reveals recovery of hypothalamic dysfunction in a woman with reversal of congenital hypogonadotrophic hypogonadism (CHH) with a heterozygous GnRHR inactivating variant","display_name":"Response to kisspeptin reveals recovery of hypothalamic dysfunction in a woman with reversal of congenital hypogonadotrophic hypogonadism (CHH) with a heterozygous GnRHR inactivating variant","publication_year":2025,"publication_date":"2025-02-19","ids":{"openalex":"https://openalex.org/W4407889306","doi":"https://doi.org/10.1530/endoabs.109.p218"},"language":"en","primary_location":{"id":"doi:10.1530/endoabs.109.p218","doi":"https://doi.org/10.1530/endoabs.109.p218","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.109.p218","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008657360","display_name":"Sandhi Nyunt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nyunt Sandhi W","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045951515","display_name":"Maria Phylactou","orcid":"https://orcid.org/0000-0002-0464-5768","observed_orcids":["https://orcid.org/0000-0002-0464-5768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Phylactou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082051781","display_name":"Kanyada Koysombat","orcid":"https://orcid.org/0000-0002-0957-927X","observed_orcids":["https://orcid.org/0000-0002-0957-927X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanyada Koysombat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088023","display_name":"Jovanna Tsoutsouki","orcid":"https://orcid.org/0000-0001-5496-2393","observed_orcids":["https://orcid.org/0000-0001-5496-2393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jovanna Tsoutsouki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020742721","display_name":"Arthur C. Yeung","orcid":"https://orcid.org/0000-0002-0344-7719","observed_orcids":["https://orcid.org/0000-0002-0344-7719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yeung Arthur C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060821969","display_name":"Megan Young","orcid":"https://orcid.org/0000-0001-7777-3966","observed_orcids":["https://orcid.org/0000-0001-7777-3966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111227119","display_name":"Anastasia Newman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anastasia Newman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036046276","display_name":"Yaasir H. Mamoojee","orcid":"https://orcid.org/0000-0002-6823-0473","observed_orcids":["https://orcid.org/0000-0002-6823-0473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaasir Mamoojee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013160218","display_name":"Nelly Pitteloud","orcid":"https://orcid.org/0000-0003-0971-3237","observed_orcids":["https://orcid.org/0000-0003-0971-3237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelly Pitteloud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047045725","display_name":"Richard Quinton","orcid":"https://orcid.org/0000-0002-4842-8095","observed_orcids":["https://orcid.org/0000-0002-4842-8095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Quinton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113201525","display_name":"Dhillo Waljit S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dhillo Waljit S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059291634","display_name":"Ali Abbara","orcid":"https://orcid.org/0000-0003-2795-5256","observed_orcids":["https://orcid.org/0000-0003-2795-5256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ali Abbara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kisspeptin","display_name":"kisspeptin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/congenital-hypogonadotropic-hypogonadism","display_name":"congenital hypogonadotropic hypogonadism","score":0.9430000185966492},{"id":"https://openalex.org/keywords/gnrh-receptor","display_name":"GnRH receptor","score":0.5490000247955322},{"id":"https://openalex.org/keywords/hypothalamic-dysfunction","display_name":"hypothalamic dysfunction","score":0.953000009059906},{"id":"https://openalex.org/keywords/female-hypogonadism","display_name":"female hypogonadism","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2910268463","wikidata":"https://www.wikidata.org/wiki/Q1641332","display_name":"Hypogonadotrophic hypogonadism","level":3,"score":0.9552832841873169},{"id":"https://openalex.org/C2776808119","wikidata":"https://www.wikidata.org/wiki/Q909371","display_name":"Kisspeptin","level":3,"score":0.8794680833816528},{"id":"https://openalex.org/C2776817873","wikidata":"https://www.wikidata.org/wiki/Q15316535","display_name":"GNRHR","level":5,"score":0.7577126026153564},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6102942228317261},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5724251866340637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5057635307312012},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.36575552821159363},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.3560735583305359},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.24014827609062195},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19005340337753296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1530/endoabs.109.p218","doi":"https://doi.org/10.1530/endoabs.109.p218","is_oa":false,"landing_page_url":"https://doi.org/10.1530/endoabs.109.p218","pdf_url":null,"source":{"id":"https://openalex.org/S4306509401","display_name":"Endocrine Abstracts","issn_l":"1470-3947","issn":["1470-3947","1479-6848","2046-0368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414207942","https://openalex.org/W2398655703","https://openalex.org/W4403149436","https://openalex.org/W7130580013","https://openalex.org/W2169232963","https://openalex.org/W4399571570","https://openalex.org/W4410980958","https://openalex.org/W3080639201","https://openalex.org/W3177122174","https://openalex.org/W7130581924"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-02-25T00:00:00"}