{"id":"https://openalex.org/W4407876088","doi":"https://doi.org/10.1186/s12864-025-11367-6","title":"Lineage-specific variation in frequency and hotspots of recombination in invasive Escherichia coli","display_name":"Lineage-specific variation in frequency and hotspots of recombination in invasive Escherichia coli","publication_year":2025,"publication_date":"2025-02-24","ids":{"openalex":"https://openalex.org/W4407876088","doi":"https://doi.org/10.1186/s12864-025-11367-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/39994515"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-025-11367-6","doi":"https://doi.org/10.1186/s12864-025-11367-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-025-11367-6","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12864-025-11367-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019002281","display_name":"Kathryn R. Piper","orcid":"https://orcid.org/0000-0003-2711-2347","observed_orcids":["https://orcid.org/0000-0003-2711-2347"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn R. Piper","raw_affiliation_strings":["Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-2711-2347","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067122919","display_name":"Stephanie S. R. Souza","orcid":"https://orcid.org/0000-0002-4207-8231","observed_orcids":["https://orcid.org/0000-0002-4207-8231"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie S. R. Souza","raw_affiliation_strings":["Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4207-8231","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017659038","display_name":"Odion O. Ikhimiukor","orcid":"https://orcid.org/0000-0002-3738-4584","observed_orcids":["https://orcid.org/0000-0002-3738-4584"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Odion O. Ikhimiukor","raw_affiliation_strings":["Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-3738-4584","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025717679","display_name":"Adrienne A. Workman","orcid":"https://orcid.org/0009-0007-5088-0690","observed_orcids":["https://orcid.org/0009-0007-5088-0690"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne A. Workman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1289422878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045511326","display_name":"Isabella W. Martin","orcid":"https://orcid.org/0000-0001-7974-9767","observed_orcids":["https://orcid.org/0000-0001-7974-9767"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I1289422878","display_name":"Dartmouth\u2013Hitchcock Medical Center","ror":"https://ror.org/00d1dhh09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isabella W. Martin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA. isabella.w.martin@hitchcock.org","Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA"],"raw_orcid":"https://orcid.org/0000-0001-7974-9767","affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA. isabella.w.martin@hitchcock.org","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1289422878"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center and Dartmouth College Geisel School of Medicine, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1289422878"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041001443","display_name":"Cheryl P. Andam","orcid":"https://orcid.org/0000-0003-4428-0924","observed_orcids":["https://orcid.org/0000-0003-4428-0924"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I392282","display_name":"University at Albany, State University of New York","ror":"https://ror.org/012zs8222","country_code":"US","type":"education","lineage":["https://openalex.org/I392282"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheryl P. Andam","raw_affiliation_strings":["Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA. candam@albany.edu","Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-4428-0924","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA. candam@albany.edu","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]},{"raw_affiliation_string":"Department of Biological Sciences,  University at Albany, State University of New York, Albany, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I392282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041001443","https://openalex.org/A5045511326"],"corresponding_institution_ids":["https://openalex.org/I107672454","https://openalex.org/I1289422878","https://openalex.org/I1327163397","https://openalex.org/I392282"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.6447,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.79360165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"26","issue":"1","first_page":"190","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9057999849319458,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9710000157356262},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.984000027179718},{"id":"https://openalex.org/keywords/recombination-hotspots","display_name":"recombination hotspots","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bloodstream-infection","display_name":"bloodstream infection","score":0.8029999732971191},{"id":"https://openalex.org/keywords/invasive-escherichia-coli","display_name":"invasive Escherichia coli","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antimicrobial-resistance-genes","display_name":"antimicrobial resistance genes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/virulence-genes","display_name":"virulence genes","score":0.996999979019165},{"id":"https://openalex.org/keywords/sequence-types","display_name":"sequence types","score":0.6840000152587891},{"id":"https://openalex.org/keywords/recombination-rate","display_name":"recombination rate","score":0.4399999976158142},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"mutation rate","score":0.5659999847412109},{"id":"https://openalex.org/keywords/tolc","display_name":"TolC","score":0.949999988079071},{"id":"https://openalex.org/keywords/core-genome-phylogeny","display_name":"core genome phylogeny","score":0.753000020980835},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8482723236083984},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.718245804309845},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.6863728761672974},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.61346834897995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5137172937393188},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.5047725439071655},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.500476598739624},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4566863775253296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1928895115852356},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12864-025-11367-6","doi":"https://doi.org/10.1186/s12864-025-11367-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-025-11367-6","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:39994515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39994515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11853335","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11853335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2dd46f4931ae4bd7b31f1314b5552d42","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2dd46f4931ae4bd7b31f1314b5552d42","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 26, Iss 1, Pp 1-14 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-025-11367-6","doi":"https://doi.org/10.1186/s12864-025-11367-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-025-11367-6","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.7400000095367432}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877021","display_name":"Population and evolutionary dynamics of recombining genes and alleles in bacteria","funder_award_id":"R35GM142924","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1538557694","https://openalex.org/W1561849362","https://openalex.org/W1569846874","https://openalex.org/W1966597734","https://openalex.org/W1972145956","https://openalex.org/W1972422447","https://openalex.org/W1986904162","https://openalex.org/W1997541288","https://openalex.org/W2012457803","https://openalex.org/W2027836512","https://openalex.org/W2038041834","https://openalex.org/W2045222584","https://openalex.org/W2047570111","https://openalex.org/W2049862828","https://openalex.org/W2055615325","https://openalex.org/W2067245736","https://openalex.org/W2096093282","https://openalex.org/W2098299258","https://openalex.org/W2101832699","https://openalex.org/W2104367488","https://openalex.org/W2106578986","https://openalex.org/W2107772251","https://openalex.org/W2112364185","https://openalex.org/W2123286413","https://openalex.org/W2123692448","https://openalex.org/W2131157113","https://openalex.org/W2134001789","https://openalex.org/W2138299120","https://openalex.org/W2141052558","https://openalex.org/W2146217823","https://openalex.org/W2153446109","https://openalex.org/W2154087633","https://openalex.org/W2154282828","https://openalex.org/W2160378127","https://openalex.org/W2161060487","https://openalex.org/W2171132114","https://openalex.org/W2214414678","https://openalex.org/W2285484490","https://openalex.org/W2337660009","https://openalex.org/W2614081736","https://openalex.org/W2615118893","https://openalex.org/W2784532673","https://openalex.org/W2789861762","https://openalex.org/W2891078715","https://openalex.org/W2898952128","https://openalex.org/W2905016621","https://openalex.org/W2916864872","https://openalex.org/W2941338699","https://openalex.org/W2949010895","https://openalex.org/W2949182334","https://openalex.org/W2949848068","https://openalex.org/W2950284789","https://openalex.org/W2950753995","https://openalex.org/W2951254987","https://openalex.org/W2955217214","https://openalex.org/W2963320878","https://openalex.org/W2980523604","https://openalex.org/W2990575195","https://openalex.org/W2993005136","https://openalex.org/W2994291374","https://openalex.org/W2999108748","https://openalex.org/W3014586572","https://openalex.org/W3036605731","https://openalex.org/W3037796174","https://openalex.org/W3045244624","https://openalex.org/W3114215764","https://openalex.org/W3119468569","https://openalex.org/W3123687963","https://openalex.org/W3151493862","https://openalex.org/W3161540023","https://openalex.org/W3174327041","https://openalex.org/W3185289119","https://openalex.org/W3196982248","https://openalex.org/W3201190653","https://openalex.org/W3205957075","https://openalex.org/W4206677002","https://openalex.org/W4221126308","https://openalex.org/W4237311846","https://openalex.org/W4282972025","https://openalex.org/W4283370105","https://openalex.org/W4285082501","https://openalex.org/W4303199283","https://openalex.org/W4309830381","https://openalex.org/W4313322841","https://openalex.org/W4318332919","https://openalex.org/W4318587902","https://openalex.org/W4376642674","https://openalex.org/W4389980232","https://openalex.org/W4390796690","https://openalex.org/W4393226541","https://openalex.org/W4394785938","https://openalex.org/W4404392746","https://openalex.org/W7073681714","https://openalex.org/W7074186493"],"related_works":["https://openalex.org/W2386430105","https://openalex.org/W2360987025","https://openalex.org/W2356521405","https://openalex.org/W2387178301","https://openalex.org/W3144733943","https://openalex.org/W2785993273","https://openalex.org/W2382269147","https://openalex.org/W4205675103","https://openalex.org/W4398166144","https://openalex.org/W2606530976"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"opportunistic":[2],"bacterium":[3],"Escherichia":[4],"coli":[5,56,329],"can":[6],"invade":[7],"normally":[8],"sterile":[9,38],"sites":[10],"in":[11,36,54,108,141,160,244,260,270,300,326],"the":[12,28,47,69,102,109,136,208,213,221,273,298,301,320,323,333,340],"human":[13],"body,":[14],"potentially":[15],"leading":[16],"to":[17,45,71,152,303,338],"life-threatening":[18],"organ":[19],"dysfunction":[20],"and":[21,49,93,174,177,184,199,226,255,265,280,316,344],"even":[22],"death.":[23],"However,":[24,249],"our":[25],"understanding":[26],"of":[27,51,62,144,147,155,164,179,195,275,291,322,335,342],"evolutionary":[29],"processes":[30],"that":[31,68,113,135,166,202,241],"shape":[32],"its":[33],"genetic":[34,324],"diversity":[35],"this":[37],"environment":[39],"remains":[40],"limited.":[41],"Here,":[42],"we":[43],"aim":[44],"quantify":[46],"frequency":[48],"characteristics":[50,143],"homologous":[52,75,307],"recombination":[53,76,156,161,173,183,259,279,308],"E.":[55,328],"from":[57],"bloodstream":[58],"infections.":[59],"RESULTS:":[60],"Analysis":[61],"557":[63],"short-read":[64],"genome":[65,111],"sequences":[66],"revealed":[67],"propensity":[70,302],"exchange":[72,304],"DNA":[73,305],"by":[74,116],"varies":[77],"within":[78,309],"a":[79,167,192,310],"distinct":[80,311],"population":[81,312],"(bloodstream)":[82],"at":[83,181,313],"narrow":[84,314],"geographic":[85,315],"(Dartmouth":[86],"Hitchcock":[87],"Medical":[88],"Center,":[89],"New":[90],"Hampshire,":[91],"USA)":[92],"temporal":[94,317],"(years":[95],"2016":[96],"-":[97],"2022)":[98],"scope.":[99],"We":[100,133,232],"identified":[101],"four":[103,137,209,246],"largest":[104],"monophyletic":[105],"sequence":[106,118,189,210,247,261],"clusters":[107,139,211,262],"core":[110],"phylogeny":[112],"are":[114],"represented":[115],"prominent":[117],"types":[119],"(ST):":[120],"BAPS1":[121],"(mainly":[122,125,128,131],"ST95),":[123],"BAPS4":[124],"ST73),":[126],"BAPS10":[127],"ST131),":[129],"BAPS14":[130],"ST58).":[132],"show":[134],"dominant":[138],"vary":[140],"different":[142],"recombination:":[145],"number":[146,154],"single":[148],"nucleotide":[149],"polymorphisms":[150],"due":[151],"recombination,":[153,283],"blocks,":[157,162],"cumulative":[158],"bases":[159],"ratio":[163,178],"probabilities":[165],"given":[168],"site":[169],"was":[170,242],"altered":[171],"through":[172],"mutation":[175,185],"(r/m),":[176],"rates":[180],"which":[182],"occurred":[186],"(\u03c1/\u03b8).":[187],"Each":[188],"cluster":[190],"contains":[191],"unique":[193],"set":[194],"antimicrobial":[196],"resistance":[197],"(AMR)":[198],"virulence":[200,215],"genes":[201,216,251],"have":[203],"experienced":[204,258],"recombination.":[205],"Common":[206],"among":[207],"were":[212],"recombined":[214,238,292],"with":[217,220,284],"functions":[218],"associated":[219],"Curli":[222],"secretion":[223],"channel":[224],"(csgG)":[225],"ferric":[227],"enterobactin":[228],"transport":[229],"(entEF,":[230],"fepEG).":[231],"did":[233],"not":[234],"identify":[235],"any":[236],"one":[237],"AMR":[239,250],"gene":[240],"present":[243],"all":[245],"clusters.":[248],"mdtABC,":[252],"baeSR,":[253],"emrKY":[254],"tolC":[256],"had":[257],"BAPS4,":[263],"BAPS10,":[264],"BAPS14.":[266],"These":[267],"differences":[268],"lie":[269],"part":[271],"on":[272],"contributions":[274],"vertically":[276],"inherited":[277],"ancestral":[278],"contemporary":[281],"branch-specific":[282],"some":[285],"genomes":[286],"having":[287],"relatively":[288],"higher":[289],"proportions":[290],"DNA.":[293],"CONCLUSIONS:":[294],"Our":[295],"results":[296],"highlight":[297],"variation":[299,325],"via":[306],"ranges.":[318],"Understanding":[319],"sources":[321],"invasive":[327],"will":[330],"help":[331],"inform":[332],"implementation":[334],"effective":[336],"strategies":[337],"reduce":[339],"burden":[341],"disease":[343],"AMR.":[345]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2025-10-10T00:00:00"}