{"id":"https://openalex.org/W4407828273","doi":"https://doi.org/10.3389/fped.2025.1514323","title":"Plasma NMDAR autoantibody: a new biomarker for the diagnosis of Hirschsprung disease","display_name":"Plasma NMDAR autoantibody: a new biomarker for the diagnosis of Hirschsprung disease","publication_year":2025,"publication_date":"2025-02-21","ids":{"openalex":"https://openalex.org/W4407828273","doi":"https://doi.org/10.3389/fped.2025.1514323","pmid":"https://pubmed.ncbi.nlm.nih.gov/40061427"},"language":"en","primary_location":{"id":"doi:10.3389/fped.2025.1514323","doi":"https://doi.org/10.3389/fped.2025.1514323","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2025.1514323","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1514323/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1514323/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023506118","display_name":"Yulu Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulu Lai","raw_affiliation_strings":["The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114170220","display_name":"Jieting Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieting Lu","raw_affiliation_strings":["The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360934","display_name":"Yanqing Liu","orcid":"https://orcid.org/0000-0003-0357-2429","observed_orcids":["https://orcid.org/0000-0003-0357-2429"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanqing Liu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050359761","display_name":"Jixiao Zeng","orcid":"https://orcid.org/0000-0003-4854-4966","observed_orcids":["https://orcid.org/0000-0003-4854-4966"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jixiao Zeng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050578817","display_name":"Shenwei Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenwei Huang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412822","display_name":"Lin Li","orcid":"https://orcid.org/0000-0001-8974-4636","observed_orcids":["https://orcid.org/0000-0001-8974-4636"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bingtong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134288","display_name":"Sanya Central Hospital","ror":"https://ror.org/03t65z939","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134288"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingtong Wang","raw_affiliation_strings":["Department of Infection Management, Sanya Central Hospital, Sanya, Hainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infection Management, Sanya Central Hospital, Sanya, Hainan, China","institution_ids":["https://openalex.org/I4210134288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077328145","display_name":"Pengfei Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Wei","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629545","display_name":"Yu Ouyang","orcid":"https://orcid.org/0000-0001-6473-9283","observed_orcids":["https://orcid.org/0000-0001-6473-9283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Ouyang","raw_affiliation_strings":["Guangzhou Women and Children's Medical Center, Liuzhou Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Women and Children's Medical Center, Liuzhou Hospital, Liuzhou, Guangxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069229479","display_name":"Junjian Lv","orcid":"https://orcid.org/0009-0005-9308-0875","observed_orcids":["https://orcid.org/0009-0005-9308-0875"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjian Lv","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhong","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020161358","display_name":"Chaoting Lan","orcid":"https://orcid.org/0000-0002-6363-9587","observed_orcids":["https://orcid.org/0000-0002-6363-9587"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chaoting Lan","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049169444","display_name":"Huimin Xia","orcid":"https://orcid.org/0000-0002-0103-1672","observed_orcids":["https://orcid.org/0000-0002-0103-1672","https://orcid.org/0000-0002-6801-3583"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huimin Xia","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019355497","display_name":"Qiuming He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I4405270171","display_name":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease","ror":"https://ror.org/0064ah252","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405270171"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiuming He","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","Guangzhou Women and Children's Medical Center, Liuzhou Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Guangzhou Women and Children's Medical Center, Liuzhou Hospital, Liuzhou, Guangxi, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019355497","https://openalex.org/A5020161358","https://openalex.org/A5049169444"],"corresponding_institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I4405270171","https://openalex.org/I58200834","https://openalex.org/I92039509"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.8924,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68286365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"1514323","last_page":"1514323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12150","display_name":"Intestinal Malrotation and Obstruction Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hirschsprung-disease","display_name":"Hirschsprung disease","score":1.0},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/colon-tissue","display_name":"colon tissue","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8768340349197388},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8677217364311218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8498833179473877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6140530109405518},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5540616512298584},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5534124374389648},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49341121315956116},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.4497345983982086},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.44402673840522766},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32994094491004944},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22714155912399292},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.1714729368686676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06712281703948975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fped.2025.1514323","doi":"https://doi.org/10.3389/fped.2025.1514323","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2025.1514323","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1514323/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},{"id":"pmid:40061427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40061427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11885489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11885489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Pediatr","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aed5ced1d8274e0db02029fb2650d4da","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aed5ced1d8274e0db02029fb2650d4da","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pediatrics, Vol 13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fped.2025.1514323","doi":"https://doi.org/10.3389/fped.2025.1514323","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fped.2025.1514323","pdf_url":"https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1514323/pdf","source":{"id":"https://openalex.org/S2596117549","display_name":"Frontiers in Pediatrics","issn_l":"2296-2360","issn":["2296-2360"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5738258436","display_name":null,"funder_award_id":"82301955","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6493753357","display_name":null,"funder_award_id":"82170528","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G748688170","display_name":null,"funder_award_id":"82370526","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407828273.pdf","grobid_xml":"https://content.openalex.org/works/W4407828273.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1479729971","https://openalex.org/W1532755881","https://openalex.org/W1949798014","https://openalex.org/W1968258762","https://openalex.org/W1974847021","https://openalex.org/W1998181805","https://openalex.org/W2026143005","https://openalex.org/W2028332032","https://openalex.org/W2068715875","https://openalex.org/W2077480292","https://openalex.org/W2104101370","https://openalex.org/W2104882581","https://openalex.org/W2108162316","https://openalex.org/W2109506831","https://openalex.org/W2148961821","https://openalex.org/W2159729949","https://openalex.org/W2322503259","https://openalex.org/W2527218251","https://openalex.org/W2585470529","https://openalex.org/W2751351410","https://openalex.org/W2786681936","https://openalex.org/W2795547023","https://openalex.org/W3038031443","https://openalex.org/W3109094113","https://openalex.org/W3154849239","https://openalex.org/W3198560904","https://openalex.org/W3211806559","https://openalex.org/W4312066508","https://openalex.org/W4320857284","https://openalex.org/W4387576573","https://openalex.org/W4403792880"],"related_works":["https://openalex.org/W4398213998","https://openalex.org/W4400803919","https://openalex.org/W4225859693","https://openalex.org/W2422158553","https://openalex.org/W4317660812","https://openalex.org/W2278981029","https://openalex.org/W2547597217","https://openalex.org/W4378550296","https://openalex.org/W3008049871","https://openalex.org/W1790481095"],"abstract_inverted_index":{"Introduction":[0],"Hirschsprung":[1],"Disease":[2],"(HSCR)":[3],"is":[4],"a":[5,28],"common":[6],"congenital":[7],"intestinal":[8,49],"disease":[9,50],"in":[10,87,122,130,146],"pediatrics.":[11],"Early":[12],"diagnosis":[13],"and":[14,35,53,64,90,166,190,199],"treatment":[15],"after":[16],"birth":[17],"alleviate":[18],"the":[19,102,106,114,131,141,158,167,178],"occurrence":[20],"of":[21,32,105,116,143,181,188],"complications.":[22],"Consequently,":[23],"we":[24],"aim":[25],"to":[26,100,156,197],"identifiy":[27],"biomarker":[29,78,212],"with":[30],"ease":[31],"use,":[33],"non-invasiveness,":[34],"highly":[36],"accurate":[37],"for":[38,192,213],"diagnosis.":[39],"Methods":[40],"Plasma":[41,202],"samples":[42,59],"were":[43,60,152],"collected":[44,61],"from":[45,62],"HSCR":[46,63,123,147,194],"group,":[47],"other":[48],"controls":[51,55],"(DC)":[52],"healthy":[54],"(HC),":[56],"while":[57],"colon":[58,88],"DC":[65,168],"groups.":[66],"We":[67,175],"conducted":[68],"human":[69],"neural":[70],"autoantibody":[71,121,204],"microarray":[72],"analyses":[73],"on":[74],"plasma.":[75,91],"The":[76,92],"candidate":[77],"was":[79,98,125],"further":[80,176],"validated":[81,177],"using":[82],"enzyme-linked":[83],"immunosorbent":[84],"assay":[85],"(ELISA)":[86],"tissue":[89],"receiver":[93],"operating":[94],"characteristic":[95],"curve":[96],"(ROC)":[97],"used":[99],"assess":[101],"diagnostic":[103,179],"performance":[104],"plasma":[107,117,138,182],"biomarker.":[108],"Results":[109],"Microarray":[110],"analysis":[111],"revealed":[112],"that":[113],"level":[115,142],"N-methyl-D-Aspartate":[118],"receptor":[119],"(NMDAR)":[120],"group":[124,133,148],"significantly":[126,153],"higher":[127],"than":[128],"those":[129],"HC":[132,159,198],"(p":[134],"=":[135,150,161,170],"0.008).":[136],"In":[137],"analyzed":[139],"cohort,":[140],"NMDAR":[144,183,203],"autoantibodies":[145],"(n":[149,160,169],"38)":[151],"elevated":[154],"compared":[155,196],"both":[157],"31,":[162],"p":[163,172],"<":[164,173],"0.0001)":[165],"20,":[171],"0.0001).":[174],"efficacy":[180],"autoantibody,":[184],"it":[185],"demonstrated":[186],"AUCs":[187],"0.96":[189],"0.81":[191],"diagnosing":[193,214],"when":[195],"DC.":[200],"Conclusions":[201],"might":[205],"be":[206],"served":[207],"as":[208],"an":[209],"efficient,":[210],"non-invasive":[211],"HSCR.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
