{"id":"https://openalex.org/W4407792011","doi":"https://doi.org/10.1016/j.tma.2025.02.002","title":"Curli protein: A potential contributor to \u03b1-synucleopathy in Parkinson's disease","display_name":"Curli protein: A potential contributor to \u03b1-synucleopathy in Parkinson's disease","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4407792011","doi":"https://doi.org/10.1016/j.tma.2025.02.002"},"language":"en","primary_location":{"id":"doi:10.1016/j.tma.2025.02.002","doi":"https://doi.org/10.1016/j.tma.2025.02.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tma.2025.02.002","pdf_url":null,"source":{"id":"https://openalex.org/S2898398589","display_name":"Translational Medicine of Aging","issn_l":"2468-5011","issn":["2468-5011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Medicine of Aging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.tma.2025.02.002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110477687","display_name":"Nabanita Ghosh","orcid":"https://orcid.org/0000-0003-1418-0017","observed_orcids":["https://orcid.org/0000-0003-1418-0017"]},"institutions":[{"id":"https://openalex.org/I4405272376","display_name":"Maulana Azad College","ror":"https://ror.org/04334z971","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405272376"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nabanita Ghosh","raw_affiliation_strings":["Assistant Professor in Zoology, Maulana Azad College, Kolkata, 700013, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor in Zoology, Maulana Azad College, Kolkata, 700013, India","institution_ids":["https://openalex.org/I4405272376"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050322243","display_name":"Krishnendu Sinha","orcid":"https://orcid.org/0000-0001-9590-3875","observed_orcids":["https://orcid.org/0000-0001-9590-3875"]},"institutions":[{"id":"https://openalex.org/I4405256066","display_name":"Jhargram Raj College","ror":"https://ror.org/03qvxc742","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405256066"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishnendu Sinha","raw_affiliation_strings":["Assistant Professor in Zoology, Jhargram Raj College, Jhargram, 721507, India"],"raw_orcid":"https://orcid.org/0000-0001-9590-3875","affiliations":[{"raw_affiliation_string":"Assistant Professor in Zoology, Jhargram Raj College, Jhargram, 721507, India","institution_ids":["https://openalex.org/I4405256066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050322243","https://openalex.org/A5110477687"],"corresponding_institution_ids":["https://openalex.org/I4405256066","https://openalex.org/I4405272376"],"apc_list":{"value":350,"currency":"USD","value_usd":350},"apc_paid":{"value":350,"currency":"USD","value_usd":350},"fwci":2.4884,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.87783401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":null,"first_page":"41","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bacterial-amyloids","display_name":"bacterial amyloids","score":0.7879999876022339},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cross-seeding","display_name":"cross-seeding","score":0.9419999718666077},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7749999761581421},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.551000714302063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41801929473876953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3852655589580536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28279387950897217}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tma.2025.02.002","doi":"https://doi.org/10.1016/j.tma.2025.02.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tma.2025.02.002","pdf_url":null,"source":{"id":"https://openalex.org/S2898398589","display_name":"Translational Medicine of Aging","issn_l":"2468-5011","issn":["2468-5011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Medicine of Aging","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:aa676aa3902c48a691ee722402fe8903","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aa676aa3902c48a691ee722402fe8903","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Medicine of Aging, Vol 9, Iss , Pp 41-48 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tma.2025.02.002","doi":"https://doi.org/10.1016/j.tma.2025.02.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tma.2025.02.002","pdf_url":null,"source":{"id":"https://openalex.org/S2898398589","display_name":"Translational Medicine of Aging","issn_l":"2468-5011","issn":["2468-5011"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Medicine of Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W183072596","https://openalex.org/W1527671059","https://openalex.org/W1619899730","https://openalex.org/W1756354197","https://openalex.org/W1860081569","https://openalex.org/W1903888485","https://openalex.org/W1934236512","https://openalex.org/W1970577444","https://openalex.org/W1977820570","https://openalex.org/W1980914602","https://openalex.org/W1998621408","https://openalex.org/W2005279391","https://openalex.org/W2007839979","https://openalex.org/W2012455832","https://openalex.org/W2013322269","https://openalex.org/W2013701725","https://openalex.org/W2018803247","https://openalex.org/W2021785060","https://openalex.org/W2031014005","https://openalex.org/W2031382376","https://openalex.org/W2031927717","https://openalex.org/W2063149940","https://openalex.org/W2064367582","https://openalex.org/W2070300719","https://openalex.org/W2073449985","https://openalex.org/W2083807859","https://openalex.org/W2084740701","https://openalex.org/W2087482196","https://openalex.org/W2103114542","https://openalex.org/W2112455323","https://openalex.org/W2124083703","https://openalex.org/W2134068760","https://openalex.org/W2145845703","https://openalex.org/W2145954079","https://openalex.org/W2165490685","https://openalex.org/W2171132114","https://openalex.org/W2399812463","https://openalex.org/W2528438579","https://openalex.org/W2548933161","https://openalex.org/W2558041282","https://openalex.org/W2584469054","https://openalex.org/W2587082207","https://openalex.org/W2587959748","https://openalex.org/W2761522803","https://openalex.org/W2768455179","https://openalex.org/W2777995939","https://openalex.org/W2890247534","https://openalex.org/W2911442568","https://openalex.org/W2921561422","https://openalex.org/W2953534538","https://openalex.org/W2964723648","https://openalex.org/W2985623760","https://openalex.org/W3006477212","https://openalex.org/W3009957334","https://openalex.org/W3016614566","https://openalex.org/W3090490957","https://openalex.org/W3100056764","https://openalex.org/W3119525290","https://openalex.org/W3134008378","https://openalex.org/W3136755667","https://openalex.org/W3173890395","https://openalex.org/W3195808516","https://openalex.org/W4206443219","https://openalex.org/W4211123396","https://openalex.org/W4281780863","https://openalex.org/W4287378318","https://openalex.org/W4288723506","https://openalex.org/W4308364988","https://openalex.org/W4311512939","https://openalex.org/W4318589283","https://openalex.org/W4319728686","https://openalex.org/W4319754508","https://openalex.org/W4321015506","https://openalex.org/W4322754763","https://openalex.org/W4323532768","https://openalex.org/W4361010653","https://openalex.org/W4362663964","https://openalex.org/W4365145710","https://openalex.org/W4365456150","https://openalex.org/W4367183963","https://openalex.org/W4383894096","https://openalex.org/W4385377425","https://openalex.org/W4386629674","https://openalex.org/W4389043204","https://openalex.org/W4389264036","https://openalex.org/W4389752501","https://openalex.org/W4390788617","https://openalex.org/W4390884025","https://openalex.org/W4391965498","https://openalex.org/W4392806824","https://openalex.org/W4396956486","https://openalex.org/W4400283253","https://openalex.org/W4403790644","https://openalex.org/W6727701451","https://openalex.org/W6851503582","https://openalex.org/W6856118129"],"related_works":["https://openalex.org/W4416674254","https://openalex.org/W4396691339","https://openalex.org/W2921561422","https://openalex.org/W3168754484","https://openalex.org/W4394583077","https://openalex.org/W4402599446","https://openalex.org/W4391772790","https://openalex.org/W2072998862","https://openalex.org/W6982119558","https://openalex.org/W6989092825"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3,33,59],"a":[4,60,90,98],"progressive":[5],"neurodegenerative":[6,67,108],"disorder":[7],"marked":[8],"by":[9,80],"the":[10,17,34,102,141,157],"gradual":[11],"loss":[12],"of":[13,30,36,45,53,63,104,159],"dopaminergic":[14],"neurons":[15],"in":[16,21,92,107],"substantia":[18],"nigra,":[19],"resulting":[20,142],"both":[22],"motor":[23],"and":[24,65,118,161],"non-motor":[25],"symptoms.":[26],"A":[27],"defining":[28],"feature":[29],"PD":[31,64,93,160],"pathology":[32],"presence":[35],"Lewy":[37],"bodies,":[38],"which":[39],"are":[40],"intracellular":[41],"inclusions":[42],"primarily":[43],"composed":[44],"aggregated":[46],"alpha-synuclein":[47],"(\u03b1-syn)":[48],"proteins.":[49],"The":[50],"abnormal":[51],"buildup":[52],"\u03b1-syn,":[54],"referred":[55],"to":[56,132,153],"as":[57,76],"\u03b1-synucleopathy,":[58],"key":[61],"aspect":[62],"other":[66],"conditions.":[68],"Recent":[69],"research":[70],"indicates":[71],"that":[72,111],"bacterial":[73],"amyloids,":[74],"such":[75],"curli":[77,112,134],"proteins":[78,113],"produced":[79],"Escherichia":[81],"coli":[82],",":[83],"may":[84],"influence":[85],"\u03b1-syn":[86,117],"aggregation,":[87],"potentially":[88],"playing":[89],"role":[91],"development.":[94],"These":[95],"discoveries":[96],"provide":[97],"new":[99,127,151],"perspective":[100],"on":[101],"involvement":[103],"microbial":[105],"factors":[106],"diseases,":[109],"suggesting":[110],"can":[114],"cross-seed":[115],"with":[116],"enhance":[119],"its":[120],"aggregation.":[121],"Understanding":[122],"these":[123],"interactions":[124],"opens":[125],"up":[126],"therapeutic":[128,146],"possibilities,":[129],"including":[130],"methods":[131],"inhibit":[133],"production,":[135],"prevent":[136],"curli-\u03b1-syn":[137],"interactions,":[138],"or":[139,155],"target":[140],"pathological":[143],"aggregates.":[144],"Such":[145],"strategies":[147],"could":[148],"offer":[149],"promising":[150],"ways":[152],"slow":[154],"stop":[156],"progression":[158],"improve":[162],"outcomes":[163],"for":[164],"patients.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-02-21T00:00:00"}
