{"id":"https://openalex.org/W4407745821","doi":"https://doi.org/10.1186/s42269-025-01310-w","title":"Haematological and serum biochemical derangements induced by acute exposure to didecyl dimethyl ammonium bromide in Gallus gallus domesticus","display_name":"Haematological and serum biochemical derangements induced by acute exposure to didecyl dimethyl ammonium bromide in Gallus gallus domesticus","publication_year":2025,"publication_date":"2025-02-19","ids":{"openalex":"https://openalex.org/W4407745821","doi":"https://doi.org/10.1186/s42269-025-01310-w"},"language":"en","primary_location":{"id":"doi:10.1186/s42269-025-01310-w","doi":"https://doi.org/10.1186/s42269-025-01310-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42269-025-01310-w","pdf_url":"https://bnrc.springeropen.com/counter/pdf/10.1186/s42269-025-01310-w","source":{"id":"https://openalex.org/S3034431341","display_name":"Bulletin of the National Research Centre/Bulletin of the National Research Center","issn_l":"1110-0591","issn":["1110-0591","2522-8307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the National Research Centre","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bnrc.springeropen.com/counter/pdf/10.1186/s42269-025-01310-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107763050","display_name":"Bello Ayema Abdul","orcid":"https://orcid.org/0009-0003-7272-4729","observed_orcids":["https://orcid.org/0009-0003-7272-4729"]},"institutions":[{"id":"https://openalex.org/I12789410","display_name":"Ahmadu Bello University","ror":"https://ror.org/019apvn83","country_code":"NG","type":"education","lineage":["https://openalex.org/I12789410"]},{"id":"https://openalex.org/I919958821","display_name":"Bayero University Kano","ror":"https://ror.org/049pzty39","country_code":"NG","type":"education","lineage":["https://openalex.org/I919958821"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bello Ayema Abdul","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria","Department of Veterinary Pharmacology and Toxicology, Bayero University, Kano, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria","institution_ids":["https://openalex.org/I12789410"]},{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, Bayero University, Kano, Nigeria","institution_ids":["https://openalex.org/I919958821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042861404","display_name":"Hamza Ibrahim Isa","orcid":"https://orcid.org/0000-0002-2928-0136","observed_orcids":["https://orcid.org/0000-0002-2928-0136"]},"institutions":[{"id":"https://openalex.org/I12789410","display_name":"Ahmadu Bello University","ror":"https://ror.org/019apvn83","country_code":"NG","type":"education","lineage":["https://openalex.org/I12789410"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Hamza Ibrahim Isa","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-2928-0136","affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria","institution_ids":["https://openalex.org/I12789410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054341591","display_name":"Muftau Shittu","orcid":"https://orcid.org/0000-0003-4212-5103","observed_orcids":["https://orcid.org/0000-0003-4212-5103"]},"institutions":[{"id":"https://openalex.org/I12789410","display_name":"Ahmadu Bello University","ror":"https://ror.org/019apvn83","country_code":"NG","type":"education","lineage":["https://openalex.org/I12789410"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Muftau Shittu","raw_affiliation_strings":["Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria, Nigeria","institution_ids":["https://openalex.org/I12789410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042861404"],"corresponding_institution_ids":["https://openalex.org/I12789410"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01661627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.18050000071525574,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quaternary-ammonium-salts","display_name":"quaternary ammonium compounds","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acute-oral-toxicity","display_name":"acute oral toxicity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hematological-changes","display_name":"hematological changes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/blood-chemistry","display_name":"serum biochemistry","score":0.9739999771118164},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.6930000185966492},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9580000042915344},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9419999718666077},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9150000214576721},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.6779999732971191},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9589999914169312},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urea-and-creatinine","display_name":"urea and creatinine","score":0.7319999933242798},{"id":"https://openalex.org/keywords/water-sanitation","display_name":"water sanitation","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2776300020","wikidata":"https://www.wikidata.org/wiki/Q422423","display_name":"Bromide","level":2,"score":0.6032842397689819},{"id":"https://openalex.org/C2779465129","wikidata":"https://www.wikidata.org/wiki/Q413982","display_name":"Ammonium bromide","level":3,"score":0.5873066782951355},{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.5672081708908081},{"id":"https://openalex.org/C2909031412","wikidata":"https://www.wikidata.org/wiki/Q780","display_name":"Gallus gallus domesticus","level":2,"score":0.48454609513282776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4645884335041046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4240504503250122},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3753144145011902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33618295192718506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32822027802467346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32600778341293335},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.19687867164611816},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1530177891254425},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13998591899871826},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s42269-025-01310-w","doi":"https://doi.org/10.1186/s42269-025-01310-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42269-025-01310-w","pdf_url":"https://bnrc.springeropen.com/counter/pdf/10.1186/s42269-025-01310-w","source":{"id":"https://openalex.org/S3034431341","display_name":"Bulletin of the National Research Centre/Bulletin of the National Research Center","issn_l":"1110-0591","issn":["1110-0591","2522-8307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the National Research Centre","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b661b6724bc0477393899ef8fc3f727a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b661b6724bc0477393899ef8fc3f727a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bulletin of the National Research Centre, Vol 49, Iss 1, Pp 1-8 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s42269-025-01310-w","doi":"https://doi.org/10.1186/s42269-025-01310-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s42269-025-01310-w","pdf_url":"https://bnrc.springeropen.com/counter/pdf/10.1186/s42269-025-01310-w","source":{"id":"https://openalex.org/S3034431341","display_name":"Bulletin of the National Research Centre/Bulletin of the National Research Center","issn_l":"1110-0591","issn":["1110-0591","2522-8307"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of the National Research Centre","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407745821.pdf","grobid_xml":"https://content.openalex.org/works/W4407745821.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W118705544","https://openalex.org/W1964719327","https://openalex.org/W1977678718","https://openalex.org/W1983310681","https://openalex.org/W1992900987","https://openalex.org/W2024120681","https://openalex.org/W2057707536","https://openalex.org/W2090661228","https://openalex.org/W2116859321","https://openalex.org/W2168024298","https://openalex.org/W2329968893","https://openalex.org/W2441647101","https://openalex.org/W2594114396","https://openalex.org/W2604121576","https://openalex.org/W2751885135","https://openalex.org/W2765129543","https://openalex.org/W2767562953","https://openalex.org/W2768101127","https://openalex.org/W2785409534","https://openalex.org/W2804848414","https://openalex.org/W2911507978","https://openalex.org/W2937862696","https://openalex.org/W2989789233","https://openalex.org/W3016671791","https://openalex.org/W3020929983","https://openalex.org/W3022183951","https://openalex.org/W3037923497","https://openalex.org/W3084178029","https://openalex.org/W3093964972","https://openalex.org/W3107241809","https://openalex.org/W3111295381","https://openalex.org/W3157957675","https://openalex.org/W3168209803","https://openalex.org/W3175264338","https://openalex.org/W3195328848","https://openalex.org/W3205283507","https://openalex.org/W3207220813","https://openalex.org/W3207906214","https://openalex.org/W3211506167","https://openalex.org/W4220729808","https://openalex.org/W4220957235","https://openalex.org/W4225009223","https://openalex.org/W4235105898","https://openalex.org/W4285591000","https://openalex.org/W4308065796","https://openalex.org/W4311684715","https://openalex.org/W4313582790","https://openalex.org/W4317932333","https://openalex.org/W4320879598","https://openalex.org/W4323826301","https://openalex.org/W4360856206","https://openalex.org/W4362465828","https://openalex.org/W4375951215","https://openalex.org/W4376133110","https://openalex.org/W4383273076","https://openalex.org/W4385786370","https://openalex.org/W4386238165","https://openalex.org/W4388139929","https://openalex.org/W4395465381","https://openalex.org/W4403140814"],"related_works":["https://openalex.org/W2614969851","https://openalex.org/W2164909720","https://openalex.org/W2468235691","https://openalex.org/W2374530989","https://openalex.org/W975841772","https://openalex.org/W4400359963","https://openalex.org/W2985739695","https://openalex.org/W4407111812","https://openalex.org/W2732182989","https://openalex.org/W420873747"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Infectious":[2],"diseases":[3,26],"have":[4,28],"negatively":[5],"impacted":[6],"poultry":[7,291],"productivity,":[8],"thereby":[9],"causing":[10],"economic":[11],"losses":[12],"and":[13,67,97,168,173,188,220,230,249,260,287],"international":[14],"trade":[15],"embargoes.":[16],"Several":[17],"chemical":[18,283],"cocktails":[19],"are":[20,35],"being":[21,39],"employed":[22],"to":[23,41,63,76,253,273],"\u2018treat\u2019":[24],"such":[25,37],"that":[27],"defied":[29],"known":[30],"interventions.":[31],"Quaternary":[32],"ammonium":[33,79],"compounds":[34],"amongst":[36],"chemicals":[38],"used":[40],"disinfect":[42],"drinking":[43],"water":[44,285],"of":[45,50,112,120],"poultry,":[46],"with":[47,72,109],"a":[48,116,127],"premise":[49],"therapeutic":[51],"effect.":[52],"Such":[53],"extra-label":[54],"use":[55],"has":[56],"limited":[57],"toxicological":[58],"data.":[59],"We":[60],"set":[61],"out":[62],"determine":[64],"the":[65,110,177,240,245],"haematological":[66],"serum":[68],"biochemical":[69,182],"derangements":[70],"associated":[71],"acute":[73,129],"oral":[74,118],"exposure":[75,105],"didecyl":[77],"dimethyl":[78],"bromide":[80],"(DDAB),":[81],"in":[82,161,176,206,257,284,290],"6-week-old":[83],"Isa":[84],"Brown":[85],"pullets.":[86],"The":[87,104],"pullets":[88],"were":[89,145,223,232,263],"haphazardly":[90],"assigned":[91],"into":[92],"control":[93],"(n":[94,99],"=":[95,100],"10)":[96,101],"DDAB":[98,121,243],"exposed":[102],"groups.":[103],"group":[106],"was":[107,211,269],"administered,":[108],"aid":[111],"an":[113],"insulin":[114],"syringe,":[115],"single":[117],"dose":[119,241],"at":[122],"360":[123],"mg/kg,":[124],"determined":[125,151],"from":[126],"previous":[128],"toxicity":[130],"study.":[131],"Results":[132],"Following":[133],"monitoring":[134],"for":[135,147,184],"toxic":[136],"signs":[137],"and/or":[138],"death":[139],"during":[140],"14":[141],"days,":[142],"blood":[143],"samples":[144],"collected":[146],"analyses.":[148],"Haematological":[149],"analyses,":[150],"following":[152],"established":[153],"principles,":[154],"revealed":[155,200],"significant":[156,201],"(p":[157,202,213,225,234],"<":[158,203,214,226,235],"0.05)":[159,204,215,227,236],"increases":[160],"packed":[162],"cell":[163],"volume,":[164],"total":[165],"erythrocyte":[166],"counts":[167],"monocytes,":[169],"but":[170,217],"decreased":[171],"heterophil":[172],"eosinophil":[174],"counts,":[175],"birds":[178],"administered":[179],"DDAB.":[180],"Serum":[181],"assay":[183],"aspartate":[185],"aminotransferase":[186],"(AST)":[187],"alkaline":[189],"phosphatase":[190],"(ALP)":[191],"activities,":[192],"appraised":[193],"using":[194,281],"appropriate":[195],"ELISA":[196],"kits":[197],"(Randox\u00ae":[198],"Laboratories),":[199],"elevations":[205],"these":[207],"enzymes.":[208],"Malondialdehyde":[209],"level":[210],"significantly":[212,224,233],"raised":[216],"glutathione":[218],"concentration":[219],"catalase":[221],"activity":[222],"decreased.":[228],"Urea":[229],"creatinine":[231],"increased.":[237],"Conclusions":[238],"At":[239],"studied,":[242],"traversed":[244],"digestive":[246],"tract":[247],"barrier":[248],"accessed":[250],"systemic":[251],"circulation":[252],"induce":[254],"haemato-biochemical":[255],"derangement":[256],"chickens.":[258],"Liver":[259],"kidney":[261],"functions":[262],"adversely":[264],"affected":[265],"while":[266,280],"oxidative":[267],"distress":[268],"induced.":[270],"Strict":[271],"adherence":[272],"manufacturer\u2019s":[274],"recommended":[275],"doses":[276],"should":[277],"be":[278],"practised":[279],"this":[282],"sanitation":[286],"other":[288],"applications":[289],"farms.":[292]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
