{"id":"https://openalex.org/W4407745752","doi":"https://doi.org/10.1007/s00210-024-03621-7","title":"\u03b1-Hederin inhibited pancreatic cancer cell malignant progression by inhibiting LDHA-mediated glycolysis","display_name":"\u03b1-Hederin inhibited pancreatic cancer cell malignant progression by inhibiting LDHA-mediated glycolysis","publication_year":2025,"publication_date":"2025-02-19","ids":{"openalex":"https://openalex.org/W4407745752","doi":"https://doi.org/10.1007/s00210-024-03621-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/39969605"},"language":"en","primary_location":{"id":"doi:10.1007/s00210-024-03621-7","doi":"https://doi.org/10.1007/s00210-024-03621-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-024-03621-7","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101205654","display_name":"Jingjing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088329","display_name":"Jiading District Central Hospital","ror":"https://ror.org/004j26v17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088329"]},{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Li","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China","institution_ids":["https://openalex.org/I4210088329","https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595112","display_name":"Jiao Liu","orcid":"https://orcid.org/0009-0001-8953-883X","observed_orcids":["https://orcid.org/0009-0001-8953-883X"]},"institutions":[{"id":"https://openalex.org/I4210088329","display_name":"Jiading District Central Hospital","ror":"https://ror.org/004j26v17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088329"]},{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Liu","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China","institution_ids":["https://openalex.org/I4210088329","https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067234965","display_name":"Yue Hui Wu","orcid":"https://orcid.org/0000-0002-7349-959X","observed_orcids":["https://orcid.org/0000-0002-7349-959X"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734390","display_name":"Yi Sun","orcid":"https://orcid.org/0000-0001-7168-4735","observed_orcids":["https://orcid.org/0000-0001-7168-4735"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210107879","display_name":"Tongren Hospital","ror":"https://ror.org/01r8rcr36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107879"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Sun","raw_affiliation_strings":["Obstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai, 200336, China. sysucceed@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai, 200336, China. sysucceed@163.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210107879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100748352","display_name":"Gang Huang","orcid":"https://orcid.org/0000-0003-3936-9123","observed_orcids":["https://orcid.org/0000-0003-3936-9123","https://orcid.org/0009-0000-4679-1766"]},"institutions":[{"id":"https://openalex.org/I4210088329","display_name":"Jiading District Central Hospital","ror":"https://ror.org/004j26v17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088329"]},{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Huang","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. huanggang@sumhs.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. huanggang@sumhs.edu.cn","institution_ids":["https://openalex.org/I4210088329","https://openalex.org/I4210135985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034104668","display_name":"Mingming Jin","orcid":"https://orcid.org/0009-0003-8688-8337","observed_orcids":["https://orcid.org/0009-0003-8688-8337"]},"institutions":[{"id":"https://openalex.org/I4210088329","display_name":"Jiading District Central Hospital","ror":"https://ror.org/004j26v17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088329"]},{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingming Jin","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. asdjinmingming@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. asdjinmingming@126.com","institution_ids":["https://openalex.org/I4210088329","https://openalex.org/I4210135985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034104668","https://openalex.org/A5100734390","https://openalex.org/A5100748352"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210088329","https://openalex.org/I4210107879","https://openalex.org/I4210135985"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.2787,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34151268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"398","issue":"8","first_page":"10285","last_page":"10294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-hederin","display_name":"\u03b1-hederin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ldha","display_name":"LDHA","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pentacyclic-triterpenoid-saponins","display_name":"pentacyclic triterpenoid saponins","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pulsatilla-chinensis","display_name":"Pulsatilla chinensis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.628000020980835},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7699999809265137},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7049999833106995},{"id":"https://openalex.org/keywords/capan-1-cells","display_name":"Capan-1 cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/bxpc-3-cells","display_name":"BxPC-3 cells","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.8567100763320923},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6469376087188721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5688682198524475},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5112226009368896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.425004780292511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40077272057533264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38939368724823},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.326812744140625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3114657402038574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27670717239379883},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2205106019973755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1894083023071289}],"mesh":[{"descriptor_ui":"D000080864","descriptor_name":"Lactate Dehydrogenase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009828","descriptor_name":"Oleanolic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009828","descriptor_name":"Oleanolic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012503","descriptor_name":"Saponins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00210-024-03621-7","doi":"https://doi.org/10.1007/s00210-024-03621-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-024-03621-7","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:39969605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39969605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3438966083","display_name":null,"funder_award_id":"82003142","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1975854213","https://openalex.org/W1988499671","https://openalex.org/W1998166655","https://openalex.org/W1999565461","https://openalex.org/W2015113316","https://openalex.org/W2017746705","https://openalex.org/W2038009564","https://openalex.org/W2047621859","https://openalex.org/W2051924508","https://openalex.org/W2052553486","https://openalex.org/W2063862686","https://openalex.org/W2068050569","https://openalex.org/W2073074051","https://openalex.org/W2096746080","https://openalex.org/W2097259163","https://openalex.org/W2117692326","https://openalex.org/W2127597456","https://openalex.org/W2135349706","https://openalex.org/W2530909575","https://openalex.org/W2570675663","https://openalex.org/W2604473882","https://openalex.org/W2751701466","https://openalex.org/W2800009007","https://openalex.org/W2892206829","https://openalex.org/W2894099702","https://openalex.org/W2900166571","https://openalex.org/W2923823140","https://openalex.org/W2970828652","https://openalex.org/W2980024480","https://openalex.org/W2984395468","https://openalex.org/W2989693574","https://openalex.org/W3036081919","https://openalex.org/W3084453386","https://openalex.org/W3116849731","https://openalex.org/W3119005666","https://openalex.org/W3184981591","https://openalex.org/W3202509277","https://openalex.org/W4210976084","https://openalex.org/W4223453460","https://openalex.org/W4243903519"],"related_works":["https://openalex.org/W4237906870","https://openalex.org/W3116849731","https://openalex.org/W4414652562","https://openalex.org/W6929265138","https://openalex.org/W4214856813","https://openalex.org/W2047621859","https://openalex.org/W4220805681","https://openalex.org/W4387336301","https://openalex.org/W2910620833","https://openalex.org/W3176742475"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-20T00:00:00"}
