{"id":"https://openalex.org/W4407698602","doi":"https://doi.org/10.70534/euuz1786","title":"Inferring HIV rebound timing from a noisy biomarker","display_name":"Inferring HIV rebound timing from a noisy biomarker","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4407698602","doi":"https://doi.org/10.70534/euuz1786"},"language":"en","primary_location":{"id":"doi:10.70534/euuz1786","doi":"https://doi.org/10.70534/euuz1786","is_oa":true,"landing_page_url":"https://doi.org/10.70534/euuz1786","pdf_url":"https://www.scienceopen.com/document_file/f81e1039-c380-4aab-ab62-840cacb80d46/ScienceOpen/COMBINE%20W-041.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inferring HIV rebound timing from a noisy biomarker","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scienceopen.com/document_file/f81e1039-c380-4aab-ab62-840cacb80d46/ScienceOpen/COMBINE%20W-041.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alejandra Donaji Herrera Reyes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alejandra Donaji Herrera Reyes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018345025","display_name":"Daniel I. S. Rosenbloom","orcid":"https://orcid.org/0000-0003-1413-3907","observed_orcids":["https://orcid.org/0000-0003-1413-3907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Rosenbloom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109602015","display_name":"Brad R. Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brad Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035712342","display_name":"Brian Squadroni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Squadroni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040146646","display_name":"Livio Azzoni","orcid":"https://orcid.org/0000-0002-4619-4248","observed_orcids":["https://orcid.org/0000-0002-4619-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Livio Azzoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087311522","display_name":"Erin E. Coppola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin Coppola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102851079","display_name":"Guoxin Wu","orcid":"https://orcid.org/0009-0008-8449-8155","observed_orcids":["https://orcid.org/0009-0008-8449-8155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoxin Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074368534","display_name":"Jill W. Maxwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Maxwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109192362","display_name":"Jessicamarie Morris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessicamarie Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108656726","display_name":"Kenneth Lynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Lynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079798188","display_name":"Paul D. Zuck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Zuck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061630637","display_name":"Pablo Tebas","orcid":"https://orcid.org/0000-0001-5345-7942","observed_orcids":["https://orcid.org/0000-0001-5345-7942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pablo Tebas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013318234","display_name":"Karam Mounzer","orcid":"https://orcid.org/0000-0001-8537-7103","observed_orcids":["https://orcid.org/0000-0001-8537-7103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karam Mounzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025539228","display_name":"Brian N. Ross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Ross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090189236","display_name":"Matthew G. Fair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Fair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057398938","display_name":"Emmanouil Papasavvas","orcid":"https://orcid.org/0009-0005-2794-3361","observed_orcids":["https://orcid.org/0009-0005-2794-3361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanouil Papasavvas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025040921","display_name":"Emily Hiserodt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Hiserodt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Welch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Welch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116310778","display_name":"Kevin Baterman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Baterman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069209710","display_name":"Luis J. Montaner","orcid":"https://orcid.org/0000-0001-5799-6759","observed_orcids":["https://orcid.org/0000-0001-5799-6759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis J. Montaner Montaner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060742318","display_name":"Bonnie J. Howell","orcid":"https://orcid.org/0000-0002-5915-9943","observed_orcids":["https://orcid.org/0000-0002-5915-9943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie Howell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50717213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.4381999969482422,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-rebound","display_name":"HIV rebound","score":0.9490000009536743},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.6159999966621399},{"id":"https://openalex.org/keywords/hiv-dynamics","display_name":"HIV dynamics","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5821941494941711},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.545463502407074},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5418549180030823},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3341980576515198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16137120127677917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14162060618400574},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.13955578207969666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08822959661483765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.70534/euuz1786","doi":"https://doi.org/10.70534/euuz1786","is_oa":true,"landing_page_url":"https://doi.org/10.70534/euuz1786","pdf_url":"https://www.scienceopen.com/document_file/f81e1039-c380-4aab-ab62-840cacb80d46/ScienceOpen/COMBINE%20W-041.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inferring HIV rebound timing from a noisy biomarker","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.70534/euuz1786","doi":"https://doi.org/10.70534/euuz1786","is_oa":true,"landing_page_url":"https://doi.org/10.70534/euuz1786","pdf_url":"https://www.scienceopen.com/document_file/f81e1039-c380-4aab-ab62-840cacb80d46/ScienceOpen/COMBINE%20W-041.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inferring HIV rebound timing from a noisy biomarker","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407698602.pdf","grobid_xml":"https://content.openalex.org/works/W4407698602.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2962878859","https://openalex.org/W2920868300","https://openalex.org/W3041424501","https://openalex.org/W6884910473","https://openalex.org/W2509320190","https://openalex.org/W2622667702","https://openalex.org/W7167626510","https://openalex.org/W4312038169","https://openalex.org/W4415210837","https://openalex.org/W4394729437"],"abstract_inverted_index":{"Objectives:":[0],"The":[1],"gold":[2],"standard":[3],"clinical":[4],"endpoint":[5,248],"for":[6,135,192,281,285,293,317,361,463,469],"a":[7,136,251,442],"candidate":[8],"HIV":[9,24,398],"cure":[10],"therapy":[11],"is":[12,28,254,272,390,405],"delayed":[13],"viral":[14,25,464],"rebound":[15,33,234,299,304,315,332,358,370,420],"during":[16],"analytical":[17,67],"treatment":[18],"interruption":[19],"(ATI).":[20],"While":[21],"in":[22,60,83,386,474],"ATI,":[23],"load":[26,465],"(VL)":[27],"monitored":[29],"frequently":[30],"to":[31,35,69,113,147,169,187,223,231,257,347,394,429],"detect":[32],"(visits":[34],"clinic":[36],"every":[37],"1-2":[38],"weeks).":[39],"At-home":[40],"sampling":[41,76,461,473],"would":[42,249],"allow":[43,468],"the":[44,180,207,220,294,324,383,387,406,432,436],"reduction":[45],"on":[46,236],"participant":[47],"burden":[48],"and":[49,52,72,97,107,141,173,392,411,446,466],"study":[50],"complexity":[51],"dry":[53],"blood":[54],"(db)":[55],"samples":[56,86,116,186,204,212,389],"can":[57,412,439],"be":[58,413],"used":[59],"this":[61],"case.":[62],"Here,":[63],"we":[64,178,227],"assessed":[65],"new":[66],"methods":[68,230,462],"improve":[70],"precision":[71,172],"interpretability":[73],"of":[74,78,117,138,159,183,211,264,327,345,351,375,396,409,431,458],"at-home":[75],"tools":[77],"db":[79,115,143,185,270],"VL":[80,99,289,449],"(dbVL)":[81],"samples,":[82],"particular":[84],"those":[85,133],"form":[87],"Tasso-M50":[88,122],"devices":[89,123],"[":[90,124,241],"1-":[91],"3]":[92],"Methods:":[93],"We":[94,126,244,267,379],"analyzed":[95,127],"dbVL":[96,151,175,197,217,239,282,346,388,437],"plasma":[98],"(pVL)":[100],"data":[101,128,438],"from":[102,120,129,132],"two":[103],"BEAT-HIV":[104],"trials":[105,477],"(NCT03588715":[106],"NCT03617198)":[108],"where":[109],"participants":[110,131],"collected":[111],"up":[112,146,428],"8":[114],"~40uL":[118],"each":[119,318],"2":[121,164],"1].":[125],"15":[130],"trials,":[134],"total":[137],"324":[139],"pVL":[140,203,215,233,303,335,425],"449":[142],"assays":[144,279],"(with":[145],"16":[148],"replicates).":[149],"Our":[150,298,357],"measurements":[152,166,198],"were":[153,199,364],"highly":[154],"variable":[155],"between":[156],"replicates":[157],"(66%":[158],"timepoints":[160],"contain":[161],"at":[162,206,334,367,444,459],"least":[163],"replicate":[165,416],">2-fold":[167],"apart);":[168],"examine":[170],"assay":[171,271],"asses":[174],"noise":[176,384],"levels,":[177],"compared":[179],"between-replicate":[181],"variability":[182],"our":[184,237,419,456],"6":[188],"agency-approved":[189],"assays,":[190],"correcting":[191,292],"different":[193],"input":[194,296],"volumes.":[195],"Moreover,":[196],"often":[200],"discordant":[201],"with":[202,213,415],"taken":[205],"same":[208],"time":[209],"(64%":[210],"undetectable":[214],"have":[216],"counts":[218],"above":[219],"detection":[221],"limit);":[222],"assess":[224],"such":[225],"discrepancies,":[226],"developed":[228],"non-parametric":[229],"predict":[232,423],"based":[235],"repeated":[238],"measures":[240],"2,":[242],"3].":[243],"then":[245],"tested":[246],"which":[247],"provide":[250],"prediction":[252,305,326],"that":[253,269,381,395,401,435],"most":[255],"appropriate":[256],"drive":[258],"decisions":[259],"(e.g.":[260],"threshold":[261,316],"vs.":[262],"probability":[263],"rebound)":[265,427],"Results:":[266],"showed":[268,301,380],"modestly":[273,365],"less":[274],"precise":[275],"than":[276],"commercially":[277],"approved":[278],"(43%CV":[280],"vs":[283,372],"10-33%CV,":[284],"5000-10":[286],"5":[287],"cp/mL":[288],"range),":[290],"when":[291,312],"smaller":[295],"volume.":[297],"tests":[300,359,421],"good":[302],"power":[306],"(e.g.,":[307],"ROC":[308],"curve":[309],"AUC":[310],"83%-90%":[311],"1000c/mL).":[313],"A":[314],"test":[319,337],"was":[320],"selected":[321],"by":[322],"maximizing":[323],"correct":[325,376],"low":[328,424],"pVL,":[329],"i.e.":[330],"no":[331,369],"(rebound":[333],"\u22651000c/mL,":[336],"thresholds":[338],"at:":[339],"1000c/ml":[340],"median":[341],"dbVL,":[342],"1.8":[343],"radio":[344],"background":[348,362],"medians,":[349],"p-val":[350],"0.007":[352],"Mann":[353],"Whitney":[354],"U":[355],"test).":[356],"accounting":[360],"signal":[363],"better":[366],"predicting":[368],"(0.92":[371],"0.87":[373],"proportion":[374],"predictions)":[377],"Conclusions:":[378],"(a)":[382],"observed":[385],"measurable":[391],"comparable":[393],"other":[397],"tests,":[399],"suggesting":[400,434],"small":[402],"sample":[403],"size":[404],"primary":[407],"cause":[408],"imprecision,":[410],"controlled":[414],"measurements;":[417],"(b)":[418],"correctly":[422],"(no":[426],"92%":[430],"time,":[433],"help":[440],"keep":[441],"patient":[443,471],"home":[445,460],"determine":[447],"if":[448],"has":[450],"rebounded.":[451],"This":[452],"project":[453],"further":[454],"advances":[455],"knowledge":[457],"may":[467],"improved":[470],"centric":[472],"future":[475],"ATI":[476]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-02-19T00:00:00"}
