{"id":"https://openalex.org/W4407687531","doi":"https://doi.org/10.15760/etd.3852","title":"Characterizing the Influence of Metabolism on Steady State Water Exchange in Yeast as a Potential MRI Diagnostic Biomarker","display_name":"Characterizing the Influence of Metabolism on Steady State Water Exchange in Yeast as a Potential MRI Diagnostic Biomarker","publication_year":2024,"publication_date":"2024-10-09","ids":{"openalex":"https://openalex.org/W4407687531","doi":"https://doi.org/10.15760/etd.3852"},"language":"en","primary_location":{"id":"doi:10.15760/etd.3852","doi":"https://doi.org/10.15760/etd.3852","is_oa":false,"landing_page_url":"https://doi.org/10.15760/etd.3852","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Portland State University","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087283726","display_name":"Sunni L. Mumford","orcid":"https://orcid.org/0000-0003-0133-3176","observed_orcids":["https://orcid.org/0000-0003-0133-3176"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mumford, Samantha","raw_affiliation_strings":["Portland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland State University","institution_ids":["https://openalex.org/I126345244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087283726"],"corresponding_institution_ids":["https://openalex.org/I126345244"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h-atpase","display_name":"H+-ATPase","score":0.7609999775886536},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8370000123977661},{"id":"https://openalex.org/keywords/chemostat-culture","display_name":"chemostat culture","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glucose-levels","display_name":"glucose concentration","score":0.6259999871253967},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mitochondrial-inhibitors","display_name":"mitochondrial inhibitors","score":0.6639999747276306},{"id":"https://openalex.org/keywords/oligomycin-a","display_name":"oligomycin A","score":0.7839999794960022},{"id":"https://openalex.org/keywords/2-4-dinitrophenol","display_name":"2,4-dinitrophenol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hormesis","display_name":"hormesis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mri-biomarkers","display_name":"MRI biomarkers","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6865358948707581},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5935144424438477},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4123304784297943},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33317410945892334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33079326152801514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32951074838638306},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15457379817962646}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15760/etd.3852","doi":"https://doi.org/10.15760/etd.3852","is_oa":false,"landing_page_url":"https://doi.org/10.15760/etd.3852","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Portland State University","raw_type":"dissertation"},{"id":"pmh:oai:pdxscholar.library.pdx.edu:open_access_etds-7819","doi":null,"is_oa":false,"landing_page_url":"https://pdxscholar.library.pdx.edu/open_access_etds/6730","pdf_url":null,"source":{"id":"https://openalex.org/S4377196300","display_name":"PDXScholar  (Portland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126345244","host_organization_name":"Portland State University","host_organization_lineage":["https://openalex.org/I126345244"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations and Theses","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7018842834","https://openalex.org/W4416934716","https://openalex.org/W4390063539","https://openalex.org/W2111446513","https://openalex.org/W2043359240","https://openalex.org/W2042466073","https://openalex.org/W2892661543","https://openalex.org/W2984219364","https://openalex.org/W1025443955","https://openalex.org/W2065872661"],"abstract_inverted_index":{"Under":[0],"conditions":[1],"of":[2,103,113,155,161,168,200,225,263,320,326,331,335,388,391],"ionic":[3],"equilibrium":[4],"with":[5,19],"the":[6,20,64,69,92,109,129,133,176,182,310,324,333],"environment":[7],"a":[8,11,81,122,159,306,367,394],"cell":[9,65,198,247],"maintains":[10],"constant":[12,25],"volume":[13],"yet":[14],"rapidly":[15],"exchanges":[16],"water":[17,29,43],"molecules":[18],"extracellular":[21],"space.":[22],"The":[23,41,101,125,237,270,291,313,386],"rate":[24],"for":[26,85,175,289,309],"steady":[27],"state":[28,203],"efflux,":[30],"kio,":[31,294],"can":[32,242],"be":[33,80,243,257,279],"measured":[34,398],"using":[35,117],"contrast":[36],"enhanced":[37],"magnetic":[38],"resonance":[39],"(CE-MR).":[40],"active":[42],"cycling":[44],"(AWC)":[45],"hypothesis":[46,127,131,178],"is":[47,52,77,106,128,170,316,374],"puts":[48],"forward":[49],"that":[50,95,185,240,276],"kio":[51,72,76,97,116,226,241,277,344],"primarily":[53],"influenced":[54],"by":[55,318],"cellular":[56,295],"ATP":[57,74,231,296,346,365,399],"levels":[58,232,347],"and":[59,73,135,157,179,207,260,266,285,298,340,345,382],"H+":[60],"ATPase":[61],"activity":[62,300],"at":[63],"membrane.":[66],"Due":[67],"to":[68,79,107,172,213,229,234,245,256,281,351,361,377],"correlation":[70],"between":[71,293],"levels,":[75],"thought":[78],"probable":[82],"MRI":[83],"biomarker":[84],"metabolic":[86,111,162,202,251,268,307],"diseases":[87],"such":[88],"as":[89,121,305],"cancer.":[90,290],"Yet,":[91],"molecular":[93,110,183],"mechanisms":[94,184],"drive":[96,186],"remain":[98],"incompletely":[99],"understood.":[100],"objective":[102],"this":[104,189],"work":[105,190],"understand":[108],"origins":[112],"differences":[114],"in":[115,132,145,195,227,303,323,364,370],"yeast":[118,139,191,304,332,378],"(S.":[119],"cerevisiae)":[120],"model":[123,308],"organism.":[124],"AWC":[126,177],"main":[130],"field":[134],"came":[136],"about":[137],"when.":[138],"cells":[140,156,169,192,221],"were":[141,193,211],"observed":[142],"when":[143],"grown":[144,194],"batch":[146,149],"culture.":[147],"However,":[148],"culture":[150,199],"yields":[151],"an":[152,362],"inhomogeneous":[153],"population":[154],"promotes":[158],"changing":[160],"profile":[163],"overtime.":[164],"A":[165,358],"homogenous":[166],"platform":[167],"required":[171],"provide":[173],"support":[174],"further":[180,384],"characterize":[181],"kio.":[187,371],"In":[188],"chemostats,":[196],"where":[197],"uniform":[201],"was":[204,301,348],"obtained.":[205],"Low":[206],"high":[208],"glucose":[209],"concentrations":[210,390],"used":[212,244,280],"promote":[214],"distinct":[215,355],"metabolisms:":[216],"respiratory":[217],"or":[218],"fermentative.":[219],"Respiring":[220],"demonstrated":[222],"higher":[223],"values":[224],"addition":[228,387],"greater":[230],"compared":[233],"respiro-fermenting":[235],"cells.":[236],"results":[238],"indicate":[239],"differentiate":[246],"cultures":[248,330],"utilizing":[249],"different":[250],"pathways.":[252],"Tumors":[253],"are":[254],"known":[255],"metabolically":[258],"heterogonous":[259],"exhibit":[261],"regions":[262,284],"both":[264],"fermentative":[265],"hyper-respiratory":[267],"state.":[269],"experiments":[271],"presented":[272],"here":[273],"presumably":[274],"suggest":[275],"could":[278],"delineate":[282],"these":[283],"inform":[286],"targeted":[287],"treatment":[288],"relationship":[292],"concentration,":[297],"mitochondrial":[299,336,352],"investigated":[302],"Warburg":[311,314],"effect.":[312],"effect":[315,396],"defined":[317],"upregulation":[319],"fermentation,":[321],"even":[322],"presence":[325],"oxygen.":[327],"Using":[328],"chemostat":[329],"impact":[334],"modulators":[337],"(2,4-Dinitrophenol":[338],"(DNP)":[339],"oligomycin":[341,380],"A)":[342],"on":[343,397],"investigated.":[349],"Exposure":[350],"inhibitors":[353],"elicited":[354],"responses:":[356],"Oligomycin":[357],"exposure":[359],"led":[360],"increase":[363],"but":[366],"weaker":[368],"response":[369],"This":[372],"result":[373],"likely":[375],"due":[376],"exhibiting":[379],"resistance":[381],"requires":[383],"investigation.":[385],"increasing":[389],"DNP":[392],"caused":[393],"hormetic":[395]},"counts_by_year":[],"updated_date":"2026-06-25T06:16:34.145877","created_date":"2025-02-19T00:00:00"}