{"id":"https://openalex.org/W4407685250","doi":"https://doi.org/10.1002/jmr.70003","title":"Signal Transduction by Phase Separation\u2014Unnoticed Revolution in Molecular Biology","display_name":"Signal Transduction by Phase Separation\u2014Unnoticed Revolution in Molecular Biology","publication_year":2025,"publication_date":"2025-02-18","ids":{"openalex":"https://openalex.org/W4407685250","doi":"https://doi.org/10.1002/jmr.70003","pmid":"https://pubmed.ncbi.nlm.nih.gov/39965630"},"language":"en","primary_location":{"id":"doi:10.1002/jmr.70003","doi":"https://doi.org/10.1002/jmr.70003","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmr.70003","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmr.70003","source":{"id":"https://openalex.org/S205370667","display_name":"Journal of Molecular Recognition","issn_l":"0952-3499","issn":["0952-3499","1099-1352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Recognition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmr.70003","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015518861","display_name":"Semen V. Nesterov","orcid":"https://orcid.org/0000-0002-4215-9963","observed_orcids":["https://orcid.org/0000-0002-4215-9963"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]},{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Semen V. Nesterov","raw_affiliation_strings":["Kurchatov Complex of NBICS-Technologies, National Research Center Kurchatov Institute, Moscow, Russia","Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia","Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy Pereulok, Dolgoprudny, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kurchatov Complex of NBICS-Technologies, National Research Center Kurchatov Institute, Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]},{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]},{"raw_affiliation_string":"Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy Pereulok, Dolgoprudny, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022117115","display_name":"Nikolay S. Ilyinsky","orcid":"https://orcid.org/0000-0002-8812-5849","observed_orcids":["https://orcid.org/0000-0002-8812-5849"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolay S. Ilyinsky","raw_affiliation_strings":["Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy Pereulok, Dolgoprudny, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy Pereulok, Dolgoprudny, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084662018","display_name":"Alexander V. Fonin","orcid":"https://orcid.org/0000-0003-4469-2531","observed_orcids":["https://orcid.org/0000-0003-4469-2531"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210104940","display_name":"Institute of Cytology","ror":"https://ror.org/01p3q4q56","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104940","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander V. Fonin","raw_affiliation_strings":["Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210104940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083199032","display_name":"Vladimir Nikolaevich Uversky","orcid":"https://orcid.org/0000-0002-4037-5857","observed_orcids":["https://orcid.org/0000-0002-4037-5857"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210140006","display_name":"USF Health Byrd Alzheimer's Institute","ror":"https://ror.org/048768v87","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210140006"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir N. Uversky","raw_affiliation_strings":["Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-4037-5857","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I4210140006"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015518861","https://openalex.org/A5083199032"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I153845743","https://openalex.org/I2613432","https://openalex.org/I2800235667","https://openalex.org/I4210104940","https://openalex.org/I4210140006"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":3.8806,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.94629316,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"38","issue":"2","first_page":"e70003","last_page":"e70003"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0568000003695488,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-liquid-phase-separation","display_name":"liquid-liquid phase separation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8709999918937683},{"id":"https://openalex.org/keywords/biomolecular-condensates","display_name":"biomolecular condensates","score":0.9520000219345093},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8999999761581421},{"id":"https://openalex.org/keywords/membrane-binding-proteins","display_name":"membrane-binding proteins","score":0.8090000152587891},{"id":"https://openalex.org/keywords/transmembrane-signaling","display_name":"transmembrane signaling","score":0.9229999780654907},{"id":"https://openalex.org/keywords/membrane-compartmentalization","display_name":"membrane compartmentalization","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.8627122640609741},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7183451652526855},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.6687964200973511},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5481921434402466},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.532270073890686},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5305172801017761},{"id":"https://openalex.org/C178300618","wikidata":"https://www.wikidata.org/wiki/Q1898509","display_name":"Extant taxon","level":2,"score":0.5086649060249329},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5028042793273926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49610695242881775},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.43849048018455505},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.4191305637359619},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4163636863231659},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4055519700050354},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.361493319272995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3359054625034332},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3341640830039978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2473028302192688},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21932297945022583},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.10460463166236877},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095496","descriptor_name":"Phase Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jmr.70003","doi":"https://doi.org/10.1002/jmr.70003","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmr.70003","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmr.70003","source":{"id":"https://openalex.org/S205370667","display_name":"Journal of Molecular Recognition","issn_l":"0952-3499","issn":["0952-3499","1099-1352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Recognition","raw_type":"journal-article"},{"id":"pmid:39965630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39965630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular recognition : JMR","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jmr.70003","doi":"https://doi.org/10.1002/jmr.70003","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmr.70003","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmr.70003","source":{"id":"https://openalex.org/S205370667","display_name":"Journal of Molecular Recognition","issn_l":"0952-3499","issn":["0952-3499","1099-1352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Recognition","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3733575368","display_name":null,"funder_award_id":"23\u201045\u201000041","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407685250.pdf","grobid_xml":"https://content.openalex.org/works/W4407685250.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2021874838","https://openalex.org/W2049315117","https://openalex.org/W2061021274","https://openalex.org/W2172098255","https://openalex.org/W2270516315","https://openalex.org/W2275093375","https://openalex.org/W2335345046","https://openalex.org/W2949816023","https://openalex.org/W3012073806","https://openalex.org/W3031257155","https://openalex.org/W3159305558","https://openalex.org/W3178621961","https://openalex.org/W3186741035","https://openalex.org/W3193644145","https://openalex.org/W3202257805","https://openalex.org/W4200467183","https://openalex.org/W4220743971","https://openalex.org/W4283816558","https://openalex.org/W4307290996","https://openalex.org/W4313594712","https://openalex.org/W4315781347","https://openalex.org/W4362457999","https://openalex.org/W4367059102","https://openalex.org/W4385282365","https://openalex.org/W4386203823","https://openalex.org/W4388421094","https://openalex.org/W4389305250","https://openalex.org/W4390052503","https://openalex.org/W4392990415"],"related_works":["https://openalex.org/W4308798329","https://openalex.org/W3202257805","https://openalex.org/W3118362723","https://openalex.org/W4394742477","https://openalex.org/W2508376386","https://openalex.org/W2924206910","https://openalex.org/W4407898239","https://openalex.org/W7130545725","https://openalex.org/W7118018513","https://openalex.org/W3191096373"],"abstract_inverted_index":{"Recent":[0],"scientific":[1],"findings":[2],"highlight":[3],"the":[4,13,21,70,81,91],"crucial":[5],"role":[6,100],"of":[7,15,20,50,80,119],"liquid-liquid":[8],"phase":[9,32],"separation":[10,33],"(LLPS)":[11],"in":[12,37,42,101,105,117],"compartmentalization":[14],"enzyme":[16],"systems.":[17,45],"A":[18],"synthesis":[19],"extant":[22],"data":[23],"indicates":[24],"that":[25,95],"lipid":[26,84],"rafts":[27],"and":[28],"condensates":[29,73],"formed":[30],"by":[31],"are":[34],"also":[35],"implicated":[36],"signal":[38,88,121],"transduction,":[39],"including":[40],"participation":[41],"recognized":[43],"receptor":[44],"The":[46,93],"intrinsically":[47],"disordered":[48],"nature":[49],"many":[51],"membrane-binding":[52],"proteins,":[53],"coupled":[54],"with":[55],"their":[56],"propensity":[57],"for":[58],"LLPS,":[59],"provides":[60],"condensate":[61],"formation,":[62],"which":[63],"can":[64,74],"bind":[65],"to":[66],"or":[67],"form":[68,75],"on":[69,77],"membranes.":[71],"Moreover,":[72],"simultaneously":[76],"both":[78],"sides":[79],"membrane":[82],"at":[83],"raft":[85],"regions":[86],"facilitating":[87],"transmission":[89],"across":[90],"membrane.":[92],"finding":[94],"LLPS":[96],"plays":[97],"a":[98,111],"direct":[99],"cell":[102],"signaling,":[103],"especially":[104],"well-defined":[106],"transmembrane":[107],"signaling":[108],"pathways,":[109],"represents":[110],"substantial,":[112],"yet":[113],"largely":[114],"unrecognized,":[115],"advancement":[116],"understanding":[118],"intracellular":[120],"transduction":[122],"mechanisms.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-19T00:00:00"}
