{"id":"https://openalex.org/W4407680972","doi":"https://doi.org/10.26442/18151434.2024.4.202908","title":"The molecular basis of thyroid status formation and its role in the initiation and promotion of gastric and colorectal cancer: A review","display_name":"The molecular basis of thyroid status formation and its role in the initiation and promotion of gastric and colorectal cancer: A review","publication_year":2025,"publication_date":"2025-02-18","ids":{"openalex":"https://openalex.org/W4407680972","doi":"https://doi.org/10.26442/18151434.2024.4.202908"},"language":"en","primary_location":{"id":"doi:10.26442/18151434.2024.4.202908","doi":"https://doi.org/10.26442/18151434.2024.4.202908","is_oa":true,"landing_page_url":"https://doi.org/10.26442/18151434.2024.4.202908","pdf_url":"https://modernonco.orscience.ru/1815-1434/article/download/654052/169892","source":{"id":"https://openalex.org/S4210239067","display_name":"Journal of Modern Oncology","issn_l":"1815-1434","issn":["1815-1434","1815-1442"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Modern Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://modernonco.orscience.ru/1815-1434/article/download/654052/169892","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078058918","display_name":"\u0421\u0442\u0430\u043d\u043e\u0435\u0432\u0438\u0447 \u0418\u0440\u0438\u043d\u0430 \u0412\u0430\u0441\u0438\u043b\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-9681-672X","observed_orcids":["https://orcid.org/0000-0002-9681-672X"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina V. Stanoevich","raw_affiliation_strings":["Endocrinology Research Centre","Kursk State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-9681-672X","affiliations":[{"raw_affiliation_string":"Endocrinology Research Centre","institution_ids":[]},{"raw_affiliation_string":"Kursk State Medical University","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027744300","display_name":"\u0412. \u0410. \u0418\u043e\u0443\u0442\u0441\u0438","orcid":"https://orcid.org/0000-0001-9002-1662","observed_orcids":["https://orcid.org/0000-0001-9002-1662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vitaliy A. Ioutsi","raw_affiliation_strings":["Endocrinology Research Centre"],"raw_orcid":"https://orcid.org/0000-0001-9002-1662","affiliations":[{"raw_affiliation_string":"Endocrinology Research Centre","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093282723","display_name":"\u041b\u044b\u0441\u043e\u0432\u043e\u043b\u0435\u043d\u043a\u043e \u041d\u0430\u0442\u0430\u043b\u044c\u044f \u041b\u0435\u043e\u043d\u0438\u0434\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0001-7747-2784","observed_orcids":["https://orcid.org/0000-0001-7747-2784"]},"institutions":[{"id":"https://openalex.org/I4210138864","display_name":"Kursk Regional Clinical Oncology Center","ror":"https://ror.org/03qacnx75","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210138864"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalya L. Lysovolenko","raw_affiliation_strings":["Ostroverkhov Kursk Oncology Scientific And Clinical Center"],"raw_orcid":"https://orcid.org/0000-0001-7747-2784","affiliations":[{"raw_affiliation_string":"Ostroverkhov Kursk Oncology Scientific And Clinical Center","institution_ids":["https://openalex.org/I4210138864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102719506","display_name":"\u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432 \u0418\u043b\u044c\u044f \u042d\u043c\u0437\u0430\u0440\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0003-3745-0307","observed_orcids":["https://orcid.org/0000-0003-3745-0307"]},"institutions":[{"id":"https://openalex.org/I4210138864","display_name":"Kursk Regional Clinical Oncology Center","ror":"https://ror.org/03qacnx75","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210138864"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ilya E. Alekseev","raw_affiliation_strings":["Ostroverkhov Kursk Oncology Scientific And Clinical Center"],"raw_orcid":"https://orcid.org/0000-0003-3745-0307","affiliations":[{"raw_affiliation_string":"Ostroverkhov Kursk Oncology Scientific And Clinical Center","institution_ids":["https://openalex.org/I4210138864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094211158","display_name":"\u041a\u043e\u043d\u0434\u0440\u0430\u0448\u043a\u0438\u043d\u0430 \u0410\u043b\u0438\u043d\u0430 \u0414\u043c\u0438\u0442\u0440\u0438\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0009-9271-7810","observed_orcids":["https://orcid.org/0009-0009-9271-7810"]},"institutions":[{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alina D. Kondrashkina","raw_affiliation_strings":["Kursk State Medical University"],"raw_orcid":"https://orcid.org/0009-0009-9271-7810","affiliations":[{"raw_affiliation_string":"Kursk State Medical University","institution_ids":["https://openalex.org/I44327541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065132897","display_name":"Maxim Borisovich Polyansky","orcid":"https://orcid.org/0000-0002-5996-6024","observed_orcids":["https://orcid.org/0000-0002-5996-6024"]},"institutions":[{"id":"https://openalex.org/I4210138864","display_name":"Kursk Regional Clinical Oncology Center","ror":"https://ror.org/03qacnx75","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210138864"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maksim B. Polyansky","raw_affiliation_strings":["Ostroverkhov Kursk Oncology Scientific And Clinical Center"],"raw_orcid":"https://orcid.org/0000-0002-5996-6024","affiliations":[{"raw_affiliation_string":"Ostroverkhov Kursk Oncology Scientific And Clinical Center","institution_ids":["https://openalex.org/I4210138864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009326616","display_name":"\u0415. \u0412. \u041f\u0438\u0441\u044c\u043c\u0435\u043d\u043d\u0430\u044f","orcid":"https://orcid.org/0009-0004-6417-1949","observed_orcids":["https://orcid.org/0009-0004-6417-1949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina V. Pis'mennaia","raw_affiliation_strings":["Ministry of Health of the Kursk Region"],"raw_orcid":"https://orcid.org/0009-0004-6417-1949","affiliations":[{"raw_affiliation_string":"Ministry of Health of the Kursk Region","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":630,"currency":"EUR","value_usd":679},"apc_paid":{"value":630,"currency":"EUR","value_usd":679},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"4","first_page":"478","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.9789999723434448},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.6930000185966492},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.7250000238418579},{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.871999979019165},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/iodine-intake","display_name":"iodine intake","score":0.7039999961853027},{"id":"https://openalex.org/keywords/deiodinases","display_name":"deiodinases","score":0.8019999861717224},{"id":"https://openalex.org/keywords/iodinated-contrast-media","display_name":"iodinated contrast media","score":0.6330000162124634},{"id":"https://openalex.org/keywords/radiation-induced-thyroid-disease","display_name":"radiation-induced thyroid disease","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6052648425102234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5834546089172363},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5207971930503845},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5167026519775391},{"id":"https://openalex.org/C98147612","wikidata":"https://www.wikidata.org/wiki/Q215599","display_name":"Promotion (chess)","level":3,"score":0.5155025124549866},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4408329129219055},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4269792437553406},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4258328080177307},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.4166856110095978},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.07992851734161377},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26442/18151434.2024.4.202908","doi":"https://doi.org/10.26442/18151434.2024.4.202908","is_oa":true,"landing_page_url":"https://doi.org/10.26442/18151434.2024.4.202908","pdf_url":"https://modernonco.orscience.ru/1815-1434/article/download/654052/169892","source":{"id":"https://openalex.org/S4210239067","display_name":"Journal of Modern Oncology","issn_l":"1815-1434","issn":["1815-1434","1815-1442"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Modern Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.26442/18151434.2024.4.202908","doi":"https://doi.org/10.26442/18151434.2024.4.202908","is_oa":true,"landing_page_url":"https://doi.org/10.26442/18151434.2024.4.202908","pdf_url":"https://modernonco.orscience.ru/1815-1434/article/download/654052/169892","source":{"id":"https://openalex.org/S4210239067","display_name":"Journal of Modern Oncology","issn_l":"1815-1434","issn":["1815-1434","1815-1442"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Modern Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407680972.pdf","grobid_xml":"https://content.openalex.org/works/W4407680972.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1972878113","https://openalex.org/W1979576102","https://openalex.org/W2044085818","https://openalex.org/W2071596157","https://openalex.org/W2114830434","https://openalex.org/W2118994157","https://openalex.org/W2140066648","https://openalex.org/W2142345434","https://openalex.org/W2159336253","https://openalex.org/W2165821124","https://openalex.org/W2405920067","https://openalex.org/W2474553105","https://openalex.org/W2611647435","https://openalex.org/W2808596768","https://openalex.org/W2950995063","https://openalex.org/W2981893043","https://openalex.org/W2997901286","https://openalex.org/W3021924627","https://openalex.org/W3036565822","https://openalex.org/W3046498709","https://openalex.org/W3091985994","https://openalex.org/W3118856666","https://openalex.org/W3121364493","https://openalex.org/W3168557754","https://openalex.org/W4282932056","https://openalex.org/W4285021128"],"related_works":["https://openalex.org/W1972878113","https://openalex.org/W7127601486","https://openalex.org/W2107887155","https://openalex.org/W2894824168","https://openalex.org/W2095132001","https://openalex.org/W2443133650","https://openalex.org/W2066650794","https://openalex.org/W2131775058","https://openalex.org/W2942966139","https://openalex.org/W2735654257"],"abstract_inverted_index":{"The":[0,133,194],"concept":[1],"of":[2,12,28,37,49,57,64,74,116,125,135,180,196],"thyroid":[3,13,19,69,93,155,172,181],"status":[4,70,94,182],"is":[5,83,138,192,205],"much":[6],"broader":[7],"than":[8],"assessing":[9],"the":[10,22,44,54,62,65,72,80,123],"levels":[11],"stimulating":[14],"hormone,":[15],"free":[16,105],"and":[17,39,53,77,108,151,167,170,177,189],"bound":[18],"hormones":[20],"in":[21,51,79,99,104,121,127,140,143,187,207],"systemic":[23],"circulation.":[24],"It":[25,174],"includes":[26],"features":[27],"transport,":[29],"tissue":[30],"bioavailability,":[31],"receptor":[32],"interaction,":[33],"metabolism,":[34],"biomolecular":[35],"mechanisms":[36,66],"action":[38],"inactivation,":[40],"as":[41,43],"well":[42],"physiological":[45,176],"or":[46,147],"pathophysiological":[47],"basis":[48],"changes":[50],"function":[52],"pathomorphological":[55],"substrate":[56],"diseases,":[58],"including":[59],"malignancies.":[60],"Therefore,":[61],"question":[63],"through":[67],"which":[68],"influences":[71],"processes":[73],"tumor":[75],"initiation":[76],"promotion":[78],"gastrointestinal":[81],"tract":[82],"extremely":[84],"relevant.":[85],"Regarding":[86],"colorectal":[87],"cancer,":[88,119],"an":[89,102],"ambiguous":[90],"link":[91],"between":[92,165],"has":[95],"been":[96],"identified":[97],"\u2013":[98],"some":[100],"studies,":[101],"increase":[103],"T4":[106],"concentration":[107],"thyrotoxicosis":[109],"are":[110],"associated":[111],"with":[112,145],"a":[113,130],"decreased":[114],"risk":[115,134],"developing":[117],"colon":[118,168,190],"while":[120],"others,":[122],"administration":[124],"levothyroxine":[126],"hypothyroidism":[128],"had":[129],"protective":[131],"effect.":[132],"gastric":[136,166,188],"cancer":[137,169,191],"elevated":[139],"men":[141],"living":[142],"regions":[144],"suboptimal":[146],"above-normal":[148],"iodine":[149],"consumption":[150],"suffering":[152],"from":[153],"various":[154],"pathologies.":[156],"This":[157],"paper":[158],"analyzes":[159],"modern":[160],"ideas":[161],"about":[162],"pathogenetic":[163],"relationship":[164],"patients'":[171],"status.":[173],"presents":[175],"biochemical":[178],"basics":[179],"formation.":[183],"Deiodinase":[184],"expression":[185],"profile":[186],"stated.":[193],"problem":[195],"iodine-induced":[197],"disthyroidoses":[198],"following":[199],"radiation":[200],"procedures":[201],"using":[202],"iodine-containing":[203],"contrasts":[204],"described":[206],"detail.":[208]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-02-18T00:00:00"}
