{"id":"https://openalex.org/W4407624554","doi":"https://doi.org/10.1080/2162402x.2025.2466305","title":"Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses","display_name":"Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses","publication_year":2025,"publication_date":"2025-02-17","ids":{"openalex":"https://openalex.org/W4407624554","doi":"https://doi.org/10.1080/2162402x.2025.2466305","pmid":"https://pubmed.ncbi.nlm.nih.gov/39960413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11834457"},"language":"en","primary_location":{"id":"doi:10.1080/2162402x.2025.2466305","doi":"https://doi.org/10.1080/2162402x.2025.2466305","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2025.2466305","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2025.2466305?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2025.2466305?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034405699","display_name":"Rita Turpin","orcid":"https://orcid.org/0000-0002-5094-5032","observed_orcids":["https://orcid.org/0000-0002-5094-5032"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Rita Turpin","raw_affiliation_strings":["University of Helsinki","University of Turku","Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"University of Turku","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036333727","display_name":"Karita Peltonen","orcid":"https://orcid.org/0000-0002-3063-451X","observed_orcids":["https://orcid.org/0000-0002-3063-451X"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Karita Peltonen","raw_affiliation_strings":["University of Helsinki","University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038472240","display_name":"Jenna H. Rannikko","orcid":"https://orcid.org/0000-0002-9506-9099","observed_orcids":["https://orcid.org/0000-0002-9506-9099"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jenna H. Rannikko","raw_affiliation_strings":["University of Turku","MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turku","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089208734","display_name":"Ruixian Liu","orcid":"https://orcid.org/0000-0002-3065-6743","observed_orcids":["https://orcid.org/0000-0002-3065-6743"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ruixian Liu","raw_affiliation_strings":["University of Helsinki","Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011433584","display_name":"Anita N. Kumari","orcid":"https://orcid.org/0009-0004-1763-1914","observed_orcids":["https://orcid.org/0009-0004-1763-1914"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anita N. Kumari","raw_affiliation_strings":["University of Helsinki","University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","Translational Immunology Research Program, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063658514","display_name":"Daniel Nicorici","orcid":"https://orcid.org/0000-0002-0278-8263","observed_orcids":["https://orcid.org/0000-0002-0278-8263"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Daniel Nicorici","raw_affiliation_strings":["University of Helsinki","Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071827538","display_name":"Moon Hee Lee","orcid":"https://orcid.org/0000-0002-3778-0237","observed_orcids":["https://orcid.org/0000-0002-3778-0237"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Moon Hee Lee","raw_affiliation_strings":["University of Helsinki","University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","Translational Immunology Research Program, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070723796","display_name":"Minna Mutka","orcid":"https://orcid.org/0000-0002-8380-7293","observed_orcids":["https://orcid.org/0000-0002-8380-7293"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Minna Mutka","raw_affiliation_strings":["Helsinki University Central Hospital and University of Helsinki","Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Central Hospital and University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009137826","display_name":"Panu E. Kovanen","orcid":"https://orcid.org/0000-0001-8218-2271","observed_orcids":["https://orcid.org/0000-0001-8218-2271"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Panu E. Kovanen","raw_affiliation_strings":["Helsinki University Central Hospital and University of Helsinki","Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Central Hospital and University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025650421","display_name":"Laura Niinikoski","orcid":"https://orcid.org/0000-0002-0838-2918","observed_orcids":["https://orcid.org/0000-0002-0838-2918"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Laura Niinikoski","raw_affiliation_strings":["Helsinki University Hospital and University of Helsinki","Division of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital and University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Division of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013569815","display_name":"Tuomo J Meretoja","orcid":"https://orcid.org/0000-0002-2691-0710","observed_orcids":["https://orcid.org/0000-0002-2691-0710"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tuomo Meretoja","raw_affiliation_strings":["Helsinki University Hospital and University of Helsinki","Division of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital and University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Division of Breast Surgery, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055312147","display_name":"Johanna Mattson","orcid":"https://orcid.org/0000-0002-9719-9110","observed_orcids":["https://orcid.org/0000-0002-9719-9110"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johanna Mattson","raw_affiliation_strings":["Helsinki University Hospital and University of Helsinki","Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital and University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091417565","display_name":"Petrus J\u00e4rvinen","orcid":"https://orcid.org/0000-0002-3751-4609","observed_orcids":["https://orcid.org/0000-0002-3751-4609"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Petrus J\u00e4rvinen","raw_affiliation_strings":["Helsinki University and Helsinki University Hospital","Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University and Helsinki University Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066761821","display_name":"Kanerva Lahdensuo","orcid":"https://orcid.org/0000-0003-0510-3546","observed_orcids":["https://orcid.org/0000-0003-0510-3546"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kanerva Lahdensuo","raw_affiliation_strings":["Helsinki University and Helsinki University Hospital","Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University and Helsinki University Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034476631","display_name":"Riikka J\u00e4rvinen","orcid":"https://orcid.org/0000-0001-6182-9793","observed_orcids":["https://orcid.org/0000-0001-6182-9793"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Riikka J\u00e4rvinen","raw_affiliation_strings":["Helsinki University and Helsinki University Hospital","Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University and Helsinki University Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068890772","display_name":"Sara Tornberg","orcid":"https://orcid.org/0000-0002-9666-2126","observed_orcids":["https://orcid.org/0000-0002-9666-2126"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sara Tornberg","raw_affiliation_strings":["Helsinki University and Helsinki University Hospital","Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University and Helsinki University Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Abdominal Center, Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040800642","display_name":"Tuomas K. Mirtti","orcid":"https://orcid.org/0000-0003-0455-9891","observed_orcids":["https://orcid.org/0000-0003-0455-9891"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tuomas Mirtti","raw_affiliation_strings":["Helsinki University Hospital and Research Program in Systems Oncology, University of Helsinki","Department of Pathology, Helsinki University Hospital and Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital and Research Program in Systems Oncology, University of Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Department of Pathology, Helsinki University Hospital and Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045732432","display_name":"Pia Bostr\u00f6m","orcid":"https://orcid.org/0000-0002-0611-3319","observed_orcids":["https://orcid.org/0000-0002-0611-3319"]},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pia Bostr\u00f6m","raw_affiliation_strings":["Turku University Hospital","Department of Pathology, Turku University Hospital, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku University Hospital","institution_ids":["https://openalex.org/I2801970007"]},{"raw_affiliation_string":"Department of Pathology, Turku University Hospital, Turku, Finland","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056454373","display_name":"Ilkka Koskivuo","orcid":"https://orcid.org/0000-0002-7186-1954","observed_orcids":["https://orcid.org/0000-0002-7186-1954"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ilkka Koskivuo","raw_affiliation_strings":["Turku University Hospital and University of Turku","Department of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku University Hospital and University of Turku","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"]},{"raw_affiliation_string":"Department of Digestive Surgery and Urology, Turku University Hospital and University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108235446","display_name":"Anil K. Thotakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]},{"id":"https://openalex.org/I81672605","display_name":"Orion Corporation (United Kingdom)","ror":"https://ror.org/01ny43313","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210118237","https://openalex.org/I81672605"]}],"countries":["FI","GB"],"is_corresponding":false,"raw_author_name":"Anil Thotakura","raw_affiliation_strings":["Orion Corporation","Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion Corporation","institution_ids":["https://openalex.org/I4210118237","https://openalex.org/I81672605"]},{"raw_affiliation_string":"Immuno-Oncology, Oncology Research, Orion Corporation, Turku, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075171256","display_name":"Jeroen Pouwels","orcid":"https://orcid.org/0000-0002-5388-6103","observed_orcids":["https://orcid.org/0000-0002-5388-6103"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jeroen Pouwels","raw_affiliation_strings":["University of Helsinki","Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075137021","display_name":"Maija Hollm\u00e9n","orcid":"https://orcid.org/0000-0002-3250-7653","observed_orcids":["https://orcid.org/0000-0002-3250-7653"]},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Maija Hollm\u00e9n","raw_affiliation_strings":["University of Turku","MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turku","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"MediCity Research Laboratory and InFLAMES Flagship, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008868111","display_name":"Satu M. Mustjoki","orcid":"https://orcid.org/0000-0002-0816-8241","observed_orcids":["https://orcid.org/0000-0002-0816-8241"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Satu Mustjoki","raw_affiliation_strings":["University of Helsinki","University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Translational Immunology Research Program, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074241901","display_name":"Juha T. Klefstr\u00f6m","orcid":"https://orcid.org/0000-0001-7124-8431","observed_orcids":["https://orcid.org/0000-0001-7124-8431"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4405268884","display_name":"Finnish Cancer Institute","ror":"https://ror.org/02cwbja97","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4405268884"]}],"countries":["FI","US"],"is_corresponding":true,"raw_author_name":"Juha Klefstr\u00f6m","raw_affiliation_strings":["Finnish Cancer Institute","Helsinki University Hospital","University of California","University of Helsinki","Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","Department of Cell & Tissue Biology, University of California, San Francisco, USA","FICAN South, Helsinki University Hospital, Helsinki, Finland","Finnish Cancer Institute, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-7124-8431","affiliations":[{"raw_affiliation_string":"Finnish Cancer Institute","institution_ids":["https://openalex.org/I4405268884"]},{"raw_affiliation_string":"Helsinki University Hospital","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"University of California","institution_ids":["https://openalex.org/I2803209242"]},{"raw_affiliation_string":"University of Helsinki","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Cancer Cell Circuitry Laboratory, Translational Cancer Medicine, Medical Faculty, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Cell & Tissue Biology, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"FICAN South, Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Finnish Cancer Institute, Helsinki, Finland","institution_ids":["https://openalex.org/I4405268884"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5074241901"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I180670191","https://openalex.org/I2800394112","https://openalex.org/I2803209242","https://openalex.org/I4405268884"],"apc_list":{"value":2375,"currency":"GBP","value_usd":2913},"apc_paid":{"value":2375,"currency":"GBP","value_usd":2913},"fwci":4.4987,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.95568141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"2466305","last_page":"2466305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9430000185966492},{"id":"https://openalex.org/keywords/patient-derived-tumor-explants","display_name":"patient-derived tumor explants","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ex-vivo-tumor-model","display_name":"ex vivo tumor model","score":0.8109999895095825},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7820000052452087},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8339999914169312},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.8880000114440918},{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.8999999761581421},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cytokine-profile","display_name":"cytokine profile","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7746418118476868},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7246236801147461},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.631882905960083},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5363159775733948},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5140386819839478},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.4890521466732025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48657262325286865},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3247268795967102}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1080/2162402x.2025.2466305","doi":"https://doi.org/10.1080/2162402x.2025.2466305","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2025.2466305","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2025.2466305?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},{"id":"doi:10.1101/2024.05.11.593502","doi":"https://doi.org/10.1101/2024.05.11.593502","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.05.11.593502","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11834457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11834457","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Text"},{"id":"pmid:39960413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39960413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoimmunology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0k9264xf","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0k9264xf","pdf_url":"https://escholarship.org/content/qt0k9264xf/qt0k9264xf.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, vol 14, iss 1","raw_type":"article"},{"id":"pmh:oai:utupub.fi:11111/52485","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/52485","pdf_url":"https://www.utupub.fi/bitstreams/7cc109c0-3536-4487-aaa6-618f372777bd/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/187341","raw_type":null},{"id":"pmh:oai:www.utupub.fi:10024/187341","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/10024/187341","pdf_url":"https://www.utupub.fi/bitstream/10024/187341/1/Patient-derived%20tumor%20explant%20models%20of%20tumor%20immune%20microenvironment%20reveal%20distinct%20and%20reproducible%20immunotherapy%20responses.pdf","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:db08a631545c4f98b3e838cbbef2e099","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db08a631545c4f98b3e838cbbef2e099","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoImmunology, Vol 14, Iss 1 (2025)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/593068","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/593068","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1080/2162402x.2025.2466305","doi":"https://doi.org/10.1080/2162402x.2025.2466305","is_oa":true,"landing_page_url":"https://doi.org/10.1080/2162402x.2025.2466305","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2025.2466305?needAccess=true","source":{"id":"https://openalex.org/S2497914550","display_name":"OncoImmunology","issn_l":"2162-4011","issn":["2162-4011","2162-402X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoImmunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3993334097","display_name":null,"funder_award_id":"847912","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G501826644","display_name":"RESISTANCE UNDER COMBINATORIAL TREATMENT IN ER+ AND ER- BREAST CANCER.","funder_award_id":"847912","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G702072549","display_name":"COMBINING IMMUNOTHERAPY AND MYC SYNTHETIC LETHALITY FOR METASTATIC BREAST CANCER","funder_award_id":"W81XWH2110773","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310461","display_name":"Sihtasutus Archimedes","ror":"https://ror.org/02pagex14"},{"id":"https://openalex.org/F4320317353","display_name":"Finnish Cancer Institute","ror":"https://ror.org/02cwbja97"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322282","display_name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03vxy9y38"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320326591","display_name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0113k5861"},{"id":"https://openalex.org/F4320328501","display_name":"Business Finland","ror":"https://ror.org/05bgf9v38"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320333873","display_name":"Helsinki Institute of Life Science, Helsingin Yliopisto","ror":"https://ror.org/018bh0m68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407624554.pdf","grobid_xml":"https://content.openalex.org/works/W4407624554.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1488814076","https://openalex.org/W1898887656","https://openalex.org/W2063204257","https://openalex.org/W2069027997","https://openalex.org/W2090867005","https://openalex.org/W2097147259","https://openalex.org/W2110065044","https://openalex.org/W2134007339","https://openalex.org/W2222086386","https://openalex.org/W2254503304","https://openalex.org/W2303301650","https://openalex.org/W2406851765","https://openalex.org/W2591189187","https://openalex.org/W2655262992","https://openalex.org/W2766123339","https://openalex.org/W2796207838","https://openalex.org/W2886498337","https://openalex.org/W2898911355","https://openalex.org/W2905027070","https://openalex.org/W2912137016","https://openalex.org/W2913745075","https://openalex.org/W2928665623","https://openalex.org/W3012668557","https://openalex.org/W3042043324","https://openalex.org/W3130576199","https://openalex.org/W3180646962","https://openalex.org/W3196207248","https://openalex.org/W3204548506","https://openalex.org/W3214240356","https://openalex.org/W3214787171","https://openalex.org/W4225093777","https://openalex.org/W4286487968","https://openalex.org/W4324046169","https://openalex.org/W4394759769","https://openalex.org/W4399282535"],"related_works":["https://openalex.org/W7164903126","https://openalex.org/W2591851770","https://openalex.org/W3034149425","https://openalex.org/W4388048140","https://openalex.org/W4410707284","https://openalex.org/W7148675768","https://openalex.org/W3081921647","https://openalex.org/W4410810642","https://openalex.org/W4282916504","https://openalex.org/W4282961681"],"abstract_inverted_index":{"ABSTRACT":[0],"Tumor-resident":[1],"immune":[2,29,39,55,139,158],"cells":[3,40],"play":[4],"a":[5,93,154],"crucial":[6],"role":[7],"in":[8,103,113,160,188],"eliciting":[9],"anti-tumor":[10],"immunity":[11,194],"and":[12,41,63,79,106,119,146,195],"immunomodulatory":[13,66,170],"drug":[14,67,171],"responses,":[15],"yet":[16],"these":[17],"functions":[18],"have":[19],"been":[20],"difficult":[21],"to":[22,52,115],"study":[23],"without":[24],"tractable":[25],"models":[26,35,74,89,112,145,163,178,187],"of":[27,65,75,81,95,135,149,164,169,179,184,192],"tumor":[28,53],"microenvironment":[30],"(TIME).":[31],"Patient-derived":[32],"ex":[33,72,161,176],"vivo":[34,73,162,177],"contain":[36],"authentic":[37],"resident":[38],"therefore,":[42],"could":[43],"provide":[44],"new":[45],"mechanistic":[46],"insights":[47],"into":[48],"how":[49],"TIME":[50,78,88,180],"responds":[51],"or":[54,137],"cell-directed":[56],"therapies.":[57],"Here,":[58],"we":[59,129],"assessed":[60],"the":[61,110,182,190],"reproducibility":[62,168],"robustness":[64],"responses":[68,140,172],"across":[69,142,174],"two":[70,131],"different":[71],"breast":[76],"cancer":[77],"one":[80],"renal":[82],"cell":[83,117],"carcinoma.":[84],"These":[85],"independently":[86],"developed":[87],"were":[90],"treated":[91],"with":[92],"panel":[94],"clinically":[96],"relevant":[97],"immunomodulators,":[98],"revealing":[99],"remarkably":[100],"similar":[101],"changes":[102],"gene":[104],"expression":[105],"cytokine":[107],"profiles":[108],"among":[109],"three":[111,144],"response":[114,126],"T":[116],"activation":[118,159],"STING-agonism":[120],"while":[121],"still":[122],"preserving":[123],"individual":[124],"patient-specific":[125],"patterns.":[127],"Moreover,":[128],"found":[130],"common":[132],"core":[133],"signatures":[134],"adaptive":[136],"innate":[138],"present":[141],"all":[143],"both":[147],"types":[148],"cancer,":[150],"potentially":[151],"serving":[152],"as":[153],"benchmark":[155],"for":[156],"drug-induced":[157],"TIME.":[165],"The":[166],"robust":[167],"observed":[173],"diverse":[175],"underscores":[181],"significance":[183],"human":[185],"patient-derived":[186],"elucidating":[189],"complexities":[191],"antitumor":[193],"therapeutic":[196],"interventions.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-02-17T00:00:00"}
