{"id":"https://openalex.org/W4407527005","doi":"https://doi.org/10.1016/j.oraloncology.2025.107211","title":"Mitoxantrone hydrochloride liposome injection for the treatment of Recurrent/Metastatic head and neck squamous cell Carcinoma: A Multicenter, Open-label, Single-arm, phase 1b study","display_name":"Mitoxantrone hydrochloride liposome injection for the treatment of Recurrent/Metastatic head and neck squamous cell Carcinoma: A Multicenter, Open-label, Single-arm, phase 1b study","publication_year":2025,"publication_date":"2025-02-13","ids":{"openalex":"https://openalex.org/W4407527005","doi":"https://doi.org/10.1016/j.oraloncology.2025.107211","pmid":"https://pubmed.ncbi.nlm.nih.gov/39952083"},"language":"en","primary_location":{"id":"doi:10.1016/j.oraloncology.2025.107211","doi":"https://doi.org/10.1016/j.oraloncology.2025.107211","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.oraloncology.2025.107211","pdf_url":null,"source":{"id":"https://openalex.org/S102916872","display_name":"Oral Oncology","issn_l":"1368-8375","issn":["1368-8375","1879-0593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101775498","display_name":"Hang Yang","orcid":"https://orcid.org/0000-0002-5777-3800","observed_orcids":["https://orcid.org/0000-0002-5777-3800"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang Yang","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: yanghang@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: yanghang@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021140829","display_name":"Peng Sun","orcid":"https://orcid.org/0000-0003-2771-9181","observed_orcids":["https://orcid.org/0000-0003-2771-9181"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Sun","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: sunp@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: sunp@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115596413","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0002-8833-9564","observed_orcids":["https://orcid.org/0000-0002-8833-9564"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: wangyu@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: wangyu@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087215545","display_name":"Xicheng Wang","orcid":"https://orcid.org/0000-0001-6073-2869","observed_orcids":["https://orcid.org/0000-0001-6073-2869"]},"institutions":[{"id":"https://openalex.org/I4210119024","display_name":"First Affiliated Hospital of Guangdong Pharmaceutical University","ror":"https://ror.org/02gr42472","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xicheng Wang","raw_affiliation_strings":["The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China. Electronic address: 13902400598@139.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, PR China. Electronic address: 13902400598@139.com","institution_ids":["https://openalex.org/I4210119024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100416811","display_name":"Yanyan Liu","orcid":"https://orcid.org/0000-0002-3887-0840","observed_orcids":["https://orcid.org/0000-0002-3887-0840"]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]},{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Liu","raw_affiliation_strings":["CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: liuyanping@cspc.cn","Henan Cancer Hospital, Zhengzhou, PR China. Electronic address: yyliu@zzu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: liuyanping@cspc.cn","institution_ids":["https://openalex.org/I4387153926"]},{"raw_affiliation_string":"Henan Cancer Hospital, Zhengzhou, PR China. Electronic address: yyliu@zzu.edu.cn","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022790301","display_name":"Jiyong Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121805","display_name":"Jiangxi Pingxiang People's Hospital","ror":"https://ror.org/02qkhx131","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121805"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiyong Peng","raw_affiliation_strings":["Pingxiang People's Hospita, Pingxiang, PR China. Electronic address: 13879987998@139.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingxiang People's Hospita, Pingxiang, PR China. Electronic address: 13879987998@139.com","institution_ids":["https://openalex.org/I4210121805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062072304","display_name":"Hui Zhou","orcid":"https://orcid.org/0000-0001-9909-5051","observed_orcids":["https://orcid.org/0000-0001-9909-5051"]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhou","raw_affiliation_strings":["Hunan Cancer Hospital, Changsha, PR China. Electronic address: zhouhui9403@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Cancer Hospital, Changsha, PR China. Electronic address: zhouhui9403@126.com","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yajun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yajun Li","raw_affiliation_strings":["Hunan Cancer Hospital, Changsha, PR China. Electronic address: liyajun@hnca.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Cancer Hospital, Changsha, PR China. Electronic address: liyajun@hnca.org.cn","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430241","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0001-7670-626X","observed_orcids":["https://orcid.org/0000-0001-7670-626X"]},"institutions":[{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["West China Hospital of Sichuan University, Chengdu, PR China. Electronic address: reus_0102@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West China Hospital of Sichuan University, Chengdu, PR China. Electronic address: reus_0102@qq.com","institution_ids":["https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011202842","display_name":"Jianbing Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianbing Hu","raw_affiliation_strings":["Yueyang Central Hospital, Yueyang, PR China. Electronic address: jianbinghu409@sohu.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yueyang Central Hospital, Yueyang, PR China. Electronic address: jianbinghu409@sohu.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389664","display_name":"Bing Zhang","orcid":"https://orcid.org/0000-0001-8676-2425","observed_orcids":["https://orcid.org/0000-0001-8676-2425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Zhang","raw_affiliation_strings":["Yiyang Central Hospital, Yiyang, PR China. Electronic address: 348682512@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yiyang Central Hospital, Yiyang, PR China. Electronic address: 348682512@qq.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009358228","display_name":"Shunhuan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122949","display_name":"Dongguan People\u2019s Hospital","ror":"https://ror.org/022s5gm85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122949"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunhuan Lin","raw_affiliation_strings":["Dongguan People's Hospital, Dongguan, PR China. Electronic address: 1974269473@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dongguan People's Hospital, Dongguan, PR China. Electronic address: 1974269473@qq.com","institution_ids":["https://openalex.org/I4210122949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109298209","display_name":"Chunwei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunwei Yang","raw_affiliation_strings":["Tianjin Union Medical Center, Tianjin, PR China. Electronic address: yangchunwei1979@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Union Medical Center, Tianjin, PR China. Electronic address: yangchunwei1979@163.com","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087227832","display_name":"Yanping Liu","orcid":"https://orcid.org/0000-0002-8338-5991","observed_orcids":["https://orcid.org/0000-0002-8338-5991"]},"institutions":[{"id":"https://openalex.org/I4210153921","display_name":"Guangzhou Medical University Cancer Hospital","ror":"https://ror.org/046c18a90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weidong Li","raw_affiliation_strings":["Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, PR China. Electronic address: lwdlyn_hky@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, PR China. Electronic address: lwdlyn_hky@126.com","institution_ids":["https://openalex.org/I4210153921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087227832","display_name":"Yanping Liu","orcid":"https://orcid.org/0000-0002-8338-5991","observed_orcids":["https://orcid.org/0000-0002-8338-5991"]},"institutions":[{"id":"https://openalex.org/I4210143608","display_name":"Henan Cancer Hospital","ror":"https://ror.org/043ek5g31","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143608"]},{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanping Liu","raw_affiliation_strings":["CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: liuyanping@cspc.cn","Henan Cancer Hospital, Zhengzhou, PR China. Electronic address: yyliu@zzu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: liuyanping@cspc.cn","institution_ids":["https://openalex.org/I4387153926"]},{"raw_affiliation_string":"Henan Cancer Hospital, Zhengzhou, PR China. Electronic address: yyliu@zzu.edu.cn","institution_ids":["https://openalex.org/I4210143608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004036181","display_name":"Meng Ji","orcid":"https://orcid.org/0000-0002-2327-9820","observed_orcids":["https://orcid.org/0000-0002-2327-9820"]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Ji","raw_affiliation_strings":["CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: lcjimeng@cspc.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: lcjimeng@cspc.cn","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinghua Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghua Zhao","raw_affiliation_strings":["CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: zhaojh@cspc.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: zhaojh@cspc.cn","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113696491","display_name":"Jianfei Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153926","display_name":"CSPC Pharmaceutical Group","ror":"https://ror.org/016mq8947","country_code":"CN","type":"company","lineage":["https://openalex.org/I4387153926"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfei Xue","raw_affiliation_strings":["CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: xjianfei@cspc.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSPC Pharmaceutical Group Co., Ltd. Shijiazhuang, PR China. Electronic address: xjianfei@cspc.cn","institution_ids":["https://openalex.org/I4387153926"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiajia Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Huang","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: huangjiaj@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: huangjiaj@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726299","display_name":"Zhiming Li","orcid":"https://orcid.org/0000-0001-5589-1136","observed_orcids":["https://orcid.org/0000-0001-5589-1136"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiming Li","raw_affiliation_strings":["Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: lizhm@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address: lizhm@sysucc.org.cn","institution_ids":["https://openalex.org/I4210146711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5087227832","https://openalex.org/A5100726299"],"corresponding_institution_ids":["https://openalex.org/I4210115624","https://openalex.org/I4210146711","https://openalex.org/I4210153921"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":null,"fwci":3.371,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.92015776,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"162","issue":null,"first_page":"107211","last_page":"107211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-or-metastatic-head-and-neck-squamous-cell-carcinoma","display_name":"recurrent or metastatic head and neck squamous cell carcinoma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nasopharyngeal-carcinoma","display_name":"nasopharyngeal carcinoma","score":0.9490000009536743},{"id":"https://openalex.org/keywords/liposomal-chemotherapy","display_name":"liposomal chemotherapy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hematological-adverse-events","display_name":"hematologic adverse events","score":0.6769999861717224},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.9449999928474426},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.809023380279541},{"id":"https://openalex.org/C2780923524","wikidata":"https://www.wikidata.org/wiki/Q239426","display_name":"Mitoxantrone","level":3,"score":0.6791510581970215},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.6105251312255859},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6035184264183044},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.5261635184288025},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5085078477859497},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.49984025955200195},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4641023874282837},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40704888105392456},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.38112330436706543},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3427867889404297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3023989200592041},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2635275721549988},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.1774480938911438},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.17154178023338318}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.oraloncology.2025.107211","doi":"https://doi.org/10.1016/j.oraloncology.2025.107211","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.oraloncology.2025.107211","pdf_url":null,"source":{"id":"https://openalex.org/S102916872","display_name":"Oral Oncology","issn_l":"1368-8375","issn":["1368-8375","1879-0593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral Oncology","raw_type":"journal-article"},{"id":"pmid:39952083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39952083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oral oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1943010815","https://openalex.org/W1971390843","https://openalex.org/W1971730203","https://openalex.org/W1978580856","https://openalex.org/W2010894565","https://openalex.org/W2059779802","https://openalex.org/W2069681280","https://openalex.org/W2088062002","https://openalex.org/W2123607342","https://openalex.org/W2127264662","https://openalex.org/W2264224358","https://openalex.org/W2373960291","https://openalex.org/W2401455386","https://openalex.org/W2589134582","https://openalex.org/W2903241832","https://openalex.org/W2938731144","https://openalex.org/W2997608354","https://openalex.org/W3095673600","https://openalex.org/W3107533236","https://openalex.org/W3161122257","https://openalex.org/W3180153055","https://openalex.org/W3206536402","https://openalex.org/W4225105893","https://openalex.org/W4308921406","https://openalex.org/W4323966472"],"related_works":["https://openalex.org/W4281934259","https://openalex.org/W4407977061","https://openalex.org/W2891444650","https://openalex.org/W7163328298","https://openalex.org/W2988363733","https://openalex.org/W6946374126","https://openalex.org/W3095673600","https://openalex.org/W1981126320","https://openalex.org/W2147704736","https://openalex.org/W4415396696"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-14T00:00:00"}
