{"id":"https://openalex.org/W4407463539","doi":"https://doi.org/10.1016/j.jtocrr.2025.100807","title":"Combination of Lurbinectedin and Osimertinib for Treatment of EGFR-Mutated Transformed SCLC: A Brief Report","display_name":"Combination of Lurbinectedin and Osimertinib for Treatment of EGFR-Mutated Transformed SCLC: A Brief Report","publication_year":2025,"publication_date":"2025-02-14","ids":{"openalex":"https://openalex.org/W4407463539","doi":"https://doi.org/10.1016/j.jtocrr.2025.100807","pmid":"https://pubmed.ncbi.nlm.nih.gov/40336673"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtocrr.2025.100807","doi":"https://doi.org/10.1016/j.jtocrr.2025.100807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2025.100807","pdf_url":"https://www.jtocrr.org/article/S2666-3643(25)00023-2/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jtocrr.org/article/S2666-3643(25)00023-2/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012424924","display_name":"Aditi Singh","orcid":"https://orcid.org/0000-0002-9937-7048","observed_orcids":["https://orcid.org/0000-0002-9937-7048"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aditi Singh","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-9937-7048","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Arthi Sridhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthi Sridhar","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109760008","display_name":"Aastha Poddar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aastha Poddar","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic, College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic, College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073550585","display_name":"Anastasios Dimou","orcid":"https://orcid.org/0000-0002-3950-3305","observed_orcids":["https://orcid.org/0000-0002-3950-3305"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasios Dimou","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101829295","display_name":"Kaushal Parikh","orcid":"https://orcid.org/0000-0001-6759-9351","observed_orcids":["https://orcid.org/0000-0001-6759-9351"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaushal Parikh","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073524795","display_name":"Mohamed Shanshal","orcid":"https://orcid.org/0009-0005-0775-2680","observed_orcids":["https://orcid.org/0009-0005-0775-2680"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Shanshal","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113189312","display_name":"Anna Schwecke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Schwecke","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075458388","display_name":"Jenesse Nicole Moffett","orcid":"https://orcid.org/0000-0003-2331-8153","observed_orcids":["https://orcid.org/0000-0003-2331-8153"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Moffett","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Manish R. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish R. Patel","raw_affiliation_strings":["Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023803145","display_name":"Konstantinos Leventakos","orcid":"https://orcid.org/0000-0001-9784-8603","observed_orcids":["https://orcid.org/0000-0001-9784-8603"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantinos Leventakos","raw_affiliation_strings":["Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012424924"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.1811,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75889766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"6","issue":"6","first_page":"100807","last_page":"100807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lurbinectedin","display_name":"lurbinectedin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":1.0},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/histological-transformation","display_name":"histologic transformation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.9760659337043762},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4897048771381378},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3986899256706238},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38004395365715027},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3684232234954834},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31075096130371094},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2610546946525574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19671255350112915},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jtocrr.2025.100807","doi":"https://doi.org/10.1016/j.jtocrr.2025.100807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2025.100807","pdf_url":"https://www.jtocrr.org/article/S2666-3643(25)00023-2/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},{"id":"pmid:40336673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40336673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO clinical and research reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:10867517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12052803","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12052803/pdf/main.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12052803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12052803","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTO Clin Res Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b19a2235edb043bca0ae5ba14dddc8f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b19a2235edb043bca0ae5ba14dddc8f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JTO Clinical and Research Reports, Vol 6, Iss 6, Pp 100807- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jtocrr.2025.100807","doi":"https://doi.org/10.1016/j.jtocrr.2025.100807","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtocrr.2025.100807","pdf_url":"https://www.jtocrr.org/article/S2666-3643(25)00023-2/pdf","source":{"id":"https://openalex.org/S4210220242","display_name":"JTO Clinical and Research Reports","issn_l":"2666-3643","issn":["2666-3643"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JTO Clinical and Research Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7099999785423279,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407463539.pdf","grobid_xml":"https://content.openalex.org/works/W4407463539.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2041380745","https://openalex.org/W2770828094","https://openalex.org/W2905529840","https://openalex.org/W2952506496","https://openalex.org/W2976334328","https://openalex.org/W3013383466","https://openalex.org/W3173930299","https://openalex.org/W4306247391","https://openalex.org/W4307032729","https://openalex.org/W4309942542","https://openalex.org/W4382502217","https://openalex.org/W4386815932"],"related_works":["https://openalex.org/W3184060414","https://openalex.org/W3112920278","https://openalex.org/W3139019175","https://openalex.org/W2582477737","https://openalex.org/W4294935045","https://openalex.org/W3205941621","https://openalex.org/W4388045361","https://openalex.org/W4406269684","https://openalex.org/W2804490319","https://openalex.org/W3164824741"],"abstract_inverted_index":{"-mutated":[0],"NSCLC.":[1],"After":[2],"an":[3],"initial":[4],"response,":[5],"patients":[6,65],"on":[7],"this":[8,58,61],"therapy":[9],"ultimately":[10],"develop":[11],"resistance":[12,20],"leading":[13],"to":[14,25,48,74,84],"disease":[15],"progression.":[16],"One":[17],"of":[18,31,36,42],"the":[19,34,40,80],"mechanisms":[21],"is":[22,28,46],"histological":[23],"transformation":[24,73],"SCLC.":[26,38,75],"There":[27],"no":[29],"standard":[30],"care":[32],"for":[33,57],"management":[35],"transformed":[37,43],"Given":[39],"rarity":[41],"SCLC,":[44],"it":[45],"important":[47],"study":[49],"treatment":[50,67],"options":[51],"that":[52],"are":[53],"safe":[54],"and":[55],"effective":[56],"disease.":[59],"In":[60,76],"case":[62],"series,":[63],"three":[64],"received":[66],"with":[68],"lurbinectedin":[69],"plus":[70],"osimertinib":[71],"after":[72],"our":[77],"limited":[78],"experience,":[79],"combination":[81],"was":[82],"found":[83],"be":[85],"safe.":[86]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-02-14T00:00:00"}