{"id":"https://openalex.org/W4407399652","doi":"https://doi.org/10.1186/s12872-025-04560-8","title":"Invasive versus conservative strategies for non-ST-elevation acute coronary syndrome in the elderly: an updated systematic review and meta-analysis of randomized controlled trials","display_name":"Invasive versus conservative strategies for non-ST-elevation acute coronary syndrome in the elderly: an updated systematic review and meta-analysis of randomized controlled trials","publication_year":2025,"publication_date":"2025-02-12","ids":{"openalex":"https://openalex.org/W4407399652","doi":"https://doi.org/10.1186/s12872-025-04560-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39939951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11823017"},"language":"en","primary_location":{"id":"doi:10.1186/s12872-025-04560-8","doi":"https://doi.org/10.1186/s12872-025-04560-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04560-8","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/s12872-025-04560-8","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/s12872-025-04560-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093318583","display_name":"Erfan Kohansal","orcid":"https://orcid.org/0000-0002-4095-4824","observed_orcids":["https://orcid.org/0000-0002-4095-4824"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Erfan Kohansal","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070895986","display_name":"Sepehr Jamalkhani","orcid":"https://orcid.org/0000-0003-2054-389X","observed_orcids":["https://orcid.org/0000-0003-2054-389X"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sepehr Jamalkhani","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011964580","display_name":"Alireza Hosseinpour","orcid":"https://orcid.org/0000-0002-4175-8059","observed_orcids":["https://orcid.org/0000-0002-4175-8059"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Hosseinpour","raw_affiliation_strings":["School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059846228","display_name":"Fateme Yousefimoghaddam","orcid":"https://orcid.org/0000-0002-6069-8151","observed_orcids":["https://orcid.org/0000-0002-6069-8151"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fateme Yousefimoghaddam","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030925624","display_name":"Amir Askarinejad","orcid":"https://orcid.org/0000-0003-2803-079X","observed_orcids":["https://orcid.org/0000-0003-2803-079X"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Askarinejad","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042697224","display_name":"Elnaz Hekmat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801441769","display_name":"Broomfield Hospital","ror":"https://ror.org/00hn92440","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801441769","https://openalex.org/I4210113937"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elnaz Hekmat","raw_affiliation_strings":["Mid and South Essex NHS Foundation Trust, Broomfield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mid and South Essex NHS Foundation Trust, Broomfield, UK","institution_ids":["https://openalex.org/I2801441769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082109212","display_name":"Amir Ghaffari Jolfayi","orcid":"https://orcid.org/0000-0002-9223-5565","observed_orcids":["https://orcid.org/0000-0002-9223-5565"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]},{"id":"https://openalex.org/I4210157063","display_name":"Shaheed Rajaei Cardiovascular Medical and Research Center","ror":"https://ror.org/054zftm42","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210157063"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Ghaffari Jolfayi","raw_affiliation_strings":["Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I161106909","https://openalex.org/I4210157063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064376779","display_name":"Armin Attar","orcid":"https://orcid.org/0000-0002-4133-4870","observed_orcids":["https://orcid.org/0000-0002-4133-4870"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Armin Attar","raw_affiliation_strings":["Department of Cardiovascular Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. attar_armin@yahoo.com","Department of Cardiovascular Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. attar_armin@yahoo.com","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064376779"],"corresponding_institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.7617,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84663655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"96","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-st-elevation-acute-coronary-syndrome","display_name":"non-ST-elevation acute coronary syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8840000033378601},{"id":"https://openalex.org/keywords/invasive-versus-conservative-strategy","display_name":"invasive versus conservative strategy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8119999766349792},{"id":"https://openalex.org/keywords/coronary-angiography","display_name":"coronary angiography","score":0.8460000157356262},{"id":"https://openalex.org/keywords/revascularization","display_name":"revascularization","score":0.6909999847412109},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.7260000109672546},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.597000002861023},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9010000228881836},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.3840000033378601},{"id":"https://openalex.org/keywords/underrepresentation-in-clinical-trials","display_name":"underrepresentation in clinical trials","score":0.6800000071525574},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.3630000054836273},{"id":"https://openalex.org/keywords/shared-decision-making","display_name":"shared decision-making","score":0.5559999942779541},{"id":"https://openalex.org/keywords/patient-preferences","display_name":"patient preferences","score":0.3319999873638153},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C555175668","wikidata":"https://www.wikidata.org/wiki/Q539690","display_name":"Angiology","level":2,"score":0.8169349431991577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7826032638549805},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7097499370574951},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.69541335105896},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.6443085670471191},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5780860185623169},{"id":"https://openalex.org/C37054046","wikidata":"https://www.wikidata.org/wiki/Q641888","display_name":"Elevation (ballistics)","level":2,"score":0.4851978123188019},{"id":"https://openalex.org/C2776291336","wikidata":"https://www.wikidata.org/wiki/Q7394928","display_name":"ST elevation","level":3,"score":0.4787932336330414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47222307324409485},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.466727614402771},{"id":"https://openalex.org/C2777010666","wikidata":"https://www.wikidata.org/wiki/Q1498222","display_name":"Vascular surgery","level":3,"score":0.45913368463516235},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41160207986831665},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3371555805206299},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.15939444303512573},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.13006770610809326},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072658","descriptor_name":"Non-ST Elevated Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000072658","descriptor_name":"Non-ST Elevated Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000072658","descriptor_name":"Non-ST Elevated Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000072700","descriptor_name":"Conservative Treatment","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000072700","descriptor_name":"Conservative Treatment","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D054058","descriptor_name":"Acute Coronary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D062645","descriptor_name":"Percutaneous Coronary Intervention","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D062645","descriptor_name":"Percutaneous Coronary Intervention","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12872-025-04560-8","doi":"https://doi.org/10.1186/s12872-025-04560-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04560-8","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/s12872-025-04560-8","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11823017","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11823017","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11823017/pdf/12872_2025_Article_4560.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovasc Disord","raw_type":"Text"},{"id":"pmid:39939951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39939951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cardiovascular disorders","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:29227f5de5f647b79a50853960845f4d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29227f5de5f647b79a50853960845f4d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cardiovascular Disorders, Vol 25, Iss 1, Pp 1-17 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12872-025-04560-8","doi":"https://doi.org/10.1186/s12872-025-04560-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12872-025-04560-8","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/s12872-025-04560-8","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407399652.pdf","grobid_xml":"https://content.openalex.org/works/W4407399652.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1538863617","https://openalex.org/W1598602811","https://openalex.org/W2016199445","https://openalex.org/W2024263256","https://openalex.org/W2096002945","https://openalex.org/W2118300501","https://openalex.org/W2122779695","https://openalex.org/W2149011208","https://openalex.org/W2157207159","https://openalex.org/W2163815180","https://openalex.org/W2164642379","https://openalex.org/W2170655291","https://openalex.org/W2171827669","https://openalex.org/W2238329036","https://openalex.org/W2466202731","https://openalex.org/W2496578873","https://openalex.org/W2500518163","https://openalex.org/W2553715569","https://openalex.org/W2567362164","https://openalex.org/W2568227459","https://openalex.org/W2625363116","https://openalex.org/W2734391420","https://openalex.org/W2786176979","https://openalex.org/W2888543854","https://openalex.org/W2970684805","https://openalex.org/W3007002161","https://openalex.org/W3037286339","https://openalex.org/W3108335733","https://openalex.org/W3122220979","https://openalex.org/W3146142859","https://openalex.org/W3161159358","https://openalex.org/W3184177771","https://openalex.org/W4200424042","https://openalex.org/W4238277289","https://openalex.org/W4295941642","https://openalex.org/W4323295172","https://openalex.org/W4386153206","https://openalex.org/W4387450607","https://openalex.org/W4388623159","https://openalex.org/W4392499018","https://openalex.org/W4394692676","https://openalex.org/W4402110924","https://openalex.org/W4402340993"],"related_works":["https://openalex.org/W4411978277","https://openalex.org/W4284671051","https://openalex.org/W4415098431","https://openalex.org/W3212372692","https://openalex.org/W4409460142","https://openalex.org/W4407184958","https://openalex.org/W4408884139","https://openalex.org/W7216144000","https://openalex.org/W7139776596","https://openalex.org/W2734391420"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advances":[1],"in":[2,25,51,107,156,184],"managing":[3],"non-ST-elevation":[4],"acute":[5],"coronary":[6],"syndrome":[7],"(NSTE-ACS)":[8],"have":[9],"yet":[10],"to":[11,29],"clarify":[12],"the":[13,202,253],"optimal":[14],"treatment":[15,262],"for":[16,42,187],"elderly":[17,52,234],"patients,":[18],"whose":[19],"complex":[20],"health":[21],"profiles":[22],"and":[23,40,66,81,92,159,190,208,220,271],"underrepresentation":[24],"trials":[26,45,100],"add":[27],"challenges":[28],"decision-making.":[30],"METHODS:":[31],"We":[32],"systematically":[33],"searched":[34],"PubMed,":[35],"Embase,":[36],"Web":[37],"of":[38,98,182,204,255],"Science,":[39],"Scopus":[41],"randomized":[43],"controlled":[44],"comparing":[46],"invasive":[47,136,239],"versus":[48],"conservative":[49],"strategies":[50],"patients":[53,235],"(\u2265":[54],"70":[55],"years)":[56],"with":[57,69,179,236],"NSTE-ACS":[58],"through":[59],"October":[60],"2024.":[61],"Co-primary":[62],"outcomes":[63,71,193],"were":[64,85,194],"all-cause":[65,108],"cardiovascular":[67,121],"mortalities,":[68],"secondary":[70],"including":[72],"myocardial":[73],"infarction":[74],"(MI),":[75],"revascularization,":[76],"stroke,":[77],"decompensated":[78],"heart":[79,191],"failure,":[80],"bleeding":[82,210,222,257,269],"events.":[83],"Outcomes":[84],"analyzed":[86],"using":[87],"both":[88,157,205],"risk":[89,161,203,211,247,270],"ratios":[90,94],"(RR)":[91],"hazard":[93],"(HR).":[95],"RESULTS:":[96],"Analysis":[97],"11":[99],"(4,114":[101],"patients)":[102],"showed":[103],"no":[104],"significant":[105],"differences":[106],"mortality":[109,122],"(RR:":[110,123,142,162,212,224],"1.04,":[111],"95%":[112,117,125,130,144,149,164,172,214,226],"CI:":[113,118,126,131,145,150,165,173,215,227],"0.98-1.11;":[114],"HR:":[115,128,147,170],"1.10,":[116],"0.94-1.29)":[119],"or":[120],"0.98,":[124],"0.85-1.12;":[127],"0.94,":[129],"0.73-1.20)":[132],"between":[133,196],"strategies.":[134,197],"The":[135],"approach":[137],"significantly":[138,200],"reduced":[139],"subsequent":[140],"revascularization":[141,242],"0.41,":[143],"0.27-0.62;":[146],"0.30,":[148],"0.19-":[151],"0.47;":[152],"p":[153,167,175,217,229],"<":[154,176],"0.01":[155],"analyses)":[158],"MI":[160,246],"0.75,":[163],"0.57-0.99,":[166],"=":[168,218,230],"0.04;":[169],"0.64,":[171],"0.49-0.83,":[174],"0.01),":[177],"though":[178],"some":[180],"levels":[181],"heterogeneity":[183],"sensitivity":[185],"analyses":[186],"MI.":[188],"Stroke":[189],"failure":[192],"comparable":[195],"However,":[198],"it":[199],"increased":[201,256],"composite":[206],"major":[207,221],"minor":[209],"1.50,":[213],"1.02-2.20,":[216],"0.04)":[219],"alone":[223],"1.92,":[225],"1.04-3.56,":[228],"0.04).":[231],"CONCLUSION:":[232],"In":[233],"NSTE-ACS,":[237],"an":[238],"strategy":[240],"reduces":[241],"needs":[243],"and,":[244],"potentially,":[245],"without":[248],"impacting":[249],"survival,":[250],"but":[251],"at":[252],"cost":[254],"risk.":[258],"This":[259],"supports":[260],"individualized":[261],"decisions":[263],"based":[264],"on":[265],"patient-specific":[266],"characteristics,":[267],"particularly":[268],"geriatric":[272],"factors.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-02-13T00:00:00"}