{"id":"https://openalex.org/W4407362347","doi":"https://doi.org/10.1136/jitc-2024-009574","title":"Pooled screening for CAR function identifies novel IL-13R\u03b12-targeted CARs for treatment of glioblastoma","display_name":"Pooled screening for CAR function identifies novel IL-13R\u03b12-targeted CARs for treatment of glioblastoma","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4407362347","doi":"https://doi.org/10.1136/jitc-2024-009574","pmid":"https://pubmed.ncbi.nlm.nih.gov/38766252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11100612"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2024-009574","doi":"https://doi.org/10.1136/jitc-2024-009574","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-009574","pdf_url":"https://jitc.bmj.com/content/13/2/e009574.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/13/2/e009574.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014554320","display_name":"Khloe S. Gordon","orcid":"https://orcid.org/0000-0003-3652-7245","observed_orcids":["https://orcid.org/0000-0003-3652-7245"]},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Khloe S. Gordon","raw_affiliation_strings":["Massachusetts Institute of Technology;","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Singapore-MIT Alliance for Research and Technology Centre, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Singapore-MIT Alliance for Research and Technology Centre, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032131378","display_name":"Caleb R. Perez","orcid":"https://orcid.org/0000-0001-8709-6145","observed_orcids":["https://orcid.org/0000-0001-8709-6145"]},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Caleb R. Perez","raw_affiliation_strings":["Massachusetts Institute of Technology;","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Singapore-MIT Alliance for Research and Technology Centre, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Singapore-MIT Alliance for Research and Technology Centre, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066703834","display_name":"Andrea Garmilla","orcid":"https://orcid.org/0000-0002-5093-1423","observed_orcids":["https://orcid.org/0000-0002-5093-1423"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Garmilla","raw_affiliation_strings":["Massachusetts Institute of Technology;","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Program in Immunology, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Program in Immunology, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022437541","display_name":"Maxine S. Y. Lam","orcid":"https://orcid.org/0000-0002-5605-0475","observed_orcids":["https://orcid.org/0000-0002-5605-0475"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Maxine S.Y. Lam","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089615626","display_name":"Joey Aw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Joey Jy Aw","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anisha Datta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anisha Datta","raw_affiliation_strings":["Massachusetts Institute of Technology;","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060106170","display_name":"Douglas A. Lauffenburger","orcid":"https://orcid.org/0000-0002-0050-989X","observed_orcids":["https://orcid.org/0000-0002-0050-989X"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A. Lauffenburger","raw_affiliation_strings":["Massachusetts Institute of Technology;","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-0050-989X","affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891753","display_name":"Andrea Pavesi","orcid":"https://orcid.org/0000-0003-2777-1043","observed_orcids":["https://orcid.org/0000-0003-2777-1043"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Andrea Pavesi","raw_affiliation_strings":["Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science, Technology and Research","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Institute of Molecular and Cell Biology, Agency for Science Technology and Research (A*STAR), Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000535117","display_name":"Michael E. Birnbaum","orcid":"https://orcid.org/0000-0002-2281-3518","observed_orcids":["https://orcid.org/0000-0002-2281-3518"]},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":true,"raw_author_name":"Michael E. Birnbaum","raw_affiliation_strings":["Massachusetts Institute of Technology;","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","Singapore-MIT Alliance for Research and Technology Centre, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-2281-3518","affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology;","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Singapore-MIT Alliance for Research and Technology Centre, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5000535117"],"corresponding_institution_ids":["https://openalex.org/I4210167254","https://openalex.org/I4390039253","https://openalex.org/I63966007"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":3.4226,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.93382588,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"2","first_page":"e009574","last_page":"e009574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/il13ralpha2","display_name":"IL13R\u03b12","score":0.8899999856948853},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cancer-testis-antigens","display_name":"cancer-testis antigens","score":0.8569999933242798},{"id":"https://openalex.org/keywords/car-t-cell-persistence","display_name":"CAR T cell persistence","score":0.6990000009536743},{"id":"https://openalex.org/keywords/solid-tumor-immunotherapy","display_name":"solid tumor immunotherapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7582054138183594},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.651517927646637},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5545213222503662},{"id":"https://openalex.org/C2780427980","wikidata":"https://www.wikidata.org/wiki/Q749649","display_name":"Carpool","level":2,"score":0.54461669921875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5083302855491638},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4884280264377594},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.48632580041885376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4476895034313202},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42406585812568665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.388126015663147},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.35036301612854004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26843902468681335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14189675450325012},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1136/jitc-2024-009574","doi":"https://doi.org/10.1136/jitc-2024-009574","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-009574","pdf_url":"https://jitc.bmj.com/content/13/2/e009574.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"doi:10.1101/2024.04.04.586240","doi":"https://doi.org/10.1101/2024.04.04.586240","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.04.04.586240","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/04/09/2024.04.04.586240.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11815465","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11815465","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11815465/pdf/jitc-13-1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"},{"id":"pmid:38766252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38766252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39933837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39933837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for immunotherapy of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11100612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11100612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:47a0181307bb467b978b7f1a5f0e1785","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/47a0181307bb467b978b7f1a5f0e1785","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 13, Iss 2 (2025)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/206224","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10356/206224","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2024-009574","doi":"https://doi.org/10.1136/jitc-2024-009574","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2024-009574","pdf_url":"https://jitc.bmj.com/content/13/2/e009574.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360436881","display_name":null,"funder_award_id":"P30-CA14051","funder_id":"https://openalex.org/F4320316943","funder_display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"},{"id":"https://openalex.org/G2608246928","display_name":null,"funder_award_id":"W911NF\u201019\u20102\u20100026","funder_id":"https://openalex.org/F4320338295","funder_display_name":"Army Research Laboratory"},{"id":"https://openalex.org/G4774430914","display_name":null,"funder_award_id":"CA14051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5108852245","display_name":null,"funder_award_id":"P30-CA14051","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G582811279","display_name":null,"funder_award_id":"W911NF-19-2-0026","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G608057831","display_name":null,"funder_award_id":"W911NF-19","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G783422742","display_name":null,"funder_award_id":"W911NF-19-2-0026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8415477955","display_name":null,"funder_award_id":"W911NF-19","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8922830400","display_name":null,"funder_award_id":"C210112058","funder_id":"https://openalex.org/F4320320696","funder_display_name":"Agency for Science, Technology and Research"},{"id":"https://openalex.org/G9000891960","display_name":"Cancer Center Support (Core) Grant","funder_award_id":"P30CA014051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000901346","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM144273","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306079","display_name":"David and Lucile Packard Foundation","ror":"https://ror.org/032atxq54"},{"id":"https://openalex.org/F4320306148","display_name":"Pew Charitable Trusts","ror":"https://ror.org/02xhk2825"},{"id":"https://openalex.org/F4320316943","display_name":"Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","ror":"https://ror.org/01xd6q208"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332423","display_name":"Deshpande Center for Technological Innovation, Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320335265","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"},{"id":"https://openalex.org/F4320338295","display_name":"Army Research Laboratory","ror":"https://ror.org/011hc8f90"},{"id":"https://openalex.org/F4562087700","display_name":"National Science Foundation Graduate Research Fellowship Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407362347.pdf","grobid_xml":"https://content.openalex.org/works/W4407362347.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W574602253","https://openalex.org/W1978071531","https://openalex.org/W1994001573","https://openalex.org/W1995457719","https://openalex.org/W1997424206","https://openalex.org/W1997882452","https://openalex.org/W2015541518","https://openalex.org/W2018118610","https://openalex.org/W2038410065","https://openalex.org/W2042304873","https://openalex.org/W2043796950","https://openalex.org/W2064341586","https://openalex.org/W2094945699","https://openalex.org/W2105879190","https://openalex.org/W2114147900","https://openalex.org/W2125966088","https://openalex.org/W2133997960","https://openalex.org/W2144010265","https://openalex.org/W2144796561","https://openalex.org/W2149208882","https://openalex.org/W2158387165","https://openalex.org/W2167664605","https://openalex.org/W2171669261","https://openalex.org/W2286752153","https://openalex.org/W2401536218","https://openalex.org/W2402659606","https://openalex.org/W2567424265","https://openalex.org/W2766649683","https://openalex.org/W2769408674","https://openalex.org/W2785085486","https://openalex.org/W2787301955","https://openalex.org/W2787578932","https://openalex.org/W2790362095","https://openalex.org/W2796584001","https://openalex.org/W2801641802","https://openalex.org/W2803369586","https://openalex.org/W2888019042","https://openalex.org/W2903062212","https://openalex.org/W2903960245","https://openalex.org/W2906344733","https://openalex.org/W2913575757","https://openalex.org/W2917576966","https://openalex.org/W2936522106","https://openalex.org/W2949177718","https://openalex.org/W2955822504","https://openalex.org/W2963298310","https://openalex.org/W2964103826","https://openalex.org/W2973021197","https://openalex.org/W2980897730","https://openalex.org/W2989818721","https://openalex.org/W2997416007","https://openalex.org/W3009187475","https://openalex.org/W3015438710","https://openalex.org/W3024276903","https://openalex.org/W3045641859","https://openalex.org/W3083637057","https://openalex.org/W3134309694","https://openalex.org/W3136259893","https://openalex.org/W3139549049","https://openalex.org/W3157520262","https://openalex.org/W3160448061","https://openalex.org/W3164692211","https://openalex.org/W3164860015","https://openalex.org/W3198344470","https://openalex.org/W3207415538","https://openalex.org/W3210347941","https://openalex.org/W4200201081","https://openalex.org/W4205567487","https://openalex.org/W4210589143","https://openalex.org/W4210924686","https://openalex.org/W4280516111","https://openalex.org/W4281666488","https://openalex.org/W4282976776","https://openalex.org/W4293835365","https://openalex.org/W4307921408","https://openalex.org/W4308623157","https://openalex.org/W4311887602","https://openalex.org/W4312190745","https://openalex.org/W4312191705","https://openalex.org/W4378713677","https://openalex.org/W4386305022","https://openalex.org/W4386629408","https://openalex.org/W4392201034","https://openalex.org/W4392560879","https://openalex.org/W4392741152","https://openalex.org/W4392779080","https://openalex.org/W4407574557","https://openalex.org/W6765198443","https://openalex.org/W6847902382"],"related_works":["https://openalex.org/W4205590869","https://openalex.org/W2608184359","https://openalex.org/W3160217129","https://openalex.org/W4212964281","https://openalex.org/W2225524101","https://openalex.org/W2219167334","https://openalex.org/W4220994516","https://openalex.org/W2797313337","https://openalex.org/W2554239322","https://openalex.org/W7028993288"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chimeric":[1],"antigen":[2,67,84],"receptor":[3],"(CAR)":[4],"therapies":[5],"have":[6,15],"demonstrated":[7,140],"potent":[8,104],"efficacy":[9],"in":[10,70,110,124,128,170],"treating":[11],"B-cell":[12],"malignancies,":[13],"but":[14,138],"yet":[16],"to":[17,20,48,51,157,174],"meaningfully":[18],"translate":[19],"solid":[21],"tumors.":[22],"Nonetheless,":[23],"they":[24],"are":[25],"of":[26,32,39,135,144,154,167],"particular":[27],"interest":[28],"for":[29,75,94],"the":[30,53,92,152,164],"treatment":[31],"glioblastoma,":[33,137],"which":[34,95],"is":[35],"an":[36],"aggressive":[37],"form":[38],"brain":[40],"cancer":[41,65],"with":[42],"few":[43],"effective":[44],"therapeutic":[45],"options,":[46],"due":[47],"their":[49],"ability":[50],"cross":[52],"highly":[54],"selective":[55],"blood-brain":[56],"barrier.":[57],"METHODS:":[58],"third":[59],"generation":[60],"CARs":[61],"targeting":[62],"IL-13R\u03b12,":[63],"a":[64,125,132],"testis":[66],"commonly":[68],"expressed":[69],"glioblastoma.":[71],"Selections":[72],"were":[73],"performed":[74],"cytotoxicity,":[76],"proliferation,":[77],"memory":[78],"formation,":[79],"and":[80,99,106,120,131,162],"persistence":[81,119],"on":[82,109],"repeated":[83],"challenge.":[85],"RESULTS:":[86],"Each":[87],"enriched":[88,101],"CAR":[89,102],"robustly":[90],"produced":[91],"phenotype":[93],"it":[96],"was":[97],"selected,":[98],"one":[100],"triggered":[103],"cytotoxicity":[105],"long-term":[107],"proliferation":[108],"vitro":[111,129],"tumor":[112,122],"rechallenge.":[113],"It":[114],"also":[115,139],"showed":[116],"significantly":[117],"improved":[118],"comparable":[121],"control":[123],"microphysiological":[126],"human":[127,136,171],"model":[130,134],"xenograft":[133],"increased":[141],"off-target":[142],"recognition":[143],"IL-13R\u03b11.":[145],"CONCLUSION:":[146],"Taken":[147],"together,":[148],"this":[149],"work":[150],"demonstrates":[151],"utility":[153],"extending":[155],"CARPOOL":[156],"diseases":[158],"beyond":[159],"hematological":[160],"malignancies":[161],"represents":[163],"largest":[165],"exploration":[166],"signaling":[168],"combinations":[169],"primary":[172],"cells":[173],"date.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-12T00:00:00"}
