{"id":"https://openalex.org/W4407348796","doi":"https://doi.org/10.1002/pmic.202400011","title":"Key Considerations on CITE\u2010Seq for Single\u2010Cell Multiomics","display_name":"Key Considerations on CITE\u2010Seq for Single\u2010Cell Multiomics","publication_year":2025,"publication_date":"2025-02-09","ids":{"openalex":"https://openalex.org/W4407348796","doi":"https://doi.org/10.1002/pmic.202400011","pmid":"https://pubmed.ncbi.nlm.nih.gov/39924789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12645808"},"language":"en","primary_location":{"id":"doi:10.1002/pmic.202400011","doi":"https://doi.org/10.1002/pmic.202400011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202400011","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/pmic.202400011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055190406","display_name":"Hye-Wong Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye\u2010Wong Song","raw_affiliation_strings":["Single\u2010Cell Multiomics Team BD Biosciences  San Diego California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Single\u2010Cell Multiomics Team BD Biosciences  San Diego California USA","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047690691","display_name":"Jody Martin","orcid":"https://orcid.org/0000-0002-1421-4179","observed_orcids":["https://orcid.org/0000-0002-1421-4179"]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jody Martin","raw_affiliation_strings":["Single\u2010Cell Multiomics Team BD Biosciences  San Diego California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Single\u2010Cell Multiomics Team BD Biosciences  San Diego California USA","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019802538","display_name":"Xiaoshan Shi","orcid":"https://orcid.org/0000-0001-7931-8684","observed_orcids":["https://orcid.org/0000-0001-7931-8684","https://orcid.org/0000-0001-5838-2265"]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoshan Shi","raw_affiliation_strings":["Applied Research &amp; Technology, Medical Scientific Affairs BD Biosciences  Milpitas California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research &amp; Technology, Medical Scientific Affairs BD Biosciences  Milpitas California USA","institution_ids":["https://openalex.org/I4210116987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000121750","display_name":"Aaron J. Tyznik","orcid":"https://orcid.org/0000-0002-9120-8530","observed_orcids":["https://orcid.org/0000-0002-9120-8530"]},"institutions":[{"id":"https://openalex.org/I4210116987","display_name":"BD Biosciences (United States)","ror":"https://ror.org/02h9td068","country_code":"US","type":"company","lineage":["https://openalex.org/I146461966","https://openalex.org/I4210116987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron J. Tyznik","raw_affiliation_strings":["Applied Research &amp; Technology, Medical Scientific Affairs BD Biosciences  San Diego California USA"],"raw_orcid":"https://orcid.org/0000-0002-9120-8530","affiliations":[{"raw_affiliation_string":"Applied Research &amp; Technology, Medical Scientific Affairs BD Biosciences  San Diego California USA","institution_ids":["https://openalex.org/I4210116987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000121750","https://openalex.org/A5019802538"],"corresponding_institution_ids":["https://openalex.org/I4210116987"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":{"value":4650,"currency":"USD","value_usd":4650},"fwci":1.4048,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79888882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"21-22","first_page":"206","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cite-seq","display_name":"CITE-seq","score":0.9900000095367432},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.984000027179718},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6539999842643738},{"id":"https://openalex.org/keywords/single-cell-proteomics","display_name":"single-cell proteomics","score":0.8370000123977661},{"id":"https://openalex.org/keywords/library-preparation","display_name":"library preparation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/data-analysis","display_name":"data analysis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cell-staining","display_name":"cell staining","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7399293780326843},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7276158928871155},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6835977435112},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6163914203643799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5733371376991272},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.5350618958473206},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.47008681297302246},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.4533107876777649},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4405538737773895},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37107545137405396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28989678621292114},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2527936100959778},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24544021487236023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2433963418006897},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15321728587150574},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.09674450755119324},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pmic.202400011","doi":"https://doi.org/10.1002/pmic.202400011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202400011","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},{"id":"pmid:39924789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39924789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pmic.202400011","doi":"https://doi.org/10.1002/pmic.202400011","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202400011","pdf_url":null,"source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W146169322","https://openalex.org/W1519760941","https://openalex.org/W1561227903","https://openalex.org/W1956539927","https://openalex.org/W2033063052","https://openalex.org/W2047355957","https://openalex.org/W2058890595","https://openalex.org/W2069382861","https://openalex.org/W2081596189","https://openalex.org/W2082233908","https://openalex.org/W2098454110","https://openalex.org/W2102212449","https://openalex.org/W2125323026","https://openalex.org/W2128551987","https://openalex.org/W2136086657","https://openalex.org/W2153602357","https://openalex.org/W2165835604","https://openalex.org/W2331702551","https://openalex.org/W2340761255","https://openalex.org/W2591733518","https://openalex.org/W2605810679","https://openalex.org/W2635415917","https://openalex.org/W2739492614","https://openalex.org/W2746479894","https://openalex.org/W2785085486","https://openalex.org/W2785792383","https://openalex.org/W2810689242","https://openalex.org/W2900606897","https://openalex.org/W2900732663","https://openalex.org/W2937687190","https://openalex.org/W2940119236","https://openalex.org/W2943150971","https://openalex.org/W2953584518","https://openalex.org/W2980147288","https://openalex.org/W3003692243","https://openalex.org/W3019365805","https://openalex.org/W3023456235","https://openalex.org/W3047402958","https://openalex.org/W3082784685","https://openalex.org/W3091874907","https://openalex.org/W3129866267","https://openalex.org/W3152371839","https://openalex.org/W3153732845","https://openalex.org/W3156558106","https://openalex.org/W3164692211","https://openalex.org/W3164706810","https://openalex.org/W3164839005","https://openalex.org/W3186467019","https://openalex.org/W3188249445","https://openalex.org/W3202159881","https://openalex.org/W3206496003","https://openalex.org/W3212143351","https://openalex.org/W3214478476","https://openalex.org/W4213286472","https://openalex.org/W4220951502","https://openalex.org/W4225287808","https://openalex.org/W4225731526","https://openalex.org/W4306832366","https://openalex.org/W4307407679","https://openalex.org/W4311114212","https://openalex.org/W4311666516","https://openalex.org/W4313626995","https://openalex.org/W4321611267","https://openalex.org/W4322744485","https://openalex.org/W4362737448","https://openalex.org/W4367676419","https://openalex.org/W4385638791","https://openalex.org/W4385685356","https://openalex.org/W4385720269","https://openalex.org/W4386156610","https://openalex.org/W4388801365","https://openalex.org/W4391592180","https://openalex.org/W4391724306","https://openalex.org/W4391813984","https://openalex.org/W4392947530","https://openalex.org/W4393043550","https://openalex.org/W4393095303","https://openalex.org/W4393231367","https://openalex.org/W4394919069","https://openalex.org/W4400249174"],"related_works":["https://openalex.org/W7155087204","https://openalex.org/W4393151821","https://openalex.org/W7214896626","https://openalex.org/W2999284763","https://openalex.org/W7117979978","https://openalex.org/W4387157036","https://openalex.org/W4252375339","https://openalex.org/W4414066369","https://openalex.org/W4244692163","https://openalex.org/W3206496003"],"abstract_inverted_index":{"CITE-Seq":[0,73,97,115],"(Cellular":[1],"Indexing":[2],"of":[3,41,62,72],"Transcriptomes":[4],"and":[5,20,45,55,83,101],"Epitopes":[6],"by":[7],"Sequencing)":[8],"is":[9],"an":[10,81],"advanced":[11],"single-cell":[12,28,77],"sequencing":[13,30],"method":[14],"to":[15,112],"profile":[16],"both":[17,42],"gene":[18],"expression":[19],"protein":[21,37],"abundance":[22],"simultaneously":[23],"in":[24],"individual":[25],"cells":[26,51,89],"using":[27,74],"mRNA":[29],"techniques":[31],"alongside":[32],"antibody-derived":[33],"tags":[34],"(ADTs),":[35],"for":[36,58,87,96],"detection.":[38],"The":[39],"characterization":[40],"the":[43,46,49,60,70],"transcriptome":[44],"proteome":[47],"from":[48],"same":[50],"provides":[52,84,106],"a":[53,75,107],"powerful":[54],"multiomic":[56],"approach":[57],"understanding":[59],"mechanisms":[61],"complex":[63],"biological":[64],"processes.":[65],"This":[66],"review":[67,105],"focuses":[68],"on":[69],"workflow":[71],"microwell-based":[76],"analysis":[78],"system":[79],"as":[80],"example":[82],"key":[85],"considerations":[86],"staining":[88],"with":[90,110],"ADTs.":[91],"By":[92],"highlighting":[93],"critical":[94],"information":[95],"library":[98],"preparation,":[99],"sequencing,":[100],"data":[102],"analysis,":[103],"this":[104],"practical":[108],"guide":[109],"which":[111],"perform":[113],"comprehensive":[114],"workflow.":[116]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-11T00:00:00"}
