{"id":"https://openalex.org/W4407285649","doi":"https://doi.org/10.20944/preprints202502.0509.v1","title":"The Effect of Telomerase Activator ASTCOQ02 on Cognitive Factors in Middle-Aged Adults: A randomized Double-Bling Study","display_name":"The Effect of Telomerase Activator ASTCOQ02 on Cognitive Factors in Middle-Aged Adults: A randomized Double-Bling Study","publication_year":2025,"publication_date":"2025-02-07","ids":{"openalex":"https://openalex.org/W4407285649","doi":"https://doi.org/10.20944/preprints202502.0509.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202502.0509.v1","doi":"https://doi.org/10.20944/preprints202502.0509.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202502.0509.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/32d8785e8d863c11092d7fe7394e09e0/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/frontend/manuscript/32d8785e8d863c11092d7fe7394e09e0/download_pub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078583885","display_name":"Christophe de Jaeger","orcid":"https://orcid.org/0000-0002-4440-546X","observed_orcids":["https://orcid.org/0000-0002-4440-546X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christophe de Jaeger","raw_affiliation_strings":["Institute of Medicine and Physiology of Longevity (Institut de Jaeger) , 127, rue de la Faisanderie , 75016 Paris , France"],"raw_orcid":"https://orcid.org/0000-0002-4440-546X","affiliations":[{"raw_affiliation_string":"Institute of Medicine and Physiology of Longevity (Institut de Jaeger) , 127, rue de la Faisanderie , 75016 Paris , France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106969121","display_name":"Hani Baramki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hani Baramki","raw_affiliation_strings":["Inserm UMR S_1139 , 75015 Paris , France","Institute of Medicine and Physiology of Longevity (Institut de Jaeger) , 127, rue de la Faisanderie , 75016 Paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm UMR S_1139 , 75015 Paris , France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institute of Medicine and Physiology of Longevity (Institut de Jaeger) , 127, rue de la Faisanderie , 75016 Paris , France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109194578","display_name":"Jean Louis Beaudeux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Louis Beaudeux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066076898","display_name":"Patrick Cherin","orcid":"https://orcid.org/0000-0003-2781-7195","observed_orcids":["https://orcid.org/0000-0003-2781-7195"]},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Cherin","raw_affiliation_strings":["Service de M\u00e9decine Interne 2 , Institut E3M , Sorbonne Universit\u00e9 , Assistance Publique-H\u00f4pitaux de Paris ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de M\u00e9decine Interne 2 , Institut E3M , Sorbonne Universit\u00e9 , Assistance Publique-H\u00f4pitaux de Paris ,","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210097159"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078583885"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activators","display_name":"telomerase activators","score":0.8960000276565552},{"id":"https://openalex.org/keywords/astragalus","display_name":"Astragalus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.8130000233650208},{"id":"https://openalex.org/keywords/middle-aged-adults","display_name":"middle-aged adults","score":0.7940000295639038},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7620000243186951},{"id":"https://openalex.org/keywords/p300-latency","display_name":"P300 latency","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8358975052833557},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7740859389305115},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5399283170700073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5104957818984985},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.4968560039997101},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.47890153527259827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46790844202041626},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.41734617948532104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3517836928367615},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3359218239784241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17073675990104675},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15265464782714844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12658438086509705},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.12392634153366089},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11594176292419434},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202502.0509.v1","doi":"https://doi.org/10.20944/preprints202502.0509.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202502.0509.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/32d8785e8d863c11092d7fe7394e09e0/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202502.0509.v1","doi":"https://doi.org/10.20944/preprints202502.0509.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202502.0509.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/32d8785e8d863c11092d7fe7394e09e0/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324526","display_name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","ror":"https://ror.org/01g80gk13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407285649.pdf","grobid_xml":"https://content.openalex.org/works/W4407285649.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1895538680","https://openalex.org/W2034370779","https://openalex.org/W2075402786","https://openalex.org/W2097529540","https://openalex.org/W2101800098","https://openalex.org/W2104640717","https://openalex.org/W2149450071","https://openalex.org/W2160427616","https://openalex.org/W2290642869","https://openalex.org/W2890004445","https://openalex.org/W3121300443"],"related_works":["https://openalex.org/W4307380896","https://openalex.org/W3200938121","https://openalex.org/W4388185503","https://openalex.org/W4402199002","https://openalex.org/W7131652718","https://openalex.org/W2025145992","https://openalex.org/W2969400161","https://openalex.org/W2049929300","https://openalex.org/W4403989423","https://openalex.org/W4307812771"],"abstract_inverted_index":{"Background/Objectives:":[0],"Telomere":[1],"shortening":[2],"is":[3,9],"a":[4,23,100,178],"hallmark":[5],"of":[6,21],"aging":[7],"and":[8,42,77,93,134,177],"implicated":[10],"in":[11,33,110,161,180,199],"cognitive":[12,31,111,197,217],"decline.":[13],"This":[14],"study":[15],"aimed":[16],"to":[17,169,185],"evaluate":[18],"the":[19],"effects":[20],"ASTCOQ02,":[22],"natural":[24],"telomerase":[25,40,204],"activator":[26],"derived":[27],"from":[28],"Astragalus,":[29],"on":[30],"performance":[32,71,198],"middle-aged":[34,200],"adults.":[35],"Secondary":[36],"objectives":[37],"included":[38],"assessing":[39],"activation":[41,82,155],"antioxidant":[43,95],"capacity.":[44],"Methods:":[45],"A":[46],"randomized":[47],"double-blind,":[48],"placebo-controlled":[49],"trial":[50],"was":[51,72,83,97,156],"conducted":[52],"with":[53],"40":[54],"healthy":[55],"volunteers":[56],"(mean":[57],"age":[58],"56.1":[59],"\u00b1":[60,118,125,140,146,166,171],"6.0":[61],"years)":[62],"receiving":[63],"ASTCOQ02":[64,105,195],"or":[65],"placebo":[66],"for":[67,214],"six":[68,129,149],"months.":[69],"Cognitive":[70],"assessed":[73,98],"using":[74],"P300":[75,115],"potentials":[76],"Rey\u2019s":[78,136],"15-word":[79],"test.":[80],"Telomerase":[81,154],"evaluated":[84],"through":[85],"telomere":[86,163,221],"length":[87,164],"dynamics":[88],"measured":[89],"by":[90,158],"HT":[91],"Q-FISH,":[92],"plasma":[94],"capacity":[96,191],"as":[99,211],"secondary":[101],"outcome.":[102],"Results:":[103],"The":[104],"group":[106],"showed":[107],"significant":[108],"improvements":[109],"metrics,":[112],"including":[113],"reduced":[114],"latency":[116],"(274.1":[117],"17.5":[119],"ms":[120,127],"at":[121,128,142,148],"baseline":[122,143],"vs.":[123,144],"262.4":[124],"19.2":[126],"months;":[130,150],"p":[131,151,174,187],"=":[132,152,175,188],"0.017)":[133],"in-creased":[135],"test":[137],"scores":[138],"(58.5":[139],"8.7":[141],"61.6":[145],"8.4":[147],"0.02).":[153],"evidenced":[157],"an":[159,212],"increase":[160],"median":[162],"(9.81":[165],"0.82":[167],"kb":[168],"10.28":[170],"0.88":[172],"kb;":[173],"0.008)":[176],"reduction":[179],"critically":[181],"short":[182],"telomeres":[183],"(6.65%":[184],"4.87%;":[186],"0.04).":[189],"Antioxidant":[190],"remained":[192],"unchanged.":[193],"Conclusions:":[194],"enhanced":[196],"adults,":[201],"likely":[202],"via":[203],"activation.":[205],"These":[206],"results":[207],"support":[208],"its":[209],"potential":[210],"intervention":[213],"mitigating":[215],"age-related":[216],"de-cline":[218],"while":[219],"maintaining":[220],"integrity.":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-02-10T00:00:00"}
