{"id":"https://openalex.org/W4407219665","doi":"https://doi.org/10.1073/pnas.2419884122","title":"The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly","display_name":"The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly","publication_year":2025,"publication_date":"2025-02-06","ids":{"openalex":"https://openalex.org/W4407219665","doi":"https://doi.org/10.1073/pnas.2419884122","pmid":"https://pubmed.ncbi.nlm.nih.gov/39913209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11831141"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2419884122","doi":"https://doi.org/10.1073/pnas.2419884122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2419884122","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2419884122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084950637","display_name":"Heidi Schubert","orcid":"https://orcid.org/0000-0003-1762-8390","observed_orcids":["https://orcid.org/0000-0003-1762-8390"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heidi L. Schubert","raw_affiliation_strings":["Department of Biochemistry, University of Utah"],"raw_orcid":"https://orcid.org/0000-0003-1762-8390","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448978","display_name":"Feng Li","orcid":"https://orcid.org/0000-0003-2795-1693","observed_orcids":["https://orcid.org/0000-0003-2795-1693"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feng Li","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086715753","display_name":"Christopher P. Hill","orcid":"https://orcid.org/0000-0001-6796-7740","observed_orcids":["https://orcid.org/0000-0001-6796-7740"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher P. Hill","raw_affiliation_strings":["Department of Biochemistry, University of Utah"],"raw_orcid":"https://orcid.org/0000-0001-6796-7740","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026990624","display_name":"Eric W. Schmidt","orcid":"https://orcid.org/0000-0001-5839-694X","observed_orcids":["https://orcid.org/0000-0001-5839-694X"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric W. Schmidt","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Utah"],"raw_orcid":"https://orcid.org/0000-0001-5839-694X","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026990624","https://openalex.org/A5084950637","https://openalex.org/A5086715753","https://openalex.org/A5100448978"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":3.3662,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.91906767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"122","issue":"6","first_page":"e2419884122","last_page":"e2419884122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.6401000022888184,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.1826999932527542,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-carrier-protein","display_name":"acyl carrier protein","score":0.7590000033378601},{"id":"https://openalex.org/keywords/polyketide-biosynthesis","display_name":"polyketide biosynthesis","score":0.824999988079071},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/sea-slugs","display_name":"sea slugs","score":0.41200000047683716},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7649999856948853},{"id":"https://openalex.org/keywords/enzyme-dynamics","display_name":"enzyme dynamics","score":0.5600000023841858},{"id":"https://openalex.org/keywords/product-specificity","display_name":"product specificity","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.9183475375175476},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6479892134666443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.527353823184967},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5139610171318054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4944603443145752},{"id":"https://openalex.org/C2780786045","wikidata":"https://www.wikidata.org/wiki/Q1087229","display_name":"Acyl carrier protein","level":4,"score":0.47553133964538574},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4633057713508606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3814956545829773},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.334070086479187},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.33101436495780945},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000213","descriptor_name":"Acyl Carrier Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000213","descriptor_name":"Acyl Carrier Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2419884122","doi":"https://doi.org/10.1073/pnas.2419884122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2419884122","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2024.07.22.604177","doi":"https://doi.org/10.1101/2024.07.22.604177","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.07.22.604177","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/07/23/2024.07.22.604177.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11831141","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11831141","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11831141/pdf/pnas.202419884.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:39913209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39913209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2419884122","doi":"https://doi.org/10.1073/pnas.2419884122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2419884122","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1213529597","display_name":null,"funder_award_id":"436923","funder_id":"https://openalex.org/F4320309233","funder_display_name":"Oregon Health and Science University"},{"id":"https://openalex.org/G3203396834","display_name":"Structure and Function of Animal Polyketide Synthases: Bridging Lipid and Polyketide Biology","funder_award_id":"2203613","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4429615956","display_name":null,"funder_award_id":"U24GM129547","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5868986941","display_name":"Pacific Northwest Center for Cryo-EM","funder_award_id":"U24GM129547","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6681929179","display_name":"Pacific Northwest Center for Cryo-EM","funder_award_id":"1r24gm154185-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G786093667","display_name":null,"funder_award_id":"R24 GM154185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1485234841","https://openalex.org/W1535893202","https://openalex.org/W1985565418","https://openalex.org/W2004481736","https://openalex.org/W2006530855","https://openalex.org/W2019477751","https://openalex.org/W2028669766","https://openalex.org/W2030203546","https://openalex.org/W2035349744","https://openalex.org/W2042605249","https://openalex.org/W2054474037","https://openalex.org/W2074749288","https://openalex.org/W2100071542","https://openalex.org/W2104130324","https://openalex.org/W2127549782","https://openalex.org/W2136959581","https://openalex.org/W2142161929","https://openalex.org/W2142925821","https://openalex.org/W2152570093","https://openalex.org/W2155028909","https://openalex.org/W2159489517","https://openalex.org/W2253512406","https://openalex.org/W2298603048","https://openalex.org/W2334993585","https://openalex.org/W2412202512","https://openalex.org/W2587625522","https://openalex.org/W2606755062","https://openalex.org/W2765322245","https://openalex.org/W2783874839","https://openalex.org/W2795648902","https://openalex.org/W2802753271","https://openalex.org/W2888241393","https://openalex.org/W2960717536","https://openalex.org/W2979618178","https://openalex.org/W2993066507","https://openalex.org/W3033090677","https://openalex.org/W3106966775","https://openalex.org/W3127183542","https://openalex.org/W3177828909","https://openalex.org/W3210495999","https://openalex.org/W3211302022","https://openalex.org/W4206824777","https://openalex.org/W4280603417","https://openalex.org/W4281485879","https://openalex.org/W4281790889","https://openalex.org/W4296868043","https://openalex.org/W4324044833","https://openalex.org/W4365445427","https://openalex.org/W4376126459","https://openalex.org/W4377245863","https://openalex.org/W4381490617","https://openalex.org/W4385827630","https://openalex.org/W4386590200","https://openalex.org/W4387772977","https://openalex.org/W4388516122","https://openalex.org/W4390099267","https://openalex.org/W4390533861","https://openalex.org/W4390828789","https://openalex.org/W4392091326","https://openalex.org/W4395445773","https://openalex.org/W6888870772","https://openalex.org/W6907353637","https://openalex.org/W6907453529","https://openalex.org/W6926362118","https://openalex.org/W6945262569"],"related_works":["https://openalex.org/W4386590200","https://openalex.org/W3004930795","https://openalex.org/W4389025658","https://openalex.org/W4390533861","https://openalex.org/W7071702248","https://openalex.org/W2048796834","https://openalex.org/W2586430589","https://openalex.org/W3024247376","https://openalex.org/W3082756599","https://openalex.org/W2588495019"],"abstract_inverted_index":{"The":[0],"polyketide":[1,92,205],"synthases":[2,11],"(PKSs)":[3],"in":[4,12,31,52,79,125],"microbes":[5],"and":[6,61,91,175,199,204],"the":[7,50,76,94,102,113,130,146,153,156,176,183,187,191,208],"cytoplasmic":[8],"fatty":[9,89],"acid":[10,90],"humans":[13],"(FASs)":[14],"are":[15],"related":[16],"enzymes":[17,86],"that":[18,71,87,163],"have":[19,69],"been":[20],"well":[21],"studied.":[22],"As":[23],"a":[24,28,38,53,82,161],"result,":[25],"there":[26],"is":[27,141,150],"paradigm":[29],"explaining":[30],"general":[32],"terms":[33],"how":[34],"FASs":[35],"repeatedly":[36],"use":[37,49],"set":[39],"of":[40,85,106,123,132,155,186,210],"enzymatic":[41,147],"domains":[42,51,148,174,209],"to":[43,58,75,189],"produce":[44,59],"simple":[45],"fats,":[46],"while":[47],"PKSs":[48,70,97,124],"much":[54],"more":[55],"complex":[56],"manner":[57],"pharmaceuticals":[60],"other":[62],"elaborate":[63,197],"molecules.":[64],"However,":[65],"most":[66],"animals":[67],"also":[68],"do":[72],"not":[73,143],"conform":[74],"rules":[77],"described":[78],"microbes,":[80],"including":[81],"large":[83],"family":[84],"bridge":[88],"metabolism,":[93],"animal":[95],"FAS-like":[96],"(AFPKs).":[98],"Here,":[99],"we":[100],"present":[101],"cryoelectron":[103],"microscopy":[104],"structures":[105],"two":[107],"AFPKs":[108,133],"from":[109],"sea":[110],"slugs.":[111],"While":[112],"AFPK":[114],"resemble":[115],"mammalian":[116],"FASs,":[117],"their":[118],"chemical":[119,139,193],"products":[120],"mimic":[121],"those":[122],"complexity.":[126],"How":[127],"then":[128],"does":[129],"architecture":[131],"facilitate":[134],"this":[135],"structural":[136],"complexity?":[137],"Unexpectedly,":[138],"complexity":[140],"controlled":[142],"solely":[144],"by":[145,152],"but":[149],"aided":[151],"dynamics":[154],"acyl":[157],"carrier":[158],"protein":[159],"(ACP),":[160],"shuttle":[162],"moves":[164],"intermediates":[165],"between":[166,172],"these":[167],"domains.":[168],"We":[169],"observed":[170],"interactions":[171],"enzyme":[173,188,200],"linker-ACP":[177],"domain,":[178],"which,":[179],"when":[180],"manipulated,":[181],"altered":[182],"kinetic":[184],"properties":[185],"change":[190],"resulting":[192],"products.":[194],"This":[195],"unveils":[196],"mechanisms":[198],"motions":[201],"underlying":[202],"lipid":[203],"biochemistry":[206],"across":[207],"life.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-07T00:00:00"}
