{"id":"https://openalex.org/W4407204368","doi":"https://doi.org/10.1055/s-0045-1802338","title":"Sensorineural Hearing Loss after Chemoradiotherapy with High-Dose Cisplatin in Patients with Head and Neck Cancer","display_name":"Sensorineural Hearing Loss after Chemoradiotherapy with High-Dose Cisplatin in Patients with Head and Neck Cancer","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4407204368","doi":"https://doi.org/10.1055/s-0045-1802338"},"language":"en","primary_location":{"id":"doi:10.1055/s-0045-1802338","doi":"https://doi.org/10.1055/s-0045-1802338","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1802338","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1802338.pdf","source":{"id":"https://openalex.org/S4210171054","display_name":"International Journal of Practical Otolaryngology","issn_l":"2569-1783","issn":["2569-1783"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Practical Otolaryngology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1802338.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066489190","display_name":"Ryosuke Kitoh","orcid":"https://orcid.org/0009-0004-8123-1835","observed_orcids":["https://orcid.org/0009-0004-8123-1835"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Kitoh","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kota Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kota Hirose","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023051676","display_name":"Mariko Kasuga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mariko Kasuga","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003283332","display_name":"Kentaro Hori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Hori","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085418090","display_name":"Yoh Yokota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoh Yokota","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046395040","display_name":"Yoh-ichiro Iwasa","orcid":"https://orcid.org/0000-0001-8989-9021","observed_orcids":["https://orcid.org/0000-0001-8989-9021"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoh-ichiro Iwasa","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026443681","display_name":"Yutaka Takumi","orcid":"https://orcid.org/0000-0003-2874-9796","observed_orcids":["https://orcid.org/0000-0003-2874-9796"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Takumi","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto-shi, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137975476"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01953777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"08","issue":"01","first_page":"e8","last_page":"e18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8880000114440918},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hearing-threshold-shift","display_name":"hearing threshold shift","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cisplatin-dose","display_name":"cisplatin dose","score":0.7289999723434448},{"id":"https://openalex.org/keywords/high-frequency-hearing-loss","display_name":"high-frequency hearing loss","score":0.6669999957084656},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.8607932329177856},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.7404541373252869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7271321415901184},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.6950282454490662},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6812636852264404},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.5017344951629639},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.4473159909248352},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.399921715259552},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.387421190738678},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36632248759269714},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32675421237945557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23989951610565186},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18159744143486023}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0045-1802338","doi":"https://doi.org/10.1055/s-0045-1802338","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1802338","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1802338.pdf","source":{"id":"https://openalex.org/S4210171054","display_name":"International Journal of Practical Otolaryngology","issn_l":"2569-1783","issn":["2569-1783"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Practical Otolaryngology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1055/s-0045-1802338","doi":"https://doi.org/10.1055/s-0045-1802338","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1802338","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1802338.pdf","source":{"id":"https://openalex.org/S4210171054","display_name":"International Journal of Practical Otolaryngology","issn_l":"2569-1783","issn":["2569-1783"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Practical Otolaryngology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407204368.pdf","grobid_xml":"https://content.openalex.org/works/W4407204368.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1834541252","https://openalex.org/W1990511111","https://openalex.org/W2018768559","https://openalex.org/W2046701188","https://openalex.org/W2053055917","https://openalex.org/W2087106022","https://openalex.org/W2148507283","https://openalex.org/W2148978886","https://openalex.org/W2186532570","https://openalex.org/W2791448640","https://openalex.org/W2990308328","https://openalex.org/W3038416958","https://openalex.org/W3179533473","https://openalex.org/W4214856762","https://openalex.org/W4241208323","https://openalex.org/W4317506875","https://openalex.org/W4321180390","https://openalex.org/W4379207640","https://openalex.org/W4399741731"],"related_works":["https://openalex.org/W1966633243","https://openalex.org/W645215213","https://openalex.org/W2737968823","https://openalex.org/W4245895529","https://openalex.org/W2148507283","https://openalex.org/W2219950720","https://openalex.org/W4281788794","https://openalex.org/W1571358543","https://openalex.org/W2071250522","https://openalex.org/W1834541252"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"To":[2],"investigate":[3],"sensorineural":[4],"hearing":[5,66,85,90,160,171],"loss":[6],"in":[7,61,133,170],"patients":[8,178],"with":[9,17,33,51,99,179,186],"head":[10,46,180],"and":[11,30,38,47,57,73,109,130,157,181],"neck":[12,48,182],"cancer":[13,49,183],"receiving":[14,184],"chemoradiotherapy":[15],"(CRT)":[16],"a":[18,100],"standard":[19],"regimen":[20],"of":[21,45,103,120,217],"high-dose":[22,34,52,187],"cisplatin,":[23,188],"focusing":[24],"on":[25],"the":[26,131,134,144,155,168,215],"acute":[27],"changes":[28,132],"before":[29,72,143],"after":[31,74,117,127,139,206],"CRT":[32,54,185],"cisplatin":[35],"(CDDP).":[36],"Materials":[37],"Methods":[39],"A":[40],"total":[41],"of,":[42],"135":[43],"cases":[44],"treated":[50],"cisplatin-based":[53],"between":[55],"2014":[56],"2023":[58],"were":[59,78,147,162],"included":[60],"this":[62],"retrospective":[63],"study.":[64],"The":[65,88,115,201],"threshold":[67,91,101,116,189,202],"shifts":[68],"at":[69,95,106,112,124,173,194],"each":[70,75,118],"frequency":[71],"CDDP":[76,121,128,150,207],"dose":[77,153],"used":[79],"as":[80,164,198],"an":[81],"indicator":[82],"to":[83,141,154],"assess":[84],"impairment.":[86],"Results":[87],"CRT-induced":[89],"shift":[92],"was":[93,122,191],"greater":[94],"frequencies":[96,195],">4,000":[97,196],"Hz,":[98,197],"increment":[102,190,203],"\u223c10":[104],"dB":[105,111],"4,000":[107],"Hz":[108],"20":[110],"8,000":[113,174],"Hz.":[114,175],"course":[119,146],"elevated":[123],"one":[125,137],"week":[126,138],"administration,":[129,208],"thresholds":[135,161,172],"from":[136],"administration":[140],"just":[142],"subsequent":[145],"small.":[148],"Total":[149],"dose,":[151],"radiation":[152],"cochlea,":[156],"mean":[158],"pretreatment":[159],"identified":[163],"significant":[165],"factors":[166],"influencing":[167],"increase":[169],"Conclusion":[176],"In":[177],"predominantly":[192],"observed":[193],"previously":[199],"reported.":[200],"occurred":[204],"immediately":[205],"which":[209],"might":[210],"be":[211],"relevant":[212],"when":[213],"considering":[214],"timing":[216],"future":[218],"interventions.":[219]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-02-07T00:00:00"}
